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A randomized controlled clinical trial: Interruption of intrauterine transmission of hepatitis B virus infection with HBIG

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World Journal of Gastroenterology 2006年第21期12卷 3434-3437页

作者： Qin XH lin xi-ao xiao-Bo Lu Yue-xin Zhang xia Cai School of public Health Xinjiang Medical University Urumqi 830054 Xinjiang Uygur Autonomous Region China The First Affiliated Hospital Xinjiang Medical University Urumqi 830054 Xinjiang Uygur Autonomous Region China

AIM： To evaluate the efficacy of interruption of intrauterine infection of HBV with HBIG in pregnant women with positive HBeAg and ***： A prospective randomized controlled trial was adopted. Sixty cases with positive HBeAg and HBsAg were coincident with the criteria of inclusion, and 8 cases were excluded. Fifty-two cases were analyzed （28 cases in trial group and 24 in control group）. All cases in trial group received 200 IU HBIG intravenously every 4 wk for 3 times from the 28^th wk. The cases of control group received placebo in the same way. All pregnant women were detected for HBeAg and HBV-DNA at the beginning of the trial and end of the trial （delivery）. The cord blood of all newborns were collected for detecting HBeAg and HBV-DNA ***： For investigation of HBeAg of newborns in trial group, 6 of 28 cases of newborns had positive HBeAg, the HBeAg positive rate being 21.4%, the total rate of 95% CI being 8%-41%. In control group, 19 of 24 cases of newborns had positive HBeAg, HBeAg positive rate was 79.2%, the rate of 95%CI being 5%-93%. By statistical analysis, 2= 17.26, P 〈 0.01, RR = 0.27, 95% CI （6.3 × 10^-6, 8.6 × 10^-5）. For investigation of HBV-DNA of newborns in trial group, 7 of 28 cases of newborns had positive HBV-DNA, HBV-DNA positive rate being 25%, the total rate of 95% CI being 11%-45%. In control group, 20 of 24 cases of newborns had positive HBV-DNA, HBV-DNA positive rate was 83.3%, the total rate of 95% CI being 63%-95%. By statistical analysis, X^2 = 17.62, P 〈 0.01, RR = 0.30, 95% CI （1.5 × 10^-5, 1.7× 10^-4）. The results indicated that there was significant difference in HBeAg positive rate and HBV-DNA positive rate of newborns between the two groups. In trial group, 7 of 28 newborns had HBV-DNA positive, but the HBV-DNA load of newborns was lower than that of their mothers. In control group, 20 of 24 newborns still had HBV-DNA positive, and the HBV-DNA load of newborns was close to those of their mothers. Statis

关键词： Interruption Intrauterine Transmission Hepatitis B virus HBIG

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Tranylcypromine upregulates Sestrin 2 expression to ameliorate NLRP3-related noise-induced hearing loss

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Neural Regeneration Research 2025年第5期20卷 1483-1494页

作者： xihang Chen Zhifeng Chen Menghua Li Weiwei Guo Shuolong Yuan Liangwei Xu Chang lin xi Shi Wei Chen Shiming Yang Senior Department of Otolaryngology Head and Neck Surgery Chinese PLA General HospitalChinese PLA Medical SchoolBeijingChina State Key Laboratory of Hearing and Balance Science BeijingChina National Clinical Research Center for Otolaryngologic Diseases BeijingChina Key Laboratory of Hearing Science Ministry of EducationBeijingChina Beijing Key Laboratory of Hearing Impairment Prevention and Treatment BeijingChina Department of Otorhinolaryngology Head and Neck Surgery The First Affiliated Hospital of Fujian Medical UniversityFuzhouFujian ProvinceChina Department of Otolaryngology Head and Neck Surgery The 940th Hospital of Joint Logistics Support Force of Chinese PLALanzhouGansu ProvinceChina Key Laboratory of Tropical Biological Resources of Ministry of Education School of Pharmaceutical SciencesHainan UniversityHaikouHainan ProvinceChina Academician Workstation of Hainan University School of Pharmaceutical SciencesYazhou BaySanyaHainan ProvinceChina

