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Diagnosis and treatment of post-cholecystectomy diarrhoea

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World Journal of Gastrointestinal Surgery 2023年第11期15卷 2398-2405页

作者： Rang-Lang Huang Wen-Kai Huang Xiang-Yi Xiao lin-feng ma He-Zi-Rui Gu Guo-Ping Yang Department of Hepatobiliary and Pancreatic Surgery The Third Xiangya Hospital of The Central South UniversityChangsha 410013Hunan ProvinceChina Department of General Medicine The Third Xiangya Hospital of The Central South UniversityChangsha 410013Hunan ProvinceChina The Xiangya School of Medicine The Central South UniversityChangsha 410013Hunan ProvinceChina Department of Clinical Pharmacy The Third Hospital of The Central South UniversityChangsha 410013Hunan ProvinceChina

The incidence of cholecystitis is relatively high in developed countries and may usually be attributed to gallstones,the treatment for which involves complete surgical removal of the gallbladder(cholecystectomy).Bile acids produced following cholecystectomy continue to flow into the duodenum but are poorly absorbed by the *** bile acids in the colon stimulate mucosal secretion of water and electrolytes leading,in severe cases,to *** acid diarrhoea(BAD)is difficult to diagnose,requiring a comprehensive medical history and physical examination in combination with laboratory *** current work reviews the diagnosis and treatment of BAD following chole-cystectomy.

关键词： Cholecystitis Gallstones Bile acids Colon Bile acid diarrhoea

淋巴瘤病灶对^(18)F-FDG摄取与不同病理亚型的关系

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癌症 2009年第4期28卷 425-430页

作者：马林峰樊卫华南肿瘤学国家重点实验室广东广州510060 中山大学肿瘤防治中心核医学科广东广州510060

背景与目的:以往研究表明恶性度越高的淋巴瘤对2-氟-18-氟-2-脱氧-D-葡萄糖(18F-FDG)摄取也越高,本研究对不同病理亚型淋巴瘤患者全身浸润病灶对FDG的摄取情况进行分析,并探讨淋巴瘤FDG的摄取与亚型之间的关系。方法:回顾性分析102例初... 详细信息

背景与目的:以往研究表明恶性度越高的淋巴瘤对2-氟-18-氟-2-脱氧-D-葡萄糖(18F-FDG)摄取也越高,本研究对不同病理亚型淋巴瘤患者全身浸润病灶对FDG的摄取情况进行分析,并探讨淋巴瘤FDG的摄取与亚型之间的关系。方法:回顾性分析102例初诊淋巴瘤患者的影像与临床资料,在PET/CT图像上对每一个单独浸润病灶测量其最大标准化摄取值(standardized uptake value,SUV),再与纵隔血池最大SUV值相比,得出每例患者全身平均肿瘤/纵隔血池比值(tumor SUVmax/mediastinal SUVmax,T/MB),进而得出各病理亚型淋巴瘤全部患者T/MB平均值。然后分析霍奇金淋巴瘤(Hodgkin's lymphoma,HL)与非霍奇金淋巴瘤(non-Hodgkin's lymphoma,NHL),HL与惰性NHL、侵袭性NHL,NHL中B细胞性NHL与NK/T细胞性NHL、弥漫大B细胞淋巴瘤不同临床分期之间差异有无显著性。同时对4例全身大部分病灶无明显FDG摄取的淋巴瘤患者及对照组高摄取FDG的淋巴瘤患者活检淋巴结Ki67指标进行分析。结果:HL与NHLT/MB值分别为4.50±1.54、5.21±2.86(P=0.154);侵袭性NHL要远高于惰性NHL、HL(P<0.001);B细胞性NHL与NK/T细胞性NHL的T/MB值分别为5.29±3.00与4.91±2.30(P=0.57);弥漫大B细胞淋巴瘤不同临床分期之间T/MB值差异无统计学意义。4例无明显FDG摄取的淋巴瘤患者,活检淋巴结Ki67阳性率低于阳性对照组。结论:淋巴瘤全身病灶摄取FDG的高低,与淋巴瘤侵袭性有关,与细胞学起源及临床分期无关。本研究中4例淋巴瘤患者全身大部分病灶无明显FDG摄取可能与Ki67阳性率低下有关。

