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脊神经后根切断术对痉挛型脑瘫髋关节发育的影响

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中国矫形外科杂志 2022年第9期30卷 791-795页

作者：于睿钦徐林刘港张厚君胡传宇任敬佩赵毅刘丽穆晓红北京中医药大学东直门医院骨科北京100700

[目的]探究腰骶段选择性脊神经后根切断术(seletive posterior rhizotomy,SPR)对痉挛型脑瘫髋关节发育的影响。[方法]回顾性分析2017年2月-2020年2月本科行SPR的痉挛型脑瘫50例患儿(共100髖)的临床资料,根据年龄分为学龄前组与学龄组。... 详细信息

[目的]探究腰骶段选择性脊神经后根切断术(seletive posterior rhizotomy,SPR)对痉挛型脑瘫髋关节发育的影响。[方法]回顾性分析2017年2月-2020年2月本科行SPR的痉挛型脑瘫50例患儿(共100髖)的临床资料,根据年龄分为学龄前组与学龄组。比较两组临床与影像学结果。[结果]两组均顺利完成手术,无严重并发症。学龄前组手术时间与术中出血量均显著少于学龄组(P0.05)。影像学方面,与术前相比,末次随访时两组髖白指数(acetabular index,AD)和颈干角(neck shaft angle,NSA)均无显著变化(P>0.05);学龄前组中心边缘角(center-edge angle,CE)显著增大(P0.05);两组股骨头偏移百分比(migration percentage,MP)均显著减小(P0.05),学龄前组CE仍显著小于学龄组(P<0.05)。[结论]腰骶段SPR术可以改善痉挛型脑瘫患儿髋关节发育。

关键词：痉挛型脑瘫腰骶段末次随访选择性脊神经后根切断术髋关节发育颈干角肌张力外展

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基于线结构光视觉的平面度误差测量方法

吉林大学学报（工学版） 2023年第12期53卷 3358-3366页

作者：刘思远侯跃谦寇莹任真胡正乙赵雪微葛云鹏吉林大学机械与航空航天工程学院长春130022 长春大学机械工程学院长春130022 华南理工大学机械与汽车工程学院广州510641 长春汽车工业高等专科学校产教融合发展中心长春130010

针对机械零部件制造及加工领域的平面度测量问题,提出了一种基于线结构光视觉技术的平面度误差测量方法。首先,采集被测平面上不同位置的光条图像,并根据每个位置所对应的光平面方程获得扫描点的空间坐标。其次,对国家标准中平面度误差... 详细信息

针对机械零部件制造及加工领域的平面度测量问题,提出了一种基于线结构光视觉技术的平面度误差测量方法。首先,采集被测平面上不同位置的光条图像,并根据每个位置所对应的光平面方程获得扫描点的空间坐标。其次,对国家标准中平面度误差评定方法进行分析,建立了基于几何约束的平面度误差视觉测量算法。最后,通过本文算法,利用扫描点空间坐标计算出评定基面及平面度误差。在实验中,选择镶块模具的定位面作为被测平面,并将视觉测量结果与采用接触式测量方法获得的结果进行对比,测量误差小于20μm。实验结果表明本文提出的平面度误差测量方法具有一定的可行性,提高了平面度误差的测量效率。

关键词：机器视觉平面度线结构光视觉公差测量

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手术室护士职业性损伤的认知及防护行为调查

护理管理杂志 2008年第5期8卷 22-24页

作者：侯琳张彦虎胡晶敏赵艺媛首都医科大学附属北京安贞医院手术室北京100029 北京大学护理学院北京100083

目的调查手术室最常见的职业性损伤及护士对损伤的认知程度和防护行为。方法采用自设问卷对70名手术室护士进行问卷调查。结果手术室护士对接触输液器、输血器等一次性物品、医疗仪器引起的辐射、吸入高频电刀使用时所产生的气味、接触... 详细信息

