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Mining Science and Technology 2009年第5期19卷 653-656页

作者： HAO Zhi-yong lin Bai-quan wu Hai-jin MENG Jie School of Safety Engineering China University of Mining ＆ Technology Xuzhou Jiangsu 221008 China

Overburden rock movements and fracture developments occur during mining activities. Consequently, relief gas reservoirs and migration in coal seams being mined as well as in near distant coal seams appear. We considered a gas disaster management project and rules on stope relief of gas flows together and explored a gas reservoir and the evolution of stope surrounding rock fractures in the process of mining near distant protective layers by physical simulation, numerical simulation and field testing. Different techniques provide evidence of the rules of interaction of gas reservoirs and the evolution of surrounding rock fractures and are able to find accurately the gas-rich regions around the stope. Finally, we found that these rules can provide a basis for taking measures to prevent gas accidents in the protective layer of the coalface as well as for demonstrating and designing programs to drain high concentrations of gas from the gob.

关键词： physical simulation numerical simulation gas reservoir evolution of fractures

Epidemiology and outcome of individuals with intraductal papillary neoplasms of the bile duct

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World Journal of Gastrointestinal Oncology 2023年第5期15卷 843-858页

作者： Rong-Shou wu Wen-Jun Liao Jing-Sheng Ma Jia-Kun Wang lin-quan wu Ping Hou Department of Hepatobiliary and Pancreatic Surgery The Second Affiliated Hospital of Nanchang UniversityNanchang 330000Jiangxi ProvinceChina Department of Organ Transplantation The Second Affiliated Hospital of Nanchang UniversityNanchang 330000Jiangxi ProvinceChina Department of General Surgery The First Affiliated Hospital of Gannan Medical CollegeNo.23 Qingnian RoadZhanggong DistrictGanzhou 341000Jiangxi ProvinceChina

BACKGROUND Intraductal papillary neoplasm of the bile duct(IPNB)is a rare distinct subtype of precursor lesions of biliary *** is considered to originate from luminal biliary epithelial cells,typically displays mucin-hypersecretion or a papillary growth pattern,and results in cystic dilatation[1].IPNB develops anywhere in the intrahepatic and extrahepatic biliary tracts,and can occur in various pathological stages from low-grade dysplasia to invasive *** have similar phenotypic changes in the occurrence and development of all subtypes,and the prognosis is significantly better than that of traditional(nonpapillary)*** To evaluate the clinicopathological features of IPNB to provide evidence-based guidance for *** Invasive IPNB,invasive intraductal papillary mucinous neoplasm of the pancreas(IPMN),and traditional cholangiocarcinoma data for affected individuals from 1975 to 2016 were obtained from the Surveillance,Epidemiology,and End Results(SEER)*** percentage changes(APCs)in the incidence and incidence-based(IB)mortality were *** identified the independent predictors of overall survival(OS)and cancer-specific survival(CSS)in indivi duals with invasive *** The incidence and IB mortality of invasive IPNB showed sustained decreases,with an APC of-4.5%(95%CI:-5.1%to-3.8%)and-3.3%(95%CI:-4.1%to-2.6%)(P<0.001),*** decreases in incidence and IB mortality were seen for invasive IPMN but not for traditional *** OS and CSS for invasive IPNB were better than for invasive IPMN and traditional cholangiocarcinoma.A total of 1635 individuals with invasive IPNB were included in our prognosis *** most common tumor sites were the pancreaticobiliary ampulla(47.9%)and perihilar tract(36.7%),but the mucin-related subtype of invasive IPNB was the main type,intrahepatically(approximately 90%).In the univariate and multivariate Cox regression analysis,age,tum

关键词： Surveillance,Epidemiology,and End Results database Intraductal papillary neoplasms of the bile duct Subtype Annual percentage changes Prognosis

Simple cholecystectomy is an adequate treatment for grade I T1bN0M0 gallbladder carcinoma:Evidence from 528 patients

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World Journal of Gastroenterology 2022年第31期28卷 4431-4441页

作者： Jun Shao Hong-Cheng Lu lin-quan wu Jun Lei Rong-Fa Yuan Jiang-Hua Shao Department of Hepatobiliary Surgery The Second Affiliated Hospital of Nanchang UniversityNanchang 330006Jiangxi ProvinceChina

