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Intestinal microbiota and juvenile idiopathic arthritis:current understanding and future prospective

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World Journal of Pediatrics 2021年第1期17卷 40-51页

作者： Le Xin feng He Sen Li Zhi-Xuan Zhou Xiao-lin ma Gynecological Minimal Invasive Center Beijing Obstetrics and Gynecology HospitalCapital Medical UniversityBeijingChina Department of Biochemistry and Immunology Capital Institute of PediatricsYabao Road No.2Chaoyang DistrictBeijingChina Department of Rheumatology Capital Institute of PediatricsBeijingChina

Background Juvenile idiopathic arthritis(JIA)characterized by arthritis of unknown origin is the most common childhood chronic rheumatic disease,caused by both host genetic factors and environmental *** evidence has mounted to focus on the intestinal microbiota,a potentially recognized set of environmental triggers affecting JIA *** we offer an overview of recently published animal and human studies that support the impact of intestinal microbiota in *** sources We searched PubMed for animal and human studies publications with the search terms"intestinal microbiota or gut microbiota"and"juvenile idiopathic arthritis or juvenile chronic arthritis or juvenile rheumatoid arthritis or childhood rheumatoid arthritis or pediatric rheumatoid arthritis".Results Several comparative studies have demonstrated that intestinal microbial alterations might be triggers in disease ***,a slice of studies has suggested environmental triggers in early life might disrupt intestinal microbial colonization,including cesarean section,formula feeding,and antibiotic *** intestinal microbiota may influence the development of JIA by mediating host immune programming and by altering mucosal *** Specific microbial factors may contribute to the pathogenesis of *** studies,however,are warranted to investigate the causality between intestinal dysbiosis and JIA and the mechanisms behind these epidemiologic *** are also needed to design the best interventional administrations to restore balanced intestinal microbial communities.

关键词： Antibiotic exposure Cesarean section Immune system reprogramming Intestinal microbiota Juvenile idiopathic arthritis

Structural and microwave absorption properties of CoFe_(2)O_(4)/residual carbon composites

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International Journal of Minerals,Metallurgy and materials 2025年第1期32卷 221-232页

作者： Yuanchun Zhang Shengtao Gao Xingzhao Zhang Dacheng ma Chuanlei Zhu Jun He Joint National-Local Engineering Research Centre for Safe and Precise Coal Mining Anhui University of Science and TechnologyHuainan 232001China School of Chemical and Blasting Engineering Anhui University of Science and TechnologyHuainan 232001China

Electromagnetic interference,which necessitates the rapid advancement of substances with exceptional capabilities for bsorbing electromagnetic waves,is of urgent concern in contemporary *** this work,CoFe_(2)O_(4)/residual carbon from coal gasification fine slag(CFO/RC)composites were created using a novel hydrothermal *** mechanisms for microwave absorption,including conductive loss,natural resonance,interfacial dipole polarization,and magnetic flux loss,are involved in these ***,compared with pure residual carbon materials,this composite offers superior capabilities in microwave *** 7.76GHz,the CFO/RC-2 composite achieves an impressive minimum reflection loss(RL_(min))of-43.99 dB with a thickness of 2.44 ***,CFO/RC-3 demonstrates an effective absorption bandwidth(EAB)of up to 4.16 GHz,accompanied by a thickness of *** study revealed the remarkable capability of the composite to diminish electromagnetic waves,providing a new generation method for microwave absorbing materials of superior quality.

关键词： coal gasification slag residual carbon hydrothermal method microwave absorption CoFe_(2)O_(4)

FK506 contributes to peripheral nerve regeneration by inhibiting neuroinflammatory responses and promoting neuron survival

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Neural Regeneration Research 2025年第7期20卷 2108-2115页

作者： Yuhui Kou Zongxue Jin Yusong Yuan Bo ma Wenyong Xie Na Han Department of Trauma and Orthopedics Peking University People’s HospitalBeijingChina National Center for Trauma Medicine Peking University People’s HospitalBeijingChina Key Laboratory of Trauma and Neural Regeneration(Peking University) Ministry of EducationBeijingChina Trauma Medicine Center Peking University People’s HospitalBeijingChina Department of Orthopedics China-Japan Friendship HospitalBeijingChina

FK506(Tacrolimus)is a systemic immunosuppressant approved by the *** and Drug ***506 has been shown to promote peripheral nerve regeneration,however,its precise mechanism of action and its pathways remain *** this study,we established a rat model of sciatic nerve injury and found that FK506 improved the morphology of the injured sciatic nerve,increased the numbers of motor and sensory neurons,reduced inflammatory responses,markedly improved the conduction function of the injured nerve,and promoted motor function *** findings suggest that FK506 promotes peripheral nerve structure recovery and functional regeneration by reducing the intensity of inflammation after neuronal injury and increasing the number of surviving neurons.

