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Proteomic characterization of four subtypes of M2 macrophages derived from human THP-1 cells

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2022年第5期23卷 407-422页

作者： Pengfei LI chen MA Jing LI Shanshan YOU Liuyi DANG Jingyu WU Zhifang HAO Jun LI Yuan ZHI lin chen Shisheng SUN College of Life Science Northwest UniversityXi'an 710069China

Macrophages are widely distributed immune cells that contribute to tissue homeostasis.Human THP-1 cells have been widely used in various macrophage-associated studies,especially those involving pro-inflammatory M1 and anti-inflammatory M2 phenotypes.However,the molecular characterization of four M2 subtypes(M2a,M2b,M2c,and M2d)derived from THP-1has not been fully investigated.In this study,we systematically analyzed the protein expression profiles of human THP-1-derived macrophages(M0,M1,M2a,M2b,M2c,and M2d)using quantitative proteomics approaches.The commonly and specially regulated proteins of the four M2 subtypes and their potential biological functions were further investigated.The results showed that M2a and M2b,and M2c and M2d have very similar protein expression profiles.These data could serve as an important resource for studies of macrophages using THP-1 cells,and provide a reference to distinguish different M2 subtypes in macrophage-associated diseases for subsequent clinical research.

关键词： Macrophage THP-1 cells M2 subtype Proteomics Biological function

幔源岩浆在地壳中分层侵位的控制因素:二维热-力学模拟

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岩石学报 2024年第4期40卷 1087-1101页

作者：崔晓娜陈林中国科学院地质与地球物理研究所岩石圈演化国家重点实验室北京100029 中国科学院大学地球与行星科学学院北京100049

幔源岩浆在地壳内的上升和聚集样式不仅依赖于岩浆自身的性质,还取决于围岩的强度和热状态。已有数值和物理模型大多关注岩浆自身物性对其上升过程的影响,而对围岩流变强度或热状态如何影响岩浆的上升和聚集过程的研究相对薄弱,尤其是... 详细信息

幔源岩浆在地壳内的上升和聚集样式不仅依赖于岩浆自身的性质,还取决于围岩的强度和热状态。已有数值和物理模型大多关注岩浆自身物性对其上升过程的影响,而对围岩流变强度或热状态如何影响岩浆的上升和聚集过程的研究相对薄弱,尤其是周期性的幔源岩浆在壳内分层侵位的受控因素仍然不清楚。本文利用二维热-力学数值模拟方法,通过发展多期岩浆脉冲和岩墙生成算法,研究了岩浆从深部地幔上升至地壳内部侵位的动力学过程,系统测试了地壳(围岩)地温梯度(上、下地壳的地温梯度分别以GUC和GLC表示)和地壳强度对岩浆上升过程和聚集样式的影响。模拟结果表明:(1)地壳地温梯度对岩浆的侵位深度有重要影响,岩浆侵入冷地壳(GUC=GLC=12.5K/km),岩浆主体在岩石圈深度聚集,地表的相对高差小于140m;岩浆侵入温地壳(GUC=GLC=15K/km)在下地壳底部聚集形成岩浆房,上升至上、下地壳界面,岩浆房上方的地表地形呈现中心拗陷两翼隆起的形态,地表最大高程可达3km;岩浆侵入热地壳(GUC=GLC=17.5K/km)仅在下地壳底部聚集形成岩浆房,地形演化特征与温地壳背景的情况类似,但最大高程小于1.5km。(2)在同等地壳地温梯度条件下,上、下地壳的相对强度决定了岩浆的聚集样式:下地壳的强度越弱,岩浆更易在下地壳聚集形成岩浆房;上地壳的强度越弱,岩浆更易在地表喷发。进一步分析表明:岩浆的聚集样式受地壳地温梯度与地壳流变分层性的共同控制,地壳越热且流变强度分层性越显著则越有利于岩浆在地壳中的多层级侵位;每一期岩浆脉冲的供给均会导致岩浆房内部的超压值骤增。我们的模拟结果对理解火山喷发前壳内岩浆的赋存状态及岩浆活动区的地形演化具有启示意义。

关键词：岩浆地壳地温梯度粘度数值模拟

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Bone Research 2023年第1期11卷 1-20页