关键词：淋巴瘤病理类型病灶 ^18F-FDG摄取 PET/CT

mainchain conformation ordering self-assembly tailored room temperature phosphorescence emission

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Science China Chemistry 2025年第01期 329-336页

作者： Yuzhu Li Yumeng Gao feng Tian Yu Wang Yuan Yao Shaoliang lin Xiang ma Binbin Xu Shanghai Key Laboratory of Advanced Polymeric materials Key Laboratory for Ultrafine Materials of Ministry of Education School of Materials Science and Engineering East China University of Science and Technology Shanghai Synchrotron Radiation Facility Shanghai Advanced Research Institute Chinese Academy of Sciences Key Laboratory for Advance materials and Feringa Noble Prize Scientist Joint Research Centre Frontiers Science for Materiobiology and Dynamic Chemistry School of Chemistry and Molecular Engineering East China University of Science & Technology

Developing organic room-temperature phosphorescence （RTP） materials with a wide range of tunable-emission is significant in expanding the applications of RTP ***,we rationally designed amphiphilic alternating copolymers poly(1,2-bis（4-alkoxyphenyl）ethane-1,2-dione-alt-（ethylene glycol）x)(P（Bz-alt-EGx）) that combined the advantage of alternating benzil and EGxskeleton,and tunable mainchain *** a mainchain conformation ordering assembly （COA） process,P（Bz-alt-EGx） self-assembled into well-defined platelets,and such assemblies emitted blue RTP at ca.425 nm due to the ordered folded-chain conformation and confined *** contrast,traditional self-assembly （TA） of P（Bz-alt-EGx） obtained less ordered aggregates,such as asymmetric worms,vesicles,and rod-like *** resultant less ordered aggregates exhibited yellow-green RTP at ca.550 *** wide-tuning RTP emission in solution （between blue and yellow-green,over125 nm） is realized using the P（Bz-alt-EGx） alternating copolymers under the treatment of different self-assembly *** study uncovers a new strategy to tailor the RTP emission through different self-assembly pathways and holds great promise for the fabrication of advanced optical materials.

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Numerical Simulation of Coalescence of Numerous Microcracks

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Numerical Simulation of Coalescence of Numerous Microcracks

Interaction of major facilitator superfamily domain containing 2A with the blood-brain barrier

The Sixth World Congress on Computational Mechanics in Conjunction with the Second Asian-Pacific Congress on Computational Mechanics

作者： Xiqiao feng~*, lin ma Department of Engineering Mechanics, Tsinghua University, Beijing 100084, China

many phenomena of deformation and failure of brittle or quasi-brittle solids are closely related to interaction and propagation of stochastically distributed microcracks. In this paper, a numerical method is presented for calculating the effective elastic moduli and the tensile strength and for simulating the failure process of brittle specimens associated with microcracking damage. By introducing two criteria for microerack growth and coalescence in terms of Griffith's energy release rate, the above numerical method is used here to simulate the coalescence process of microcracks that results in a fatal crack and the final rupture of a specimen.

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Neural Regeneration Research 2025年第8期20卷 2133-2152页

作者： Yilun ma Taiwei Dong Fei Luan Juanjuan Yang feng Miao Peifeng Wei College of Pharmacy and First Clinical Medical College Shaanxi University of Chinese MedicineXianyangShaanxi ProvinceChina National Drug Clinical Trial Agency The Second Affiliated Hospital of Shaanxi University of Chinese Medicine/Xixian New District Central HospitalXi′anShaanxi ProvinceChina

