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Journal of Advanced Ceramics 2021年第3期10卷 578-586页

作者： lin-kun shi Xiaobing ZHOU Jian-Qing DAI Ke CHEN Zhengren HUANG Qing HUANG Faculty of Materials Science and Engineering Kunming University of Science and TechnologyKunming 650093China Engineering Laboratory of Advanced Energy Materials Ningbo Institute of Materials Technology and EngineeringChinese Academy of SciencesNingbo 315201China

A nano-laminated Y_(3)Si_(2)C_(2) ceramic material was successfully synthesized via an in situ reaction between YH_(2)and SiC using spark plasma sintering technology.A MAX phase-like ternary layered structure of Y_(3)Si_(2)C_(2) was observed at the atomic-scale by high resolution transmission electron *** lattice parameters calculated from both X-ray diffraction and selected area electron diffraction patterns are in good agreement with the reported theoretical *** nano-laminated fracture of kink boundaries,delamination,and slipping were observed at the tip of the Vickers *** elastic modulus and Vickers hardness of Y_(3)Si_(2)C_(2) ceramics(with 5.5 wt%Y_(2)O_(3)) sintered at 1500℃were 156 and 6.4 GPa,*** corresponding values of thermal and electrical conductivity were 13.7 W·m^(-1)·K^(-1) and 6.3×10^(5)S·m^(-1),respectively.

关键词： Y3Si_(2)C_(2) rare earth silicide carbides spark plasma sintering(SPS) ternary layered structure ceramic properties

Selenium deficiency exacerbates ROS/ER stress mediated pyroptosis and ferroptosis induced by bisphenol A in chickens thymus

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Journal of Environmental Sciences 2025年第2期148卷 13-26页

作者： kun Wang Xu shi Hongjin lin Tong Xu shiwen Xu College of Veterinary Medicine Northeast Agricultural UniversityHarbin 150030China Key Laboratory of the Provincial Education Department of Heilongjiang for Common Animal Disease Prevention and Treatment Harbin 150030China

Bisphenol A(BPA)is an industrial pollutant that can cause immune *** acts as an antioxidant,as selenium deficiency often accompanies oxidative stress,resulting in organ *** study is the first to demonstrate that BPA and/or selenium deficiency induce pyroptosis and ferroptosis-mediated thymic injury in chicken and chicken lymphoma cell(MDCC-MSB-1)via oxidative stress-induced endoplasmic reticulum(ER)*** established a broiler chicken model of BPA and/or selenium deficiency exposure and collected thymus samples as research subjects after 42 *** results demonstrated that BPA or selenium deficiency led to a decrease in antioxidant enzyme activities(T-AOC,CAT,and GSH-Px),accumulation of peroxides(H2O2 and MDA),significant upregulation of ER stress-relatedmarkers(GRP78,IER 1,PERK,EIF-2α,ATF4,and CHOP),a significant increase in iron ion levels,significant upregulation of pyroptosis-related gene(NLRP3,ASC,Caspase1,GSDMD,IL-18 and IL-1β),significantly increase ferroptosis-related genes(TFRC,COX2)and downregulate GPX4,HO-1,FTH,*** vitro experiments conducted in MDCC-MSB-1 cells confirmed the results,demonstrating that the addition of antioxidant(NAC),ER stress inhibitor(TUDCA)and pyroptosis inhibitor(Vx765)alleviated oxidative stress,endoplasmic reticulum stress,pyroptosis,and ***,this study concludes that the combined effects of oxidative stress and ER stress mediate pyroptosis and ferroptosis in chicken thymus induced by BPA exposure and selenium deficiency.

关键词： Bisphenol A Selenium deficiency ROS/ER stress Pyroptosis Ferroptosis Thymic injury

On P-value Combination Procedures

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Acta Mathematica Sinica,English Series 2025年第2期41卷 569-587页

作者： Zhen Meng Yuke shi Jinyi lin Qizhai Li School of Statistics Capital University of Economics and BusinessBeijing 100070P.R.China Academy of Mathematics and Systems Science Chinese Academy of SciencesBeijing 100190P.R.China University of Chinese Academy of Sciences Beijing 100049P.R.China

Combining p-values is a well-known issue in statistical inference. When faced with a study involving m p-values, determining how to effectively combine them to arrive at a comprehensive and reliable conclusion becomes a significant concern in various fields, including genetics, genomics, and economics, among others. The literature offers a range of combination strategies tailored to different research objectives and data characteristics. In this work, we aim to provide users with a systematic exploration of the p-value combination problem. We present theoretical results for combining p-values using a logarithmic transformation, which highlights the benefits of this approach. Additionally, we propose a combination strategy together with its statistical properties utilizing the gold section method, showcasing its performance through extensive computer simulations. To further illustrate its effectiveness, we apply this approach to a real-world scenario.

