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Impact of immunosuppressants on tumor pulmonary metastasis: new insight into transplantation for hepatocellular carcinoma

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Cancer Biology & Medicine 2024年第11期21卷 1033-1049页

作者： Jinyan Chen Huigang Li Jianyong Zhuo Zuyuan lin Zhihang Hu Chiyu He Xiang Wu Yiru Jin Zhanyi lin Renyi Su Yiyang sun Rongsen Wang Jiancai sun Xuyong Wei Shusen Zheng Di Lu Xiao Xu Zhejiang University School of Medicine Department of Hepatobiliary and Pancreatic Surgery Hangzhou First People's Hospital School of Basic Medical Sciences and Forensic Medicine Hangzhou Medical College The Fourth School of Clinical Medicine Zhejiang Chinese Medical University Department of Hepatobiliary and Pancreatic Surgery Shulan (Hangzhou) Hospital Department of Hepatobiliary & Pancreatic Surgery and Minimally Invasive Surgery Zhejiang Provincial People's Hospital (Affiliated People's Hospital) School of Clinical Medicine Hangzhou Medical College Institute of Translational Medicine Zhejiang University School of Medicine

Pulmonary metastasis is a life-threatening complication for patients with hepatocellular carcinoma(HCC) undergoing liver transplantation(LT). In addition to the common mechanisms underlying tumor metastasis, another inevitable factor is that the application of immunosuppressive agents, including calcineurin inhibitors(CNIs) and rapamycin inhibitors(mTORis), after transplantation could influence tumor recurrence and metastasis. In recent years, several studies have reported that mTORis, unlike CNIs, have the capacity to modulate the tumorigenic landscape post-liver transplantation by targeting metastasis-initiating cells and reshaping the pulmonary microenvironment. Therefore, we focused on the effects of immunosuppressive agents on the lung metastatic microenvironment and how mTORis impact tumor growth in distant organs. This revelation has provided profound insights into transplant oncology, leading to a renewed understanding of the use of immunosuppressants after LT for HCC.

关键词： Liver transplantation hepatocellular carcinoma immunosuppressants lung immune microenvironment lung metastasis

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Synthesis of 7-Epi-howiinol A

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Chinese Chemical Letters 1997年第10期8卷 863-864页

作者： sun, SY Yu, DQ CHINESE ACAD MED SCI INST MAT MEDBEIJING 100050PEOPLES R CHINA BEIJING UNION MED COLL BEIJING 100050PEOPLES R CHINA

7-Epi-howiinol A, an antitumor lactone, has been synthesized in nine steps starting from alpha-D-glucoheptonic gamma-lactone with an overall yield of 8.5%.

关键词： Cl Synthesis of 7-Epi-howiinol A HL

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Joint Distribution of Wave Periods and Rate of Change of Wave Surface Elevation

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China Ocean Engineering 1999年第2期14卷 225-229页

作者： Shi, HD sun, F Ocean Univ Qingdao Dept Civil Engn Qingdao 266003 Peoples R China

The rate of change of wave surface elevation is of much importance in ocean engineering, especially for the determination of the limitation of wave breaking. This paper gives a kind of joint distribution of wave periods and the rate of change of wave surface elevation by means of calculation of the two-order to four-order moment of the frequency spectrum based on the linear wave theory. For the first time, the distribution density function of wave periods determined by peaks is provided, and the conclusion is drawn that the rate of change of wave surface elevation obeys the Rayleigh distribution.

关键词： rate of change wave surface elevation joint distribution wave period

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MH-STRALP:A scoring system for prognostication in patients with upper gastrointestinal bleeding

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World Journal of Gastrointestinal Surgery 2024年第3期16卷 790-806页

作者： Jun-Nan Hu Fei Xu Ya-Rong Hao Chun-Yan sun Kai-Ming Wu Yong lin Lan Zhong Xin Zeng Department of Gastroenterology Shanghai East HospitalTongji University School of MedicineShanghai 200120China Department of Gastroenterology Shanghai Changzheng HospitalNavy Military Medical UniversityShanghai 200003China

