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Treatment of refractory/relapsed extranodal NK/T cell lymphoma with decitabine plus anti-PD-1:A case report

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World Journal of Clinical Cases 2022年第28期10卷 10193-10200页

作者： lin-jie li Jun-Yu Zhang Department of Hematology Lishui Municipal Central HospitalLishui 323000Zhejiang ProvinceChina

BACKGROUND Extranodal natural killer/T cell lymphoma,nasal type(ENKL) is a highly aggressive malignancy characterized by its association with Epstein-Barr virus(EBV) and extranodal involvement,which shows a poor clinical *** L-asparaginase-based chemotherapy has improved the response rates of relapsed/refractory(R/R) ENKL,relapse occurs in up to 50% of patients with disseminated *** SUMMARY Immune evasion has emerged as a critical pathway for survival in ENKL and may be effectuated via STAT3-driven upregulation of programmed cell death ligand 1(PD-L1) or other molecular ***-PD-1 is effective for R/R ENKL with EBV-driven upregulation of PD-L1 ***-PD-1 combined with decitabine showed positive preliminary results in a patient with R/R ENKL and resistance to *** The treatment experience,in this case,demonstrated the potential ability of decitabine combined with PD-1 inhibitor to treat R/R ENKL,thus providing a new treatment strategy for this tumor.

关键词： NK-T cell lymphoma Refractory/relapsed Anti-PD-1 Decitabine Case report

Radiative decays of charmed mesons in a modified relativistic quark model

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Chinese Physics C 2022年第7期46卷 56-67页

作者： jie-lin li Dian-Yong Chen School of Physics Southeast UniversityNanjing 210094China Lanzhou Center for Theoretical Physics Lanzhou UniversityLanzhou 730000China

In this study, we perform systematic estimations of the radiative decays of the charmed mesons in a modified relativistic quark model. Our estimations indicate that the branching ratios of the processes of D^(0)_(2)(1^(3)P_(2)) →D^(0)(1^(3)S_(1)) γ , D_3^0(1D_3) o D^(0)_(2)(1^(3)P_(2)) γ , D^(0)_(2)(2D_2^) o D_1^(0)(2P_1) γ , D_3^0(2^3D_3) o D^(0)_(2)(2^3P_(2)) γ , and D^(\ast 0)(1^(3)S_(1)) o D^0(1^1S_0) γ are of the order of 10^(-2) , which are sizable to be detected experimentally. Moreover, the branching ratios of some channels, for example, D_1^0(1P_1) o D(1^1S_0)^0 γ , D^0(3^1S_0) o D_1^( 0)(2P^_(1)) γ , and D^0(3^3S_(1)) o D^(0)_(2)(2^3P_(2)) γ , are estimated to be of the order of 10^(-3) , which may be accessible with the accumulation of data in future experiments.

关键词： charmed mesons radiative decays quark model

Potential Hazards in Smoke-Flavored Fish

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Journal of Ocean University of China 2008年第3期7卷 294-298页

作者： lin Hong JIANG jie li Donghua Seafood Safety Lab College of Food Science and Engineering Ocean University of China Qingdao 266003 P. R. China

Smoking is widely used in fish processing for the color and flavor. Smoke flavorings have evolved as a successful alternative to traditional smoking. The hazards of the fish products treated by liquid-smoking process are discussed in this review. The smoke flavoring is one important ingredient in the smoke-flavored fish. This paper gives the definition of smoke flavorings and the hazard of polycyclic aromatic hydrocarbons （PAHs） residue in the smoke flavorings on the market. It gives also an assessment of chemical hazards such as carcinogenic PAHs, especially Benzo-[α]pyrene, as well as biological hazards such as listeria monocytogenes, Clostridium botulinum, histamine and parasites in smoke-flavored fish. The limitations in regulations or standards are discussed. Smoke flavored fish have lower content of PAHs as compared with the traditional smoking techniques if the PAHs residue in smoke flavorings is controlled by regulations or standards.