作者： Qin Ru Yusheng Li Wenqing Xie Yilan Ding lin chen Guodong Xu Yuxiang Wu Fudi Wang Department of Health and Physical Education Jianghan UniversityWuhan430056China Department of Orthopedics Xiangya HospitalCentral South UniversityChangsha410008China National Clinical Research Center for Geriatric Disorders Xiangya HospitalCentral South UniversityChangsha410008China The Second Affiliated Hospital School of Public HealthState Key Laboratory of Experimental HematologyZhejiang University School of MedicineHangzhouChina The First Affiliated Hospital Basic Medical SciencesSchool of Public HealthHengyang Medical SchoolUniversity of South ChinaHengyangChina

Ferroptosis, a unique type of cell death, is characterized by iron-dependent accumulation and lipid peroxidation. It is closely related to multiple biological processes, including iron metabolism, polyunsaturated fatty acid metabolism, and the biosynthesis of compounds with antioxidant activities, including glutathione. In the past 10 years, increasing evidence has indicated a potentially strong relationship between ferroptosis and the onset and progression of age-related orthopedic diseases, such as osteoporosis and osteoarthritis. Therefore, in-depth knowledge of the regulatory mechanisms of ferroptosis in age-related orthopedic diseases may help improve disease treatment and prevention. This review provides an overview of recent research on ferroptosis and its influences on bone and cartilage homeostasis. It begins with a brief overview of systemic iron metabolism and ferroptosis,particularly the potential mechanisms of ferroptosis. It presents a discussion on the role of ferroptosis in age-related orthopedic diseases, including promotion of bone loss and cartilage degradation and the inhibition of osteogenesis. Finally, it focuses on the future of targeting ferroptosis to treat age-related orthopedic diseases with the intention of inspiring further clinical research and the development of therapeutic strategies.

关键词： metabolism diseases peroxidation

Let’s all dance:Enhancing amateur dance motions

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Computational Visual Media 2023年第3期9卷 531-550页

作者： Qiu Zhou Manyi Li Qiong Zeng Andreas Aristidou Xiaojing Zhang lin chen Changhe Tu School of Computer Science&Technology Shandong UniversityQingdao 266000China School of Software Shandong UniversityJinan 250101China Department of Computer Science University of CyprusNicosia 1678Cyprus CYENS Centre of Excellence Nicosia 1016Cyprus Qingdao Institute of Humanities and Social Sciences Shandong UniversityQingdao 266000China.

Professional dance is characterized by high impulsiveness,elegance,and aesthetic beauty.In order to reach the desired professionalism,it requires years of long and exhausting practice,good physical condition,musicality,but also,a good understanding of choreography.Capturing dance motions and transferring them to digital avatars is commonly used in the film and entertainment industries.However,so far,access to high-quality dance data is very limited,mainly due to the many practical difficulties in capturing the movements of dancers,making it prohibitive for largescale data acquisition.In this paper,we present a model that enhances the professionalism of amateur dance movements,allowing movement quality to be improved in both spatial and temporal domains.Our model consists of a dance-to-music alignment stage responsible for learning the optimal temporal alignment path between dance and music,and a dance-enhancement stage that injects features of professionalism in both spatial and temporal domains.To learn a homogeneous distribution and credible mapping between the heterogeneous professional and amateur datasets,we generate amateur data from professional dances taken from the AIST++dataset.We demonstrate the effectiveness of our method by comparing it with two baseline motion transfer methods via thorough qualitative visual controls,quantitative metrics,and a perceptual study.We also provide temporal and spatial module analysis to examine the mechanisms and necessity of key components of our framework.

关键词： animation music-to-motion alignment dance motion enhancement dance motion analysis

Predictive analytics with ensemble modeling in laparoscopic surgery:A technical note

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Laparoscopic, Endoscopic and Robotic Surgery 2022年第1期5卷 25-34页

作者： Zhongheng Zhang lin chen Ping Xu Yucai Hong Department of Emergency Medicine Sir Run Run Shaw HospitalZhejiang University School of MedicineHangzhou 310016China Department of Critical Care Medicine Jinhua Hospital of Zhejiang University School of MedicineJinhua 321000China Emergency Department Zigong Fourth People's HospitalZigong 643000China Institute of Medical Big Data Zigong Academy of Artificial Intelligence and Big Data for Medical Science Artificial IntelligenceZigong 643000China Artificial Intelligence Key Laboratory of Sichuan Province Zigong 643000China

