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Predicting colorectal adenomatous polyps in patients with chronic liver disease: A novel nomogram

World Journal of Gastroenterology 2025年第2期31卷 71-84页

作者： Yu-Qin Li Wen-Tao Kuai lin chen Ming-Hui Zeng Xue-Mei Tao Jia-Xin Han Yue-Kui Wang Lian-Xin Xu Li-Ying Ge Yong-Gang Liu Shuang Li Liang Xu Yu-Qiang Mi Clinical School of the Second People’s Hospital Tianjin Medical UniversityTianjin 300192China Department of Hepatology Tianjin Second People’s HospitalTianjin 300192China Department of Pathology Clinical School of the Second People’s HospitalTianjin 300110China Endoscopy Center Tianjin Second People’s HospitalTianjin 300192China

BACKGROUND Colorectal polyps are commonly observed in patients with chronic liver disease(CLD)and pose a significant clinical concern because of their potential for *** To explore the clinical characteristics of colorectal polyps in patients with CLD,a nomogram was established to predict the presence of adenomatous polyps(AP).METHODS Patients with CLD who underwent colonoscopy at Tianjin Second People’s Hospital from January 2020 to May 2023 were *** data including laboratory results,colonoscopy findings,and pathology reports were *** variables for the nomogram were identified through least absolute shrinkage and selection operator regression,followed by multivariate logistic *** performance of the model was evaluated using the area under the receiver area under curve,as well as calibration curves and decision curve *** The study enrolled 870 participants who underwent colonoscopy,and the detection rate of AP in patients with CLD was 28.6%.Compared to individuals without polyps,six risk factors were identified as predictors for AP occurrence:Age,male sex,body mass index,alcohol consumption,overlapping metabolic dysfunction-associated steatotic liver disease,and serum ferritin *** novel nomogram(AP model)demonstrated an area under curve of 0.801(95%confidence interval:0.756-0.845)and 0.785(95%confidence interval:0.712-0.858)in the training and validation *** curves indicated good agreement among predicted and actual probabilities(training:χ^(2)=11.860,P=0.157;validation:χ^(2)=7.055,P=0.530).The decision curve analysis underscored the clinical utility of the nomogram for predicting the risk of *** The AP model showed reasonable accuracy and provided a clinical foundation for predicting the occurrence of AP in patients with CLD,which has a certain predictive value.

关键词： Metabolic dysfunction associated steatotic liver disease Fatty liver Chronic liver disease Colorectal adenomas Hepatitis Risk factors

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Gαi蛋白在恶性肿瘤中的研究进展

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医学综述 2025年第1期31卷 34-40页

作者：陈林周鹏苏州大学附属第三医院常州市第一人民医院神经外科江苏常州213003

恶性肿瘤的发生与细胞信号转导紊乱密切相关。G蛋白家族中的Gαi蛋白作为信号转导的重要参与者,在脑胶质瘤、骨肉瘤、乳腺癌和前列腺癌等恶性肿瘤中存在异常表达或活性改变。目前认为,Gαi蛋白在肿瘤的发生和发展过程中发挥作用,可能通... 详细信息

恶性肿瘤的发生与细胞信号转导紊乱密切相关。G蛋白家族中的Gαi蛋白作为信号转导的重要参与者,在脑胶质瘤、骨肉瘤、乳腺癌和前列腺癌等恶性肿瘤中存在异常表达或活性改变。目前认为,Gαi蛋白在肿瘤的发生和发展过程中发挥作用,可能通过调控细胞增殖、迁移和凋亡等途径参与癌变机制,这为靶向Gαi蛋白的个性化治疗提供了理论依据。未来的研究可以进一步探讨Gαi蛋白的具体分子机制及其在临床治疗中的应用潜力,为新型靶向药物的开发提供指导。

关键词：恶性肿瘤 Gαi蛋白胶质瘤骨肉瘤乳腺癌前列腺癌

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Attitude dynamics of a cylinder floating in immiscible fluids

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Acta Mechanica Sinica 2010年第3期26卷 383-389页

作者： Jiann lin chen Department of Mechanical and Automation Engineering I-Shou UniversityKaohsiungTaiwanChina

This study elaborates the attitude dynamics of a cylinder floating in two immiscible fluids. A cubic polyno- mial was derived based on the attitude angle, weight, center of gravity, and the density ratio of fluids. The numerical solution was validated by experimental data. Under prescribed constraints for the physical model, we have found that multiple solutions exist for cases with no radially biased center of gravity. When the center of gravity is biased, the attitude angles change abruptly around some critical values, which is related to the density ratio. Moreover, the attitude angles are less sensitive to the varying density ratios when the cylinder is heavier. The results also reveal that the cylinder tends to be vertical for nearly the whole range of density ratios when the center of gravity is slightly biased radially.