The functional and structural integrity of the blood-brain barrier is crucial in maintaining homeostasis in the brain microenvironment;however,the molecular mechanisms underlying the formation and function of the blood-brain barrier remain poorly *** major facilitator superfamily domain containing 2A has been identified as a key regulator of blood-brain barrier *** plays a critical role in promoting and maintaining the formation and functional stability of the blood-brain barrier,in addition to the transport of lipids,such as docosahexaenoic acid,across the blood-brain ***,an increasing number of studies have suggested that major facilitator superfamily domain containing 2A is involved in the molecular mechanisms of blood-brain barrier dysfunction in a variety of neurological diseases;however,little is known regarding the mechanisms by which major facilitator superfamily domain containing 2A affects the blood-brain *** paper provides a comprehensive and systematic review of the close relationship between major facilitator superfamily domain containing 2A proteins and the blood-brain barrier,including their basic structures and functions,cross-linking between major facilitator superfamily domain containing 2A and the blood-brain barrier,and the in-depth studies on lipid transport and the regulation of blood-brain barrier *** comprehensive systematic review contributes to an in-depth understanding of the important role of major facilitator superfamily domain containing 2A proteins in maintaining the structure and function of the blood-brain barrier and the research progress to *** will not only help to elucidate the pathogenesis of neurological diseases,improve the accuracy of laboratory diagnosis,and optimize clinical treatment strategies,but it may also play an important role in prognostic *** addition,the effects of major facilitator superfamily domain containing 2A on blood-brain barrier lea

关键词： blood-brain barrier(BBB) caveolin-1 central nervous system docosahexaenoic acid endothelial cells lysophosphatidylcholine major facilitator superfamily domain containing 2A(MFSD2A) transcytosis

Locally Enhanced Flow and Electric Fields Through a Tip Effect for Efficient Flow‑Electrode Capacitive Deionization

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Nano-Micro Letters 2025年第2期17卷 1-17页

作者： Ziquan Wang Xiangfeng Chen Yuan Zhang Jie ma Zhiqun lin Amor Abdelkader maria‑magdalena Titirici Libo Deng College of Chemistry and Environmental Engineering Shenzhen UniversityShenzhen 518060People’s Republic of China Research Center for Environmental Functional materials College of Environmental Science and EngineeringTongji University1239 Siping RoadShanghai 200092People’s Republic of China Department of Chemical and Biomolecular Engineering National University of SingaporeSingapore 117585Singapore Department of Engineering Faculty of Science and TechnologyBournemouth UniversityTalbot CampusFern BarrowPooleEngland BH125BBUK Institut de Chimie de Nice UniversitéCôte d’AzurUMR CNRS 727228 Av.Valrose06108 NiceFrance Department of Chemical Engineering Imperial College LondonSouth Kensington CampusExhibition RdLondon SW72AZUK

Low-electrode capacitive deionization(FCDI)is an emerging desalination technology with great potential for removal and/or recycling ions from a range of ***,it still suffers from inefficient charge transfer and ion transport kinetics due to weak turbulence and low electric intensity in flow electrodes,both restricted by the current ***,a new tip-array current collector(designated as T-CC)was developed to replace the conventional planar current collectors,which intensifies both the charge transfer and ion transport *** effects of tip arrays on flow and electric fields were studied by both computational simulations and electrochemical impedance spectroscopy,which revealed the reduction of ion transport barrier,charge transport barrier and internal *** the voltage increased from 1.0 to 1.5 and 2.0 V,the T-CC-based FCDI system(T-FCDI)exhibited average salt removal rates(ASRR)of 0.18,0.50,and 0.89μmol cm^(-2) min^(-1),respectively,which are 1.82,2.65,and 2.48 folds higher than that of the conventional serpentine current collectors,and 1.48,1.67,and 1.49 folds higher than that of the planar current ***,with the solid content in flow electrodes increased from 1 to 5 wt%,the ASRR for T-FCDI increased from 0.29 to 0.50μmol cm^(-2) min^(-1),which are 1.70 and 1.67 folds higher than that of the planar current ***,a salt removal efficiency of 99.89%was achieved with T-FCDI and the charge efficiency remained above 95%after 24 h of operation,thus showing its superior long-term stability.