Predictive analytics have been widely used in the literature with respect to laparoscopic surgery and risk stratification.However,most predictive analytics in this field exploit generalized linearmodels for predictive purposes,which are limited by model assumptionsdincluding linearity between response variables and additive interactions between variables.In many instances,such assumptions may not hold true,and the complex relationship between predictors and response variables is usually unknown.To address this limitation,machine-learning algorithms can be employed to model the underlying data.The advantage of machine learning algorithms is that they usually do not require strict assumptions regarding data structure,and they are able to learn complex functional forms using a nonparametric approach.Furthermore,two or more machine learning algorithms can be synthesized to further improve predictive accuracy.Such a process is referred to as ensemble modeling,and it has been used broadly in various industries.However,this approach has not been widely reported in the laparoscopic surgical literature due to its complexity in both model training and interpretation.With this technical note,we provide a comprehensive overview of the ensemble-modeling technique and a step-by-step tutorial on how to implement ensemble modeling.

关键词： Ensemble modeling Laparoscopic surgery Machine learning

人工智能嵌入大学治理的理论图景、价值蕴含与实现路径

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高教探索 2024年第1期 13-22页

作者：陈林南京师范大学教育科学学院南京210097

大学治理是国家治理体系与治理能力现代化的重要构成和基本要素.研究通过“理念指导—范式转型—主体协同—过程融合”的理论图景,构架了人工智能时代数字化大学治理的分析框架与实现路径.数字化大学治理在理念遵循上实现了从技术借用... 详细信息

大学治理是国家治理体系与治理能力现代化的重要构成和基本要素.研究通过“理念指导—范式转型—主体协同—过程融合”的理论图景,构架了人工智能时代数字化大学治理的分析框架与实现路径.数字化大学治理在理念遵循上实现了从技术借用到全体智能的转变,在治理范式上实现了从传统范式向现代范式的转型,在主体结构上实现了从单一固守到多元协同的转型,在过程应用上实现了从信息碎片到数据融合的升级.然而,碍于数字化工具的算法歧视、信息的数据化隐私侵犯、人工智能技术的伦理风险、智能媒介的结构性不平等风险,导致数字化大学治理在理念转变、范式转型、主体协同、过程融合等方面依然存在局限.为更好地推进人工智能技术赋能大学治理的数字化转型,还需从重塑共建理念、优化系统结构、构建完整体系、打造共生目标等多个方面进行完善和补充,从而为大学治理体系与治理能力现代化奠定基础.

关键词：人工智能大学治理数字化理论图景

人工智能嵌入大学内部治理的技术逻辑、潜在风险与优化策略

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大学教育科学 2024年第3期 22-30页

作者：陈林南京师范大学教育科学学院南京210097

人工智能技术的多方面嵌入、多主体赋能、多维度黏合与全方位融通,有利于大学内部治理形成“利益共享”的矩阵式结构、“多元协同”的主体性复归、“上下互通”的扁平化体系与“价值理性”的制度性保障。然而,囿于人工智能发展的技术过... 详细信息

人工智能技术的多方面嵌入、多主体赋能、多维度黏合与全方位融通,有利于大学内部治理形成“利益共享”的矩阵式结构、“多元协同”的主体性复归、“上下互通”的扁平化体系与“价值理性”的制度性保障。然而,囿于人工智能发展的技术过载、盲目崇拜、伦理风险与价值局限,也容易造成大学内部治理的价值危机、削弱主体地位、淡化过程体现乃至异化目标与手段。为进一步推动大学治理体系与治理能力的现代化建设,必须通过加强基础设计,细化人工智能嵌入大学内部治理的规章制度、系统规划与操作方案;强化动力支撑,夯实人工智能嵌入大学内部治理的数字基建、技术环境与配套机制;创新内在驱动,加强人工智能嵌入大学内部治理的主体素养、组织协同及项目合作;强化保障机制,促进人工智能嵌入大学内部治理的资源共享、长效变革与整体建构。