BACKGROUND T1b gallbladder carcinoma(GBC)is defined as a tumor that invades the perimuscular connective tissue without extension beyond the serosa or into the ***,controversy still exists over whether patients with T1b GBC should undergo cholecystectomy alone or radical GBC *** To explore the optimal surgical approach in patients with T1b gallbladder cancer of different pathological *** Patients with T1bN0M0 GBC who underwent surgical treatment between 2000 and 2017 were included in the Surveillance,Epidemiology,and End Results *** Kaplan-Meier method and log-rank test were used to analyze the overall survival(OS)and disease-specific survival(DSS)of patients with T1b GBC of different pathological *** regression analysis was used to identify independent predictors of mortality and explore the selection of surgical methods in patients with T1b GBC of different pathological grades and their relationship with *** Of the 528 patients diagnosed with T1bN0M0 GBC,346 underwent simple cholecystectomy(SC)(65.5%),131 underwent SC with lymph node resection(SC+LN)(24.8%),and 51 underwent radical cholecystectomy(RC)(9.7%).Without considering the pathological grade,both the OS(P<0.001)and DSS(P=0.003)of T1b GBC patients who underwent SC(10-year OS:27.8%,10-year DSS:55.1%)alone were significantly lower than those of patients who underwent SC+LN(10-year OS:35.5%,10-year DSS:66.3%)or RC(10-year OS:50.3%,10-year DSS:75.9%).Analysis of T1b GBC according to pathological classification revealed no significant difference in OS and DSS between different types of procedures in patients with grade Ⅰ T1b *** patients with grade Ⅱ T1b GBC,obvious survival improvement was observed in the OS(P=0.002)and DSS(P=0.039)of those who underwent SC+LN(10-year OS:34.6%,10-year DSS:61.3%)or RC(10-year OS:50.5%,10-year DSS:78.8%)compared with those who received SC(10-year OS:28.1%,10-year DSS:58.3%).Among patients with grade Ⅲ or Ⅳ T1b GBC,SC+

关键词： Gallbladder carcinoma Tumor-node-metastasis Survival analysis Tumor grade Surgical treatment

Inhibitory effect of humanized anti-VEGFR-2 ScFv-As_2O_3-stealth nanoparticles conjugate on growth of human hepatocellular carcinoma:in vitro and in vivo studies

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Asian Pacific Journal of Tropical Medicine 2014年第5期7卷 337-343页

作者： Xiang-Bao Yin lin-quan wu Hua-Qun Fu Ming-Wen Huang Kai Wang Fan Zhou Xin Yu Kai-Yang Wang Department of Hepatobiliary Surgery 2nd Affiliated Hospital of Nanchang University

Objective:To investigate the inhibitory effect of humanized anti-VEGFR-2 ScFv-As2O3-stealth nanoparticles conjugate on growth of human hepatocellular carcinoma both in vitro and in vivo,which may be a potential agents with sensitivity and targeting ability for human hepatocellular ***:Humanized anli-VECFR-2 ScFv-As2O3-stealth nanoparticles conjugate was previously constructed using ribosome display technology and antibody conjugate *** this combined in vitro and in vivo study,the inhibitory effects of anti-VEGFR-2 ScFv-As2O3-stealth nanoparticles conjugate on tumor growth,invasion,and metastasis was observed with human liver carcinoma cell line Bel7402 and normal cell L02 by MTT assay,Tanswell assay,Hochest33258 staining,and DNA ladder *** anticancer activity and distribution of anti-VEGFR-2 ScFv-As2O3-stealth nanoparticles was then verified in a mouse model of ***:Anti-VEGFR-2 ScFv-As2O3-stealth nanoparticles significantly inhibited the proliferation of Bel7402 in the 3-(4,5-dimethylthiazol-2-yh-2,5-diphenyltetrazolium bromide assay while had almost no effects on L02 *** the apoptosis inducing effects were proved by Hochest33258 staining and DNA ladder *** assay found that the drug also inhibited the metastasis ability of tumor ***,anti-VEGFR-2 ScFv-As^-stealth nanoparticles significantly delayed the growth of Bel7402 xenografts after administration（92.9%）,followed by As2O3-stealth nanoparticles,anti-VEGFR-2 ScFv,and As203（61.4%,58.8%,20.5%,P<0.05）.The concentration of As2O3 in anti-VEGFR-2 ScFv-As2O3-steallh nanoparticles group was more ***:Anti-VEGFR-2 ScFv-As2O3-stealth nanoparticles is a potent and selective anti-hepatocellular carcinoma agent which could inhibit the growth of liver cancer as a targeting agent both in vitro and in vivo and also significantly inhibit angiogenesis.

