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Real-time polymerase chain reaction for the diagnosis of necrotizing herpes stromal keratitis

International Journal of Ophthalmology(English edition) 2016年第5期9卷 682-686页

作者： Jun-Xin Ma lin-nong wang Ru-Xia Zhou Yang Yu Tong-Xin Du Department of Ophthalmology Nanjing First Hospital Nanjing Medical University Department of Clinical Nuclear Medicine Center Nanjing First HospitalNanjing Medical University

AIM： To design, optimize and validate a rapid,internally controlled real-time polymerase chain reaction（RT-PCR） test for herpes simplex virus（HSV） in the diagnosis of necrotizing herpes stromal keratitis.· METHODS： Tears alone or together with corneal epithelium scrapings from 30 patients（30 eyes）suspected of necrotizing herpes stromal keratitis were tested for HSV DNA by RT-PCR. The samples were collected during the first visit and then on the subsequent 7, 14, 28, 42, and 56 d. The symptoms of the patients were scored before treatment to determine the correlation between HSV concentration in the corneal epithelium scrapings and clinical scores.·RESULTS： The positive rate（46.4%） in the corneal epithelium group before the therapy was significantly higher than that（13.3%） in the tears group（P =0.006）.There were 13 positive HSV patients before the therapy,the concentration of HSV DNA in corneal epithelium scrapings group was significantly higher than that in the tears group（paired t-test, P =0.0397）. Multilevel mixedeffects model analysis showed that the difference between the corneal epithelium scrapings group and the tears group was statistically significant（P =0.0049）. The Spearman rank correlation analysis indicated a positive correlation between the HSV concentration in the corneal epithelium scrapings and clinical scores before the treatment（r =0.844, P〈 0.0001）.· CONCLUSION： RT-PCR appears to be a powerful molecular tool for the diagnosis of necrotizing herpes stromal keratitis.

关键词： necrotizingherpes stromal keratitis real-time polymerase chain reaction corneal epithelium scrapings tears

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Awareness of Cornea Donation of Registered Tissue Donors in Nanjing

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Chinese Medical Sciences Journal 2013年第1期28卷 20-27页

作者： Ting Chu lin-nong wang Hao Yu Ru-yang Zhang Department of Ophthalmology Nanjing First Hospital Affiliated to Nanjing Medical University Red Cross Eye Bank of Nanging Department of Epidemiology and Biostatistics School of Public HealthNanjing Medical University

Objective To evaluate the current cornea donation awareness of tissue donors in the city of Nanjing, China Methods Altogether 2000 registered tissue donors in the Red Cross Eye Bank of Nanjing by the end of 2010 and 2000 control residents of Nanjing in February to June 2011 were randomly selected to par- ticipate in our field questionnaire survey. The questionnaire consisted of questions regarding the understand- ing of cornea donation, the attitude toward cornea donation, and attitude toward legislation and free dona- tion. The awareness of cornea donation between the registered tissue donors and residents was compared. Related factors of the willingness to donate corneas and to become a tissue donor were evaluated with uni- variate and multiple logistic regression analysis. Results A total of 1867 （response rate： 93.4%） tissue donors and 1796 （response rate： 89.8%; ef- fective questionnaires： 1697） residents participated in this survey. For the questions about the knowledge of cornea donation, 90.3% tissue donors （residents： 78.9%） knew that donated corneas could be used for transplantations; 71.2% tissue donors （residents： 47.6%） knew that the appearance would not be destroyed after cornea donation; 70.7% tissue donors （residents： 20.0%） knew the formalities to become a cornea do- nor. For attitude toward cornea donation, 82.2% tissue donors （residents： 45.1%） were willing to donate corneas or eyeballs after death; 84.0% tissue donors （residents： 30.2%） had discussed with their families about donation; 85.1% tissue donors （residents： 24.8%） supported their families＇ or friends＇ cornea donation For attitude toward legislation and free donation, 88.3% tissue donors （residents： 61.3%） approved of legis- lation to regular cornea donation; 72.2% tissue donors （residents： 38.8%） thought that cornea or organ do- nation should be gratis. The difference between two groups was significant （P〈0.001）. However, some tissue donors did not know cornea donation well, some even

关键词： cornea donation tissue donors eye banks cross-sectional study

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MITOMYCIN C “STRAIGHT SCLERAL TUNNEL INCISION”-TRABECULECTOMY WITH A RELEASABLE SUTURE

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Chinese Medical Sciences Journal 2006年第3期21卷 157-162页