BACKGROUND Upper gastrointestinal bleeding(UGIB)is a common medical emergency and early assessment of its outcomes is vital for treatment *** To develop a new scoring system to predict its *** In this retrospective study,692 patients with UGIB were enrolled from two cen-ters and divided into a training(n=591)and a validation cohort(n=101).The clinical data were collected to develop new prognostic prediction *** en-dpoint was compound outcome defined as(1)demand for emergency surgery or vascular intervention,(2)being transferred to the intensive care unit,or(3)death during *** models’predictive ability was compared with previously esta-blished scores by receiver operating characteristic(ROC)*** Totally 22.2%(131/591)patients in the training cohort and 22.8%(23/101)in the validation cohort presented poor *** on the stepwise-forward Lo-gistic regression analysis,eight predictors were integrated to determine a new post-endoscopic prognostic scoring system(MH-STRALP);a nomogram was de-termined to present the *** with the previous scores(GBS,Rock-all,ABC,AIMS65,and PNED score),MH-STRALP showed the best prognostic prediction ability with area under the ROC curves(AUROCs)of 0.899 and 0.826 in the training and validation cohorts,*** to the calibration cur-ve,decision curve analysis,and internal cross-validation,the nomogram showed good calibration ability and net clinical benefit in both *** removing the endoscopic indicators,the pre-endoscopic model(pre-MH-STRALP score)was ***,the pre-MHSTRALP score showed better predictive value(AUROCs of 0.868 and 0.767 in the training and validation cohorts,respectively)than the other pre-endoscopic *** The MH-STRALP score and pre-MH-STRALP score are simple,convenient,and accurate tools for prognosis prediction of UGIB,and may be applied for early decision on its management strategies.

关键词： Upper gastrointestinal bleeding Prognosis prediction Retrospective study Nomogram Post-endoscopic model Pre-endoscopic model

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Precision spectroscopy of atomic helium

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National Science Review 2020年第12期7卷 1818-1827页

作者： Yu R.sun Shui-Ming Hu Hefei National Laboratory for Physical Sciences at Microscale iChem CenterUniversity of Science and Technology of China CAS Center for Excellence in Quantum Information and Quantum Physics University of Science and Technology of China

Helium is a prototype three-body system and has long been a model system for developing quantum mechanics theory and computational *** fine-structure splitting in the 2;P state of helium is considered to be the most suitable for determining the fine-structure constant α in *** more than 50 years of efforts by many theorists and experimentalists,we are now working toward a determination ofα with an accuracy of a few parts per billion,which can be compared to the results obtained by entirely different methods to verify the self-consistency of quantum ***,the precision spectroscopy of helium allows determination of the nuclear charge radius,and it is expected to help resolve the ’proton radius puzzle’.In this review,we introduce the latest developments in the precision spectroscopy of the helium atom,especially the discrepancies among theoretical and experimental results,and give an outlook on future progress.

关键词： precision spectroscopy helium quantum electrodynamics fine-structure constant nuclear charge radius

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塔中隆起奥陶系油气性质及运聚富集模式

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岩性油气藏 2025年第1期37卷 53-67页

作者：熊昶王彭刘小钰王伟赵星星孙冲中国石油塔里木油田公司勘探开发研究院新疆库尔勒841000 中国石油天然气集团有限公司超深层复杂油气藏勘探开发技术研发中心新疆库尔勒841000 新疆维吾尔自治区超深层复杂油气藏勘探开发工程研究中心新疆库尔勒841000 中国石油塔里木油田公司油气田产能建设事业部新疆库尔勒841000

以构造、断裂分布、生产动态以及地球化学等资料为基础,对塔中地区奥陶系油气性质与产能分布特征进行了分析,从油气充注、输导体系、构造与油气运聚关系等3个方面对油气富集因素进行了分析,并建立了成藏模式。研究结果表明:①塔中地区... 详细信息

以构造、断裂分布、生产动态以及地球化学等资料为基础,对塔中地区奥陶系油气性质与产能分布特征进行了分析,从油气充注、输导体系、构造与油气运聚关系等3个方面对油气富集因素进行了分析,并建立了成藏模式。研究结果表明:①塔中地区奥陶系原油以轻质原油为主,具有低密度、低黏度、低含硫的特征,密度为0.75~0.85 g/m^(3),油气藏气油比为119~82367 m^(3)/m^(3),多相态油气藏并存,且油气相态无明显边界;天然气干燥系数为0.70~0.98,天然气甲烷碳同位素为-35.7‰~-61.4‰,变化范围大;不同区域金刚烷指数(MDI)差异较大,为0.33~0.64;8个主要油气充注点具有原油密度低、气油比高、天然气甲烷同位素及MDI高的特征,沿走滑断裂带向南或远离断裂带方向密度变大,气油比、甲烷碳同位素及MDI均变小,不同区块气侵强度不同造成变化规律存在局部差异。②研究区油气分布格局主要受点状油气充注影响,8个油气充注点周缘油气井通常具有较高的产量,受储层发育规模影响会出现低产井,产能分布具有“北气南油”、“中间气、两边油”及“普遍富气、局部含油”3种类型;远离充注点的低产井及水井大范围分布。③研究区奥陶系油气富集模式为张扭性大断裂控制油气垂向充注,不整合面及走滑断裂控制油气的侧向调整,断裂破碎带叠加层间岩溶为油气聚集提供了储集空间,局部构造高部位及平台区为油气聚集有利指向区。

