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汽车零部件 2018年第4期 82-85页

作者：季金花凌琳施琦上汽大众汽车有限公司上海201805

人机工程把人-机-环境作为一个不可分割的整体,符合人机工程的设计和操作将是一种趋势。分析目前人机工程的问题以及人机工程评价的基本情况,介绍一种较为先进的人机评估方法。通过数字化的分析评价工具,大大提高评价效率,评价结果更为... 详细信息

人机工程把人-机-环境作为一个不可分割的整体,符合人机工程的设计和操作将是一种趋势。分析目前人机工程的问题以及人机工程评价的基本情况,介绍一种较为先进的人机评估方法。通过数字化的分析评价工具,大大提高评价效率,评价结果更为客观和准确。

关键词：人机工程评价数字化

Impacts of Nutlin-3a and exercise on murine double minute 2-enriched glioma treatment

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Neural Regeneration Research 2025年第4期20卷 1135-1152页

作者： Yisheng Chen Zhongcheng Fan Zhiwen Luo Xueran Kang Renwen Wan Fangqi Li Weiwei lin Zhihua Han Beijie qi Jinrong lin Yaying Sun Jiebin Huang Yuzhen Xu shiyi Chen Department of Sport Medicine Huashan HospitalFudan UniversityShanghaiChina Department of Orthopedic Surgery Hainan Province Clinical Medical CenterHaikou Affiliated Hospital of Central South University Xiangya School of MedicineHaikouHainan ProvinceChina Department of Basic Medicine Shanghai Jiao Tong University School of MedicineShanghai Jiao Tong UniversityShanghaiChina Department of Neurosurgery Second Affiliated Hospital of Zhejiang University School of MedicineZhejiang UniversityHangzhouZhejiang ProvinceChina Department of Orthopedics Shanghai General HospitalSchool of Medicine Shanghai Jiao Tong UniversityShanghaiChina Department of Infectious Diseases Children’s Hospital of Fudan UniversityNational Children’s Medical CenterShanghaiChina Department of Rehabilitation The Second Affiliated Hospital of Shandong First Medical UniversityTaianShandong ProvinceChina

Recent research has demonstrated the impact of physical activity on the prognosis of glioma patients,with evidence suggesting exercise may reduce mortality risks and aid neural *** role of the small ubiquitin-like modifier(SUMO)protein,especially post-exercise,in cancer progression,is gaining attention,as are the potential anti-cancer effects of *** used machine learning to create the exercise and SUMO-related gene signature(ESLRS).This signature shows how physical activity might help improve the outlook for low-grade glioma and other *** demonstrated the prognostic and immunotherapeutic significance of ESLRS markers,specifically highlighting how murine double minute 2(MDM2),a component of the ESLRS,can be targeted by *** underscores the intricate relationship between natural compounds such as nutlin-3 and immune *** comprehensive CRISPR screening,we validated the effects of specific ESLRS genes on low-grade glioma *** also revealed insights into the effectiveness of Nutlin-3a as a potent MDM2 inhibitor through molecular docking and dynamic ***-3a inhibited glioma cell proliferation and activated the p53 *** efficacy decreased with MDM2 overexpression,and this was reversed by Nutlin-3a or *** using a low-grade glioma mouse model highlighted the effect of physical activity on oxidative stress and molecular pathway ***,both physical exercise and Nutlin-3a administration improved physical function in mice bearing tumors derived from MDM2-overexpressing *** results suggest the potential for Nutlin-3a,an MDM2 inhibitor,with physical exercise as a therapeutic approach for glioma *** research also supports the use of natural products for therapy and sheds light on the interaction of exercise,natural products,and immune regulation in cancer treatment.

关键词： exercise and SUMO-related gene signatures(ESLRS) glioblastoma management low-grade glioma natural bioactives neural regeneration physical exercise

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清末学部编译图书局创设的缘由探析

徐州工程学院学报（社会科学版） 2019年第5期34卷 90-98页

作者：吴洪成蔺士琦河北大学教育学院

清末学部编译图书局是继京师大学堂编译处、总理学务处之后创立的官方管理学校教科书的职能机构。综观该机构的产生历程,不难发现其间交织着传统教育向近代教育转型过程中的剧烈纷争,与此同时又伴随着学制课程计划及教科书编译体制的种... 详细信息