目的调查手术室最常见的职业性损伤及护士对损伤的认知程度和防护行为。方法采用自设问卷对70名手术室护士进行问卷调查。结果手术室护士对接触输液器、输血器等一次性物品、医疗仪器引起的辐射、吸入高频电刀使用时所产生的气味、接触环氧乙烷消毒的物品、接触纱布纤维以及接触残余吸入性麻醉药物及废气等潜在的职业性损伤认知程度相对较弱。其中,使用含有聚氯乙烯(PVC)成分的一次性物品的认知和防护行为得分均较低,两者呈正相关(r=0.26,P<0.05)。结论随着医学新技术、新材料的应用,手术室职业性损伤的危险性有所增加,护士对新出现的职业性损伤认知程度较低,与之相应的防护行为有待提高。

关键词：手术室职业性损伤认知行为职业防护

矿化垃圾生物覆盖层减少垃圾填埋场CH_4、N_2O和CO_2释放的效应研究

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生态与农村环境学报 2014年第1期30卷 15-20页

作者：刘景龙张毅张后虎赵克强黄天寅严小飞苏州科技学院环境科学与工程学院江苏苏州215009 环境保护部南京环境科学研究所江苏南京210042

对利用矿化垃圾构建生物覆盖层以削减填埋场温室气体的释放问题进行了深入研究,分析了环境因素对CH4释放的作用,考察了作为生物覆盖层材料的矿化垃圾的厚度变化对CH4氧化的影响.结果表明,温度为5～45℃时,矿化垃圾对CH4的氧化速率平均... 详细信息

对利用矿化垃圾构建生物覆盖层以削减填埋场温室气体的释放问题进行了深入研究,分析了环境因素对CH4释放的作用,考察了作为生物覆盖层材料的矿化垃圾的厚度变化对CH4氧化的影响.结果表明,温度为5～45℃时,矿化垃圾对CH4的氧化速率平均值分别约为黏性土和砂性土的2.35和4.71倍,CH4氧化速率随温度的升高而增加,并在35℃时达到最大值.当含水率w为16％～ 24％时,纯矿化垃圾覆盖层、半矿化垃圾覆盖层和砂性土覆盖层CH4氧化能力均达到最大.砂性土覆盖层和半矿化垃圾覆盖层CH4释放通量平均值分别为纯矿化垃圾覆盖层的329.8倍（P＜0.05）和91.7倍（P＜0.05）,添加矿化垃圾填料会增加覆盖层N2O释放通量,纯矿化垃圾覆盖层N2O（以N计）释放通量平均值分别为半矿化垃圾覆盖层和砂性土覆盖层的2.1倍（P＜0.05）和3.5倍（P＜0.05）.

关键词：矿化垃圾生物覆盖层 CH4氧化能力温室气体效应

Clinical practice guideline for transurethral plasmakinetic resection of prostate for benign prostatic hyperplasia(2021 Edition)

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Military Medical Research 2022年第5期9卷 515-533页

