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Penpulimab,an anti-PD-1 antibody,for heavily pretreated metastatic nasopharyngeal carcinoma:a single-arm phase II study

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Signal Transduction and Targeted Therapy 2024年第7期9卷 3056-3062页

作者： Xiaozhong Chen Wei wang Qingfeng zou Xiaodong zhu Qin lin Yi Jiang Yan Sun Liangfang Shen lin wang Guorong zou Xiaoyan lin Shaojun lin Minying Li Ying wang Ruilian Xu Rui Ao Rensheng wang Haifeng lin Shuang Huang Tingting Xu Wenting Li Mengying Xia Yu Xia Zhongmin wang Baiyong Li Jingao Li Chaosu Hu Department of Radiation Oncology Cancer Hospital of the University of ChineseAcademy of Sciences(Zhejiang Cancer Hospital)HangzhouChina Gastroenterology and Urology Department II Hunan Cancer Hospital/the Affiliated Cancer Hospital of Xiangya School of MedicineCentral South UniversityChangshaChina Clinical Research Center for Gastrointestinal Cancer in Hunan Province ChangshaChina Department of Medical Oncology Affiliated Cancer Hospital&Institute of Guangzhou Medical UniversityGuangzhouChina Department of Radiation Oncology Guangxi Medical University Affiliated Tumor Hospital&Key Laboratory of Early Prevention and Treatment for Regional High Frequency Tumor(Guangxi Medical University)Ministry of Education&Guangxi Key Laboratory of Early Prevention and Treatment for Regional High Frequency TumorGuangxi Medical UniversityNanningChina Department of Radiation Oncology Cancer CenterThe First Affiliated Hospital of Xiamen UniversityXiamenChina Department of Medical Oncology Cancer Hospital of Shantou University Medical CollegeShantouChina Department of Radiation Oncology Peking University Cancer Hospital&InstituteBeijingChina Department of Oncology Xiangya Hospital Central South UniversityChangshaChina Department of Medical Oncology Hainan General HospitalHainan Affiliated Hospital of Hainan Medical UniversityHaikouChina Department of Oncology The Affiliated Panyu Central Hospital of Guangzhou Medical UniversityGuangzhouChina Department of Medical Oncology Fujian Medical University Union HospitalFuzhouChina Department of Radiation Oncology Clinical Oncology School of Fujian Medical UniversityFujian Cancer HospitalFuzhouChina Department of Radiation Therapy for Thoracic Tumors Zhongshan City People’s HospitalZhongshanChina Tumor Radiotherapy Center Chongqing University Cancer HospitalChongqing Cancer HospitalChongqing Cancer InstituteChongqingChina Department of Oncology Shenzhen People’s Hospital(The Second Clinical Medical CollegeJinan UniversityThe First Affiliated HospitalSo

Penpulimab is an anti-programmed cell death-1(PD-1)IgG1 antibody with no Fc gamma receptor(FcγR)binding activity,and thus theoretically reduced immune-related adverse events(irAEs)while maintaining *** single-arm,phase II trial conducted across 20 tertiary care centers in China enrolled adult patients with metastatic nasopharyngeal carcinoma(NPC)who had failed two or more lines of previous systemic *** received 200-mg penpulimab intravenously every 2 weeks(4 weeks per cycle)until disease progression or intolerable *** primary endpoint was objective response rate(ORR)per RECIST(version 1.1),as assessed by an independent radiological review *** secondary endpoints included progression-free survival(PFS)and overall survival(OS).One hundred thirty patients were enrolled and 125 were efficacy *** the data cutoff date(September 28,2022),1 patient achieved complete response and 34 patients attained partial *** ORR was 28.0%(95%CI 20.3–36.7%).The response was durable,with 66.8%still in response at 9 ***-three patients(26.4%)were still on *** median PFS and OS were 3.6 months(95%CI=1.9–7.3 months)and 22.8 months(95%CI=17.1 months to not reached),***(7.6%)patients experienced grade 3 or higher *** has promising anti-tumor activities and acceptable toxicities in heavily pretreated metastatic NPC patients,supporting further clinical development as third-line treatment of metastatic NPC.

