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Neoadjuvant transcatheter arterial chemoembolization and systemic chemotherapy for the treatment of undifferentiated embryonal sarcoma of the liver in children

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World Journal of Clinical Cases 2022年第19期10卷 6437-6445页

作者： Min He Jia-Bin Cai Can Lai Jun-Qing Mao jie-Ni Xiong Zhong-Hai Guan lin-jie li Qiang Shu Mei-Dan Ying Jin-Hu Wang Department of Surgical Oncology The Children’s HospitalZhejiang University School of MedicineNational Clinical Research Center for Child HealthHangzhou 310052Zhejiang ProvinceChina Department of Radiology The Children’s HospitalZhejiang University School of MedicineNational Clinical Research Center for Child HealthHangzhou 310052Zhejiang ProvinceChina Cancer Center Zhejiang UniversityHangzhou 310058Zhejiang ProvinceChina

BACKGROUND Undifferentiated embryonal sarcoma of the liver(UESL)is a rare and aggressive mesenchymal tumor in ***,we describe our experience in neoadjuvant therapy(NAT)and subsequent surgery for the treatment of UESL in *** To evaluate the efficacy of NAT and explore a new choice for successful operation of UESL in *** We retrospectively analyzed six patients newly diagnosed with unresectable UESL who received NAT and then surgery at our center between January 2004 and December *** tumor was considered unresectable if it involved a large part of both lobes of the liver or had invaded the main hepatic vessels or inferior vena *** NAT included preoperative transcatheter arterial chemoembol ization(TACE)and systemic *** patients were 4 boys and 2 girls with a mean age of 7 *** longest tumor at presentation ranged from 8.6 to 14.8 cm(mean,12 cm).Extrahepatic metastases were present in 2 *** systemic chemotherapy was administered 3 wk after *** resection was performed 3 wk after one or two cycles of *** patients received systemic chemotherapy after *** All patients successfully underwent NAT and complete *** tumor volumes decreased by 18.2%–68.7%,with a mean decrease of 36%after 1 cycle of NAT(t=3.524,P=0.017).According to the Response Evaluation Criteria In Solid Tumors criteria,4 patients had a partial response and underwent surgery,while 2 had stable disease and received another cycle of NAT before *** tumor necrosis was seen on pathological examination of the surgical specimen:>90%necrosis in two,>50%necrosis in three,and 25%necrosis in 1,with an average of 71.8%.Post-NAT complications included fever,nausea and vomiting,and mild bone marrow *** alanine transaminase levels occurred in all patients,which returned to normal within 7–10 d after *** cardiac or renal toxicity,severe hepatic dysfunction,bleeding and nontarget e

关键词： Undifferentiated embryonal sarcoma of the liver Unresectable Neoadjuvant therapy Transcatheter arterial chemoembolization Systemic chemotherapy

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High Order Centrifugal Distortion Corrections to Energy Levels of Asymmetric Top Molecules

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Chinese Physics Letters 2000年第12期17卷 879-881页

作者： liU Yu-Yan liU Xiao-Yong liU Hong-Ping GUO Yuan-Qing HUANG Guang-Ming lin jie-li GAO Hui State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics Wuhan Institute of Physics and MathematicsChinese Academy of SciencesWuhan 430071

High order centrifugal distortion terms have been derived and added to the effective Hamiltonian of asymmetric top *** on this Hamiltonian,a program in Fortran 77 has been developed for spectral analysis of asymmetric top *** high order centrifugal distortion terms are found to be non-negligible even for the low-lying rotational transitions of molecules,such as H218O,subjected to severe centrifugal distortion effect,and for the high-lying rotational transitions of molecules,such as 14N16O2 subjected to the moderate centrifugal distortion effect.

关键词： distortion Hamiltonian transitions

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Nutritional Therapy in Patients Undergoing Elective Colorectal Cancer Surgery

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Journal of Nutritional Oncology 2022年第4期7卷 175-180页

作者： lin jie li Hong Qun Zheng Yong liu ling Yu Sun Department of Oncology and Hepatobiliary Surgery The Fourth Affiliated Hospital of Harbin Medical UniversityHarbin Medical UniversityHarbin 150001HeilongjiangChina Department of Gastroenterology The Fourth Affiliated Hospital of Harbin Medical UniversityHarbin Medical UniversityHarbin 150001HeilongjiangChina

The high incidence of malnutrition in patients with colorectal cancer directly affects their clinical outcomes,and is associated with increased postoperative complications,prolonged hospital stays,and decreased tolerance of chemotherapy and ***,the nutritional management of patients with colorectal cancer is *** perioperative nutritional management of patients includes preoperative education,nutritional screening and evaluation,preoperative intestinal preparation,and postoperative nutritional *** article summarizes the current status of perioperative nutritional therapy and bowel preparation for patients with colorectal cancer.