作者： Xian-Tao Zeng ying-hui Jin Tong-Zu Liu Fang-Ming Chen De-Gang Ding Meng Fu Xin-Quan Gu Bang-Min Han Xing huang Zhi hou Wan-Li hu Xin-Li Kang Gong-hui Li Jian-Xing Li Pei-Jun Li Chao-zhao Liang Xiu-Heng Liu Zhi-Yu Liu Chun-Xiao Liu Jiu-Min Liu Guang-Heng Luo yi Luo Wei-Jun Qin Jian-Hong Qiu Jian-Xin Qiu Xue-Jun Shang Ben-Kang Shi Fa Sun Guo-Xiang Tian Ye Tian Feng Wang Feng Wang yin-huai Wang Yu-Jie Wang Zhi-Ping Wang Zhong Wang Qiang Wei Min-hui Xiao Wan-Hai Xu Fa-Xian yi Chao-yang Zhu Qian-Yuan Zhuang Li-Qun Zhou Xiao-Feng Zou Nian-Zeng Xing Da-lin He Xing-huan Wang 无 Department of Urology Institute of UrologyZhongnan Hospital of Wuhan UniversityWuhan430071China Center for Evidence-Based and Translational Medicine Zhongnan Hospital of Wuhan UniversityWuhan430071China Department of Urology Tianjin Third Central Hospital Affiliated To Nankai UniversityTianjin300170China Department of Urology Henan Provincial People’s HospitalZhengzhou University People’s HospitalZhengzhou450003China Department of Urology Beijing Tsinghua Changgung HospitalSchool of Clinical MedicineTsinghua UniversityBeijing102218China Department of Urology China-Japan Union Hospital of Jilin UniversityChangchun130033China Department of Urology Shanghai General HospitalShanghai Jiao Tong University School of MedicineShanghai200080China Department of Urology Qinghai University Affiliated HospitalXi’ning810012China Department of Urology People’s Hospital of Hainan ProvinceHainan Affiliated Hospital of Hainan Medical University HaikouHaikou570311China Department of Urology Sir Run Run Shaw HospitalZhejiang University School of MedicineHangzhou310016China Department of Urology General Hospital of Ningxia Medical UniversityYinchuan750003China Department of Urology The First Affiliated Hospital of Anhui Medical UniversityHefei230022China Department of Urology Renmin Hospital of Wuhan UniversityWuhan430060China Department of Urology The Second Hospital of Dalian Medical UniversityDalian116023LiaoningChina Department of Urology Zhujiang Hospital of Southern Medical UniversityGuangzhou510282China Department of Urology Guangdong Provincial People’s HospitalGuangdong Academy of Medical SciencesGuangzhou510080China Department of Urology Surgery Guizhou Province People’s HospitalGuiyang550002China Department of Urology Xijing Hospital of Air Force Military Medical UniversityXi’an710032China Department of Urology The 980St Hospital of the PLA Joint Logistics Support Force(Bethune International Peace Hospital of PLA)Shijiazhuang050082China Department of Urology

Benign prostatic hyperplasia (BPH) is highly prevalent among older men, impacting on their quality of life, sexual function, and genitourinary health, and has become an important global burden of disease. Transurethral plasmakinetic resection of prostate (TUPKP) is one of the foremost surgical procedures for the treatment of BPH. It has become well established in clinical practice with good efficacy and safety. In 2018, we issued the guideline “2018 Standard Edition”. However much new direct evidence has now emerged and this may change some of previous recommendations. The time is ripe to develop new evidence-based guidelines, so we formed a working group of clinical experts and methodologists. The steering group members posed 31 questions relevant to the management of TUPKP for BPH covering the following areas: questions relevant to the perioperative period (preoperative, intraoperative, and postoperative) of TUPKP in the treatment of BPH, postoperative complications and the level of surgeons’ surgical skill. We searched the literature for direct evidence on the management of TUPKP for BPH, and assessed its certainty generated recommendations using the grade criteria by the European Association of Urology. Recommendations were either strong or weak, or in the form of an ungraded consensus-based statement. Finally, we issued 36 statements. Among them, 23 carried strong recommendations, and 13 carried weak recommendations for the stated procedure. They covered questions relevant to the aforementioned three areas. The preoperative period for TUPKP in the treatment of BPH included indications and contraindications for TUPKP, precautions for preoperative preparation in patients with renal impairment and urinary tract infection due to urinary retention, and preoperative prophylactic use of antibiotics. Questions relevant to the intraoperative period incorporated surgical operation techniques and prevention and management of bladder explosion. The application to different

关键词： Transurethral plasmakinetic resection of prostate Benign prostatic hyperplasia Recommendation Treatment Guideline

趋化因子CCL5在食管癌组织中的表达及意义

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中华肿瘤杂志 2014年第11期36卷 828-833页

作者：刘金燕李峰陈新峰王丽萍岳冬丽赵松胡伟 Pawel Kalinski Stephen Thorne hou Jingzhou 张毅郑州大学第一附属医院生物细胞治疗中心 450052 郑州大学第一附属医院肿瘤科 450052 郑州大学第一附属医院胸外科 450052 美国匹兹堡大学癌症研究中心美国匹兹堡大学癌症医学中心