作者： lin-nong wang Fang Fang Yang Zhang Li-xun Chen Tai-hong Zhao Lei Xiao Hong Tang Ophthalmic Center Nanjing First Hospital Nanjing Medical University Nanjing 210006

Objective To evaluate the efficacy of ＂straight scleral tunnel incision＂-trabeculectomy with a releasable suture supplemented with mitomycin C （MMC） on reducing intraocular pressure （ IOP）, complications, and corneal astigmatism in patients with primary angle-closure glaucoma （PACG）. Methods Totally 217 acute or chronic PACG patients with occludable angle above 180℃ and IOP above 21 mm Hg were divided into 3 groups. Patients in group A （98 cases, 128 eyes）, B （71 cases, 95 eyes）, and C （48 cases, 60 eyes） were treated with ＂straight scleral tunnel incision＂-trabeculectomy with a releasable suture supplemented with MMC, releasable suture trabeculectomy with MMC, and trabeculectomy with MMC, respectively. IOP, complications, and sureicallv induced astigmatism （SIA） were evaluated oreooerativelv and up to 12 months oostoperatively. Results IOP of 2 weeks after treatment was significantly lower than preoperative IOP in all the 3 groups （ all P〈0.001）. Success rates （IOP≤20 mmHg） in groupA, B, and C were 87. 91% , 89.23%, and 83.72% respectively at 12 months after treatment （P = 0.256）. The incidence of shallow anterior chamber and hypotony had no significant difference between group A and B, but both of them were lower than that in group C （ P 〈 0.05 ）. There were no significant differences in preoperative corneal astigmatism among the 3 groups. The corneal astigmatism after 2 weeks in group A （1.71 ±1.47D） was higher than that before operation （ 1.28 ± 1.05D, P =0. 126）. With 12 months gone, the astigmatism almost returned to preoperative levels. The corneal astigmatisms after 2 weeks in group B and C （ 1.99 ± 1.20D and 2. 22 ± 1.39D） were significantly higher than those before operation （ 1.20 ± 0. 85D and 1.18 ±0.93D, P =0. 002, P =0. 001 ）, respectively. With 112 months gone, the mean astigmatisms in group B and C （ 1.87 ± 0. 91D and 1.90 ± 1.16D） were still significantly higher than those before operation （P = 0. 001, P = 0. 003 ）. The highest astigmatic polar

关键词： angle-closure glaucoma trabeculectomy incision postoperative complications surgically induced astigmatism

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超声生物显微镜评价小梁切除术治疗急性闭角型青光眼

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国际眼科杂志 2010年第10期10卷 1900-1902页

作者：曹鎏王林农中国江苏省南京市第一医院眼科 210006

目的:应用超声生物显微镜观察急性闭角型青光眼小梁切除术的有效性和安全性。方法:选取80例80眼急性闭角型青光眼病例按手术前眼压水平分为高眼压组(30例30眼,眼压≥30mmHg)和对照组(50例50眼,眼压0.05);两组患者手术后ACD,AOD,TCPD术... 详细信息

目的:应用超声生物显微镜观察急性闭角型青光眼小梁切除术的有效性和安全性。方法:选取80例80眼急性闭角型青光眼病例按手术前眼压水平分为高眼压组(30例30眼,眼压≥30mmHg)和对照组(50例50眼,眼压0.05);两组患者手术后ACD,AOD,TCPD术前术后比较差异均无显著性。结论:急性闭角型青光眼高眼压下小梁切除术是有效、安全的,在充分药物治疗后,应及时采取手术治疗。UBM检查可发现小梁切除术后睫状体脱离、恶性青光眼等严重并发症,在急性闭角型青光眼诊治过程中发挥重要作用。

关键词：超声生物显微镜急性闭角型青光眼小梁切除术

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RF Optimizer Model for Predicting Compressive Strength of Recycled Concrete

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Journal of Wuhan University of Technology(Materials Science) 2025年第1期40卷 215-223页

作者： LIU lin wang Liuyan wang Hui SUN Huayue School of Civil Engineering and Architecture Shenyang UniversityShenyang 110000China

Traditional machine learning(ML)encounters the challenge of parameter adjustment when predicting the compressive strength of reclaimed *** address this issue,we introduce two optimized hybrid models:the Bayesian optimization model(B-RF)and the optimal model(Stacking model).These models are applied to a data set comprising 438 observations with five input variables,with the aim of predicting the compressive strength of reclaimed ***,we evaluate the performance of the optimized models in comparison to traditional machine learning models,such as support vector regression(SVR),decision tree(DT),and random forest(RF).The results reveal that the Stacking model exhibits superior predictive performance,with evaluation indices including R2=0.825,MAE=2.818 and MSE=14.265,surpassing the traditional ***,we also performed a characteristic importance analysis on the input variables,and we concluded that cement had the greatest influence on the compressive strength of reclaimed concrete,followed by ***,the Stacking model can be recommended as a compressive strength prediction tool to partially replace laboratory compressive strength testing,resulting in time and cost savings.