关键词： smoke-flavored fish hazards smoke flavoring PAHs

Refractory lymphoma treated with chimeric antigen receptor T cells combined with programmed cell death-1 inhibitor:A case report

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World Journal of Clinical Cases 2022年第21期10卷 7502-7508页

作者： Cang-Jian Zhang Jun-Yu Zhang lin-jie li Neng-Wen Xu Department of Hematopathology Lishui Municipal Central HospitalLishui 323000Zhejiang ProvinceChina

BACKGROUND Diffuse large B-cell lymphoma(DLBCL)is a common aggressive non-Hodgkin's lymphoma(NHL),accounting for 30%-40%of adult *** testicular(PT)lymphoma is an uncommon extranodal disease representing approximately 1%-2%of *** 30%–40%of patients are refractory to frontline therapy or relapse after complete *** DLBCL responds poorly to other lines of chemotherapy,and experiences short-term *** SUMMARY We present a 41-year-old male patient who was diagnosed with *** disease progression was observed after multiline *** antigen receptor T cells(CAR-T)therapy salvaged the ***,a new mass was observed in the right adrenal area after six *** patient was administered programmed cell death protein-1(PD-1)inhibitor therapy and maintained progression-free survival at more than 17 mo of *** Our findings support the potential benefit of CAR-T combined with PD-1 inhibitor therapies in this type of relapsed and refractory PT-DLBCL.

关键词： Refractory diffuse large B-cell lymphoma Programmed cell death protein-1 inhibitor Chimeric antigen receptor T cells Case report

G-protein beta 3 subunit polymorphisms and essential hypertension： a case-control association study in northern Han Chinese

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Journal of Geriatric Cardiology 2015年第2期12卷 127-134页

作者： Mei li Bei ZHANG Chuang li jie-lin liU li-Juan WANG Ya liU Zuo-Guang WANG Shao-Jun WEN Department of Hypertension Research Beijing Anzhen Hospital Capital Medical University and Beijing Institute of Heart Lung and Blood Vessel DiseasesBeijing 100029 China

Objective To explore the association between the three polymorphisms [ C825T, C1429T and G（-350）A] of the gene encoding the G protein beta 3 subunit （GNB3） and hypertension by performing a case-control study in the northern Han Chinese population. Methods We recnaited 731 hypertensive patients and 673 control subjects （the calculated power value was 〉 0.8）. Genotyping was performed to identify C825T, C1429T and G（-350）A polymorphisms using the TaqMan assay. Comparisons of allelic and genotypic frequencies between cases and controls were made by using the chi-square test. Logistic regression analyses were performed to investigate the relationships between the three polymorphisms of GNB3 gene under different genetic models （additive, dominant and recessive models）. Results The genotype dis- tribution and allele frequencies of C825T, C1429T and G（-350）A polymorphisms did not differ significantly between hypertensive patients and control subjects, either when the full sample was assessed, or when the sample was stratified by gender. No significant association was observed between C825T, C 1429T and G（-350）A polymorphisms and the risk of essential hypertension in any genetic model. linkage dis- equilibrium was only detected between C825T and C 1429T polymorphisms. Haplotype analyses observed that none of the three estimated haplotypes significantly increased the risk of hypertension. Conclusions Our study suggested that the GNB3 gene polymorphisms [C825T, C 1429T and G（-350）A] were not significantly associated with essential hypertension in northern Han Chinese population.

关键词： G protein beta 3 subunit gene Haplotype Hypertension Polymorphism

Paraplegia after transcatheter artery chemoembolization in a child with clear cell sarcoma of the kidney:A case report

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World Journal of Clinical Cases 2020年第11期8卷 2332-2338页

作者： Jia-Bin Cai Min He Fa-liang Wang jie-Ni Xiong Jun-Qing Mao Zhong-Hai Guan lin-jie li Jin-Hu Wang Department of Surgical Oncology The Children’s HospitalZhejiang University School of MedicineNational Clinical Research Center for Child HealthHangzhou 310053Zhejiang ProvinceChina

BACKGROUND Transcatheter arterial chemoembolization(TACE)is a common treatment for inoperable malignant renal ***,a series of complications may follow the TACE *** cord injury caused by the embolization of intercostal or lumbar arteries is extremely *** SUMMARY We describe a case with quite uncommon spinal cord injury after TACE in a 3-year-old child with clear cell sarcoma of the *** impairment beneath the T10 dermatomes and paraplegia on the day after TACE were found in this ***,sustained paraplegia still existed for more than 2 mo after TACE despite the large dose of steroids and supportive *** We should draw attention to an uncommon complication of paraplegia after TACE treatment in malignant renal *** it is rare,the result is disastrous.

