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Impact of Antiretroviral Therapy on the Spread of Human Immunodeficiency Virus in Chaoyang District, Beijing, China： Using the Asian Epidemic Model

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Chinese Medical Journal 2017年第1期130卷 32-38页

作者： Li-Li Tao Min Liu shu-Ming Li Jue Liu shu-lin jiang Li-Juan Wang Feng-Ji Luo Ning Wang Department of Epidemiology and Biostatistics School of Public Health Peking University Beijing 100191 China Department of STD and AIDS Prevention and Control Beijing Chaoyang District Centre for Disease Control and Prevention Beijing 100021 China National Center for AIDS/STD Control and Prevention Chinese Center for Disease Control and Prevention Beijing 102206 China

Background： Successful antiretroviral therapy （ART） has been demonstrated to be effective in reducing the infectivity of human immunodeficiency virus （HIV）. We conducted a study to predict the potential effect of ART on the spread of HIV in Chaoyang District, Beijing, China, using the Asian Epidemic Model （AEM）. Methods： The AEM baseline workbook was used to determine the current infection status and to project the future spread of HIV under current conditions. We changed the input on the ART coverage from 2014 to 2025 and also modified the treatment eligibility in the AEM intervention workbook, in order to allow for analysis of the projected downstream impact of ART. Results： By gradually increasing the ART coverage rate from 29.7% （rate of 2013） to 40.0%, 50.0%, 60.0%, 70.0%, 80.0%, and 90.0% （at CD4＋ ≤350 cells/μl）, and by changing the dates of coverage from 2014 to 2020, the number of new infections showed a cumulative decline of 0.60%, 1.59%, 2.94%, 5.33%, 9.32%, and 14.98%, respectively. After 2020, the projected rates of infection rebounded slightly, so with the exception of the years with very high coverage （90.0%）, new infections continued to decrease. When we changed the initial threshold of therapy to CD4＋ cell counts ≤500 cells/μl, new infections decreased 6.00%, 11.64%, 15.92%, 21.11%, 26.92%, 33.05%, and 38.75%, respectively, under varying ART coverages. Conclusion： Our study demonstrates that the early initiation of ART for people living with HIV/acquired immune deficiency syndrome （AIDS） has a positive effect in slowing the spread of HIV.

关键词： Antiretroviral Therapy Asian Epidemic Model Human Immunodeficiency Virus Impact Transmission

Offload Strategy for Edge Computing in Satellite Networks Based on Software Defined Network

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Computers, Materials & Continua 2025年第1期82卷 863-879页

作者： Zhiguo Liu Yuqing Gui lin Wang Yingru jiang Communication and Network Laboratory Dalian UniversityDalian116622China College of Environment and Chemical Engineering Dalian UniversityDalian116622China

Satellite edge computing has garnered significant attention from researchers;however,processing a large volume of tasks within multi-node satellite networks still poses considerable *** sharp increase in user demand for latency-sensitive tasks has inevitably led to offloading bottlenecks and insufficient computational capacity on individual satellite edge servers,making it necessary to implement effective task offloading scheduling to enhance user *** this paper,we propose a priority-based task scheduling strategy based on a Software-Defined Network(SDN)framework for satellite-terrestrial integrated networks,which clarifies the execution order of tasks based on their ***,we apply a Dueling-Double Deep Q-Network(DDQN)algorithm enhanced with prioritized experience replay to derive a computation offloading strategy,improving the experience replay mechanism within the Dueling-DDQN ***,we utilize the Deep Deterministic Policy Gradient(DDPG)algorithm to determine the optimal resource allocation strategy to reduce the processing latency of *** results demonstrate that the proposed d3-DDPG algorithm outperforms other approaches,effectively reducing task processing latency and thus improving user experience and system efficiency.

关键词： Satellite network edge computing task scheduling computing offloading

Punicalagin protects bovine endometrial epithelial cells against lipopolysaccharide-induced inflammatory injury

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2017年第6期18卷 481-491页

作者： An LYU Jia-jia CHEN Hui-chuan WANG Xiao-hong YU Zhi-cong ZHANG Ping GONG lin-shu jiang Feng-hua LIU Beijing Key Laboratory for Dairy Cow Nutrition College of Animal Science and TechnologyBeijing University of AgricultureBeijing 102206China