关键词： Anti-VEGFR-2 single-chain antibody conjugate As_2O_3 stealth nanoparticles Hepatocellular carcinoma

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KLF4与原发性肝细胞癌关系的研究进展

世界华人消化杂志 2016年第4期24卷 497-504页

作者：冯潜邬林泉南昌大学第二附属医院肝胆外科江西省南昌市330006

KLFs家族是一类具有锌指结构的转录因子,参与多个生理活动的调控,在细胞增殖、凋亡、分化以及胚胎发育等过程中扮演了关键的角色,与真核基因转录调控密切相关.Kruppel样因子4(Kruppel like factor 4,KLF4)作为KLFs家族中重要的一员,KLF... 详细信息

KLFs家族是一类具有锌指结构的转录因子,参与多个生理活动的调控,在细胞增殖、凋亡、分化以及胚胎发育等过程中扮演了关键的角色,与真核基因转录调控密切相关.Kruppel样因子4(Kruppel like factor 4,KLF4)作为KLFs家族中重要的一员,KLF4在原发性肝癌组织中呈现高表达,但是KLF4在原发性肝细胞癌的作用机制仍需要进一步的探讨,本文就KLF4在原发性肝细胞癌中的生物学功能进行综述.

关键词：原发性肝细胞肝癌 Kruppel样因子4 侵袭转移增殖凋亡

NUMERICAL SIMULATION OF 3-D TURBULENT FLOWS OF PLUNGE POOL AND ENERGY DISSIPATION ANALYSIS

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Journal of Hydrodynamics 1997年第1期9卷 1-10页

作者： Liao Hua-sheng, Xu Wei-lin, Yang Yong-quan, wu Chi-gongState Key Hydraulics Laboratory of High Speed Flaws,Sichuan Union University,Chengdu610065, P. R. China

A 3-D numerical model for simulating the complicated turbulent flows was developed and the code was made. A numerical calculation of the plunge pool of Laxiwa project in China was carried on. Those 3-D distributions of velocity,pressure on bottom wall,turbulence kinetic energy and turbulence energy dissipation rate are revealed in detail and the detailed flow patterns of plunge pool were shown. By studying on the characteristics of turbulent diffusion and energy dissipation,the calculated results show that the major turbulence and energy dissipation are taken place near the axis of water jet. The calculated results also indicated that the calculated maximum impact pressures on the bottom wall of the plunge pool have a good agreement with those obtained by physical hydraulic model test.

关键词： plunge pool three dimension turbulence numerical model energy dissipation

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北仑区七姓涂围涂工程海堤沉降完工结算探讨

浙江水利科技 2015年第4期43卷 54-56页

作者：林武全宁波市北仑区河道管理处浙江宁波315800

在围垦工程项目中,沉降是不可规避的课题,由于种种原因,海堤完工后的实际沉降量往往与理论计算的沉降量不相符,因此,原位观测显得尤为重要,既为控制施工速率提供依据,又为沉降量最终结算提供可靠的数据源。现以宁波市北仑区七姓涂围涂... 详细信息

在围垦工程项目中,沉降是不可规避的课题,由于种种原因,海堤完工后的实际沉降量往往与理论计算的沉降量不相符,因此,原位观测显得尤为重要,既为控制施工速率提供依据,又为沉降量最终结算提供可靠的数据源。现以宁波市北仑区七姓涂围涂工程为例,介绍原位观测项目的测点布控、测量成果以及沉降量计算过程等,探讨沉降量完工结算的更好方法。

关键词：海堤沉降结算围涂七姓涂

N-乙酰半胱氨酸对大鼠重症急性胰腺炎肝损伤的抑制作用

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世界华人消化杂志 2010年第10期18卷 1046-1050页

作者：刘石龙廖雯俊邬林泉南昌大学第二附属医院肝胆外科江西省南昌市330006

目的:探讨N-乙酰半胱氨酸(N-acetylcysteine,NAC)对大鼠重症急性胰腺炎(SAP)肝损伤的抑制作用机制.方法:54只SD大鼠随机分为假手术组(SO组)、胰腺炎组(SAP组)及NAC干预组(NAC组),各组18只.以4%牛磺胆酸钠溶液逆行注入胰胆管制作SAP模型.... 详细信息