Noise-induced hearing loss is the primary non-genetic factor contributing to auditory ***,there are currently no effective pharmacological interventions for patients with noise-induced hearing ***,we present evidence suggesting that the lysine-specific demethylase 1 inhibitor–tranylcypromine is an otoprotective agent that could be used to treat noise-induced hearing loss,and elucidate its underlying regulatory *** established a mouse model of permanent threshold shift hearing loss by exposing the mice to white broadband noise at a sound pressure level of 120 d B for 4 *** found that tranylcypromine treatment led to the upregulation of Sestrin2(SESN2)and activation of the autophagy markers light chain 3B and lysosome-associated membrane glycoprotein 1 in the cochleae of mice treated with *** noise exposure group treated with tranylcypromine showed significantly lower average auditory brainstem response hearing thresholds at click,4,8,and 16 k Hz frequencies compared with the noise exposure group treated with *** findings indicate that tranylcypromine treatment resulted in increased SESN2,light chain 3B,and lysosome-associated membrane glycoprotein 1 expression after noise exposure,leading to a reduction in levels of 4-hydroxynonenal and cleaved caspase-3,thereby reducing noise-induced hair cell ***,immunoblot analysis demonstrated that treatment with tranylcypromine upregulated SESN2 expression via the autophagy *** treatment also reduced the production of NOD-like receptor family pyrin domaincontaining 3(NLRP3)*** conclusion,our results showed that tranylcypromine treatment ameliorated cochlear inflammation by promoting the expression of SESN2,which induced autophagy,thereby restricting NLRP3-related inflammasome signaling,alleviating cochlear hair cell loss,and protecting hearing *** findings suggest that inhibiting lysine-specific demethylase 1 is a

关键词： 4-hydroxynonenal apoptosis autophagy cleaved caspase-3 inflammation NOD-like receptor family pyrin domain-containing 3(NLRP3) noise-induced hearing loss oxidative stress Sestrin2 tranylcypromine

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棒柄花苷A对照品的制备研究

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广西科学 2014年第3期21卷 264-266页

作者：黄艳刘元陈小刚宋志钊林霄刘布鸣广西中药质量标准研究重点实验室广西南宁530022 广西中医药研究院广西南宁530022

【目的】建立从棒柄花(Cleidion brevipetiolatumPaxet Hoffm)中制备棒柄花苷A(PPGA)对照品的方法。【方法】利用硅胶柱层析、重结晶和反相制备高效液相色谱对棒柄花的乙醇提取物进行分离纯化,以HPLC对棒柄花苷A进行纯度检查和含量测定... 详细信息

【目的】建立从棒柄花(Cleidion brevipetiolatumPaxet Hoffm)中制备棒柄花苷A(PPGA)对照品的方法。【方法】利用硅胶柱层析、重结晶和反相制备高效液相色谱对棒柄花的乙醇提取物进行分离纯化,以HPLC对棒柄花苷A进行纯度检查和含量测定,并通过UV,IR,MS,1 HNMR等对其进行结构确证。【结果】从棒柄花叶中分离、纯化出棒柄花苷A对照品,质量分数W>98.0%。【结论】所建立的制备方法简单,制备出的棒柄花苷A对照品符合中药化学对照品的相关要求,可作为棒柄花药材和含棒柄花成药质量控制,以及中药药效物质基础用的化学对照品。

关键词：棒柄花棒柄花苷A 对照品制备

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Hierarchically porous Beta/SBA-16 with different silica-alumina ratios and the hydrodesulfurization performances of DBT and 4,6-DMDBT

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Petroleum Science 2022年第1期19卷 375-386页

作者： Jin-lin Mei Yu Shi Cheng-Kun xiao ao-Cheng Wang Ai-Jun Duan xi-Long Wang State Key Laboratory of Heavy Oil Processing China University of Petroleum(Beijing)Beijing 102249PR China