关键词： machine learning recycled concrete compressive strength

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Turbulent Agglomeration of Microparticles in a Cylinder Wake Flow Using LES-DEM:Focusing on the Effect of the Reynolds Number

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Journal of Thermal Science 2025年第1期34卷 34-49页

作者： wang Shuang MU lin LI Xue XIE Jun DONG Ming School of Energy and Power Engineering Dalian University of Technology School of Optical Information and Energy Engineering Wuhan Institute of Technology School of Energy and Environment Shenyang Aerospace University

Turbulent agglomeration is viewed as a promising technology for enhancing fine particle removal *** better understand particle transport,agglomeration behaviors,and fluid-particle interactions,we numerically explored these phenomena under cylindrical vortex wake influence using a coupled large eddy simulation and discrete element method（LES-DEM） *** validity of the LES approach was verified by comparison with available direct numerical simulation（DNS） *** adopted the Johnson-Kendall-Roberts（JKR） contact model for particle-particle *** particle dispersion and agglomeration characteristics of particles with different diameters（dp=2-20 μm） in the laminar and transition of shear layer（TrSL） flow regimes were *** particles were concentrated at the vortex centers,while larger particles accumulated around the *** agglomeration efficiency exhibited an M-shaped profile spanwise（y-direction）.With increasing Reynolds number,the agglomeration efficiency and turbulence intensity *** particle agglomeration efficiency peaks at a certain Reynolds ***,at higher Reynolds numbers,reducing the residence time of particles in the flow field decreases the agglomeration efficiency.

关键词： discrete element method large eddy simulation microparticle particle agglomeration

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Wafer‑Scale Vertical 1D GaN Nanorods/2D MoS_(2)/PEDOT:PSS for Piezophototronic Effect‑Enhanced Self‑Powered Flexible Photodetectors

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Nano-Micro Letters 2025年第3期17卷 102-116页

作者： Xin Tang Hongsheng Jiang Zhengliang lin Xuan wang Wenliang wang Guoqiang Li State Key Laboratory of Luminescent Materials and Devices South China University of TechnologyGuangzhou 510640People’s Republic of China Department of Electronic Materials School of Materials Science and EngineeringSouth China University of TechnologyGuangzhou 510640People’s Republic of China

van der Waals(vdW)heterostructures constructed by lowdimensional(0D,1D,and 2D)materials are emerging as one of the most appealing systems in next-generation flexible ***,hand-stacked vdW-type photodetectors are not compatible with large-areaarray fabrication and show unimpressive performance in self-powered ***,vertical 1D GaN nanorods arrays(NRAs)/2D MoS_(2)/PEDOT:PSS in wafer scale have been proposed for self-powered flexible photodetectors arrays *** as-integrated device without external bias under weak UV illumination exhibits a competitive responsivity of 1.47 A W^(−1)and a high detectivity of 1.2×10^(11)Jones,as well as a fast response speed of 54/71μs,thanks to the strong light absorption of GaN NRAs and the efficient photogenerated carrier separation in type-II ***,the strain-tunable photodetection performances of device have been ***,the device at−0.78%strain and zero bias reveals a significantly enhanced photoresponse with a responsivity of 2.47 A W^(−1),a detectivity of 2.6×10^(11)Jones,and response times of 40/45μs,which are superior to the state-of-the-art self-powered flexible *** work presents a valuable avenue to prepare tunable vdWs heterostructures for self-powered flexible photodetection,which performs well in flexible sensors.