关键词： Floating cylinder Attitude angle Density ratio

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Wall shear-stress extraction by an optical flow algorithm with a sub-grid formulation

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Acta Mechanica Sinica 2021年第1期37卷 65-79,I0003页

作者： The Hung Tran lin chen Faculty of Aerospace Engineering Le Quy Don Technical UniversityHanoi10000Vietnam Institute of Engineering Thermophysics Chinese Academy of SciencesBeijing100190China School of Aeronautics and Astronautics University of Chinese Academy of SciencesBeijing100049China

In this study,we developed a novel optical-flow algorithm for determining the wall shear-stress on the surface of *** algorithm solves the thin-oil-film equation using a numerical scheme that recovers local features neglected by smoothing filters.A variational formulation with a smoothness constraint was applied to extract the global shear-stress *** algorithm was then applied to scalar images generated using direct numerical simulation(DNS)method,which revealed that the errors were smaller than those of conventional *** application of the proposed algorithm to recover the wall shear-stress on a low-aspect-ratio wing and on an axisymmetric boattail model taken as examples in this study showed a strong potential for analysing shear-stress *** to the methods used in previous studies,proposed method reveals more local features of separation line and singular points on object surface.

关键词： Wall shear-stress Optical flow Thin-oil-film equation Sub-grid model

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Experimental and numerical investigations of the mechanical behavior of half sandwich laminate in the context of blanking

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Advances in Manufacturing 2020年第2期8卷 177-188页

作者： Sheng Cai lin chen Department of V ehicle Engineering College of EngineeringChina Agricultural UniversityBeijing 100083People's Republic of China CW Bearing GmbH Hamburg 22113Germany

In this study,the complex mechanical behavior of an aluminum/low-density polyethylene(LDPE)half sandwich structure was investigated during the blanking *** tests were conducted for the polymer and metal layer and the delamination behavior of the adhesive between the two layers.A new testing device was designed for detecting the delamination under tensile *** finite element models were established for the mechanical tests of the metal layer and the delamination of both layers for inverse parameter *** parameters for Lemaitre-type damage,Drucker-Prager,and cohesive zone modeIs were identified for the metal,polymer,and adhesive,respectively.A finiteelement(FE)model was established for the blanking process of the sandwich *** experimental forcedisplacement curves,obtained in the blanking process of the half sandwich sheet,were compared with the predicted results of the FE *** results showed that the predicted force-displacement curves and the experimental results were in good ***,the correlation between cutting clearance and changes in the forcedisplacement curves was *** feature values quantitatively described the imperfection of the experimental cutting *** effect of punch clearance on these values was studied numerically and *** results indicated that a smaller clearance generated a better cutting-edge *** stress state of the half sandwich structure during blanking was analyzed using the established FE model.

关键词： Sandwich plates Blanking Continuum damage mechanics(CDM) Drucker-Prager model Cohesive zone model

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Parameter identification and blanking simulations of DP1000 and Al6082-T6 using Lemaitre damage model

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Advances in Manufacturing 2021年第3期9卷 457-472页

作者： Sheng Cai lin chen Department of Vehicle Engineering College of EngineeringChina Agricultural UniversityBeijing100083People’s Republic of China CW Bearing GmbH 22113HamburgGermany

This work provides numerical and experimental investigations of blanking process,where the shear-enhanced Lemaitre’s damage model is fully characterized and successfully applied in blanking process to predict the cutting force and cutting edge geometry under different blanking process *** high strength steel DP1000 and an aluminum alloy Al6082-T6 are selected for series of *** obtain the damage parameters in Lemaitre’s damage model the flat rectangular notched specimens tensile test was conducted and the inverse parameter identification procedure was *** characterizing the crack closure parameter h in the shear enhanced Lemaitre’s damage model,an in-plane torsion test with novel specimen design was *** finite element model(FEM)of this test was established with the minimum mesh size of 0.01 mm which was consistent with the minimum mesh size in the shear zone of the FEM for blanking process *** longitudinal strain distributions of four kinds of initial notch radius or central-hole specimen were measured and compared with simulation results to validate the FEMs for these four *** analysis of blanking of a circular work piece also was performed under three *** effects of blanking conditions on sheared part morphology were *** triaxiality distribution of the blank sheet was revealed taking advantage of the successfully established *** availability of the testing method and the determination method of the parameters was investigated.