关键词： Logarithm transformation power p-value combination rank

Use of forestry waste as an alternative raw material for generating metallurgical coke

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Journal of Iron and Steel Research International 2025年第1期32卷 25-39页

作者： lin-bo Qin Wei Qin An-yi Wang ling shi Jun Han College of Resources and Environment Engineering Wuhan University of Science and TechnologyWuhan430081HubeiChina Hubei Key Laboratory of Industrial Fume and Dust Pollution Control Jianghan UniversityWuhan430056HubeiChina Hubei Key Laboratory for Efficient Utilization and Agglomeration of Metallurgic Mineral Resources Wuhan University of Science and TechnologyWuhan430081HubeiChina

Forestry waste(FW)is a significant renewable energy source in *** substitution of coal blends(BC)with forestry waste to produce metallurgical coke was investigated aiming at expanding alternative resources and reducing CO_(2)emissions in ironmaking *** BC with different ratios of FW were carbonized in a fixed bed reactor,and the physicochemical structure of the coke derived from FW/BC co-carbonization was characterized by Fourier transform infrared spectroscopy,X-ray photoelectron spectroscopy,solid-state^(13)C nuclear magnetic resonance,optical microscopy,and scanning electron *** results reveal that the suitable incorporation of FW in BC is 10 wt.%,and the index of coke quality exhibits a good correlation with the optical anisotropy index and the aromaticity of the as-obtained *** partial substitution of BC with FW exhibits potential benefits for colloid formation,owing to the higher hydrogen in ***,as the substitution ratio of BC with FW increases,it inhibits coke agglomeration due to more tortuous stacked structures formation during volatile releasing ***,it was identified that the substitution of higher BC ratios with FW results in the partial replacement of aromatic carbons by oxygenlinked carbons and aliphatic *** substitution leads to a reduction in the aromaticity of the as-obtained coke.

关键词： Metallurgical coke Forestry waste Coal blend Co-carbonization Chemical structure

Polymer-based smart fibers and textiles for wearable electronics

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Science China(Technological Sciences) 2025年第1期68卷 81-116页

作者： Sanming HU Li WANG Zaixian YUAN kun CHEN Wei PENG Hai YIN Zhijun shi Guang YANG School of Biomedical Engineering and Imaging Xianning Medical CollegeHubei University of Science and TechnologyXianning 437100China College of Life Science and Technology Huazhong University of Science and TechnologyWuhan 430074China Wuhan Branch of the National Science Library Chinese Academy of SciencesWuhan 430071China

Smart fibers and textiles have attracted considerable interest for application in wearable devices because of their advantages of being human-friendly,lightweight,flexible,and *** addition,they are considered to have potential applications in health monitoring,energy management,and human-machine interaction *** and polymer fibers,with excellent mechanical strength,wrinkle resistance,and heat resistance,are widely used to fabricate smart fibers and ***,a comprehensive overview of polymer-based fibers and textiles is ***,we review the design principles of various polymer-based smart textiles,including textile-based sensors,energy capture and storage textiles,and computation and display ***,materials used for preparing polymer-based smart fibers,such as metals,carbon-based materials,and natural and synthetic polymers,particularly conductive polymers,are *** addition,this review summarizes key technologies used for preparing smart fibers and the conventional structures of smart ***,the applications of smart textiles in personal health monitoring,thermal management,energy capture and storage,and computation and displays are ***,the current challenges,limitations,and future trends of smart fibers and textiles are discussed.

关键词： polymers smart fibers smart textiles wearable electronics health management

Tailoring Cathode-Electrolyte Interface for High-Power and Stable Lithium-Sulfur Batteries

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Nano-Micro Letters 2025年第4期17卷 181-211页

作者： Mengting Liu ling-Jiao Hu Zhao-kun Guan Tian-ling Chen Xin-Yu Zhang Shuai Sun Ruoli shi Panpan Jing Peng-Fei Wang Center of Nanomaterials for Renewable Energy State Key Laboratory of Electrical Insulation and Power EquipmentSchool of Electrical EngineeringXi’an Jiaotong UniversityXi’an 710049People’s Republic of China Low-Dimensional Materials and Photo/Electrochemical Technology Lab School of Materials Science and EngineeringShaanxi Key Laboratory of Green Preparation and Functionalization for Inorganic MaterialsShaanxi University of Science&TechnologyXi’an 710021People’s Republic of China