目的:探讨N-乙酰半胱氨酸(N-acetylcysteine,NAC)对大鼠重症急性胰腺炎(SAP)肝损伤的抑制作用机制.方法:54只SD大鼠随机分为假手术组(SO组)、胰腺炎组(SAP组)及NAC干预组(NAC组),各组18只.以4%牛磺胆酸钠溶液逆行注入胰胆管制作SAP模型.NAC组于造模后1h行股静脉注入NAC(200mg/kg).分别于3h、6h、12h时间点随机剖杀大鼠.采用SP免疫组织化学法检测肝组织NF-κB活性;利用逆转录-聚合酶链反应(RT-PCR)法检测肝组织iNOSmRNA表达;胰、肝组织行病理切片观察,同时行血清淀粉酶、肝功能(AST、ALT)检测.结果:SO组肝组织可见散在肝细胞NF-κB活化和iNOSmRNA低表达,SAP组NF-κB活化和iNOSmRNA高表达;NAC对肝组织NF-κB活性有抑制作用,降低iNOSmRNA表达,与SAP组比较差异显著(3h:0.32±0.05vs0.46±0.04,6h:0.56±0.07vs0.97±0.18,12h:0.87±0.14vs1.13±0.11,均P<0.05),并可降低血清淀粉酶、AST、ALT水平.结论:肝组织NF-κB活化及iNOSmRNA过度表达可能是SAP肝损伤发生的原因之一,NAC可抑制肝NF-κB活性及iNOSmRNA的表达对SAP肝损伤具有一定的抑制作用.

关键词：重症急性胰腺炎核因子-κB 诱导型一氧化氮合酶肝损伤 N-乙酰半胱氨酸

Regulation and function of endoplasmic reticulum autophagy in neurodegenerative diseases

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Neural Regeneration Research 2025年第1期20卷 6-20页

作者： Xiu-Yun Zhao De-En Xu Ming-Lei wu Ji-Chuan Liu Zi-ling Shi quan-Hong Ma Department of Neurology and Clinical Research Center of Neurological Disease the Second Affiliated Hospital of Soochow UniversitySuzhouJiangsu ProvinceChina Institute of Neuroscience&Jiangsu Key Laboratory of Translational Research and Therapy for Neuro-Psycho-Diseases Soochow UniversitySuzhouJiangsu ProvinceChina Department of Neurology Jiangnan University Medical CenterWuxiJiangsu ProvinceChina

The endoplasmic reticulum,a key cellular organelle,regulates a wide variety of cellular *** reticulum autophagy,one of the quality control systems of the endoplasmic reticulum,plays a pivotal role in maintaining endoplasmic reticulum homeostasis by controlling endoplasmic reticulum turnover,remodeling,and *** this review,we briefly describe the endoplasmic reticulum quality control system,and subsequently focus on the role of endoplasmic reticulum autophagy,emphasizing the spatial and temporal mechanisms underlying the regulation of endoplasmic reticulum autophagy according to cellular *** also summarize the evidence relating to how defective or abnormal endoplasmic reticulum autophagy contributes to the pathogenesis of neurodegenerative *** summary,this review highlights the mechanisms associated with the regulation of endoplasmic reticulum autophagy and how they influence the pathophysiology of degenerative nerve *** review would help researchers to understand the roles and regulatory mechanisms of endoplasmic reticulum-phagy in neurodegenerative disorders.

关键词： autophagy endoplasmic reticulum endoplasmic reticulum autophagy endoplasmic reticulum quality control system endoplasmic reticulum receptors endoplasmic reticulum-associated degradation neurodegeneration neurodegenerative disease selective autophagy unfolded protein response

Observation of acoustic hybrid topological phases induced by the p-d orbital interactions

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Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 132-139页

作者： Xiao Xiang Feng Gao Yu-Gui Peng Peng wu Zong-lin Li Xue-Feng Zhu School of Physics and Innovation Institute Huazhong University of Science and Technology

In spinless systems,growing attention has recently been attracted to synthetic gauge fields,which redefine the fundamental crystal symmetries by utilizing the projective algebraic ***,synthetic gauge fields have been commonly investigated in single orbital systems,and explorations on hybrid orbitals remain elusive in ***,we report the experimental observation of hybrid topological phases induced by hybrid synthetic gauge flux,which is formed by the interaction between p and d orbitals embedded in acoustic *** breaking the translation symmetries of Lxand/or Ly,we unambiguously demonstrate the first-order M?bius edge states and higher-order corner *** work establishes a platform for seeking exotic topological phases induced by hybrid-orbitals interactions and initializing the framework of hybrid-orbitalsrelated topological *** applications can be anticipated in scenarios such as high-quality sensing and robust wave trapping due to the stepwise energy distribution of the hybrid topological phase.

关键词： topological insulator synthetic gauge field projective symmetry corner states