目的探讨趋化因子CCL5在食管癌组织中的表达及意义.方法采用逆转录聚合酶链反应（RT-PCR）检测食管癌组织和癌旁组织中CCL5、CD8和CD8^＋T细胞杀伤功能相关细胞因子穿孔素（perforin）和颗粒酶B（granzyme B）的表达水平.采用流式细... 详细信息

目的探讨趋化因子CCL5在食管癌组织中的表达及意义.方法采用逆转录聚合酶链反应（RT-PCR）检测食管癌组织和癌旁组织中CCL5、CD8和CD8^＋T细胞杀伤功能相关细胞因子穿孔素（perforin）和颗粒酶B（granzyme B）的表达水平.采用流式细胞术检测食管癌患者外周血单核细胞（PBMC）和肿瘤浸润性淋巴细胞（TIL）中CD8^＋T细胞和CCR5^＋CD8^＋T细胞比例.采用Transwell实验检测CCL5对T细胞运动的影响.结果食管癌组织中CCL5和perforin mRNA的表达水平分别为0.348 2±0.300 1和0.181 9±0.118 6,癌旁组织中CCL5和perforin mRNA的表达水平分别为0.279 6±0.138 0和0.118 0±0.1098,但差异均无统计学意义（均P＞0.05）.食管癌组织中CD8和granzyme B mRNA的表达水平分别为0.4649±0.3008和0.6487±0.5160,癌旁组织中CD8和granzyme B mRNA的表达水平分别为0.279 0±0.173 4和0.469 7±0.259 1,差异有统计学意义（均P ＜0.05）.食管癌患者中CCL5与CD8、perforin和granzyme B表达呈正相关（rCD8=0.272,P=0.034;rerforin=0.305,P=0.026;rgranzymeB=0.108,P=0.012）.流式细胞术结果显示,TIL和PBMC中CD8^＋T细胞比例分别为（45.86±16.09）％和（34.05±15.07）％,差异有统计学意义（P =0.022）;TIL和PBMC中CCR5^＋ CD8^＋T细胞比例分别为（48.12±26.75）％和（19.53±13.67）％,差异有统计学意义（P＜0.001）.Transwell实验结果显示,CCL5显著增强T细胞趋化运动.CCL5表达与患者性别、年龄和淋巴结转移无关,但CCL5在早期食管癌组织中的相对表达水平为0.319 9±0.161 7,在晚期食管癌组织中的相对表达水平为0.232 8±0.121 0,差异有统计学意义（P=0.008）.早期食管癌患者TIL中CD8^＋T细胞和CCR5^＋ CD8^＋T细胞比例分别为（48.86±15.87）％和（56.23±26.23）％,而在晚期食管癌患者TIL中CD8^＋T细胞和CCR5^＋ CD8^＋T细胞比例分别为（33.25±16.49）％和（33.53±21.03）％,差异均有统计学意义（PCD8 =0.007,PccR5=0.010）.结论 CD8^＋T细胞能够在CCL5的诱导下向肿瘤部位运动,并影响患者疾病进展,CCL5可作为食管癌治疗的新靶点。

关键词：食管肿瘤 CCL5 T淋巴细胞肿瘤浸润性淋巴细胞单核细胞穿孔素颗粒酶B

基于个体化机器学习的原发性免疫性血小板减少症危重出血预测模型:一项全国前瞻性队列研究

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科学通报:英文版 2023年第18期68卷 2106-2114,M0004页