清末学部编译图书局是继京师大学堂编译处、总理学务处之后创立的官方管理学校教科书的职能机构。综观该机构的产生历程,不难发现其间交织着传统教育向近代教育转型过程中的剧烈纷争,与此同时又伴随着学制课程计划及教科书编译体制的种种探索。清末学部编译图书局的创设是清末教育行政管理体制改革的重要内容,其产生的过程与清末兴学运动对教科书编译及审定的探索紧密联系;而组织建立及功能的发挥则基于对前身同类机构的继承与超越。学部编译图书局创立于1906年,于1912年废止,在仅存的六年时间里为编译、审定教科书作了探索及努力,取得了相当丰厚的工作成效。虽然存留的时间过短,但作为学部附属的专门机构,从编纂旨意、内容、质量及价格方面加以统一管理,一定程度上克服了清末教科书市场的混乱,推进了教育教学程序化实施,其所确立的教科书编审制模式对中国近代化教科书体制具有奠基作用,在中国近代教科书史上无疑具有重要的里程碑式意义。

关键词：清末学部编译图书局教科书编审制学制课程计划新教育制度

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山西省农村地区高出生体重危险因素研究

中华疾病控制杂志 2019年第1期23卷 19-23,49页

作者：林是琦武继磊王妮张远李佳佳裴丽君北京大学人口研究所北京100871

目的探索孕期环境因素和行为因素暴露与农村高出生体重(high birth weight,HBW)发生风险之间的关联。方法从2007-2012年期间山西省平定县出生人口及不良出生结局监测系统随访到204例对照、125例≥4 200 g HBW病例和171例4 000～4 200 g ... 详细信息

目的探索孕期环境因素和行为因素暴露与农村高出生体重(high birth weight,HBW)发生风险之间的关联。方法从2007-2012年期间山西省平定县出生人口及不良出生结局监测系统随访到204例对照、125例≥4 200 g HBW病例和171例4 000～4 200 g HBW病例。采用病例对照研究探索HBW风险因素。结果 2007-2012年期间,总出生数为18 749人,高出生体重1 177例,发生率为6. 28%。HBW <4 200 g组病例对照研究结果显示,调整了父母亲生育年龄、产次后,分娩孕周≥42孕周生育HBW的风险是<42孕周的3. 10倍(95%CI:1. 67～5. 76),生育男孩发生HBW风险是生育女孩的2. 30倍(95%CI:1. 46～3. 63),孕前BMI与HBW发生风险无统计学关联; HBW≥4 200 g组病例对照研究结果显示,调整了母亲生育年龄、产次后,分娩孕周≥42孕周生育HBW的风险是<42孕周的3. 01倍(95%CI:1. 49～6. 08),母亲孕前BMI≥24生育HBW的风险是BMI <24者的1. 91倍(95%CI:1. 15～3. 16),母亲孕期每周食用豆制品次数为4～7次,生育HBW的风险是每周食用豆制品次数≤1次者的2. 59倍(95%CI:1. 06～6. 32)。结论降低高出生体重的发生风险可从育龄人群的孕前体重、孕期饮食和分娩孕周管理入手。

关键词：农村地区高出生体重危险因素

福利值与异质性:武夷山国家公园旅游者的选择实验分析

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生态与农村环境学报 2022年第1期38卷 126-135页

作者：曹辉林施琦张静娴曹爱红陈婉婷闫淑君福建农林大学经济管理学院福建福州350002 福建农林大学园林学院福建福州350002

选择实验法是国际上用于评估资源环境产品价值的重要方法。基于武夷山国家公园412份问卷数据和游憩资源状况,运用随机效用模型(M-Logit模型和C-Logit模型Ⅰ、Ⅱ共3个模型),选用自然要素(森林覆盖率、溪水能见度)、管理要素(人流拥挤程... 详细信息