关键词： metastatic nasopharyngeal supporting

Paleoenvironmental reconstruction and organic matter accumulation of the paleogene shahejie oil shale in the Zhanhua Sag, Bohai Bay Basin, Eastern China

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Petroleum Science 2024年第3期21卷 1552-1568页

作者： Xiao-lin wang Xiao-Min zhu Jin Lai Xing-Yue lin Xiang wang Yu-Shan Du Chao Huang Yu-Rui zhu State Key Laboratory of Petroleum Resources and Engineering China University of Petroleum(Beijing)Beijing102249China College of Geosciences China University of Petroleum(Beijing)Beijing102249China Shengli Oilfield SINOPECDongying257000ShandongChina

The controlling factors of organic-rich shale accumulation is essential for the exploration and development of shale oil and gas *** sedimentary environment plays a vital role in the formation of organic-rich sediments in lacustrine *** article unravels the mineralogy,geochemistry,and paleoenvironmental evolution during the deposition of the Paleogene Shahejie Formation(Es_(3)^(L)).It discusses the effects of paleoclimate,paleosalinity,paleoredox conditions,paleowater depth,and paleoproductivity on organic matter(OM)***,the OM enrichment model was *** results show that the mineralogical compositions are mainly composed of calcite(avg.40.13%),quartz(avg.21.64%)and clay minerals(avg.24.07%),accompanied by dolomite(avg.7.07%),feldspar(avg.6.36%)and pyrite(avg.2.95%).The Es_(3)^(L) shale has a high abundance of OM,with total organic carbon(TOC)ranging from 1.07%to 5.12%.The organic matter type is mainly composed of type I-II_(1) kerogen,which is generally considered a good-quality source *** source of OM is a mixture of lower bacteria,algae,and *** the early sedimentary period,the paleoclimate was dry and cold,with high salinity,intense reducibility,and relatively low *** the late sedimentary period,the climate became warmer and more *** a result,the salinity decreased to a level that was suitable for biological reproduction,and productivity increased gradually due to the input of terrigenous *** and paleoclimate determined the environment of the sedimentary period,in addition,paleoproductivity and paleoredox condition indicated the formation and preservation conditions of *** warm and humid climate,brackish water,suitable reduction conditions and high productivity are the favorable conditions for the generation and preservation of organic *** research results may have implications for the genetic mechanisms of organic matter *** will provide theoret

关键词： Elemental geochemical Paleoenvironment Organic matter accumulation Paleogene shahejie formation Zhanhua Sag Bohai Bay Basin

Effect of rare earth on primary carbides in H13 die steel and their addition method:a review

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Journal of Iron and Steel Research International 2024年第3期31卷 531-551页

作者： Jing-feng wang lin-zhu wang Chao-yi Chen Xiang wang Fei Zhao School of Materials and Metallurgy Guizhou UniversityGuiyang 550025GuizhouChina Zhengzhou Railway Vocational and Technical College Zhengzhou 450000HenanChina Guizhou Provincial University Key Laboratory of High Performance Battery Materials Guizhou UniversityGuiyang 550025GuizhouChina Shougang Guiyang Special Steel Co. Guiyang 550005GuizhouChina

Larger-sized primary carbides lead to stress concentration during the application of H13 hot-work die steel,resulting in microcracks and fatigue *** earth was usually added to modify the carbides and *** existing literature is reviewed on the effect of rare earth on primary carbides in H13 steel.A comprehensive review on the effect of rare earth on the characteristics of primary carbides,i.e.,number,size,morphology,and thermal stability in H13 steel,was *** precipitation mechanism and nucleation of primary carbides with rare earth were *** position and form of rare earth in steel and their effects on alloying elements segregation were *** addition techniques of rare earth in H13 steel were compared,and the prospects for other uncommon rare earth and emerging technology were *** on the current references,it can be known that adding rare earth facilitated refined and dispersed primary *** size of primary carbides would be reduced,and their morphology would be improved because the rare earth inclusions formed in H13 steel can act as nucleation cores forγ-Fe orδ-Fe,refining the dendritic ***,the number of primary carbides at grain boundaries would be significantly ***,rare earth had little impact on thermal *** nucleation of primary carbides tended to be inhibited due to the modification of inclusions by rare earth which were likely to be nucleation cores for primary *** earth had been reported to affect the mechanism and process of primary carbide ***,the addition of rare earth can inhibit the segregation of alloying elements and carbon diffusion by ***,laboratory experiments and theoretical calcu-lations need to be conducted to study the states and evolution of rare earth steels.

关键词： Rare earth H13 die steel Primary carbide Nucleation Dendritic structure

Security-Reliability Tradeoff Analysis for Jamming Aided Decode-and-Forward Relay Networks

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China Communications 2024年第5期21卷 218-228页

作者： zou Ronggui zou Yulong zhu Jia Li Bin School of Telecommunications and Information Engineering Nanjing University of Posts and TelecommunicationsNanjing 210003China

In this paper,we explore a cooperative decode-and-forward(DF)relay network comprised of a source,a relay,and a destination in the presence of an *** improve physical-layer security of the relay system,we propose a jamming aided decodeand-forward relay(JDFR)scheme combining the use of artificial noise and DF relaying which requires two stages to transmit a ***,in stage one,the source sends confidential message to the relay while the destination acts as a friendly jammer and transmits artificial noise to confound the *** stage two,the relay forwards its re-encoded message to the destination while the source emits artificial noise to confuse the *** addition,we analyze the security-reliability tradeoff(SRT)performance of the proposed JDFR scheme,where security and reliability are evaluated by deriving intercept probability(IP)and outage probability(OP),*** the purpose of comparison,SRT of the traditional decode-and-forward relay(TDFR)scheme is also *** results show that the SRT performance of the proposed JDFR scheme is better than that of the TDFR ***,it is shown that for the JDFR scheme,a better SRT performance can be obtained by the optimal power allocation(OPA)between the friendly jammer and user.