关键词： FK506 inflammation motor neurons nerve regeneration neuron peripheral nerve injury sensory neurons

Human induced pluripotent stem cell-derived therapies for regeneration after central nervous system injury

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Neural Regeneration Research 2025年第11期20卷 3063-3075页

作者： Stephen Vidman Yee Hang Ethan ma Nolan Fullenkamp Giles W.Plant Department of Neuroscience Ohio State UniversityColumbusOHUSA

In recent years,the progression of stem cell therapies has shown great promise in advancing the nascent field of regenerative *** the non-regenerative nature of the mature central nervous system,the concept that“blank”cells could be reprogrammed and functionally integrated into host neural networks remained *** work has also demonstrated the ability of such cells to stimulate intrinsic growth programs in post-mitotic cells,such as *** embryonic stem cells demonstrated great potential in treating central nervous system pathologies,ethical and technical concerns *** barriers,along with the clear necessity for this type of treatment,ultimately prompted the advent of induced pluripotent stem *** advantage of pluripotent cells in central nervous system regeneration is multifaceted,permitting differentiation into neural stem cells,neural progenitor cells,glia,and various neuronal *** precise spatiotemporal application of extrinsic growth factors in vitro,in addition to microenvironmental signaling in vivo,influences the efficiency of this directed *** the pluri-or multipotency of these cells is appealing,it also poses the risk of unregulated differentiation and teratoma *** of the neuroectodermal lineage,such as neuronal subpopulations and glia,have been explored with varying degrees of *** the risk of cancer or teratoma formation is greatly reduced,each subpopulation varies in effectiveness and is influenced by a myriad of factors,such as the timing of the transplant,pathology type,and the ratio of accompanying progenitor ***,successful transplantation requires innovative approaches to develop delivery vectors that can mitigate cell death and support ***,host immune responses to allogeneic grafts must be thoroughly characterized and further developed to reduce the need for *** to a clinical setting wi

关键词： axon regeneration central nervous system regeneration induced pluripotent stem cells neurotrauma regenerative medicine spinal cord injury stem cell therapy

Morphology engineering of ZnO micro/nanostructures under mild conditions for optoelectronic application

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International Journal of Minerals,Metallurgy and materials 2025年第2期32卷 498-503页

作者： Liang Chu Haoyu Shen Hudie Wei Hongyu Chen Guoqiang ma Wensheng Yan Institute of Carbon Neutrality and New Energy&School of Electronics and Information Hangzhou Dianzi UniversityHangzhou 310018China School of Applied Physics and materials Wuyi UniversityJiangmen 529020China

Zinc oxide(ZnO)serves as a crucial functional semiconductor with a wide direct bandgap of approximately 3.37 *** reaction is commonly used in the synthesis of ZnO micro/nanostructures,given its low cost,simplicity,and easy ***,ZnO morphology engineering has become desirable through the alteration of minor conditions in the reaction process,particularly at room *** this work,ZnO micro/nanostructures were synthesized in a solution by varying the amounts of the ammonia added at low temperatures(including room temperature).The formation of Zn^(2+)complexes by ammonia in the precursor regulated the reaction rate of the morphology engineering of ZnO,which resulted in various structures,such as nanoparticles,nanosheets,microflowers,and single ***,the obtained ZnO was used in the optoelectronic application of ultraviolet detectors.