关键词： Vertical nanorod arrays van der Waals heterostructure Piezophototronic effect Self-powered photodetection Flexible sensors

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前房穿刺术在急性闭角型青光眼高眼压持续状态下的应用

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国际眼科杂志 2011年第6期11卷 1044-1045页

作者：周欣曹鎏王林农中国江苏省南京市第一医院眼科 210006

目的:研究前房穿刺术处理青光眼高眼压持续状态下的疗效。方法:急性闭角型青光眼病例80例80眼按手术前处理方法分为前房穿刺组(40例40眼)和药物治疗对照组(40例40眼),治疗前眼压均≥50mmHg,对两组病例治疗后视力、眼压、房角开放情况以... 详细信息

目的:研究前房穿刺术处理青光眼高眼压持续状态下的疗效。方法:急性闭角型青光眼病例80例80眼按手术前处理方法分为前房穿刺组(40例40眼)和药物治疗对照组(40例40眼),治疗前眼压均≥50mmHg,对两组病例治疗后视力、眼压、房角开放情况以及手术并发症情况进行统计比较。结果:两组病例治疗后大多数保留了较好的视力;两组病例治疗后眼压均下降,对照组下降幅度小于前房穿刺组;房角镜检查,前房穿刺组房角重新开放病例多于对照组;抗青光眼手术后前房穿刺组无明显并发症,对照组1例发生恶性青光眼,3例发生睫状体脱离,4例发生Ⅱ°浅前房。结论:前房穿刺术治疗急性闭角型青光眼高眼压持续状态是安全、有效的,操作简便,减轻因高眼压造成的视功能损害,为青光眼的进一步治疗创造了条件。

关键词：前房穿刺术急性闭角型青光眼高眼压

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Pyroptosis,ferroptosis,and autophagy in spinal cord injury:regulatory mechanisms and therapeutic targets

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Neural Regeneration Research 2025年第10期20卷 2787-2806页

作者： Qingcong Zheng Du wang Rongjie lin Weihong Xu Department of Spinal Surgery the First Affiliated Hospital of Fujian Medical UniversityFuzhouFujian ProvinceChina Arthritis Clinical and Research Center Peking University People’s HospitalBeijingChina Department of Orthopedic Surgery Fujian Medical University Union HospitalFuzhouFujian ProvinceChina

Regulated cell death is a form of cell death that is actively controlled by *** studies have shown that regulated cell death plays a key role after spinal cord *** and ferroptosis are newly discovered types of regulated cell deaths that have been shown to exacerbate inflammation and lead to cell death in damaged spinal ***,a complex form of cell death that is interconnected with various regulated cell death mechanisms,has garnered significant attention in the study of spinal cord *** injury triggers not only cell death but also cellular survival *** signaling pathways play pivotal roles in influencing the processes of both deterioration and repair in spinal cord injury by regulating pyroptosis,ferroptosis,and ***,this review aims to comprehensively examine the mechanisms underlying regulated cell deaths,the signaling pathways that modulate these mechanisms,and the potential therapeutic targets for spinal cord *** analysis suggests that targeting the common regulatory signaling pathways of different regulated cell deaths could be a promising strategy to promote cell survival and enhance the repair of spinal cord ***,a holistic approach that incorporates multiple regulated cell deaths and their regulatory pathways presents a promising multi-target therapeutic strategy for the management of spinal cord injury.

关键词： autophagy cell death ferroptosis inflammation pathological mechanisms pyroptosis regulated cell death regulatory pathways spinal cord injury therapeutic targets

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Offload Strategy for Edge Computing in Satellite Networks Based on Software Defined Network

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Computers, Materials & Continua 2025年第1期82卷 863-879页

作者： Zhiguo Liu Yuqing Gui lin wang Yingru Jiang Communication and Network Laboratory Dalian UniversityDalian116622China College of Environment and Chemical Engineering Dalian UniversityDalian116622China

Satellite edge computing has garnered significant attention from researchers;however,processing a large volume of tasks within multi-node satellite networks still poses considerable *** sharp increase in user demand for latency-sensitive tasks has inevitably led to offloading bottlenecks and insufficient computational capacity on individual satellite edge servers,making it necessary to implement effective task offloading scheduling to enhance user *** this paper,we propose a priority-based task scheduling strategy based on a Software-Defined Network(SDN)framework for satellite-terrestrial integrated networks,which clarifies the execution order of tasks based on their ***,we apply a Dueling-Double Deep Q-Network(DDQN)algorithm enhanced with prioritized experience replay to derive a computation offloading strategy,improving the experience replay mechanism within the Dueling-DDQN ***,we utilize the Deep Deterministic Policy Gradient(DDPG)algorithm to determine the optimal resource allocation strategy to reduce the processing latency of *** results demonstrate that the proposed d3-DDPG algorithm outperforms other approaches,effectively reducing task processing latency and thus improving user experience and system efficiency.

关键词： Satellite network edge computing task scheduling computing offloading

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