关键词： decode-and-forward relay friendly jammer physical layer security power allocation security-reliability tradeoff

A novel optical emission spectroscopy method for diagnostics of contribution of different ionization mechanisms and flux of ions in different valences in discharge channel of a Hall thruster

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Chinese Journal of Aeronautics 2024年第4期37卷 294-307页

作者： Yanfei wang Ximing zhu Renqiu zou Shilin YAN Junwei JIA Zhongxi NING Daren YU School of Energy Science and Engineering Harbin Institute of TechnologyHarbin 150001China Key Laboratory of Aerospace Plasma Propulsion Ministry of Industry and Information TechnologyHarbin 150001China Beijing Orient Institute of Measurement and Test Beijing 100094China Beijing Aerospace Long March Aircraft Research Institute Beijing 100076China

The mass application of Hall thrusters poses the need for a diagnostic method of ionization mechanism in the discharge channel to boost the iteration and optimization of thruster *** work presents an Optical Emission Spectroscopy (OES) method for diagnostics of the contribution of different ionization mechanisms and the flux of ions in different valences in the discharge channel of a Hall *** emission spectra in the discharge channel are analyzed by jointly utilizing a collisional-radiative model,an ionization-excitation model,and a flux-conservation *** is found that the intensities of some spectral lines can be converted into the reaction rates of collision processes,e.g.,electron-induced excitation and ionization *** latter can further be used to determine the evolutions of particle fluxes by utilizing the conservation law of *** novel method is demonstrated on a kilo-watt Hall *** evolutions of several parameters are determined using this method along the discharge channel,including the ionization rates of different mechanisms,particle fluxes,particle densities,and particle *** novel method can be further developed by being jointly utilized with spectral imaging and tomography techniques,enabling diagnostics of multi-dimensional distributions of the above-mentioned parameters in the discharge channel and near-field plume.

关键词： Hall thruster Optical emission spectroscopy Ionization mechanism Particle flux Divalent ion

High-efficiency CO_(2) sequestration through direct aqueous carbonation of carbide slag: determination of carbonation reaction and optimization of operation parameters

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Frontiers of Environmental Science & Engineering 2024年第1期18卷 157-167页

作者： Zhiqiang wang Longpeng Cui Yanfang Liu Jili Hou Hongwei Li Liang zou Fuxia zhu Department of Coal and Syngas Conversion Sinopec Research Institute of Petroleum Processing Co.Ltd.Beijing 100083China

Under the dual-carbon target, CO_(2) mineralization through solid wastes presents a mutually beneficial approach for permanent carbon emission reduction at a low material cost, while also enabling the resource utilization of these wastes. However, despite its potential, a comprehensive understanding about the effect of industrial solid waste properties and operating parameters on the carbonation process, and the mechanism of direct aqueous carbonation is still lacking. A series of experiments were conducted to compare the carbonation performance of fly ash, steel slag, and carbide slag. Subsequently, CO_(2) mineralization by carbide slag was systematically studied under various operating parameters due to its high CO_(2) sequestration capacity. Results showed the reactivity of CaO and Ca(OH)2 was higher than that of CaO·SiO_(2) and 2CaO·SiO_(2). Carbide slag demonstrated a sequestration capacity of 610.8 g CO_(2)/kg and carbonation efficiency ζCa of 62.04% under the conditions of 65 ℃, 1.5 MPa initial CO_(2) pressure, 15 mL/g liquid-to-solid ratio, and 200 r/min stirring speed. Moreover, the formation of carbonates was confirmed through XRD, SEM-EDS, TG, and FTIR. A mechanism analysis revealed that initially, the rate of the carbonation process was primarily controlled by the mass transfer of CO_(2) in the gas–liquid interface. However, the rate-determining step gradually shifted to the mass transfer of Ca2+ in the solid–liquid interface as the reaction time increased. This study lays the foundation for the large-scale implementation of CO_(2) sequestration through carbide slag carbonation.