Objective：Bovine endometritis is one of the most common reproductive disorders in *** aim of this study was to investigate the anti-inflammation potential of punicalagin in lipopolysaccharide（LPS）-induced bovine endometrial epithelial cells（bE ECs）and to uncover the underlying ***：bE ECs were stimulated with different concentrations（1,10,30,50,and 100μg/ml）of LPS for 3,6,9,12,and 18 *** assay was used to assess cell viability and to identify the conditions for inflammatory injury and effective concentrations of *** real-time polymerase chain reaction（q RT-PCR）was used to assess gene expression of pro-inflammatory *** blotting was used to assess levels of inflammation-related ***：Treatment of b EECs with 30μg/ml LPS for 12 h induced cell injury and reduced cell ***（5,10,or 20μg/ml）pretreatment significantly decreased LPS-induced productions of interleukin（IL）-1β,IL-6,IL-8,and tumor necrosis factor-α（TNF-α）in bE *** research showed that punicalagin inhibited the activation of the upstream mediator nuclear factor-κB（NF-κB）by suppressing the production of inhibitorκBα（IκBα）and phosphorylation of *** also indicated that punicalagin can suppress the phosphorylation of mitogen-activated protein kinases（MAPKs）including p38,c-Jun N-terminal kinase（JNK）,and extracellular signal-regulated kinase（ERK）.Conclusions：Punicalagin may attenuate LPS-induced inflammatory injury and provide a potential option for the treatment of dairy cows with Escherichia coli endometritis.

关键词： Bovine endometrial epithelial cell Cytokine Inflammatory injury Punicalagin

Magnolol pretreatment attenuates heat stress-induced IEC-6 cell injury

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2016年第6期17卷 413-424页

作者： Chen MEI Sha-sha HE Peng YIN Lei XU Ya-ran SHI Xiao-hong YU An LYU Feng-hua LIU lin-shu jiang Beijing Key Laboratory for Dairy Cow Nutrition College of Animal Science and Technology Beijing University of Agriculture College of Veterinary Medicine China Agricultural University (CAU)

Objective： Heat stress （HS） is an important environmental stressor that adversely influences livestock during the summer. The aim of this study was to investigate whether magnolol protects against HS-induced intestinal epithelial cell injury. Materials and methods： An intestinal epithelial cell line （IEC-6） was subjected to HS at 42℃, with and without magnolol pretreatment. Cell injury was detected by monitoring lactate dehydrogenase （LDH） release. MTS （3-（4,5-dimethyithiazol-2-yl）-5-（3-carboxymethoxyphenyl）-2-（4-sulfophenyl）-2H-tetrazolium） assay was used to as- sess cell proliferation and viability, including identifying effective concentrations of magnolol. Flow cytometry confirmed Gl-phase cell-cycle arrest and its alleviation by magnolol. Active DNA synthesis was measured by incorporation of nucleic acid 5-ethynyl-2＇-deoxyuridine （EdU）. Gl-phase cell-cycle-related gene expression was assessed by real-time reverse transcription polymerase chain reaction （RT-PCR） and levels of Gl-phase-related proteins by Western blotting Results： HS induced IEC-6 cell injury and decreased cell viability, as demonstrated by data from LDH and MTS assays respectively. Based on a number of criteria, IEC-6 cells subjected to HS were arrested in the G1 phase Of the cell cycle. Magnolol pretreatment decreased HS-induced cell injury through relief of this cell-cycle arrest. Conclusions： Magnolol pretreatment attenuates HS-induced injury in IEC-6 cells. Magnolol is potentially promising as a protective strategy for HS in livestock.

关键词： Cell-cycle arrest Cell injury Heat stress IEC-6 cell line Magnolol

Wafer‑Scale Vertical 1D GaN Nanorods/2D MoS_(2)/PEDOT:PSS for Piezophototronic Effect‑Enhanced Self‑Powered Flexible Photodetectors

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Nano-Micro Letters 2025年第3期17卷 102-116页