关键词： morphology engineering low temperature ZnO nanosheets microflowers ultraviolet detector

The Mechanical Characteristics and Damage Model of Helan Mountain Rock based on Acoustic Emission

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Journal of Wuhan University of Technology(materials Science) 2021年第6期36卷 845-864页

作者： YANG Youzhen ZHAO Yishen ma Hailong CHEN Wenwu feng Haiyan JIN Menghua lin Qingqing ma Wenguo School of Physics and Electronic and Electrical Engineering Ningxia UniversityYinchuan 750021China Institute of Solid Mechanics Ningxia UniversityYinchuan 750021China College of Civil Engineering and Mechanics Lanzhou UniversityYinchuan 750021China Institute of Ethnic Preparatory Education Ningxia UniversityLanzhou 730000China Shanghai Junnel Engineering Co.Ltd. Shanghai 200030China

With the risk of disappearing for the rock paintings considering long-term exposure in Helan Mountain,the freeze-thaw(F-T)cycling experiments were carried out with 12-hour F-T cycling(0,10,20,30,and 40 F-T cycles)under five kinds of confining pressures(5,10,20,30,and 40 MPa).The acoustic emission(AE)detect technology was used to reveal the rock fracturing characteristics during the triaxial compression test whole *** stress-strain relation changes along with different confining pressures and F-T *** stress and residual stress changes along with different confining pressures and damages,and the variation of axial stress-AE ringing counts-time changes along with different confining pressures and F-T *** damage variable with AE parameter under F-T and force coupling was defined for the first time,and the damages model was *** experimental results show that the F-T cycles lead to the decrease of rock strength and the gradual transformation of compression failure mode from brittleness to *** confining pressure provides a certain ability to resist deformation and inhibit crack growth for rock samples after F-T *** temporal and spatial evolution law of AE counts well corresponds to the loading and failure process of the rock *** AE 3D positioning technology can accurately capture the development position and direction of internal cracks and pores of rock,and the failure form is conical shear *** established damage model has a better fittingness between the theoretical calculation results and the test results,and is reasonable to be used in the future for protection of Helan Mountain rock painting.

关键词： helan mountain rock freeze-thaw(F-T) acoustic emission(AE) damage model

Controlling Roll Temperature by Fluid-Solid Coupled Heat Transfer

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Chinese Journal of Mechanical Engineering 2018年第5期31卷 66-79页

作者： Jing-feng Zou Li-feng ma Guo-Hua Zhang Zhi-Quan Huang Jin-Bao lin Peng-Tao Liu Heavy machinery Engineering Research Center of the Ministry Education Taiyuan University of Science and Technology Taiyuan 030024 China School of Mechanical Engineering Taiyuan University of Technology Taiyuan 030024 China

Currently, when magnesium alloy sheet is rolled, the method of controlling roll temperature is simple and inaccurate. Furthermore, roll temperature has a large influence on the quality of magnesium alloy sheet; therefore, a new model using circular fluid flow control roll temperature has been designed. A fluid heat transfer structure was designed, the heat transfer process model of the fluid heating roll was simplified, and the finite di erence method was used to cal?culate the heat transfer process. Fluent software was used to simulate the fluid?solid coupling heat transfer, and both the trend and regularity of the temperature field in the heat transfer process were identified. The results show that the heating e ciency was much higher than traditional heating methods(when the fluid heat of the roll and tempera?ture distribution of the roll surface was more uniform). Moreover, there was a bigger temperature di erence between the input and the output, and after using reverse flow the temperature di erence decreased. The axial and circum?ferential temperature distributions along the sheet were uniform. Both theoretical calculation results and numerical simulation results of the heat transfer between fluid and roll were compared. The error was 1.8%–12.3%, showing that the theoretical model can both forecast and regulate the temperature of the roll(for magnesium alloy sheets) in the rolling process.

关键词： magnesium alloy Fluid heating Heat transfer model Numerical simulation of fluid?solid coupling

VOC emitted by biopharmaceutical industries:Source profiles,health risks,and secondary pollution

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Journal of Environmental Sciences 2024年第1期135卷 570-584页

作者： Jiawei ma lin Li State Key Laboratory of Environmental Aquatic Chemistry Research Center for Eco-Environmental SciencesChinese Academy of SciencesBeijing 100085China University of Chinese Academy of Sciences Beijing 100049China National Engineering Laboratory for VOCs Pollution Control material&Technology University of Chinese Academy of SciencesBeijing 101408China