关键词： Complication Chemoembolization Spinal cord injury Clear cell sarcoma of the kidney Pediatric Case report

Transformation of marginal zone lymphoma into high-grade B-cell lymphoma expressing terminal deoxynucleotidyl transferase:A case report

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World Journal of Clinical Cases 2024年第15期12卷 2655-2663页

作者： Zhi-Min Fan Dao-Lei Wu Neng-Wen Xu li Ye li-Ping Yan lin-jie li Jun-Yu Zhang Department of Hematology Lishui Municipal Central HospitalLishui 323000Zhejiang ProvinceChina Department of Ophthalmology Lishui Municipal Central HospitalLishui 323000Zhejiang ProvinceChina Department of General Practice Lishui Municipal Central HospitalLishui 323000Zhejiang ProvinceChina Department of Pathology Lishui Municipal Central HospitalLishui 323000Zhejiang ProvinceChina

BACKGROUND High-grade B-cell lymphoma(HGBL)is an unusual malignancy that includes myelocytomatosis viral oncogene(MYC),B-cell lymphoma-2(BCL-2),and/or BCL-6 rearrangements,termed double-hit or triple-hit lymphomas,and HGBL-not otherwise specific(HGBL-NOS),which are morphologically characteristic of HGBL but lack MYC,BCL-2,or BCL-6 *** is partially transformed by follicular lymphoma and other indolent lymphoma,with few cases of marginal zone lymphoma(MZL)*** often has a poor prognosis and intensive therapy is currently mainly advocated,but there is no good treatment for these patients who cannot tolerate *** SUMMARY We reported a case of MZL transformed into HGBL-NOS with TP53 mutation and terminal deoxynucleotidyl transferase *** analysis revealed the gene expression profile was identical in the pre-and post-transformed tissues,suggesting that the two diseases are homologous,not secondary *** chemotherapy was ineffective and the side effect was severe,so we tried combination therapy including venetoclax and *** patient tolerated treatment well,and reached partial *** patient had recurrence of hepatocellular carcinoma and died of multifunctional organ *** survived for 12 months after *** Venetoclax combined with obinutuzumab might improve the survival in some HGBL patients,who are unsuitable for chemotherapy.

关键词： Marginal zone lymphoma High-grade B-cell lymphoma Terminal deoxynucleotidyl transferase Venetoclax TP53 mutation Case report

Application of Laser Magnetic Resonance Spectroscopy to the Measurement of Electric Dipole Moment of Free Radicals

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Chinese Physics Letters 2001年第6期18卷 774-775页

作者： liU Yu-Yan GUO Yuan-Qing HUANG Guang-Ming lin jie-li DUAN Chuan-Xi li Feng-Yan li Jin-Rui Key Laboratory for Optical and Magnetic Resonance Spectroscopy Department of PhysicsEast China Normal UniversityShanghai 200062 The State Key Laboratory of Magnetic Resonance and Atomic&Molecular Physics Wuhan Institute of Physics and MathematicsChinese Academy of SciencesWuhan 430071 Department of Physics Huazhong Normal UniversityWuhan 430070

An intracavity CO laser magnetic resonance spectrometer with homogeneous dc electric field applied via a pair of parallel Stark plates in the absorption cell is used to measure the electric dipole moments of free *** advantage of high sensitivity and high resolution of this technique and the Stark effect,highly-resolved saturated absorption spectra of v=1-0 transition of ^(15)N^(16)O in the ground state X^(2)II_(3/2) have been successfully observed in the presence of a low electric *** electric dipole moment of NO in the electronic ground state is determined asμ=0.1566±14 D(Debye)from the analysis of the observed spectra,confirming that,combined with the Stark field,the laser magnetic resonance technique can be an effective and reliable approach for the precise measurement of electric dipole moments of free radicals,especially the unstable ones.

关键词： dipole absorption Stark

Women Protecting Endangered Animals

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Women of China 1997年第9期 18-19页

作者： lin MING li jie

ON the Yongding River, 40 kilometers south of Beijing lies the Beijing Center for Breeding Endangered *** more than 10 years ago it is the only rare and endangered animal base in China, incorporating such functions as Scientific research, raising, breeding and medical treatment. There are more than 30 national and international rare species, with a total of more than 1,000 animals. Among them, the snub-nosed golden monkey, Chinese monal pheasant and eared pheasant account for the largest number of man-bred species in the world.

关键词： Women Protecting Endangered Animals Zhang