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Comprehensive bibliometric analysis of pharmacotherapy for bipolar disorders:Present trends and future directions

World Journal of Psychiatry 2025年第1期15卷 153-167页

作者： Bo-Fan Chen Li Liu Fang-Zhen lin Hai-Min Zeng Hai-Qiang Huang Chun-Fang Zhang Cong-Cong Liu Xiang Chen Jie Peng Yun-Fa Wang zhi-lin Wang Bin Chen De-Le Liu Yun Liu Zheng-Zheng Li Xin-Xing Zeng The Second Affiliated Hospital Jiangxi Medical CollegeNanchang UniversityNanchang 330006Jiangxi ProvinceChina The Second Clinical Medical College Jiangxi Medical CollegeNanchang UniversityNanchang 330006Jiangxi ProvinceChina Department of Rehabilitation Medicine The Second Affiliated HospitalJiangxi Medical CollegeNanchang UniversityNanchang 330006Jiangxi ProvinceChina Jiangxi Provincial People’s Hospital The First Affiliated Hospital of Nanchang Medical CollegeNanchang 330006Jiangxi ProvinceChina Department of Psychiatry Jiangxi Mental HospitalHospital of Nanchang UniversityNanchang UniversityNanchang 330029Jiangxi ProvinceChina

BACKGROUND Bipolar disorder(BD)is a severe mental illness characterized by significant mood *** drug treatment modalities are crucial for managing *** To analyze the current status and future trends of global research on BD drug treatment over the last *** The Web of Science Core Collection database spanning from 2015 to 2024 was utilized to retrieve literature related to BD drug treatment.A total of 2624 articles were *** visualization and analysis were conducted using CiteSpace,VOSviewer,Pajek,Scimago Graphica,and R-studio bibliometrix to identify RESULTS The United States,China,and the United Kingdom have made the most significant contributions to research on BD drug treatment and formed notable research collaboration *** University of Pittsburgh,Massachusetts General Hospital,and the University of Michigan have been identified as the major research institutions in this *** Journal of Affective Disorders is the most influential journal.A keyword analysis revealed research hotspots related to clinical symptoms,drug efficacy,and genetic mechanisms.A citation analysis identified the management guidelines published by Yatham et al in 2018 as the most cited *** This study provides a detailed overview of the field of BD drug treatment,highlighting key contributors,research hotspots,and future *** study findings can be employed as a reference for future research and policymaking,which may enable further development and optimization of BD pharmacotherapy.

关键词： Bipolar disorder Drug treatment Bibliometric analysis Visualization Mental disorder

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Modified constructions of binary sequences using multiplicative inverse

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Applied Mathematics(A Journal of Chinese Universities) 2008年第4期23卷 490-500页

作者： CHEN zhi-xiong lin zhi-xing Key Laboratory of Applied Mathematics Putian University Putian 351100 China Key Laboratory of Network Security and Cryptology Fujian Normal University Fuzhou 350007China

Two new families of finite binary sequences are constructed using multiplicative inverse. The sequences are shown to have strong pseudorandom properties by using some estimates of certain exponential sums over finite fields. The constructions can be implemented fast since multiplicative inverse over finite fields can be computed in polynomial time.

关键词： stream cipher binary sequence multiplicative inverse pseudorandomness exponential sum

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Constructing quasi-random subsets of Z_N by using elliptic curves

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Applied Mathematics(A Journal of Chinese Universities) 2012年第1期27卷 105-113页

作者： lin zhi-xing CHEN zhi-xiong Department of Mathematics Putian UniversityPutianFujian 351100China State Key Laboratory of Information Security Institute of SoftwareChinese Academy of SciencesBeijing 100049China

Let ε ： y^2 = x3 ＋ Ax ＋ B be an elliptic curve defined over the finite field Zp（p 〉 3） and G be a rational point of prime order N on ε. Define a subset of ZN, the residue class ring modulo N, asS：={n：n∈ZN,n≠0,（X（nG）/p）=1} where X（nG） denotes the x-axis of the rational points nC and （＊/P） is the Legendre symbol. Some explicit results on quasi-randomness of S are investigated. The construction depends on the intrinsic group structures of elliptic curves and character sums along elliptic curves play an important role in the proofs.

关键词： elliptic curve quasi-random subset quasi-randomness character sum Legendre symbol.

