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Journal of Environmental Sciences 2021年第8期33卷 147-160页

作者： Jingjing jiang Jiaying Gao shu Niu Xingyue Wang Tianren Li Shengda Liu Yanhong lin Tengfeng Xie shuangshi Dong Key Laboratory of Groundwater Resources and Environment Ministry of EducationJilin UniversityChangchun 130021China Jilin Provincial Key Laboratory of Water Resources and Environment Jilin UniversityChangchun 130021China College of Chemistry Jilin UniversityChangchun 130012

The extensive use of tetracycline hydrochloride(TCH)poses a threat to human health and the aquatic ***,magnetic p-n Bi2WO6/CuFe2O4 catalyst was fabricated to efficiently remove *** obtained Bi2WO6/CuFe2O4 exhibited 92.1%TCH degradation efficiency and 50.7%and 35.1%mineralization performance for TCH and raw secondary effluent from a wastewater treatment plant in a photo-Fenton-like system,*** remarkable performance was attributed to the fact that photogenerated electrons accelerated the Fe(III)/Fe(II)and Cu(II)/Cu(I)conversion for the Fenton-like reaction between Fe(II)/Cu(I)and H2O2,thereby generating abundant·OH for pollutant *** environmental factors including H2O2 concentration,initial pH,catalyst dosage,TCH concentration and inorganic ions were *** reactive oxidation species(ROS)quenching results and electron spin resonance(ESR)spectra confirmed that·O2-and·OH were responsible for the dark and photo-Fenton-like systems,*** degradation mechanisms and pathways of TCH were proposed,and the toxicity of products was *** work contributes a highly efficient and environmentally friendly catalyst and provides a clear mechanistic explanation for the removal of antibiotic pollutants in environmental remediation.

关键词： Magnetic Bi2WO6/CuFe2O4 Tetracycline hydrochloride Degradation Reactive oxidation species Toxicity assessment

Charge effects on quinoline hydrodenitrogenation catalyzed by Ni-Mo-S active sites-A theoretical study by DFT calculation

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Petroleum Science 2022年第1期19卷 339-344页

作者： Si-Jia Ding Shao-Zhong Peng Zuo-Jie Yan Ji-Feng Wang shu-Jiao jiang Zhan-lin Yang Dalian Research Institute of Petroleum and Petrochemicals SINOPECDalian116041China Fushun Petrochemical Company FushunLiaoning113001China

The charge distribution on Ni-Mo-S active sites can affect hydrodenitrogenation(HDN)*** this study,a series of model Ni-Mo-S were developed with various charge *** comparison,the charge distribution effects on quinoline HDN were *** results show that a lack of electrons and extra protons can both lower the orbital eigenvalue of the Ni-Mo-S,leading to stronger adsorption of nitrogen-containing compounds and inhibition of ammonia *** deficiency will improve the generation of active hydrogen on the active sites but inhibit hydrogen transfer to the nitrogen compounds;extra protons can provide H^(+)to the nitrogen compounds,which will flexibly transfer between the nitrogen compound and active sites,thus improving the cleavage of the C-N bond.

关键词： Charge distribution Ni-Mo-S active Sites Quinoline Hydrodenitrogenation Quantum chemistry calculation

Self-adaptive Algorithm for Simulating Sand Painting in Real-Time

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Chinese Journal of Electronics 2019年第3期28卷 559-568页

作者： YANG Meng jiang Luyan DING shu ZHANG Xinyang YAN shu YANG Gang School of Information Science and Technology Beijing Forestry University

Sand painting is a form of combination of arts and modern aesthetic, which relies on profound cultural heritage and cultural connotation. To provide the public and artists with an opportunity to better understand sand painting and make art creations surprisingly, this paper proposes a self-adaptive algorithm to simulate sand painting in a real-time way. Our simulation system exploits the height field to simulate sand flow to achieve a fast even real-time target. Seven frequently-used styles of painting techniques are elaborately defined and successfully simulated in our system, including pouring,seeping, dotting, stroking, sweeping, multi-stroking, and pinching. The procedure of sand flow is mainly consist of two key parts: sand accumulation and collapse. The direction field is introduced into the system to control a similar appearance of a normal distribution, which will be of benefit to sand accumulation algorithm. A selfadaptive approach is taken advantage of into sand collapse algorithm to present certain appearances with various details. A color factor is also considered for realistic simulation in this paper in two ways: one is the background color of sand table/canvas and the other is the natural color of sand particles themselves. User feedbacks and experimental results reveal that the algorithm of sand painting simulation in this paper can realize kinds of sand painting arts of creations easily, realistically, effectively and interactively.