关键词： Industrial by-products Direct aqueous carbonation CO_(2)sequestration Mass transfer

A Multi-AGV Routing Planning Method Based on Deep Reinforcement Learning and Recurrent Neural Network

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IEEE/CAA Journal of Automatica Sinica 2024年第7期11卷 1720-1722页

作者： Yishuai lin Gang Hu Liang wang Qingshan Li Jiawei zhu the School of Computer Science and Technology Xidian UniversityXi’an 710000China Suzhou Mingyi Intelligence Warehousing Information Technology Co. Ltd.Kunshan 215300China the School of Information Engineering Chang’an UniversityXi’an 710000China

Dear Editor,This letter presents a multi-automated guided vehicles(AGV) routing planning method based on deep reinforcement learning(DRL)and recurrent neural network(RNN), specifically utilizing proximal policy optimi... 详细信息

关键词： network AGV Deep

Detour for the inexperienced? Migration count data suggest mostly juvenile Greater Spotted Eagles appear in coastal peninsulas in China

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Avian Research 2024年第2期15卷 249-254页

作者： Xu Shi Xiaoping wang Qian Wei Qiwei lin Lei zhu School of the Environment The University of QueenslandSt LuciaQLD4072AustraliaAustralia Centre for Ecology and Conservation and Environment and Sustainability InstituteUniversity of ExeterPenrynCornwallTR109FEUK Guangxi Biodiversity Research and Conservation Association Nanning530022China Snake Island Laotieshan National Nature Reserve Dalian116041China Chongqing Birdwatching Society Chongqing400054China Huqiu Rd Gusu DistrictSuzhou215008China Raptor Research Group of Chengdu Chengdu610000China Guangxi Academy of Marine Science Nanning530007China

Soaring bird migration often relies on suitable terrain and airflow;therefore,route selection is vital for successful *** age and experience have been identified as key factor influencing migration route selection among soaring raptors in the African-Eurasian Flyway,how they shape the migration route of soaring raptors in East Asia is still largely *** this study,we investigated potential variations in the routes and timing in autumn migration of juvenile and older soaring birds,using count data of Greater Spotted Eagles(Clanga clanga)from two coastal sites and two inland sites in *** 2020 to 2023,we recorded a total of 340 individuals,with the highest site averaging over 90 individuals per autumn,making it one of the world’s top single-season counts and thus a globally important site for this *** found that 82% and 61% records from coastal sites were juveniles,significantly higher than inland sites(15% and 24%).Juveniles at all four sites exhibited markedly earlier median passage time than non-juveniles,with brief overlapping in their main migration *** coastal sites are located on the tip of peninsulas stretching southwest,requiring long overwater flights if crossing the Bohai Bay or Beibu Gulf,which would be energetically demanding and increase mortality *** individuals may have learned to avoid such terrain and subsequent detour,while juveniles are more prone to enter these peninsulas due to lack of experience and opportunities for social learning,or following other raptor species that are more capable of powered *** findings highlight the importance of age and experience in migration route selection of large soaring birds.

关键词： Clanga clanga East Asia Greater Spotted Eagle Juvenile Migration route Social learning

Efficient piezo-catalytic dye degradation using piezoelectric 6H-SiC under harsh conditions

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Rare Metals 2024年第7期43卷 3173-3184页

作者： lin-lin Zhou Tao Yang Kang wang Lai-Pan zhu En-Hui wang Kuo-Chih Chou Hai-Long wang Xin-Mei Hou Institute for Carbon Neutrality University of Science and Technology BeijingBeijing 100083China Institute of Steel Sustainable Technology Liaoning Academy of MaterialsShenyang 110000China Beijing Institute of Nanoenergy and Nanosystems Chinese Academy of SciencesBeijing 101400China School of Materials Science Engineering Zhengzhou UniversityZhengzhou 450001China Beijing Advanced Innovation Center for Materials Genome Engineering Beijing University of Science and TechnologyBeijing 100083China

The development of novel piezoelectric catalysts against harsh conditions is indeed crucial for improving the piezo-catalytic degradation efficiency of colored organic dyes in *** this work,6H-SiC nanoparticles(NPs)are utilized to piezo-catalytic degrade rhodamine B(RhB)and methylene blue(MB)under ultrasonic vibration for the first *** degradation efficiency of RhB and MB reaches 98.8%and 98.7%within 80 *** piezoelectricity of 6H-SiC is comprehensively analyzed by the piezoresponse force microscope(PFM)and finite element method(FEM).The strong oxidizing active free radicals generated by the continuous piezoelectric polarized electric field of 6H-SiC,i.e.,·O_(2)^(-)and·OH,induce the decomposition reactions of colored organic dyes in *** the dyes are proven to degrade to harmless or less-harmful products gradually during the piezo-catalysis process by high-performance liquid chromatography tandem mass spectrometry(HPLC-MS).Moreover,RhB is also decomposed efficiently by 6HSiC NPs under acidic and alkaline *** results prove the feasibility of 6H-SiC for decomposing common water pollutants under harsh conditions and provide a new perspective for water purification.

关键词： Piezo-catalytic degradation 6H-SiC Rhodamine B(RhB) Methylene blue(MB) Harsh conditions