关键词：轻质原油金刚烷指数张扭性大断裂走滑断裂不整合面断裂破碎带岩溶作用奥陶系塔中隆起塔里木盆地

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Degradation of BPB in photocatalysis enhanced by photosensitizer

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Rare Metals 2006年第2期25卷 138-143页

作者： CUI Yumin sun Wenzhong Department of Chemistry Fuyang Teacher＇s College Fuyang 236032 China

The treatment of wastewater containing bromphenol blue （BPB） by WO3/α-Fe203 was studied. Reaction mechanism of photocatalysis enhanced by photosensitizer was probed. The relationships between the composition of heterogeneous photocatalyst, the starting concentration of BPB, amount of photocatalyst, pH, amount of H2O2, illumination time and the decoloring rate of BPB were discussed. The results show that the decoloring rate of BPB can reach 99.1% by using WO3/α-FeaO3 as heterogeneous photocatalyst, with the composition of m（WO3）：m（α-Fe2O3 ）=3：1, the initial concentration of BPB = 15mg/L, the amount of catalyst = 0.300 g, pH= 6.3, the amount of H2O2 =0.2 mL, and the illumination time = 6 h.

关键词： physical chemistry photocatalytic degradation of bromphenol blue photocatalytic method tungsten trioxide α-iron trioxide

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The evolution simulation of zinc finger domain sequence——Application of genetic algorithms in protein structure study

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Chinese Science Bulletin 1997年第22期42卷 1925-1928页

作者： sun, ZR Han, H Tsing Hua Univ Dept Biol Sci & Biotechnol Beijing 100084 Peoples R China

GENETIC algorithms are very efficient search mechanisms. The application of genetic algo-rithms in the protein structure study provides not only a convenience algorithm for the searchof the lowest energy status (accor... 详细信息

关键词： genetic algorithm zinc finger domain evolution simulation protein sequence.

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Biomarkers identified by serum metabonomics for HSP:Progression from HSP to HSPN

Biomarkers identified by serum metabonomics for HSP:Progress...

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2017年中国卫生统计学学术年会

作者： lin sun Meina Liu Department of Biostatistics Harbin Medical University

＜正＞BACKGROUND AND OBJECTIVE:Henoch-Schonlein purpura nephritis（HSPN）,one of the most common glomerular diseases in the childhood,is renal involvement resulting from Henoch-Schonlein purpura（HSP）.The severity of HSPN is considered responsible for the prognosis of *** pathological process from HSP to HSPN is not clear yet and current diagnostic tools have shortcomings in accurate diagnosis of

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贮藏温度对高温高压海参体壁组织结构变化的作用

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食品与发酵工业 2019年第19期45卷 194-199页

作者：林琳孙霄侯虎中国海洋大学食品科学与工程学院

为研究贮藏温度对高温高压海参体壁组织结构变化的影响,将预处理后的刺参组织分别在4、20、37、50和60 ℃进行恒温贮藏。通过质构(texture profile analysis,TPA)参数、水分状态、扫描电镜(scanning electron microscopy,SEM)和透射电镜... 详细信息

为研究贮藏温度对高温高压海参体壁组织结构变化的影响,将预处理后的刺参组织分别在4、20、37、50和60 ℃进行恒温贮藏。通过质构(texture profile analysis,TPA)参数、水分状态、扫描电镜(scanning electron microscopy,SEM)和透射电镜(transmission electron microscopy,TEM)图像的变化情况,研究贮藏温度对高温高压海参体壁稳定性的影响。结果表明,高温高压热处理过程中微生物和内源酶已完全失活,并且在贮藏0~30 d过程中仍然保持失活状态。在高温高压热处理过程中,胶原纤维束的结构被破坏,胶原蛋白的三螺旋结构也逐渐解旋和降解。在贮藏过程中,胶原纤维束和胶原蛋白的结构被进一步破坏和降解,且被破坏的程度与贮藏温度呈正相关。因此,可以通过降低贮藏温度进而有效地减小对组织结构的破坏程度,从而延长高温高压海参产品的货架期。

关键词：高温高压海参贮藏温度胶原蛋白结构贮藏

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