选择实验法是国际上用于评估资源环境产品价值的重要方法。基于武夷山国家公园412份问卷数据和游憩资源状况,运用随机效用模型(M-Logit模型和C-Logit模型Ⅰ、Ⅱ共3个模型),选用自然要素(森林覆盖率、溪水能见度)、管理要素(人流拥挤程度、垃圾数量)和经济要素(门票价格)3类5要素进行实验。在模型分析结果中,5个属性指标大多数呈明显的显著性,总体拟合结果较好,选择实验模型有一定的适用性;模型I研究结果表明森林覆盖率(Plant指标)和溪水能见度(Water指标)与游客效用呈正相关关系,对旅游者而言,更在意游览体验,而非门票价格(未达显著水平);模型Ⅱ研究结果表明垃圾数量Garbage3系数值达-1.160,垃圾是最大的负效用属性;人群拥挤程度(Crowd指标)与游客体验度并未呈正相关关系,10人·(100 m^(2))^(-1)是最适宜人流量;溪水能见度(Water指标)存在显著的水质效用递减现象;武夷山国家公园旅游者总福利值的测算结果显示,模型Ⅰ为32.43亿元,模型Ⅱ当前状态、最佳状态和最差状态值分别为28.62亿、51.35亿和-55.33亿元;收入与受教育程度两个因素是引起旅游者效用异质性的主要来源。

关键词：选择实验法国家公园福利异质性

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聚合物超分子体系：设计、组装与功能

高分子学报 2019年第10期50卷 973-987页

作者：张希王力彦徐江飞陈道勇史林启周永丰沈志豪清华大学化学系北京100084 吉林大学化学学院长春130012 复旦大学高分子科学系上海200438 南开大学化学院高分子化学研究所天津300071 上海交通大学化学化工学院上海200240 北京大学化学与分子工程学院北京100871

高分子科学和超分子化学的相互作用产生了多种多样的聚合物超分子体系,其可能具有丰富的超分子结构,并由此带来特殊的性质与功能.我国许多高校和科研院所自20世纪80年代开始从事聚合物超分子体系的研究,并在高分子自组装、超分子聚合以... 详细信息

高分子科学和超分子化学的相互作用产生了多种多样的聚合物超分子体系,其可能具有丰富的超分子结构,并由此带来特殊的性质与功能.我国许多高校和科研院所自20世纪80年代开始从事聚合物超分子体系的研究,并在高分子自组装、超分子聚合以及功能超分子体系等研究方面取得了一系列重要创新成果.由于篇幅有限,此综述只选择介绍了几个代表性的研究实例,展示了如何从分子设计出发,发展和建立自组装的方法,将结构构筑与功能组装结合,构建多种多样的聚合物超分子体系的思想和成果.

关键词：高分子科学超分子化学分子自组装功能组装体

Tranylcypromine upregulates Sestrin 2 expression to ameliorate NLRP3-related noise-induced hearing loss

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Neural Regeneration Research 2025年第5期20卷 1483-1494页

作者： Xihang Chen Zhifeng Chen Menghua Li Weiwei Guo Shuolong Yuan Liangwei Xu Chang lin Xi shi Wei Chen shiming Yang Senior Department of Otolaryngology Head and Neck Surgery Chinese PLA General HospitalChinese PLA Medical SchoolBeijingChina State Key Laboratory of Hearing and Balance Science BeijingChina National Clinical Research Center for Otolaryngologic Diseases BeijingChina Key Laboratory of Hearing Science Ministry of EducationBeijingChina Beijing Key Laboratory of Hearing Impairment Prevention and Treatment BeijingChina Department of Otorhinolaryngology Head and Neck Surgery The First Affiliated Hospital of Fujian Medical UniversityFuzhouFujian ProvinceChina Department of Otolaryngology Head and Neck Surgery The 940th Hospital of Joint Logistics Support Force of Chinese PLALanzhouGansu ProvinceChina Key Laboratory of Tropical Biological Resources of Ministry of Education School of Pharmaceutical SciencesHainan UniversityHaikouHainan ProvinceChina Academician Workstation of Hainan University School of Pharmaceutical SciencesYazhou BaySanyaHainan ProvinceChina

Noise-induced hearing loss is the primary non-genetic factor contributing to auditory ***,there are currently no effective pharmacological interventions for patients with noise-induced hearing ***,we present evidence suggesting that the lysine-specific demethylase 1 inhibitor–tranylcypromine is an otoprotective agent that could be used to treat noise-induced hearing loss,and elucidate its underlying regulatory *** established a mouse model of permanent threshold shift hearing loss by exposing the mice to white broadband noise at a sound pressure level of 120 d B for 4 *** found that tranylcypromine treatment led to the upregulation of Sestrin2(SESN2)and activation of the autophagy markers light chain 3B and lysosome-associated membrane glycoprotein 1 in the cochleae of mice treated with *** noise exposure group treated with tranylcypromine showed significantly lower average auditory brainstem response hearing thresholds at click,4,8,and 16 k Hz frequencies compared with the noise exposure group treated with *** findings indicate that tranylcypromine treatment resulted in increased SESN2,light chain 3B,and lysosome-associated membrane glycoprotein 1 expression after noise exposure,leading to a reduction in levels of 4-hydroxynonenal and cleaved caspase-3,thereby reducing noise-induced hair cell ***,immunoblot analysis demonstrated that treatment with tranylcypromine upregulated SESN2 expression via the autophagy *** treatment also reduced the production of NOD-like receptor family pyrin domaincontaining 3(NLRP3)*** conclusion,our results showed that tranylcypromine treatment ameliorated cochlear inflammation by promoting the expression of SESN2,which induced autophagy,thereby restricting NLRP3-related inflammasome signaling,alleviating cochlear hair cell loss,and protecting hearing *** findings suggest that inhibiting lysine-specific demethylase 1 is a