Global interest in lithium-sulfur batteries as one of the most promising energy storage technologies has been sparked by their low sulfur cathode cost,high gravimetric,volumetric energy densities,abundant resources,and environmental ***,their practical application is significantly impeded by several serious issues that arise at the cathode-electrolyte interface,such as interface structure degradation including the uneven deposition of Li_(2)S,unstable cathode-electrolyte interphase(CEI)layer and intermediate polysulfide shuttle ***,an optimized cathode-electrolyte interface along with optimized electrodes is required for overall ***,we comprehensively outline the challenges and corresponding strategies,including electrolyte optimization to create a dense CEI layer,regulating the Li_(2)S deposition pattern,and inhibiting the shuttle effect with regard to the solid-liquid-solid pathway,the transformation from solid-liquid-solid to solid-solid pathway,and solid-solid pathway at the cathode-electrolyte *** order to spur more perceptive research and hasten the widespread use of lithium-sulfur batteries,viewpoints on designing a stable interface with a deep comprehension are also put forth.

关键词： Lithium-sulfur batteries Shuttle effect Cathode-electrolyte interface Structural enhancement Reaction pathway

Bidirectional regulation of the brain-gut-microbiota axis following traumatic brain injury

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Neural Regeneration Research 2025年第8期20卷 2153-2168页

作者： Xinyu You lin Niu Jiafeng Fu shining Ge Jiangwei shi Yanjun Zhang Pengwei Zhuang National Key Laboratory of Chinese Medicine Modernization Tianjin University of Traditional Chinese MedicineTianjinChina Haihe Laboratory of Modern Chinese Medicine Tianjin University of Traditional Chinese MedicineTianjinChina First Teaching Hospital of Tianjin University of Traditional Chinese Medicine TianjinChina National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion TianjinChina

Traumatic brain injury is a prevalent disorder of the central nervous *** addition to primary brain parenchymal damage,the enduring biological consequences of traumatic brain injury pose long-term risks for patients with traumatic brain injury;however,the underlying pathogenesis remains unclear,and effective intervention methods are *** dysfunction is a significant consequence of traumatic brain *** the most densely innervated peripheral tissue in the body,the gut possesses multiple pathways for the establishment of a bidirectional“brain-gut axis”with the central nervous *** gut harbors a vast microbial community,and alterations of the gut niche contribute to the progression of traumatic brain injury and its unfavorable prognosis through neuronal,hormonal,and immune pathways.A comprehensive understanding of microbiota-mediated peripheral neuroimmunomodulation mechanisms is needed to enhance treatment strategies for traumatic brain injury and its associated *** comprehensively reviewed alterations in the gut microecological environment following traumatic brain injury,with a specific focus on the complex biological processes of peripheral nerves,immunity,and microbes triggered by traumatic brain injury,encompassing autonomic dysfunction,neuroendocrine disturbances,peripheral immunosuppression,increased intestinal barrier permeability,compromised responses of sensory nerves to microorganisms,and potential effector nuclei in the central nervous system influenced by gut ***,we reviewed the mechanisms underlying secondary biological injury and the dynamic pathological responses that occur following injury to enhance our current understanding of how peripheral pathways impact the outcome of patients with traumatic brain *** review aimed to propose a conceptual model for future risk assessment of central nervous system-related diseases while elucidating novel insights into the bidirectional effec

关键词： traumatic brain injury brain-gut-microbiome axis gut microbiota neuroimmune immunosuppression host defense vagal afferents bacterial infection dorsal root ganglia nociception neural circuitry

Complete response of gallbladder cancer treated with gemcitabine and cisplatin chemotherapy combined with durvalumab:A case report and review of literature

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World Journal of Gastrointestinal Oncology 2025年第1期17卷 226-232页

作者： Kai Chen Xu Feng Yuan shi Xin-lin Li Zheng-Rong shi Xiang Lan Department of Hepatobiliary Surgery The First Affiliated Hospital of Chongqing Medical UniversityChongqing 400016China