Hierarchically porous Beta/SBA-16(BS)composite materials,combining the characteristics of the acidity from the Beta zeolite and the three-dimensional structure from SBA-16,were synthesized successfully through a two-step in-situ assembly hydrothermal crystallization method.A series of Ni Mo catalysts supported on BS with different silica-alumina ratios were *** supports and the corresponding catalysts were characterized by XRD,N_(2) physisorption,^(27)Al MAS NMR,TEM,pyridine-FTIR,Raman,XPS and *** activities of series catalysts were evaluated by the hydrodesulfurization(HDS)performances of dibenzothiophene(DBT)and 4,6-dimethyldibenzothiophene(4,6-DMDBT).It was found that the Beta crystallites were embedded into SBA-16 through silanols accompanied by dealumination on the T3-T9 sites of Beta *** Mo/BS-3 with a silica-alumina ratio of 100 exhibited the highest DBT and 4,6-DMDBT HDS activities at the WHSV value of 10 h^(-1),with the conversions of 95.9%and 86.9%respectively,due to the synergistic effects of the suitable specific surface areas,the relatively large pore size,appropriate acidity,the relatively high sulfidation degree,moderate dispersity and good stacking degree of Mo S;active phases.

关键词： Beta/SBA-16 Dibenzothiophene 4,6-Dimethyldibenzothiophene Hydrodesulfurization

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Multi-model ensemble learning for battery state-of-health estimation:Recent advances and perspectives

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Journal of Energy Chemistry 2025年第1期100卷 739-759页

作者： Chuanping lin Jun Xu Delong Jiang Jiayang Hou Ying Liang Zhongyue Zou Xuesong Mei State Key Laboratory for Manufacturing Systems Engineering Xi'an Jiaotong University Shaanxi Key Laboratory of Intelligent Robots School of Mechanical Engineering Xi'an Jiaotong University Department of Electrical Engineering and Automation Luoyang Institute of Science and Technology School of Mechanical Engineering Hangzhou Dianzi University

The burgeoning market for lithium-ion batteries has stimulated a growing need for more reliable battery performance monitoring. Accurate state-of-health(SOH) estimation is critical for ensuring battery operational performance. Despite numerous data-driven methods reported in existing research for battery SOH estimation, these methods often exhibit inconsistent performance across different application scenarios. To address this issue and overcome the performance limitations of individual data-driven models,integrating multiple models for SOH estimation has received considerable attention. Ensemble learning(EL) typically leverages the strengths of multiple base models to achieve more robust and accurate outputs. However, the lack of a clear review of current research hinders the further development of ensemble methods in SOH estimation. Therefore, this paper comprehensively reviews multi-model ensemble learning methods for battery SOH estimation. First, existing ensemble methods are systematically categorized into 6 classes based on their combination strategies. Different realizations and underlying connections are meticulously analyzed for each category of EL methods, highlighting distinctions, innovations, and typical applications. Subsequently, these ensemble methods are comprehensively compared in terms of base models, combination strategies, and publication trends. Evaluations across 6 dimensions underscore the outstanding performance of stacking-based ensemble methods. Following this, these ensemble methods are further inspected from the perspectives of weighted ensemble and diversity, aiming to inspire potential approaches for enhancing ensemble performance. Moreover, addressing challenges such as base model selection, measuring model robustness and uncertainty, and interpretability of ensemble models in practical applications is emphasized. Finally, future research prospects are outlined, specifically noting that deep learning ensemble is poised to advance ens

关键词： Contrastive Learning

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副干酪乳酪杆菌HNU502和粪菌移植缓解抗生素副作用的机制

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食品科学 2025年第3期46卷 1-10页

作者：陈琳李敖黎嘉和张增张家超海南大学食品科学与工程学院海南海口570228

抗生素能够有效治疗细菌感染,但是会使肠道菌群紊乱,从而引起腹泻、胀气和消化不良等副作用。益生菌和粪菌移植(fecal microbiota transplantation,FMT)因具有恢复肠道菌群平衡并缓解各种病症的功能引起广泛关注。本实验以常见的抗生素... 详细信息