作者： Zhuo-Yu An Ye-Jun Wu Yu hou Heng Mei Wei-Xia Nong Wen-Qian Li hu Zhou Ru Feng Jian-Ping Shen Jun Peng Hai Zhou yi Liu Yong-Ping Song lin-hua yang Mei-Yun Fang Jian-Yong Li Yun-Feng Cheng Peng Liu Ya-Jing Xu zhao Wang yi Luo Zhen Cai hui Liu Jing-Wen Wang Juan Li Xi Zhang Zi-Min Sun Xiao-Yu Zhu Xin Wang Rong Fu Liang huang Shao-Yuan Wang Tong-hua yang Li-Ping Su Liang-Ming Ma Xie-Qun Chen Dai-Hong Liu Hong-Xia Yao Jia Feng Hong-Yu Zhang Ming Jiang Ze-Ping Zhou Wen-sheng Wang Xu-Liang Shen yangjin Baima Yue-ying Li Qian-Fei Wang Qiu-Sha huang Hai-Xia Fu Xiao-Lu Zhu Yun He Qian Jiang Hao Jiang Jin Lu Xiang-Yu zhao ying-Jun Chang Tao Wu Yao-Zhu Pan lin Qiu Da Gao A-Rong Jin Wei Li Su-Jun Gao Lei Zhang Ming hou Xiao-Jun huang Xiao-hui Zhang on behalf of the National Cooperative ITP Working Group Peking University People’s Hospital Peking University Institute of HematologyBeijing 100044China Collaborative Innovation Center of Hematology Peking UniversityBeijing 100044China Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation Beijing 100044China National Clinical Research Center for Hematologic Disease Beijing 100044China Department of Hematology Qilu HospitalCheeloo College of MedicineShandong UniversityJinan 250014China Institute of Hematology Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430074China Department of Hematology First Affiliated HospitalSchool of MedicineShihezi UniversityShihezi 832002China Department of Hematology Qinghai Provincial People’s HospitalXining 810007China Henan Cancer Hospital Affiliated Cancer Hospital of Zhengzhou UniversityHenan Institute of HematologyZhengzhou 450008China Department of Hematology Beijing HospitalBeijing 100044China Department of Hematology Zhejiang Provincial Hospital of Traditional Chinese MedicineHangzhou 310006China Department of Hematology Senior Department of Hematologythe Fifth Medical Center of PLA General HospitalBeijing 100044China Department of Hematology the Second Hospital of Shanxi Medical UniversityTaiyuan 030001China Department of Hematology Affiliated Zhongshan Hospital of Dalian UniversityDalian 116001China Department of Hematology The First Affiliated Hospital with Nanjing Medical University(Jiangsu Province Hospital)Nanjing 210029China Department of Hematology Zhongshan HospitalFudan UniversityShanghai 200032China Department of Hematology Xiangya HospitalCentral South UniversityChangsha 410008China Department of Hematology Beijing Friendship HospitalCapital Medical UniversityBeijing 100044China Institute of Hematology the First Affiliated HospitalZhejiang UniversityHangzhou 310058China Department of Hematology Beijing Tongren HospitalBeijing 100005China Department of Hematology The First Affiliated HospitalSun Yat-sen UniversityGuang

原发性免疫性血小板减少症(ITP)中少见但至关重要的危重出血事件,给患者的预后、生活质量和治疗决策带来严重影响。尽管有一些研究探讨了ITP中与危重出血相关的风险因素,但目前尚缺乏大样本数据、大规模多中心研究结果以及针对ITP患者... 详细信息

原发性免疫性血小板减少症(ITP)中少见但至关重要的危重出血事件,给患者的预后、生活质量和治疗决策带来严重影响。尽管有一些研究探讨了ITP中与危重出血相关的风险因素,但目前尚缺乏大样本数据、大规模多中心研究结果以及针对ITP患者致命出血事件的预测模型。本研究首次采用国际血栓与止血学会新提出的ITP致命出血标准,利用大样本数据开发了首个基于机器学习的在线应用,用于预测ITP患者的致命出血.研究中,我们使用中国各地大型多中心数据进行开发,并对全国39家医疗中心进行为期一年的外部测试,得到了较好的训练、验证和测试数据集预测能力该基于新算法的便捷网络工具能够快速识别ITP患者的出血风险,辅助临床决策,有望未来降低不良事件的发生。