BACKGROUND Gallbladder cancer(GBC)is the most common and aggressive subtype of biliary tract cancer(BTC)and has a poor prognosis.A newly developed regimen of gemcitabine,cisplatin,and durvalumab shows promise for the treatment of advanced ***,the efficacy of this treatment for GBC remains *** SUMMARY In this report,we present a case in which the triple-drug regimen exhibited marked effectiveness in treating locally advanced GBC,thus leading to a long-term survival benefit.A 68-year-old man was diagnosed with locally advanced GBC,which rendered him ineligible for curative *** three cycles of therapy,a partial response was *** one year of combined therapy,a clinical complete response was successfully *** maintenance therapy with durvalumab monotherapy resulted in a disease-free survival of 9 months for the *** patient experienced tolerable toxicities of reversible grade 2 nausea and *** adverse events were observed in the patient throughout the entirety of the *** The combination of gemcitabine and cisplatin chemotherapy with durvalumab was proven to be an effective treatment approach for advanced GBC,with manageable adverse *** research is warranted to substantiate the effectiveness of the combined regimen in the context of GBC.

关键词： Gallbladder cancer Chemotherapy Immunotherapy Durvalumab Complete response Case report

Design of multifunctional interfaces on ceramic solid electrolytes for high-performance lithium-air batteries

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Green Energy & Environment 2025年第1期10卷 183-192页

作者： Yunxin shi Ziyang Guo Changhong Wang Mingze Gao Xiaoting lin Hui Duan Yonggang Wang Xueliang Sun College of Energy Material and Chemistry College of Chemistry and Chemical EngineeringInner Mongolia UniversityHohhot010021China Department of Mechanical and Materials Engineering Western UniversityLondonONN6A 5B9Canada Department of Chemistry and Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials Institute of New EnergyiChEM(Collaborative Innovation Center of Chemistry for Energy Materials)Fudan UniversityShanghai200433China Eastern Institute for Advanced Study Eastern Institute of TechnologyNingboZhejiang315100China

High-energy-density lithium(Li)–air cells have been considered a promising energy-storage system,but the liquid electrolyte-related safety and side-reaction problems seriously hinder their *** address these above issues,solid-state Li–air batteries have been widely ***,many commonly-used solid electrolytes generally face huge interface impedance inLi–air cells and also showpoor stability towards ambient air/Li ***,we fabricate a differentiating surface-regulated ceramic-based composite electrolyte(DSCCE)by constructing disparately LiI-containing polymethyl methacrylate(PMMA)coating and Poly(vinylidene fluoride-co-hexafluoropropylene)(PVDF-HFP)layer on both sides of Li_(1.5)Al_(0.5)Ge_(1.5)(PO_(4))_(3)(LAGP).The cathode-friendly LiI/PMMA layer displays excellent stability towards superoxide intermediates and also greatly reduces the decomposition voltage of discharge products in Li–air ***,the anode-friendly PVDF-HFP coating shows low-resistance properties towards ***,Li dendrite/passivation derived from liquid electrolyte-induced side reactions and air/I-attacking can be obviously suppressed by the uniformand compact composite *** a result,the DSCCE-based Li–air batteries possess high capacity/low voltage polarization(11,836mAh g^(-1)/1.45Vunder 500mAg^(-1)),good rate performance(capacity ratio under 1000mAg^(-1)/250mAg^(-1) is 68.2%)and longterm stable cell operation(~300 cycles at 750 mA g^(-1) with 750 mAh g^(-1))in ambient air.

关键词： Li-air batteries Li_(1.5)Al_(0.5)Ge_(1.5)(PO_(4))_(3) Polymers Composite electrolyte Ambient air

Integrated Medicine Treatment of Rare Bone Marrow Tuberculosis in Systemic Lupus Erythematosus and Potentiating and Detoxifying Effects of Chinese Medicine:A Case Report

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Chinese Journal of Integrative Medicine 2025年第2期31卷 153-156页

作者： CHEN Wu HUANG lin shi Wei-man MA Ke WEN Cheng-ping DAI Qiao-ding School of Basic Medical Science Zhejiang Chinese Medical UniversityHangzhou(310000)China The Key Laboratory of Chinese Medicine Rheumatology of Zhejiang Province Hangzhou(310000)China Department of Rheumatology and Immunology The First Affiliated Hospital of Zhejiang Chinese Medical University(Zhejiang Provincial Hospital of Chinese Medicine)Hangzhou(310000)China

Systemic lupus erythematosus(SLE)is an autoimmune disease that affects multiple organ systems.(1,2)Patients with SLE who undergo long-term immunosuppressive and glucocorticoids therapy are at an elevated risk of devel... 详细信息

关键词： Systemic tuberculosis erythematosus