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Evaluation of preoperative staging for esophageal squamous cell carcinoma

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World Journal of Gastroenterology 2016年第29期22卷 6683-6689页

作者： lin-Na Luo Long-Jun He Xiao-Yan Gao Xin-Xin Huang Hong-Bo Shan Guang-Yu Luo Yin Li shi-Yong lin Guo-Bao Wang Rong Zhang Guo-Liang Xu Jian-Jun Li Department of Endoscopy Sun Yat-sen University Cancer Center State Key Laboratory of Oncology in South China Guangdong Esophageal Cancer Institute Collaborative Innovation Center for Cancer Medicine

Esophageal squamous cell carcinoma(ESCC) is known for its rapid progression and poor outcomes. China has the highest incidence and mortality in the world. Diagnoses made at early stages and accurate staging are associated with better outcomes, all of which can play a significant role in the selection of treatment protocols. ESCC is staged according to the widely accepted TNM system. Common imaging modalities used in staging ESCC before treatment include endoscopy, computed tomography(CT), positron emission tomography(PET) and magnetic resonance imaging(MRI). Endoscopic ultrasound is useful for staging tumor depth and nodal status. Narrow band imaging is valuable for early stage disease assessment. CT and PET provide additional valuable information regarding node and metastasis staging. The ability of MRI to delineate ESCC is continuously being improved and adds information regarding locoregional status to routine examinations.

关键词： Esophageal squamous cell carcinoma Endoscopic ultrasound Computed tomography Positron emission tomography Magnetic resonance imaging Staging

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并行组合扩频非等概超宽带系统误码性能研究

系统工程与电子技术 2011年第3期33卷 659-664页

作者：齐琳郭黎利哈尔滨工程大学信息与通信工程学院黑龙江哈尔滨150001

基于并行组合扩频的超宽带通信系统,结合了并行组合扩频通信系统的高效通信能力和超宽带通信系统的良好保密性能,可以同时满足通信系统对高效性和安全性的要求。该系统中的并行组合扩频部分输出的信号具有非等概出现的特点,推导了在非... 详细信息

基于并行组合扩频的超宽带通信系统,结合了并行组合扩频通信系统的高效通信能力和超宽带通信系统的良好保密性能,可以同时满足通信系统对高效性和安全性的要求。该系统中的并行组合扩频部分输出的信号具有非等概出现的特点,推导了在非等概情况下超宽带系统跳时M进制-脉冲幅度调制(time hopping M-arypulse amplitude modulation,TH M-PAM)方式的解调差错概率,并通过仿真验证了公式推导的正确性。在加性高斯白噪声信道条件下,建立系统仿真模型,对系统整体性能进行仿真。仿真结果表明,基于并行组合扩频的超宽带通信系统具有良好的误码性能,并且优于常规超宽带通信系统和基于连续波调制的并行组合扩频通信系统。

关键词：并行组合扩频非等概超宽带数据映射 M进制-脉冲幅度调制

Protective effect of astrocyte-conditioned medium on neurons following hypoxia and mechanical injury

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Chinese Journal of Traumatology 2013年第1期16卷 3-9页

作者： YAN Ji-wen TAN Tong-yan HUANG qi-lin Department of Surgery CAPF 8710 Hospital PutianCity 351100 Fujian Province China Medical Team of 95100 Troops Guangzhou 510405China Department of Neurosurgery Xinqiao Hospital ThirdMilitary Medical University Chongqing 400037 China

Objective： To investigate the protective effect of mouse astrocyte-conditioned medium （ACM） on hypoxic and mechanically injured neurons by a cell model in vitro, and to explore the possible mechanism. Methods： The model of hypoxic neuronal injury was caused by 3% 02 in three-gas incubator. Neurons were cultured with ordinary medium or 20% ACM respectively and randomly divided into hypoxic group （hypoxia for 4, 8, 24 h and marked as H4R0, H8R0, H24R0） and hypoxia reoxygenation group （H4R24, H8R24, H24R24）. Mechanical injury model was developed by scratching neurons cultured in 20% ACM or ordinary medium to different degrees. Neu- rons in both medium were divided into normal control group, mild, moderate and severe injury groups. The 20% ACM was added 24 h before hypoxia/reoxygenation or mechanical injury. The morphology and survival of neurons were observed and counted by trypan blue staining. The concentration of NO, lactic dehydrogenase （LDH） and membrane ATPase activity were detected by corresponding kits. Results： It was showed that 20% ACM can obviously promote the survival rate of hypoxia/reoxygenated neurons and scratched neurons as well. The morphology and num- ber of neurons exposed to hypoxia or scratch injury showed great difference between groups with or without ACM treatment. Compared with control group, the concentration of NO and LDH was much lower in hypoxic/reoxygenated neurons treated with 20% ACM, and the ATPase activity was higher. For the mechanical injury model, neurons with moderate injury also revealed a lower NO and LDH concen- tration than the control group. All the differences were sta- tistically significant （P〈0.05）. Conclusion： ACM can promote the survival and func- tional recovery of neurons following hypoxia or scratching to a certain degree. The mechanism may be associated with reducing the synthesis and release of NO and LDH as well as increasing the activity of membrane ATPase.