关键词： 4-hydroxynonenal apoptosis autophagy cleaved caspase-3 inflammation NOD-like receptor family pyrin domain-containing 3(NLRP3) noise-induced hearing loss oxidative stress Sestrin2 tranylcypromine

Mizagliflozin ameliorates diabetes induced kidney injury by inhibitor inhibit inflammation and oxidative stress

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World Journal of Diabetes 2025年第1期16卷 91-103页

作者： Zhi-Min lin Han-Yuan Gao Shu-Han shi Yue-Ting Li Department of Nephrology The Second Affiliated Hospital of Fujian Medical UniversityQuanzhou 362000Fujian ProvinceChina

BACKGROUND Mizagliflozin(MIZ)is a specific inhibitor of sodium-glucose cotransport protein 1(SGLT1)originally developed as a medication for *** To explore the impact of MIZ on diabetic nephropathy(DN).METHODS Diabetic mice were created using db/db *** were administered either a low dose(0.5 mg/kg)or a high dose(1.0 mg/kg)of the SGLT1 inhibitor MIZ via stomach gavage for 8 ***,mesangial cells(MCs)were isolated and subjected to high glucose conditions in culture to assess the effects of MIZ on *** The results showed that low doses of MIZ significantly reduced albuminuria to a level comparable to that achieved with high doses in db/db *** doses of MIZ led to a substantial increase in body weight in mice,along with decreased blood glucose levels and food ***,the intervention with high-dose MIZ notably decreased the expression of extracellular matrix genes,such as collagen type 1 alpha 1 mRNA *** the expression of SGLT1 increased after exposure to high glucose,it decreased following treatment with ***,MIZ intervention was more effective in improving lactate dehydrogenase levels in MCs induced by high glucose compared to *** also significantly elevated levels of antioxidant enzymes superoxide dismutase,catalase,and glutathione,while reducing malondialdehyde *** These findings indicate that MIZ can ameliorate DN by inhibiting SGLT1,inflammation,and oxidative stress.

关键词： Mizagliflozin Sodium-glucose cotransport protein 1 Diabetic nephropathy Mesangial cells

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冲压机械手的模块化技术研究与应用

机电工程技术 2016年第12期45卷 58-61页

作者：梁健文林彩麟李仕奇江门市大光明电力设备厂有限公司广东江门529100

模块化冲压机械手主要包括机械机构的模块化、电气及通信接口的模块化等。其中机械机构的主要模块为:升降模块、摆臂模块、推送模块、取料模块等,同时实现电气及通信接口的标准化。模块化冲压机械手将实现部件、构件的通用化、标准化、... 详细信息

模块化冲压机械手主要包括机械机构的模块化、电气及通信接口的模块化等。其中机械机构的主要模块为:升降模块、摆臂模块、推送模块、取料模块等,同时实现电气及通信接口的标准化。模块化冲压机械手将实现部件、构件的通用化、标准化、模块化设计,实现机械手系统多样化。并通过快接夹具模块实现不同需求的模块进行快速更换操作,具有较高的灵活性。

关键词：模块化冲压机械手快接

论大型地网接地电阻测试误差分析的内容和方法

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价值工程 2012年第29期31卷 104-107页

作者：叶平林世祺熊芳瑜中山市防雷设施检测所中山528400

本文分析了引起大型地网接地电阻测试过程中误差产生的原因,提出了减少误差的方法,并对测试现场进行误差分析,确保测试准确可信,为大型地网接地电阻的测试提供借鉴。

关键词：大型地网接地电阻误差分析内容和方法