关键词： Flow-electrode Capacitive deionization Current collector Tip effect Desalination

Local magnetic moment oscillation around an Anderson impurity on graphene

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Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 192-201页

作者： Shuai Li Zhen ma Jin-Hua Gao School of Science Hebei University of Science and Technology School of Electronics and Information Zhengzhou University of Light Industry School of Physics and Wuhan National High magnetic Field Center Huazhong University of Science and Technology

We theoretically investigate the spin resolved Friedel oscillation （FO） and quasiparticle interference （QPI） in graphene induced by an Anderson *** the impurity becomes magnetic,the resulted FO becomes spin dependent,which gives rise to a local magnetic moment oscillation with an envelop decaying as r-2in real space in the doping ***,at half filling,the electron density and local magnetic moment will not oscillate but decay as *** spin resolved FO has both sublattice and spin ***,the local magnetic moment decay at half filling only occurs at one sublattice of graphene,which is quite like the phenomenon observed in the STM experiment (***ález-Herrero et al.,Science 352,437 （2016）).We further give an analytic formula about such spin dependent FO based on the stationary phase ***,we study the interference of quasiparticles around the magnetic impurity by calculating the spin dependent Fourier-transformed local density of states （FT-LDOS）.Our work gives a comprehensive understanding about the local magnetic moment oscillation around an Anderson impurity on graphene.

关键词： Friedel oscillation local magnetic moment graphene Anderson impurity

CNKSR2 interactome analysis indicates its association with the centrosome/microtubule system

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Neural Regeneration Research 2025年第8期20卷 2420-2432页

作者： lin Yin Yalan Xu Jie Mu Yu Leng Lei ma Yu Zheng Ruizhi Li Yin Wang Peifeng Li Hai Zhu Dong Wang Jing Li Institute for Translational Medicine The Affiliated Hospital of Qingdao UniversityMedical CollegeQingdao UniversityQingdaoShandong ProvinceChina School of Basic Medicine Qingdao UniversityQingdaoShandong ProvinceChina College of Life Sciences and School of PharmacyMedical CollegeQingdao UniversityQingdaoShandong ProvinceChina Department of Urology Qingdao Municipal Hospital Affiliated to Qingdao UniversityQingdaoShandong ProvinceChina

The protein connector enhancer of kinase suppressor of Ras 2(CNKSR2),present in both the postsynaptic density and cytoplasm of neurons,is a scaffolding protein with several protein-binding *** of the CNKSR2 gene have been implicated in neurodevelopmental disorders,particularly intellectual disability,although the precise mechanism involved has not yet been fully *** has demonstrated that CNKSR2 plays a role in facilitating the localization of postsynaptic density protein complexes to the membrane,thereby influencing synaptic signaling and the morphogenesis of dendritic ***,the function of CNKSR2 in the cytoplasm remains to be *** this study,we used immunoprecipitation and high-resolution liquid chromatography-mass spectrometry to identify the interactors of *** a combination of bioinformatic analysis and cytological experiments,we found that the CNKSR2 interactors were significantly enriched in the proteome of the *** also showed that CNKSR2 interacted with the microtubule protein DYNC1H1 and with the centrosome marker *** colocalization analysis confirmed the centrosomal localization of *** we downregulated CNKSR2 expression in mouse neuroblastoma cells(Neuro 2A),we observed significant changes in the expression of numerous centrosomal *** manipulation also affected centrosome-related functions,including cell size and shape,cell proliferation,and ***,we found that CNKSR2 interactors were highly enriched in de novo variants associated with intellectual disability and autism spectrum *** findings establish a connection between CNKSR2 and the centrosome,and offer new insights into the underlying mechanisms of neurodevelopmental disorders.

关键词： autism spectrum disorder centrosome CNKSR2 intellectual disability interactome mass spectrometry microtubule neurodevelopmental disease protein complexes protein-protein interactions

Harnessing therapeutic potential of induced pluripotent stem cell–derived endothelial cells for remyelination in the central nervous system

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Neural Regeneration Research 2025年第6期20卷 1715-1716页

作者： Dan ma Nona Pop Aston Medical School College of Health and Life SciencesAston UniversityBirminghamUK

Myelin is the protective sheath surrounding nerve fibers, and its damage(demyelination) occurs in many central nervous system(CNS) diseases, including multiple sclerosis(MS), traumatic injury, neurodegenerative diseases such as Alzheimer's disease, and mental disorders such as schizophrenia(Barateiro et al., 2016). Repair of damaged myelin sheaths(remyelination) often fails in MS, leading to neuronal loss and irreversible functional deficits.

关键词： myelin protective diseases