关键词： Colorectal cancer Nutritional Therapy Oral nutrition supplements Nutritional assessment tools

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CD58 expression of liver tissue in patients with chronic hepatitis B virus infection

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Chinese Medical Journal 2008年第6期121卷 557-560页

作者： WANG Ping QI Bao-tai CHEN Ping HE lin-jing li jie JI Yu-qiang XIE Ming Department of Pathogenic Microbiology and Immunology Medical School of Xi'an Jiaotong University Xi'an Shaanxi710061 China

Background Several kinds of intercellular adhesion molecules closely relate to hepatitis B. The complex of CD2 and CD58 plays an important role in enhancing the adhesion of T lymphocytes to target cells, hyperplasia and activation of T lymphocytes. In this study, we explored the relationship between the expression of CD58 in liver tissue and chronic hepatitus B infection. Methods We determined the expression of the CD58 molecule on the surface of hepatoc^es by using immunohistochemistry and the levels of serum HBV DNA from patients with HBV infection and from normal controls. The biochemical parameters of hepatic function were analyzed as well. Results CD58 expression in hepatocytes significantly increased with the severity progression of chronic HBV infection. The IOD levels （log10） of CD58 in the control, mild, moderate, and severe chronic HBV infection groups were 0, （7.20±4.64）×10^3, （25.63±7.41）×10^3 and （37.47±11.17）×10^3 respectively （P〈O.05 compared with the control group, respectively） Conclusion CD58 probably increases cell mediated immunity to eliminate hepatitis B virus and leads to damage of hepatocytes.

关键词： hepatitis B, chronic CD58 immunohistochemistry

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实验不可分辨的Voigt线型重叠谱线的压致展宽线宽的偏差确定

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光谱学与光谱分析 2005年第1期25卷 128-132页

作者：林洁丽黄义清路洪广东省佛山科学技术学院物理系广东佛山528000

通过仿真和拟合Voigt线型重叠谱线,讨论了将实验上不可分辨的两条谱线重叠后视为单条谱线时所得到的压致展宽线宽与其实际值的相对误差ε,分析了该误差与两谱线的中心位置距离δν0和实际的压致展宽线宽δν0L的变化规律。发现ε在谱线... 详细信息

通过仿真和拟合Voigt线型重叠谱线,讨论了将实验上不可分辨的两条谱线重叠后视为单条谱线时所得到的压致展宽线宽与其实际值的相对误差ε,分析了该误差与两谱线的中心位置距离δν0和实际的压致展宽线宽δν0L的变化规律。发现ε在谱线的压致展宽线宽远小于多普勒线宽δνD时显得很大,与δν0和δν0L的变化规律较复杂;当δν0L可与δνD比拟时,ε随δν0的变化趋于呈光滑的二次项函数曲线,但曲线的斜率在δν0L小于δνD情况下为负,而在δν0L大于δνD时为正。整体来说,随着δν0L对总线宽的影响越大,ε越小。所有这些结论和相应关系数据为修正压致展宽线宽的拟合值具有积极的参考价值,并且为进一步从实验上不可分辨的重叠谱线确定精确的压致展宽系数提出了极有意义的方法和思路。

关键词：不可分线宽谱线分辨中心位置函数曲线系数仿真总线重叠

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不确定广义大系统有限时间鲁棒分散控制

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控制与决策 2017年第8期32卷 1493-1498页

作者：沃松林赵俊杰李博江苏理工学院电气信息工程学院江苏常州213001

研究不确定连续广义大系统的有限时间鲁棒分散控制问题,设计系统的有限时间鲁棒分散状态反馈控制器.首先应用广义Lyapunov函数法,给出不确定广义大系统有限时间鲁棒稳定的充分条件;其次,给出不确定广义大系统应用分散状态反馈控制器鲁... 详细信息

研究不确定连续广义大系统的有限时间鲁棒分散控制问题,设计系统的有限时间鲁棒分散状态反馈控制器.首先应用广义Lyapunov函数法,给出不确定广义大系统有限时间鲁棒稳定的充分条件;其次,给出不确定广义大系统应用分散状态反馈控制器鲁棒镇定的充分条件和有限时间鲁棒分散控制器的设计方法;最后,通过仿真例子验证所提出方法的有效性.

关键词：不确定广义大系统有限时间鲁棒稳定分散状态反馈有限时间鲁棒镇定

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Nanostructured ZnO/BiVO_(4)I-scheme heterojunctions for piezocatalytic degradation of organic dyes via harvesting ultrasonic vibration energy

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International Journal of Minerals,Metallurgy and Materials 2025年第2期32卷 488-497页

作者： Yiling li Xiaoyao Yu Yingjie Zhou Yao lin Ying Wu Key Laboratory of the Ministry of Education for Advanced Catalysis Materials College of Chemistry and Materials ScienceZhejiang Normal UniversityJinhua 321004China

BiVO_(4)porous spheres modified by ZnO were designed and synthesized using a facile two-step *** resulting ZnO/BiVO_(4)composite catalysts have shown remarkable efficiency as piezoelectric catalysts for degrading Rhodamine B(RhB)unde mechanical vibrations,they exhibit superior activity compared to pure *** 40wt%ZnO/BiVO_(4)heterojunction composite displayed the highest activity,along with good stability and *** enhanced piezoelectric catalytic activity can be attributed to the form ation of an I-scheme heterojunction structure,which can effectively inhibit the electron-hole ***,hole(h+)and superoxide radical(·O_(2)^(-))are proved to be the primary active ***,ZnO/BiVO_(4)stands as an efficient and stable piezoelectric catalyst with broad potential application in the field of environmental water pollution treatment.