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Biosynthesis-based artificial evolution of microbial natural products

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Science China Chemistry 2016年第9期59卷 1175-1187页

作者： zhi lin Dandan Chen Wen Liu Shanghai Institute of Organic Chemistry Chinese Academy of Sciences Shanghai 200032 China Huzhou Center of Bio-Synthetic Innovation Huzhou 313000 China

Natural products are often secondary metabolites in living organisms with a wide variety of biological activities. The diversification of their structures, aiming to the search for biologically active small molecules by expanding chemical and functional spaces, is a major area of current interest in synthetic chemistry. However, developing synthetic accessibility and efficiency often faces challenges associated with structural complexity. Synthetic biology has recently emerged and is promising to accomplish complex molecules; by contrast, the application to structural diversification of natural products relies on the understanding, development and utilization of compatible biosynthetic machinery. Here, we review the strategies primarily concerning the artificial evolution of microbial natural products whose biosynthesis features template enzymology, including ribosomaUy synthesized and post-translationally modified peptides as well as the assembly line-resultant polyketides, non-ribosomal peptides and hybrids. The establishment of these approaches largely facilitates the expansion of the molecular diversity and utility through bioengineering at different stages/levels of biosynthetic pathways.

关键词： biosynthesis artificial evolution RiPPs NRPS PKS enzymatic diversity

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Study of primordial deuterium abundance in Big Bang nucleosynthesis

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Nuclear Science and Techniques 2024年第3期35卷 208-215页

作者： zhi-lin Shen Jian-Jun He Key Laboratory of Beam Technology of Ministry of Education College of Nuclear Science and TechnologyBeijing Normal UniversityBeijing 100875China Institute of Radiation Technology Beijing Academy of Science and TechnologyBeijing 100875China

Big Bang nucleosynthesis(BBN)theory predicts the primordial abundances of the light elements^(2) H(referred to as deuterium,or D for short),^(3)He,^(4)He,and^(7) Li produced in the early *** these,deuterium,the first nuclide produced by BBN,is a key primordial material for subsequent *** date,the uncertainty in predicted deuterium abundance(D/H)remains larger than the observational *** this study,the Monte Carlo simulation code PRIMAT was used to investigate the sensitivity of 11 important BBN reactions to deuterium *** found that the reaction rate uncertainties of the four reactions d(d,n)^(3)He,d(d,p)t,d(p,γ)^(3)He,and p(n,γ)d had the largest influence on the calculated D/H ***,the calculated D/H uncertainty cannot reach observational precision even with the recent LUNA precise d(p,γ)^(3) He *** the nuclear physics aspect,there is still room to largely reduce the reaction-rate uncertainties;hence,further measurements of the important reactions involved in BBN are still necessary.A photodisintegration experiment will be conducted at the Shanghai Laser Electron Gamma Source Facility to precisely study the deuterium production reaction of p(n,γ)d.

关键词： Big Bang nucleosynthesis Abundance of deuterium Reaction cross section Reaction rate Monte Carlo method

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Analytic calculation of high-order corrections to quantum phase transitions of ultracold Bose gases in bipartite superlattices

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Frontiers of physics 2018年第5期13卷 133-140页

作者： zhi lin Wanli Liu Department of Physics and State Key Laboratory of Surface Physics Fudan University Shanghai 200433 China Shenzhen Institute of Research and Innovation The University of Hong Kong Shenzhen 518063 China

We clarify some technical issues in the present generalized effective-potential Landau theory （GEPLT） to make the GEPLT more consistent and complete. Utilizing this clarified GEPLT, we analytically study the quantum phase transitions of ultracold Bose gases in bipartite superlattices at zero temper- ature. The corresponding quantum phase boundaries are analytically calculated up to the third-order hopping, which are in excellent agreement with the quantum Monte Carlo （QMC） simulations.

关键词： ultracold Bose gases quantum phase transition bipartite superlattice generalizedeffective-potential Landau theory

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Progress in the Study of Molecular Genetic Improvements of Poplar in China

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Journal of Integrative Plant Biology 2006年第9期48卷 1001-1007页

作者： Shan-zhi lin zhi-Yi Zhang Qian Zhang Yuan-Zhen lin Key Laboratory for Genetics and Breeding in Forest Trees and Ornamental Plants of Ministry of Education Beijing Forestry University Beijing 100083 China

The poplar is one of the most economically important and intensively studied tree species owing to its wide application in the timber industry and as a model material for the study of woody plants. The natural resource of poplars in China is replete. Over the past 10 years, the application of molecular biological techniques to genetic improvements in poplar species has been widely studied in China. Recent advances in molecular genetic improvements of poplar, including cDNA library construction, gene cloning and identification, genetic engineering, gene expression, genetic linkage map construction, mapping of quantitative trait loci （QTL） and molecular-assisted selection, are reviewed in the present paper. In addition, the application of modern biotechnology to molecular improvements in the genetic traits of the poplar and some unsolved problems are discussed.