关键词： Glial cell line-derived neurotrophic factor Neurons Cell hypoxia

BrdU-labelled neurons regeneration after cerebral cortex injury in rats

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Chinese Medical Journal 2006年第12期119卷 1026-1029页

作者： ZHANG Yue-lin qiU Shu-dong ZHANG Peng-bo shi Wei School of Medicine Xi＇an Jiaotong University Xi＇an 710061China Department of Neurosurgery Shaanxi Provincial People＇s HospitalXi＇an 710068 China

Mechanical injuries to the external regions of the brain including the cerebral cortex and other parts of the telencephalon are common yet relatively untreatable. The predicament in recovery from brain injury is that the adult central nervous system is generally thought to be incapable of replacing dead neurons. As the subventricular zone （SVZ） is now known to be neurogenic and is in close proximity to the cerebral cortex and other functionally important forebrain areas, the neurogeny of SVZ brings hope to the repair of brain injury. Because of the high frequency of injuries to the cerebral cortex and its functional importance in humans, many laboratories have studied the results of unilateral aspiration or percussion injury of the cerebral cortex. However,

关键词： neural stem cells neural progenitor cells neurogenesis brain injury

基于距离检测的自动识别系统和对海雷达航迹抗差关联算法

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电子与信息学报 2015年第8期37卷 1855-1861页

作者：齐林崔亚奇熊伟王聪海军航空工程学院信息融合研究所烟台264001

现有的多传感器航迹抗差关联算法,如基于图像配准技术、基于参照拓扑关系的关联算法,计算流程复杂,难以在工程实践中实时应用。该文结合海面舰船目标航迹分布特点,基于单元平均恒虚警检测原理,提出了适用于自动识别系统(AIS)和雷达航迹... 详细信息

现有的多传感器航迹抗差关联算法,如基于图像配准技术、基于参照拓扑关系的关联算法,计算流程复杂,难以在工程实践中实时应用。该文结合海面舰船目标航迹分布特点,基于单元平均恒虚警检测原理,提出了适用于自动识别系统(AIS)和雷达航迹数据的可信关联算法,为对海雷达系统误差配准和海战场多传感器信息融合的快速有效实现提供保证。蒙特卡洛仿真结果表明,可信关联算法在海面目标环境下具有较高的关联准确性;算法的平均耗时与现有抗差关联算法相比显著降低;基于航迹可信关联结果完成对雷达的自动标校,将雷达量测数据的平均误差降低了近90%。

关键词：对海雷达抗差关联自动识别系统单元平均恒虚警检测实时性

Ambient air pollution and low temperature associated with case fatality of COVID-19: A nationwide retrospective cohort study in China

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The Innovation 2021年第3期2卷 86-93页

作者： Fei Tian Xiaobo Liu qingchen Chao Zhengmin(Min)qian Siqi Zhang Li qi Yanlin Niu Lauren DArnold shiyu Zhang Huan Li Hualiang lin qiyong Liu Department of Epidemiology School of Public HealthSun Yat-sen UniversityGuangzhou 510080China State Key Laboratory of Infectious Disease Prevention and Control Collaborative Innovation Center for Diagnosis and Treatment of Infectious DiseasesWHO Collaborating Centre for Vector Surveillance and ManagementNational Institute for Communicable Disease Control and PreventionChinese Center for Disease Control and PreventionBeijing 102206China Laboratory for Climate Studies National Climate CenterChina Meteorological AdministrationBeijing 100081China Department of Epidemiology and Biostatistics College for Public Health&Social JusticeSaint Louis University3545 Lafayette AvenueSaint LouisMO 63104USA