关键词： piezoelectric catalytic heterojunction dye degradation ultrasonic vibration

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CNKSR2 interactome analysis indicates its association with the centrosome/microtubule system

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Neural Regeneration Research 2025年第8期20卷 2420-2432页

作者： lin Yin Yalan Xu jie Mu Yu Leng Lei Ma Yu Zheng Ruizhi li Yin Wang Peifeng li Hai Zhu Dong Wang Jing li Institute for Translational Medicine The Affiliated Hospital of Qingdao UniversityMedical CollegeQingdao UniversityQingdaoShandong ProvinceChina School of Basic Medicine Qingdao UniversityQingdaoShandong ProvinceChina College of life Sciences and School of PharmacyMedical CollegeQingdao UniversityQingdaoShandong ProvinceChina Department of Urology Qingdao Municipal Hospital Affiliated to Qingdao UniversityQingdaoShandong ProvinceChina

The protein connector enhancer of kinase suppressor of Ras 2(CNKSR2),present in both the postsynaptic density and cytoplasm of neurons,is a scaffolding protein with several protein-binding *** of the CNKSR2 gene have been implicated in neurodevelopmental disorders,particularly intellectual disability,although the precise mechanism involved has not yet been fully *** has demonstrated that CNKSR2 plays a role in facilitating the localization of postsynaptic density protein complexes to the membrane,thereby influencing synaptic signaling and the morphogenesis of dendritic ***,the function of CNKSR2 in the cytoplasm remains to be *** this study,we used immunoprecipitation and high-resolution liquid chromatography-mass spectrometry to identify the interactors of *** a combination of bioinformatic analysis and cytological experiments,we found that the CNKSR2 interactors were significantly enriched in the proteome of the *** also showed that CNKSR2 interacted with the microtubule protein DYNC1H1 and with the centrosome marker *** colocalization analysis confirmed the centrosomal localization of *** we downregulated CNKSR2 expression in mouse neuroblastoma cells(Neuro 2A),we observed significant changes in the expression of numerous centrosomal *** manipulation also affected centrosome-related functions,including cell size and shape,cell proliferation,and ***,we found that CNKSR2 interactors were highly enriched in de novo variants associated with intellectual disability and autism spectrum *** findings establish a connection between CNKSR2 and the centrosome,and offer new insights into the underlying mechanisms of neurodevelopmental disorders.

关键词： autism spectrum disorder centrosome CNKSR2 intellectual disability interactome mass spectrometry microtubule neurodevelopmental disease protein complexes protein-protein interactions

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NMR research on deterioration characteristics of microscopic structure of sandstones in freeze-thaw cycles

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Transactions of Nonferrous Metals Society of China 2016年第11期26卷 2997-3003页

作者：李杰林周科平刘伟杰邓红卫中南大学资源与安全工程学院长沙410083

In order to study the deterioration characteristics of the microscopic structure of sandstones in freeze-thaw cycles, tests of180 freeze-thaw cycles were performed on sandstone specimens. The nuclear magnetic resonance （NMR） technique was applied tothe measurement of sandstone specimens and analysis of the magnetic resonance imaging. Then, the fractal theory was employed tocompute the fractal dimension values of pore development of rocks after different freeze-thaw cycles. The results show that the massand porosity of rocks grow with the increase of freeze-thaw cycles. According to the NMR T2 distribution of sandstones, the poresizes of rock specimens increase after 180 freeze-thaw cycles, especially that of the medium-sized and small-sized pores. The spatialdistribution of sandstone pores after freeze-thaw cycles has fractal features within certain range, and the fractal dimension ofsandstones tends to increase gradually.

关键词： nuclear magnetic resonance (NMR) freeze-thaw cycles deterioration of rocks microscopic structure fractal dimension

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面向多种总线测试设备的软件设计

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现代电子技术 2015年第3期38卷 85-86页

作者：林立杰耿涛中国工程物理研究院电子工程研究所四川绵阳621900

介绍了一种面向多种总线测试设备的软件设计,通过GPIB、TCP网络、RS 485串口等总线编程技术,采用多线程编程方法实现对GPIB-IEEE488.2接口测量设备、网络接口示波器以及串口测量设备的分时通信,最终实现数据采集的目的。

关键词：总线接口数据采集多线程分时通信

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