关键词： Height and direction fields Self-adaptive Accumulation Collapse Colorized sand

Discovery of novel inhibitors of anti-apoptotic Bcl-2 proteins derived from Bim BH3 domain

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Chinese Chemical Letters 2017年第7期28卷 1523-1527页

作者： Chuan-Liang Zhang Shan Liu Xiao-Chun Liu jiang-Ming Gao shu-lin Wang School of Medicine and Pharmacy Key Laboratory of Marine DrugsMinistry of EducationOcean University of ChinaQingdao 266003China Marine Biomedical Research Institute Qingdao 266071China

The BH3 mimetics targeting the interaction between the BH3-only proteins and their prosurvival Bcl-2family proteins have shown enormous potential as cancer therapeutics. Herein, seven analogues targeting anti-apoptotic Bcl-2 proteins derived from the Bim BH3 domain via sequence simplification and/or modification are described. The in vitro binding affinity on anti-apoptotic Bcl-2 proteins and cell killing activity were evaluated. The results showed that analogues could significantly bind to target proteins and exhibited anti-cancer effect against three cancer cell lines. Of particular interest were the analogue SM-5（KD= 9.48 nmol/L for Bcl-2） and SM-6（KD= 0.08 nmol/L for Bcl-xL）, which exhibited improved binding affinity compared with the lead Bim（KD= 16.90 nmol/L for Bcl-2 and 22.2 nmol/L for Bcl-xL, respectively）. These results indicated that the peptide sequence containing the four hydrophobic side chains occupying pockets within the BH3-recognition cleft of anti-apoptotic Bcl-2 proteins might be the minimum sequence required for the bioactivity and the active core region of Bim. Promising inhibitors of anti-apoptotic Bcl-2 proteins with high bioactivity might be designed based on the active core.

关键词： Apoptosis Anti-apoptotic Bcl-2 proteins Bim BH3 domain Binding affinity Anti-cancer activity

Multilayer perceptron neural network activated by adaptive Gaussian radial basis function and its application to predict lid-driven cavity flow

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Acta Mechanica Sinica 2021年第12期37卷 1757-1772页

作者： Qinghua jiang Lailai Zhu Chang shu Vinothkumar Sekar Department of Mechanical Engineering National University of Singapore10 Kent Ridge CrescentSingapore 117576Singapore

To improve the performance of multilayer perceptron(MLP)neural networks activated by conventional activation functions,this paper presents a new MLP activated by univariate Gaussian radial basis functions(RBFs)with adaptive centers and widths,which is composed of more than one hidden *** the hidden layer of the RBF-activated MLP network(MLPRBF),the outputs of the preceding layer are first linearly transformed and then fed into the univariate Gaussian RBF,which exploits the highly nonlinear property of *** RBFs might address the issues of saturated outputs,low sensitivity,and vanishing gradients in MLPs activated by other prevailing nonlinear ***,we apply four MLP networks with the rectified linear unit(ReLU),sigmoid function(sigmoid),hyperbolic tangent function(tanh),and Gaussian RBF as the activation functions to approximate the one-dimensional(1D)sinusoidal function,the analytical solution of viscous Burgers’equation,and the two-dimensional(2D)steady lid-driven cavity *** the same network structure,MLP-RBF generally predicts more accurately and converges faster than the other ***-RBF using less hidden layers and/or neurons per layer can yield comparable or even higher approximation accuracy than other MLPs equipped with more layers or neurons.

关键词： Multilayer perceptron neural network Activation function Radial basis function Numerical approximation

Critical Content of MgO in Spheroidisers

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Journal of Iron and Steel Research International 2006年第1期13卷 1-4页

作者： SHENG Da LI shu-jiang LU Yue-mei lin Xiao-ying CHEN Shao-chun Department of Mechanical Engineering Tsinghua University Beijing 100084 China Mechanical Engineering and Automation Institute Fuzhou University Fuzhou 350002 Fuiian China

Magnesium oxide in spheroidiser is harmful to the production of ductile iron for decreasing active magnesium content. To obtain quality ductile iron, the effects of magnesium oxide content in spheroidisers on spheroidising treatment, microstrucure and properties of ductile iron were researched, and the critical magnesium oxide in spheroidisers was determined.