The biopharmaceutical industry contributes substantially to volatile organic compounds(VOCs)emissions,causing growing concerns and social developmental *** study conducted an on-site investigation of the process-based emission of VOCs from three biopharmaceutical *** the workshops of the three enterprises,26 VOCs were detected,which could be sorted into 4 classes:hydrocarbons,aromatic hydrocarbons,oxygen-containing compounds,and nitrogen-containing *** were the main components of waste gases,accounting for 44.13%-77.85%of the overall ***-based source profiles were compiled for each process unit,with the fermentation and extraction units of tiamulin fumarate being the main source of VOC *** heptanone,vinyl acetate,diethylamine,propylene glycol methyl ether(PGME),and benzene were screened as priority pollutants through a fuzzy comprehensive evaluation *** level concentration simulation results of the Gauss plume diffusion model demonstrated that the diffusivity of VOCs in the atmosphere was relatively high,indicating potential non-carcinogenic and carcinogenic risks 1.5-2 km ***,the process-based formation potentials of ozone and secondary organic aerosols(SOAs)were determined and indicated that N-methyl-2-pyrrolidone,dimethyl heptanone,and PGME should be preferentially controlled to reduce the ozone formation potential,whereas the control of benzene and chlorobenzene should be prioritized to reduce the generation of *** results provide a basis for understanding the characteristics of VOC emission by biopharmaceutical industries and their diffusion,potentially allowing the development of measures to reduce health risks and secondary pollution.

关键词： Biopharmaceutical Volatile organic compound Priority pollutant Exposure risk Secondary pollution

Development of an in-situ H_(2)reduction and moderate oxidation method for 3,5-dimethylpyridine hydrogenation in trickle bed reactor

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Frontiers of Chemical Science and Engineering 2022年第12期16卷 1807-1817页

作者： Tao lin Xiaoxun ma School of Chemical Engineering Northwest UniversityXi’an 710069China Kaili Catalyst&New materials Co. Ltd.Xi’an 710201China Shaanxi Key Laboratory of Catalytic materials and Technology Xi’an 710201China Chemical Engineering Research Center of the Ministry of Education(MOE)for Advanced Use Technology of Shanbei Energy Xi’an 710069China Shaanxi Research Center of Engineering Technology for Clean Coal Conversion Xi’an 710069China Collaborative Innovation Center for Development of Energy and Chemical Industry in Northern Shaanxi Xi’an 710069China International Scientific and Technological Cooperation Base of the Ministry of Science and Technology(MOST)for Clean Utilization of Hydrocarbon Resources Xi’an 710069China

The Ru/C catalyst prepared by impregnation method was used for hydrogenation of 3,5-dimethylpyridine in a trickle bed *** the same reduction conditions(300°C in H_(2)),the catalytic activity of the non-in-situ reduced Ru/C-n catalyst was higher than that of the in-situ reduced Ru/C-y ***,an in-situ H_(2)reduction and moderate oxidation method was developed to increase the catalyst ***,the influence of oxidation temperature on the developed method was *** catalysts were characterized by Brunauer–Emmett–Teller method,hydrogen temperature programmed reduction H_(2)-TPR,hydrogen temperature-programmed dispersion(H_(2)-TPD),X-ray diffraction,energy dispersive spectroscopy,X-ray photoelectron spectroscopy,Raman spectroscopy,O2 chemisorption and oxygen temperature-programmed dispersion(O2-TPD)*** results showed that there existed an optimal Ru/RuO_(x)ratio for the catalyst,and the highest 3,5-dimethylpyridine conversion was obtained for the Ru/C-i1 catalyst prepared by in-situ H_(2)reduction and moderate oxidation(oxidized at 100°C).Excessive oxidation(200°C)resulted in a significant decrease in the Ru/RuO_(x)ratio of the in-situ H_(2)reduction and moderate oxidized Ru/C-i2 catalyst,the interaction between RuO_(x)species and the support changed,and the hard-to-reduce RuO_(x)species was formed,leading to a significant decrease in catalyst *** developed in-situ H_(2)reduction and moderate oxidation method eliminated the step of the non-in-situ reduction of catalyst outside the trickle bed reactor.

关键词： Ru C catalyst in-situ H_(2)reduction and moderate oxidation in-situ reduction non-in-situ reduction hydrogenation of 3,5-dimethylpyridine