关键词： Critical bleeding Severe bleeding Immune thrombocytopenia Machine learning Prediction model

Optimization of performance of the KM2A full array using the Crab Nebula

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Chinese Physics C 2024年第6期48卷 169-178页

作者：曹臻 F.Aharonian 安琪阿西克古白云翔包逸炜 D.Bastieri 毕效军毕玉江蔡金庭曹晴曹文羽曹喆常进常劲帆陈尚明陈恩生陈亮陈林陈龙陈明君陈玛丽陈起辉陈素弘陈天禄陈阳程宁程耀东崔明阳崔树旺崔晓红崔昱东戴本忠代洪亮戴子高单增罗布 D.della Volpe 董绪强段凯凯樊军辉范一中方军方堃冯存峰封莉冯少辉丰晓婷冯有亮 S.Gabici 高博高川东高林青高启高卫高伟康葛茂茂耿利斯 G.Giacinti 龚光华苟全补顾旻皓郭福来郭晓磊郭义庆郭莹莹韩毅昂何会海贺昊宁何佳银何新波何钰 M.Heller 贺远强侯博文侯超侯贤胡红波胡铨胡世聪黄代绘黄天奇黄文俊黄性涛黄晓渊黄勇黄志成季筱璐贾焕玉贾康江琨姜晓巍姜泽军金敏康明铭柯通 D.Kuleshov.K.Kurinov 李兵兵李澄李骢李丹李飞李海波李会财李华阳李军李剑李捷李凯李文龙李文莲李秀荣李昕李一卓李哲黎卓梁恩维梁云峰林苏杰刘冰刘成刘栋刘虎刘海东刘佳刘江来刘金艳刘茂元柳若愚刘四明刘伟刘怡刘以农鲁睿罗晴吕洪魁马伯强马玲玲马欣华毛基荣闵振 W.Mitthumsiri 穆慧君南云程 A.Neronov 区子维庞彬宇 P.Pattarakijwanich 裴致远齐孟尧祁业情乔冰强秦家军 D.Ruffolo A.Sáiz D.Semikoz 邵澄宇邵琅 O.Shchegolev 盛祥东舒富文宋慧超 Yu.V.Stenkin V.Stepanov 苏扬孙秦宁孙晓娜孙志斌谭柏轩唐庆文唐泽波田文武王超王昌贝王广威王洪光王惠惠王建成汪凯王利苹王玲玉王培汉王冉王为王祥高王祥玉王阳王玉东王岩谨王忠海王仲翔王振王铮韦大明魏俊杰魏永健文韬吴超勇吴含荣武莎吴雪峰吴雨生席邵强夏捷夏君集项光漫肖迪泫肖刚辛广广辛玉良邢祎熊峥徐东莲徐仁峰徐仁新徐伟立薛良闫大海颜景志颜田杨朝文杨帆杨冯帆杨何文杨佳盈杨莉莉杨明洁杨睿智杨深邦姚玉华姚志国叶一锰尹丽巧尹娜游晓浩游智勇于艳红袁强岳华曾厚敦曾婷轩曾玮查敏张彬彬张丰张海明张恒英张建立张丽霞张力张鹏飞张佩佩张瑞张少博张少如张寿山张潇张笑鹏张云峰张毅张勇赵兵赵静赵雷赵立志赵世平郑福周斌周浩周佳能周猛周平周荣周勋秀祝成光祝凤荣朱辉朱科军左雄 LHAASO Collaboration Key Laboratory of Particle Astrophyics&Experimental Physics Division&Computing Center Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China University of Chinese Academy of Sciences Beijing 100049China Tianfu Cosmic Ray Research Center Chengdu 610000China Dublin Institute for Advanced Studies 31 Fitzwilliam Place2 DublinIreland Max-Planck-Institut for Nuclear Physics P.O.Box 10398069029 HeidelbergGermany State Key Laboratory of Particle Detection and Electronics China University of Science and Technology of China Hefei 230026China School of Physical Science and Technology&School of Information Science and Technology Southwest Jiaotong UniversityChengdu 610031China School of Astronomy and Space Science Nanjing UniversityNanjing 210023China Center for Astrophysics Guangzhou UniversityGuangzhou 510006China Hebei Normal University Shijiazhuang 050024China Key Laboratory of Dark Matter and Space Astronomy&Key Laboratory of Radio Astronomy Purple Mountain ObservatoryChinese Academy of SciencesNanjing 210023China Tsung-Dao Lee Institute&School of Physics and Astronomy Shanghai Jiao Tong UniversityShanghai 200240China Key Laboratory for Research in Galaxies and Cosmology Shanghai Astronomical ObservatoryChinese Academy of SciencesShanghai 200030China Key Laboratory of Cosmic Rays(Tibet University) Ministry of EducationLhasa 850000TibetChina National Astronomical Observatories Chinese Academy of SciencesBeijing 100101China School of Physics and Astronomy(Zhuhai)&School of Physics(Guangzhou)&Sino-French Institute of Nuclear Engineering and Technology(Zhuhai) Sun Yat-sen UniversityZhuhai 519000&Guangzhou 510275China School of Physics and Astronomy Yunnan UniversityKunming 650091China Département de Physique Nucléaire et Corpusculaire Facultéde SciencesUniversitéde Genève24 Quai Ernest Ansermet1211 GenevaSwitzerland Institute of Frontier and Interdisciplinary Science Shandong UniversityQingdao 266237China APC Universit'e Paris Cit'eCNRS/IN2P3CEA/IRFUObservat