关键词：人工智能技术赋能大学治理价值逻辑功能偏差

Interleukin-34 deficiency aggravates development of colitis and colitis-associated cancer in mice

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World Journal of Gastroenterology 2022年第47期28卷 6752-6768页

作者： Zhao-Xiu Liu Wei-Jie chen Yang Wang Bing-Qian chen Yi-Cun Liu Tiao-Chun cheng Lei-Lei Luo lin chen lin-ling Ju Yuan Liu Ming Li Nan Feng Jian-Guo Shao Zhao-Lian Bian Department of Gastroenterology and Hepatology Affiliated Hospital of Nantong UniversityNantong 226001Jiangsu ProvinceChina Medical School Nantong UniversityNantong 226001Jiangsu ProvinceChina Department of Gastroenterology and Hepatology Nantong Third People’s HospitalAffiliated Nantong Hospital 3 of Nantong UniversityNantong 226006Jiangsu ProvinceChina Nantong Institute of Liver Diseases Nantong Third People’s HospitalAffiliated Nantong Hospital 3 of Nantong UniversityNantong 226006Jiangsu ProvinceChina Department of Gastroenterology and Hepatology The Sixth People’s Hospital Affiliated to Shanghai Jiaotong UniversityShanghai 200233China Department of Traditional Chinese Medicine Nantong Third People’s HospitalAffiliated Nantong Hospital 3 of Nantong UniversityNantong 226006Jiangsu ProvinceChina Division of Emergency Ren Ji HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghai 200120China

BACKGROUND Although expression of interleukin(IL)-34 is upregulated in active ulcerative colitis(UC),the molecular function and underlying mechanism are largely unclear.AIM To investigate the function of IL-34 in acute colitis,in a wound healing model and in colitis-associated cancer in IL-34-deficient mice.METHODS Colitis was induced by administration of dextran sodium sulfate(DSS),and carcinogenesis was induced by azoxymethane(AOM).Whether the impact of IL-34 on colitis was dependent on macrophages was validated by depletion of macrophages in a murine model.The association between IL-34 expression and epithelial proliferation was studied in patients with active UC.RESULTS IL-34 deficiency aggravated murine colitis in acute colitis and in wound healing phase.The effect of IL-34 on experimental colitis was not dependent on macrophage differentiation and polarization.IL-34-deficient mice developed more tumors than wild-type mice following administration of AOM and DSS.No significant difference was shown in degree of cellular differentiation in tumors between wild-type and IL-34-deficient mice.IL-34 was dramatically increased in the active UC patients as previously reported.More importantly,expression of IL-34 was positively correlated with epithelial cell proliferation in patients with UC.CONCLUSION IL-34 deficiency exacerbates colonic inflammation and accelerates colitis-associated carcinogenesis in mice.It might be served as a potential therapeutic target in UC.

关键词： Interleukin-34 Ulcerative colitis Mucosal healing Colitis-associated cancer Macrophage Murine model

毛泽东对新中国农业现代化道路的探索--基于对《1956年到1967年全国农业发展纲要》的考察

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湖南科技大学学报（社会科学版） 2024年第1期27卷 8-16页

作者：林晨清华大学马克思主义学院北京100084

农业是民生之本,立国之纲。1955年底,在农业社会主义改造工作加速完成之际,为了更好地指导农业发展,给亿万农民指明一个奋斗方向,毛泽东统筹考量我国现实国情和国内外社会主义建设经验,领导制定了《1956年到1967年全国农业发展纲要》这... 详细信息

农业是民生之本,立国之纲。1955年底,在农业社会主义改造工作加速完成之际,为了更好地指导农业发展,给亿万农民指明一个奋斗方向,毛泽东统筹考量我国现实国情和国内外社会主义建设经验,领导制定了《1956年到1967年全国农业发展纲要》这一指导农业发展的专门规划。这一规划集中体现了毛泽东对中国社会主义农业生产、农村建设和农民进步等重大问题的集中思考和实践总结,是党独立自主探索新中国农业现代化道路的一次伟大尝试。这一规划的出台与实施为党在改革开放和社会主义现代化建设新时期解决好“三农”问题并成功开辟中国特色社会主义农业现代化道路提供了历史经验。

关键词：毛泽东《1956年到1967年全国农业发展纲要》农业现代化思想