关键词： magnesium oxide critical content spheroidiser ductile iron

Beneficial effects of antidepressant mirtazapine in functional dyspepsia patients with weight loss

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World Journal of Gastroenterology 2016年第22期22卷 5260-5266页

作者： shu-Man jiang lin Jia Jing Liu Man-Man Shi Ming-Zhi Xu Department of Gastroenterology Guangzhou First People’s Hospital Guangzhou Medical University Department of Gastroenterology Guangzhou Nansha Central Hospital Department of Psychology Guangdong General Hospital

AIM: To explore the effects and mechanism of action of antidepressant mirtazapine in functional dyspepsia(FD) patients with weight ***: Sixty depressive FD patients with weight loss were randomly divided into a mirtazapine group(MG), a paroxetine group(PG) or a conventional therapy group(CG) for an 8-wk clinical trial. Adverse effects and treatment response were recorded. The Nepean Dyspepsia Index-symptom(NDSI) checklist and the 17-item Hamilton Rating Scale of Depression(HAMD-17) were used to evaluate dyspepsia and depressive symptoms, respectively. The body composition analyzer was used to measure body weight and fat. Serum hormone levels were measured by ***:(1) After 2 wk of treatment, NDSI scores were significantly lower for the MG than for the PG and CG;(2) After 4 or 8 wk of treatment, HAMD-17 scores were significantly lower for the MG and PG than for the CG;(3) After 8 wk of treatment, patients in the MG experienced a weight gain of 3.58 ± 1.57 kg, which was significantly higher than that observed for patients in the PG and CG. Body fat increased by 2.77 ± 0.14kg, the body fat ratio rose by 4%, and the visceral fat area increased by 7.56 ± 2.25 cm2; and(4) For the MG, serum hormone levels of ghrelin, neuropeptide Y(NPY), motilin(MTL) and gastrin(GAS) were significantly upregulated; in contrast, those of leptin, 5-hydroxytryptamine(5-HT) and cholecystokinin(CCK) were significantly downregulated. CONCLUSION: Mirtazapine not only alleviates symptoms associated with dyspepsia and depression linked to FD in patients with weight loss but also significantly increases body weight(mainly the visceral fat in body fat). The likely mechanism of mirtazapine action is regulation of brain-gut or gastrointestinal hormone levels.

关键词： Mirtazapine Functional dyspepsia weight loss Depression

Can snakes use yolk reserves to maximize body size at hatching?

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Current Zoology 2019年第6期65卷 627-631页

作者： Yan-Fu QU shu-Zhan ZHAO Xu-Fei jiang Long-Hui lin Xiang JI jiangsu Key Laboratory for Biodiversity and Biotechnology College of Life SciencesNanjing Normal UniversityNanjingJiangsuChina Hangzhou Key Laboratory for Animal Adaptation and Evolution College of Life and Environmental SciencesHangzhou Normal UniversityHangzhouZhejiangChina

We experimentally miniaturized freshly laid eggs of the Chinese cobra Naja atra(Elapidae)by removing^10%and^20%of original *** tested if yolk-reduced eggs would produce 1)normal-sized hatchlings with invariant yolk-free body mass(and thus invariant linear size)but dramatically reduced or even completely depleted residual yolk,2)smaller hatchlings with normalsized residual yolk but reduced yolk-free body mass,or 3)smaller hatchlings of which both yolk-free body mass and residual yolk are proportionally *** quantity affected hatchling linear size(both snout-vent length and tail length)and body ***,changes in yolk quantity did not affect incubation length or any hatchling trait examined after accounting for egg mass at laying(for control and sham-manipulated eggs)or after yolk removal(for manipulated eggs).Specifically,yolk-reduced eggs produced hatchlings of which all major components(carcass,residual yolk,and fat bodies)were scaled down *** show that snakes cannot use yolk reserves to maximize their body size at ***,our data also suggest that the partitioning of yolk in embryonic snakes is species-specific.