The evidence for the effects of environmental factors on COVID-19 case fatality remains controversial,and it is crucial to understand the role of preventable environmental factors in driving COVID-19 *** thus conducted a nationwide cohort study to estimate the effects of environmental factors(temperature,particulate matter[PM2.5,PM10],sulfur dioxide[SO2],nitrogen dioxide[NO2],and ozone[O3])on COVID-19 case fatality.A total of 71,808 confirmed COVID-19 cases were identified and followed up for their vital status through April 25,*** to ambient air pollution and temperature were estimated by linking the city-and county-level monitoring data to the residential community of each *** each participant,two windows were defined:the period from symptom onset to diagnosis(exposure window I)and the period from diagnosis date to date of death/recovery or end of the study period(exposure window II).Cox proportional hazards models were used to estimate the associations between these environmental factors and COVID-19 case ***-19 case fatality increased in association with environmental factors for the two exposure *** example,each 10 mg/m^(3) increase in PM2.5,PM10,O3,and NO2 in window I was associated with a hazard ratio of 1.11(95%CI 1.09,1.13),1.10(95%CI 1.08,1.13),1.09(95 CI 1.03,1.14),and 1.27(95%CI 1.19,1.35)for COVID-19 fatality,respectively.A significant effect was also observed for low temperature,with a hazard ratio of 1.03(95%CI 1.01,1.04)for COVID-19 case fatality per 1C *** analysis indicated that these effects were stronger in the elderly,as well as in those with mild symptoms and living in Wuhan or ***,the sensitivity analyses also yielded consistent ***-term exposure to ambient air pollution and low temperature during the illness would play a nonnegligible part in causing case fatality due to *** exposures to high concentrations of PM2.5,PM10,O3,SO2,and NO2 and low

关键词： temperature air pollution COVID-19 fatality cohort study

Diagnosis and treatment of Gardner syndrome with gastric polyposis: A case report and review of the literature

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World Journal of Gastroenterology 2008年第13期14卷 2121-2123页

作者： Guo-Li Gu shi-lin Wang Xue-Ming Wei Li Bai Department of General Surgery the General Hospital of Chinese PLA Air Force Beijing 100036 China Department of Digestive Disease the General Hospital of Chinese PLA Air Force Beijing 100036 China

Gardner syndrome (GS) is an autosomal dominant disease characterized by the presence of colonic polyposis, osteoma and soft tissue tumors. It is regarded as a clinical subgroup of familial adenomatous polyposis (FAP) and may present at any age from 2 mo to 70 years with a variety of symptoms, either colonic or extracolonic. We present a case of a 23-year-old female patient with GS who presented with gastric polyposis and was successively treated with restorative proctocolectomy in combination with ileal pouch anal anastomosis (RPC/ IPAA), ileostomy, ileostomy closure operation, snare polypectomy during 8 mo. After operation, the patient took oral traditional Chinese medicine pills made of Fructus mume and Bombyx batryticatu for about 6 mo. The innutrition and anaemia of this patient were gradually improved. Gastroscopy showed that the remnant gastric polypi gradually decreased and finally disappeared 19 mo after the first operation. The patient had 2-3 times of solid stool per day at the time we wrote this paper.

关键词： Gardner syndrome Familial adenomatous polyposis Colectomy Ileal pouch anal anastomosis Stomach polyposis Hereditary nonpolyposis colorectalcancer

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碳市场发电企业违约分级累进处罚机制研究

中国环境科学 2020年第2期40卷 919-928页

作者：魏琦李林静兰州理工大学经济管理学院甘肃兰州730050

在确保减排效率的前提下,以全国碳市场中的发电企业为研究对象,以实现碳市场经济剩余最大化为目标,构建政府和双寡头企业的两阶段动态博弈模型,研究分级累进处罚机制对大型和小型企业发电量、利润的影响,以及在实行分级累进处罚机制的... 详细信息

在确保减排效率的前提下,以全国碳市场中的发电企业为研究对象,以实现碳市场经济剩余最大化为目标,构建政府和双寡头企业的两阶段动态博弈模型,研究分级累进处罚机制对大型和小型企业发电量、利润的影响,以及在实行分级累进处罚机制的碳市场中经济剩余的实现.算例结果表明:随着罚款系数的增加,违约企业是大型发电企业时,总发电量、企业总利润和经济剩余大幅减少7.47%、15.34%、5.88%;违约企业是小型发电企业时,总发电量小幅减少1.43%,企业总利润小幅减少3.39%或上升0.03%,经济剩余小幅上升0.13%;大型违约企业未参与碳交易时,企业总利润大幅减少16.35%,参与碳交易时,企业总利润小幅减少15.34%;小型违约企业未参与碳交易时,企业总利润大幅减少3.39%,参与碳交易时,企业总利润小幅上升0.03%,分级累进处罚机制能够有效的遏制企业的违约行为.因此,在设计发电行业处罚机制时,应加大处罚力度;设置分级累进处罚机制,分别根据企业规模和碳市场参与度进行分级和累进,并建立有效的监管制度.

关键词：碳排放权交易处罚机制分级累进动态博弈

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浅谈大型挡土墙基础处理

水利水电技术 2006年第6期37卷 54-54,68页

作者：石林中国人民武装警察部队水电第九支队四川成都610036

1工程概况1.1工程简介金河--打倮公路是官地水电站与外部交通联系的主要通道,尤其在施工期间,水泥、钢材等大宗物资、变压器、水轮机组等大件必须经过该公路,具有运输荷载大、运输高峰期明显集中等特点.

关键词：挡土墙基础锚固