关键词： Blanking Lemaitre damage model Stress triaxiality Finite element model(FEM)

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STABILITY OF THE STOCHASTIC θ-METHOD FOR SUPER-linEAR STOCHASTIC DIFFERENTIAL EQUATIONS WITH UNBOUNDED DELAY

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Journal of Computational Mathematics 2019年第5期37卷 704-720页

作者： lin chen School of Statistics Jiangxi University of Finance and Economics Nanchang 330013China Research Center of Applied Statistics Jiangxi University of Finance and Economics Nanchang 330013China

This paper deals with numerical stability properties of super-linear stochastic differential equations with unbounded delay. Sufficient conditions for mean square and almost sure decay stability of the above system and its stochastic θ-method approximation are investigated in this paper. The author establishes numerical stability under a monotone-type condition in unbounded delay setting. An example is presented to illustrate the result.

关键词： Unbounded delay Monotone condition Polynomial condition Stochastic θ- method Decay stability.

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Regression Analysis for the Additive Hazards Model with General Biased Survival Data

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Acta Mathematicae Applicatae Sinica 2020年第3期36卷 545-556页

作者： Xiao-lin chen School of Statistics Qufu Normal UniversityQufu 273165China

In survival analysis,data are frequently collected by some complex sampling schemes,e.g.,length biased sampling,case-cohort sampling and so *** this paper,we consider the additive hazards model for the general biased survival data.A simple and unified estimating equation method is developed to estimate the regression parameters and baseline hazard *** asymptotic properties of the resulting estimators are also ***,to check the adequacy of the fitted model with general biased survival data,we present a test statistic based on the cumulative sum of the martingale-type *** studies are conducted to evaluate the performance of proposed methods,and applications to the shrub and Welsh Nickel Refiners datasets are given to illustrate the methodology.

关键词： additive hazards model estimating equation general biased sampling model checking survival data

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Mie scatterers bring a resonator to an exceptional point

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Light(Science & Applications) 2023年第9期12卷 1715-1716页

作者： Kai Hong lin chen Wuhan National Laboratory for Optoelectronics and School of Optical and Electronic Information Huazhong University of Science and TechnologyWuhan430074China

Exceptional points have given rise to many intriguing optical phenomena that are of fundamental importance for a variety of breakthrough *** pre-defined Mie scatterers can bring a resonator to an exceptional point,and... 详细信息

关键词： resonator scattering. exceptional

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Practical compensation for nonlinear dynamic thrust measurement system

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Chinese Journal of Aeronautics 2015年第2期28卷 418-426页

作者： chen lin chen Jie Li Jianxun Department of Automation Shanghai Jiao Tong University Shanghai Institute of Space Propulsion Shanghai Academy of Spaceflight Technology

The real dynamic thrust measurement system usually tends to be nonlinear due to the complex characteristics of the rig, pipes connection, etc. For a real dynamic measuring system, the nonlinearity must be eliminated by some adequate methods. In this paper, a nonlinear model of dynamic thrust measurement system is established by using radial basis function neural network （RBF-NN）, where a novel multi-step force generator is designed to stimulate the nonlinearity of the system, and a practical compensation method for the measurement system using left inverse model is proposed. Left inverse model can be considered as a perfect dynamic compensation of the dynamic thrust measurement system, and in practice, it can be approximated by RBF-NN based on least mean square （LMS） algorithms. Different weights are set for producing the multi-step force, which is the ideal input signal of the nonlinear dynamic thrust measurement system. The validity of the compensation method depends on the engine＇s performance and the tolerance error 0.5%, which is commonly demanded in engineering. Results from simulations and experiments show that the practical compensation using left inverse model based on RBF-NN in dynamic thrust measuring system can yield high tracking accuracy than the conventional methods.

关键词： Digital compensation Dynamic thrust measure-ment system Identification Left inverse model Nonlinear model Radial basis function neuralnetwork

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