The full array of the Large High Altitude Air Shower Observatory(LHAASO)has been in operation since July *** its kilometer-square array(KM2A),we optimized the selection criteria for very high and ultrahigh energyγ-rays using data collected from August 2021 to August 2022,resulting in an improvement in significance of the detection in the Crab Nebula of approximately 15%,compared with that of previous *** the implementation of these new selection criteria,the angular resolution was also significantly improved by approximately 10%at tens of *** aspects of the full KM2A array performance,such as the pointing error,were also calibrated using the Crab *** resulting energy spectrum of the Crab Nebula in the energy range of 10-1000 TeV are well fitted by a log-parabola model,which is consistent with the previous results from LHAASO and other experiments.

关键词： γ-ray Crab Nebula significance

壳聚糖-g-水杨酸高分子药物的制备及其性能

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中国药科大学学报 2006年第6期37卷 503-506页

作者：武雪芬胡建梅侯益民赵晓玉张莉董梁河南中医学院药学院郑州450008

目的:制备不同接枝率的壳聚糖-g-水杨酸,并对其理化性能进行考察。方法:一步合成法制备壳聚糖-g-水杨酸(CTS-g-SA);用IR光谱1、H NMR谱、热分析等方法对其进行表征;络合滴定法测定Pb2+、Zn2+、Fe3+和Fe2+的吸附作用;小鼠耳肿胀法测试其... 详细信息

目的:制备不同接枝率的壳聚糖-g-水杨酸,并对其理化性能进行考察。方法:一步合成法制备壳聚糖-g-水杨酸(CTS-g-SA);用IR光谱1、H NMR谱、热分析等方法对其进行表征;络合滴定法测定Pb2+、Zn2+、Fe3+和Fe2+的吸附作用;小鼠耳肿胀法测试其抗炎作用。结果:壳聚糖-g-水杨酸的接枝率达75%,溶解度随接枝率的增加而增加,对金属离子的吸附性能不同程度的有所下降,对Zn2+的吸附作用降低的最多;对二甲苯引起的小鼠耳廓肿胀有明显的抑制作用。结论:壳聚糖-g-水杨酸的溶解度远高于壳聚糖,在pH 3时溶解度最大,接枝率大于等于50%的壳聚糖-g-水杨酸对Zn2+已无吸附作用;壳聚糖-g-水杨酸具有药效学协同作用,值得进一步研究。

关键词：壳聚糖水杨酸接枝物金属离子络合抗炎作用