关键词： poplar gene engineering genetic improvement genetic linkage maps molecular marker quantitative trait loci (QTL) mapping

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Bounds on the overall properties of composites with ellipsoidal inclusions

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Acta Mechanica Sinica 2012年第5期28卷 1340-1355页

作者： lin-zhi Wu Shi-Dong Pan Center for Composite Materials Harbin Institute of Technology

A new model is put forward to bound the effective elastic moduli of composites with ellipsoidal inclusions. In the present paper, transition layer for each ellipsoidal inclusion is introduced to make the trial displacement field for the upper bound and the trial stress field for the lower bound satisfy the continuous interface conditions which are absolutely necessary for the application of variational principles. According to the principles of minimum potential energy and minimum complementary energy, the upper and lower bounds on the effective elastic moduli of composites with ellipsoidal inclusions are rigorously derived. The effects of the distribution and geometric parameters of ellipsoidal in- clusions on the bounds of the effective elastic moduli are an- alyzed in details. The present upper and lower bounds are still finite when the bulk and shear moduli of ellipsoidal inclusions tend to infinity and zero, respectively. It should be mentioned that the present method is simple and needs not calculate the complex integrals of multi-point correlation functions. Meanwhile, the present paper provides an entirely different way to bound the effective elastic moduli of composites with ellipsoidal inclusions, which can be developed to obtain a series of bounds by taking different trial displacement and stress fields.

关键词： Composites Ellipsoidal inclusions Effectiveelastic moduli Upper and lower bounds Transition layer

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Selective Laser Melting of 30CrMnSiA Steel: Laser Energy Density Dependence of Microstructural and Mechanical Properties

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Acta Metallurgica Sinica(English Letters) 2018年第8期31卷 807-814页

作者： lin-zhi Wang Wen-Hou Wei Chongqing Key Laboratory of Additive Manufacturing Technology and Systems Chongqing Institute of Green and Intelligent Technology Chinese Academy of Sciences

Three-dimensional parts of the 30 CrMnSiA steel were successfully fabricated using selective laser melting（SLM）. The microstructures and mechanical properties of the SLM-processed 30 CrMnSiA samples were investigated by scanning electron microscope and transmission electron microscopy. The results indicate that the microstructures of the 30 CrMnSiA samples consist mainly of lath martensite and acicular martensite. The value of the surface roughness decreases with increasing laser energy density（LED） before it reaches a minimum and then increases with further increasing LED. The relative density, microhardness and ultimate tensile strength of the SLM-processed samples initially increase and then decrease with increasing LED. By taking the relative density, surface roughness, microhardness and ultimate tensile strength into account, the optimized LED should be in the range of 46.15–51.28 J mm^（-3） for the SLM-processed30 CrMnSiA alloys. In addition, the differences in the microstructures and mechanical properties between the conventionally wrought 30 CrMnSiA sample and SLM-processed 30 CrMnSiA samples were also studied.

关键词： 30CrMnSiA Selective laser melting Laser energy density Microstructure Mechanical properties

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Numerical Simulation of the Vortex-Induced Vibration of A Curved Flexible Riser in Shear Flow

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China Ocean Engineering 2018年第3期32卷 301-311页

作者： ZHU Hong-jun lin Peng-zhi State Key Laboratory of Oil and Gas Reservoir Geology and Exploitation Southwest Petroleum University State Key Laboratory of Hydraulics and Mountain River Engineering Sichuan University

A series of fully three-dimensional(3 D) numerical simulations of flow past a free-to-oscillate curved flexible riser in shear flow were conducted at Reynolds number of 185–1015. The numerical results obtained by the two-way fluid–structure interaction(FSI) simulations are in good agreement with the experimental results reported in the earlier study. It is further found that the frequency transition is out of phase not only in the inline(IL) and crossflow(CF) directions but also along the span direction. The mode competition leads to the non-zero nodes of the rootmean-square(RMS) amplitude and the relatively chaotic trajectories. The fluid–structure interaction is to some extent reflected by the transverse velocity of the ambient fluid, which reaches the maximum value when the riser reaches the equilibrium position. Moreover, the local maximum transverse velocities occur at the peak CF amplitudes, and the values are relatively large when the vibration is in the resonance regions. The 3 D vortex columns are shed nearly parallel to the axis of the curved flexible riser. As the local Reynolds number increases from 0 at the bottom of the riser to the maximum value at the top, the wake undergoes a transition from a two-dimensional structure to a 3 D one. More irregular small-scale vortices appeared at the wake region of the riser, undergoing large amplitude responses.

关键词： vortex-induced vibration flexible riser shear flow fluid–structure interaction computational fluid dynamics

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