作者： Xin Tang Hongsheng jiang Zhengliang lin Xuan Wang Wenliang Wang Guoqiang Li State Key Laboratory of Luminescent Materials and Devices South China University of TechnologyGuangzhou 510640People’s Republic of China Department of Electronic Materials School of Materials Science and EngineeringSouth China University of TechnologyGuangzhou 510640People’s Republic of China

van der Waals(vdW)heterostructures constructed by lowdimensional(0D,1D,and 2D)materials are emerging as one of the most appealing systems in next-generation flexible ***,hand-stacked vdW-type photodetectors are not compatible with large-areaarray fabrication and show unimpressive performance in self-powered ***,vertical 1D GaN nanorods arrays(NRAs)/2D MoS_(2)/PEDOT:PSS in wafer scale have been proposed for self-powered flexible photodetectors arrays *** as-integrated device without external bias under weak UV illumination exhibits a competitive responsivity of 1.47 A W^(−1)and a high detectivity of 1.2×10^(11)Jones,as well as a fast response speed of 54/71μs,thanks to the strong light absorption of GaN NRAs and the efficient photogenerated carrier separation in type-II ***,the strain-tunable photodetection performances of device have been ***,the device at−0.78%strain and zero bias reveals a significantly enhanced photoresponse with a responsivity of 2.47 A W^(−1),a detectivity of 2.6×10^(11)Jones,and response times of 40/45μs,which are superior to the state-of-the-art self-powered flexible *** work presents a valuable avenue to prepare tunable vdWs heterostructures for self-powered flexible photodetection,which performs well in flexible sensors.

关键词： Vertical nanorod arrays van der Waals heterostructure Piezophototronic effect Self-powered photodetection Flexible sensors

Multi-model ensemble learning for battery state-of-health estimation:Recent advances and perspectives

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Journal of Energy Chemistry 2025年第1期100卷 739-759页

作者： Chuanping lin Jun Xu Delong jiang Jiayang Hou Ying Liang Zhongyue Zou Xuesong Mei State Key Laboratory for Manufacturing Systems Engineering Xi'an Jiaotong University Shaanxi Key Laboratory of Intelligent Robots School of Mechanical Engineering Xi'an Jiaotong University Department of Electrical Engineering and Automation Luoyang Institute of Science and Technology School of Mechanical Engineering Hangzhou Dianzi University

The burgeoning market for lithium-ion batteries has stimulated a growing need for more reliable battery performance monitoring. Accurate state-of-health(SOH) estimation is critical for ensuring battery operational performance. Despite numerous data-driven methods reported in existing research for battery SOH estimation, these methods often exhibit inconsistent performance across different application scenarios. To address this issue and overcome the performance limitations of individual data-driven models,integrating multiple models for SOH estimation has received considerable attention. Ensemble learning(EL) typically leverages the strengths of multiple base models to achieve more robust and accurate outputs. However, the lack of a clear review of current research hinders the further development of ensemble methods in SOH estimation. Therefore, this paper comprehensively reviews multi-model ensemble learning methods for battery SOH estimation. First, existing ensemble methods are systematically categorized into 6 classes based on their combination strategies. Different realizations and underlying connections are meticulously analyzed for each category of EL methods, highlighting distinctions, innovations, and typical applications. Subsequently, these ensemble methods are comprehensively compared in terms of base models, combination strategies, and publication trends. Evaluations across 6 dimensions underscore the outstanding performance of stacking-based ensemble methods. Following this, these ensemble methods are further inspected from the perspectives of weighted ensemble and diversity, aiming to inspire potential approaches for enhancing ensemble performance. Moreover, addressing challenges such as base model selection, measuring model robustness and uncertainty, and interpretability of ensemble models in practical applications is emphasized. Finally, future research prospects are outlined, specifically noting that deep learning ensemble is poised to advance ens

关键词： Contrastive Learning

CaH2-promoted activity of Ni-carbonate interface for CO2 methanation

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Journal of Energy Chemistry 2025年第1期100卷 522-532页

作者： Jin-Peng Wang Guo-Cui Mao Hui-lin jiang Bao-Xia Dong Yun-Lei Teng School of Chemistry and Chemical Engineering Yangzhou University

Transition metal-carbonate interfaces often act as active sites in heterogeneous catalytic *** interface between transition metal and metal carbonate exhibits a dynamic equilibrium during the CO2hydrogenation reaction,involving surface carbonate hydrogenation and ***,there have been few reports on engineering the activity of the interface between transition metal and alkaline earth metal carbonate for catalytic *** work demonstrated that the incorporation of CaH2in Ni/CaCO3enhances the CO2methanation activity of the *** CO2conversion for Ni/CaH2-CaCO3reached 68.5%at 400°C,which was much higher than that of the Ni/CaCO3（31.6%） and Ni/CaH2-CaO （42.4%） ***,the Ni/CaH2-CaCO3catalysts remained stable during the stability test for 24 h at 400°C and 8 *** research revealed that CaH2played a crucial role in promoting the activity of the Ni-carbonate interface for ***2could modify the electronic structure of Ni and tune the structural properties of CaCO3to generate medium basic sites （OH groups）,which are favorable for the activation of H2and ***-situ Fourier transform infrared spectroscopy （FTIR） analysis combined with density functional theory calculations demonstrated that CO2activation occurs at the hydroxyl group （OH） on the CaH2-modified Ni-carbonate surface,leading to the formation of CO3H****,our study has confirmed that CO2methanation over the Ni/CaH2-CaCO3catalysts proceeds via the formate pathway.