关键词： hatchling phenotype Naja atra residual yolk snake yolk partitioning yolk removal

Effect of low-dose amitriptyline on globus pharyngeus and its side effects

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World Journal of Gastroenterology 2013年第42期19卷 7455-7460页

作者： Le-Qing You Jing Liu lin Jia shu-Man jiang Gui-Qin Wang Department of Gastroenterology Guangzhou First People’s HospitalGuangzhou Medical University Department of Gastroenterology Guangzhou Nansha Central Hospital

AIM:To compare the efficacy and side effects of lowdose amitriptyline(AMT)with proton pump inhibitor treatment in patients with globus ***:Thirty-four patients who fulfilled the RomeⅢcriteria for functional esophageal disorders were included in this *** were randomly assigned to receive either 25 mg AMT before bedtime(AMT group)or 40 mg Pantoprazole once daily for 4 wk(conventional group).The main efficacy endpoint was assessed using the Glasgow Edinburgh Throat Scale(GETS).The secondary efficacy endpoints included the Medical Outcomes Study 36-item short form health survey[social functioning(SF)-36]and the Pittsburgh Sleep Quality *** response was defined as a>50%reduction in GETS *** patients entering this study recorded side effects at days 1,8,15,22 and 29 using a visual analogue ***:Thirty patients completed the *** 4 wk of treatment,the AMT group had a greater response than the conventional group(75%vs 35.7%,P=0.004).At day 3,the AMT group showed significantly more improvement than the Conventional group in GETS score(3.69±1.14 vs 5.64±1.28,P=0.000).After 4 wk of treatment,the AMT group showed significantly greater improvement in GETS score and sleep quality than the Conventional group(1.25±1.84 vs 3.79±2.33,4.19±2.07 vs 8.5±4.97;P<0.01 for both).Additionally,the AMT group was more likely than the Conventional group to experience improvement in the SF-36,including general health,vitality,social functioning and mental health(P=0.044,0.024,0.049 and 0.005).Dry mouth,sleepiness,dizziness and constipation were the most common side ***:Low-dose AMT is well tolerated and can significantly improve patient symptoms,sleep and quality of ***,low-dose AMT may be an effective treatment for globus pharyngeus.

关键词： Amitriptyline Globus pharyngeus Side effect Pantoprazole Treatment response

Endocast Morphological Variation and Its Driving Forces in Scutiger boulengeri

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Asian Herpetological Research 2022年第4期13卷 269-283页

作者： Yinmeng HOU Xiaoxiao shu Shengchao SHI Xiuqin lin Luyao XIAO Jianping jiang jianghong RAN Feng XIE CAS Key Laboratory of Mountain Ecological Restoration and Bioresource Utilization Ecological Restoration and Biodiversity Conservation Key Laboratory of Sichuan ProvinceChengdu Institute of BiologyChinese Academy of SciencesChengdu 610041SichuanChina College of Life Sciences Sichuan UniversityChengdu 610065SichuanChina University of the Chinese Academy of Sciences Bejing 100049China Mangkang Biodiversity and Ecological Station Tibet Ecological Safety Monitor NetworkChangdu 854500TibetChina

Cranialendocasts canbeusedasareliable proxy for brain size,reflecting the evolutionary and environmental selection pressure of *** studies on endocasts in amphibians have increased in recent years,those performed on endocasts of Anura are comparatively rare,especially at the intraspecific ***,using a high-altitude endemic toad-Scutiger boulengeri-as a model,through the application of integrative methods(morphology,anatomy,phylogeny,and ecology),we studied intraspecific variations in endocast morphology and explored its driving ***-dimensional reconstruction and the brain-to-endocranial cavity(BEC)index suggested that the endocast of *** can reflect brain morphology to a large *** Fourier analysis andprincipal componentanalysis revealedgreat variability in the cranial endocast morphology among individuals,as well as the variation concentrated in the regions of telencephalon and optic *** the species,individuals with large bodies are accompanied by a larger endocast size;the relative endocast sizes have significant cladedifferences but no sexual ***,the relative endocast sizes of *** were not associated with phylogenetic history and aquatic preference but were positively correlated with altitude and negatively correlated with oxygen content,temperature,and precipitation factors(annual mean temperature,temperature seasonality,annual precipitation,and precipitation seasonality).Thesefindings suggested that high-altitude and extreme environmental conditions acted as important selectiveforces in morphological variation of the cranial endocastof ***.

关键词： aquatic preference cranial endocast ecological adaptation phylogenetichistory shapevariation