关键词： CO 2 methanation Metal hydride Ni catalysts Carbonate Metal-carbonate interface

英文歌曲及电影的欣赏与学生英语听力成绩相关性的研究

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新余高专学报 2011年第1期16卷 144-147页

作者：林树江广州大学外国语学院广东广州510006

通过问卷调查和英语听力测试,对英文歌曲及电影在学生英语学习当中的应用情况以及与学生听力成绩之间的相关性进行简要的研究和分析。通过研究发现,欣赏英语歌曲及电影的习惯在学生当中的应用形式不容乐观,但它与英语听力成绩之间存在... 详细信息

通过问卷调查和英语听力测试,对英文歌曲及电影在学生英语学习当中的应用情况以及与学生听力成绩之间的相关性进行简要的研究和分析。通过研究发现,欣赏英语歌曲及电影的习惯在学生当中的应用形式不容乐观,但它与英语听力成绩之间存在显著的正相关。

关键词：英语歌曲及电影英语听力相关性

Study of HIV-1 Drug Resistance in Patients Receiving Free Antiretroviral Therapy in China

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中国病毒学 2007年第3期22卷 233-240页

作者： Xin-ping LIP　 Hui XING　 Zhe WANG　 Xue-feng SI Lian-en WANG　 Hua CHENG　 Wei-guo CUI　 shu-lin jiang　 ling-jie LIAO　 Hai-wei ZHOU　 jiang-hong HUANG　 Hong PENG　 Peng-fei MA　 Yi-ming SHAO State key laboratory of virology Wuhan Institute of Virology Chinese Academy of Science Wuhan 430071 China State key laboratory for Infectious disease prevention and control Division of Research on Virology and Immunology National Center for AIDS/STD Control and Prevention Chinese Center for Disease Control and Prevention Beijing 100050 China Henan Center for Disease Control and Prevention Zhengzhou 450003 China Queshan Center for Disease Control and Prevention Henan 463200 China Graduate University of Chinese Academy of Sciences Beijing 100080 China

To investigate the prevalence of drug-resistance mutations,resistance to antiretroviral drugs,and the subsequent virological response to therapy in treatment-naive and antiretroviral-treated patients infected with HIV/AIDS in Henan,China,a total of 431 plasma samples were collected in Queshan county between 2003 and 2004,from patients undergoing the antiretroviral regimen Zidovudine + Didanosine + Nevirapine(Azt+Ddi+Nvp).Personal information was collected by face to face *** load and genotypic drug resistance were *** resistance mutation data were obtained by analyzing patient-derived sequences through the HIVdb Program(http://***).Overall,38.5% of treatment-naive patients had undetectable plasma viral load(VL),the rate significantly increased to 61.9% in 0 to 6 months treatment patients(mean 3 months)(P<0.005)but again significantly decrease to 38.6% in 6 to 12 months treatment patients(mean 9 months)(P<0.001)and 40.0% in patients receiving more than 12 months treatment(mean 16 months)(P<0.005).The prevalence of drug resistance in patients who had a detectable VL and available sequences were 7.0%,48.6%,70.8%,72.3% in treatment-na?ve,0 to 6 months treatment,6 to 12 months treatment,and treatment for greater than 12 months patients,*** mutation associated with resistance to Protease inhibitor(PI)was detected in this *** RT inhibitor(NRTI)mutations always emerged after non-nucleoside RT inhibitor(NNRTI)mutations,and were only found in patients treated for more than 6 months,with a frequency less than 5%,with the exception of mutation T215Y(12.8%,6/47)which occurred in patients treated for more than 12 *** mutations emerged quickly after therapy begun,and increased significantly in patients treated for more than 6 months(P<0.005),and the most frequent mutations were K103N,V106A,Y181C,*** had been optimal viral suppression in patients undergoing treatment for less than 6 months in Queshan,Henan

关键词：艾滋病病毒艾滋病治疗抗药性逆转录酶