抗生素能够有效治疗细菌感染,但是会使肠道菌群紊乱,从而引起腹泻、胀气和消化不良等副作用。益生菌和粪菌移植(fecal microbiota transplantation,FMT)因具有恢复肠道菌群平衡并缓解各种病症的功能引起广泛关注。本实验以常见的抗生素头孢噻肟为代表,结合宏基因组学、病理学分析和气相色谱技术开展FMT和益生菌副干酪乳酪杆菌(Lacticaseibacillus paracasei HNU502)缓解抗生素副作用的机制研究。结果表明,FMT通过恢复紊乱的肠道菌群缓解抗生素副作用,而HNU502通过重建肠道菌群平衡发挥作用。FMT和益生菌补充不同程度地改善了肠道菌群组成,并能够防止杯状细胞缺失,增加黏蛋白2和紧密连接蛋白1含量,从而帮助肠道黏膜恢复。这两种手段也能改善短链脂肪酸代谢紊乱,抑制促炎细胞因子白细胞介素(interleukin,IL)-1β、IL-6、肿瘤坏死因子-α和血清尿素氮分泌,有效减少毒力因子的富集。本研究有助于更好地理解人体健康与肠道菌群之间的联系,可为缓解抗生素副作用提供新的治疗方案,对于改善患者健康状况和生活质量具有现实意义。

关键词：抗生素粪菌移植副干酪乳酪杆菌HNU502 肠道菌群

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HIGH VOLTAGE SAFETY MANAGEMENT SYSTEM OF ELECTRIC VEHICLE

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Chinese Journal of Mechanical Engineering 2008年第6期21卷 63-68页

作者： QIANG Jiaxi ao Guoqiang YANG lin nstitute of Automobile Electronic Technology Shanghai Jiaotong University Shanghai 200240 China

In order to improve the drivability and energy efficiency of electric vehicle （EV）, more and more batteries are connected in series with high voltage which makes it necessary to monitor the electric parameters of high voltage system （HVS） to ensure the high voltage safety. A high voltage safety management system is developed to solve this critical issue. Several key electric parameters including pre-charge, contact resistance, insulation resistance and remaining capacity are monitored and analyzed based on the presented equivalent models. An electronic unit called high voltage safety controller is developed. By the help of hardware-in-loop system, the equivalent models integrated in the high voltage safety controller are validated and the on-line electric parameters monitor strategy is discussed. The real vehicle experiment results indicate that the high voltage safety management system designed is suitable for EV application.

关键词： High voltage safety Pre-charge Contact resistance Insulation resistance Remaining capacity

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ESTIMATION METHOD ON THE BATTERY STATE OF CHARGE FOR HYBRID ELECTRIC VEHICLE

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Chinese Journal of Mechanical Engineering 2008年第3期21卷 20-25页

作者： QIANG Jiaxi ao Guoqiang YANG lin School of Mechanical Engineering Shanghai Jiaotong University Shanghai 200030 China

A combined algorithm for battery state of charge （SOC） estimation is proposed to solve the critical issue of hybrid electric vehicle （HEV）. To obtain a more accurate SOC, both coulomb-accumulation and battery resistance-capacitor （RC） model are weighted combined to compensate the deficiencies of individual methods. In order to solve the key issue of coulomb-accumulation, the battery thermal model is used. Based on the principle of energy conservation, the heat generated from battery charge and discharge process is converted into the equivalent electricity to calculate charge and discharge efficiency under variable current. The extended Kalman filter （EKF） as a closed loop algorithm is applied to estimate the parameters of resistance-capacitor model. The input variables do not increase much computing difficulty. The proposed combined algorithm is implemented by adjusting the weighting factor of coulomb- accumulation and resistance-capacitor model. In the end, four different methods including Ah-efficiency, Ah-Equip, RC-SOC and Combined-SOC are compared in federal testing procedure （FTP） drive cycle. The experiment results show that the proposed method has good robustness and high accuracy which is suitable for HEV application.

关键词： State of charge Coulomb-accumulation Resistance-capacitor modelHybrid electric vehicle

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Efficient production of hydrogen peroxide in microbial reverse-electrodialysis cells coupled with thermolytic solutions

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Frontiers of Environmental Science & Engineering 2023年第9期17卷 137-146页

作者： xi Luo ao Li Xue xia Peng Liang xia Huang College of Life and Environmental Sciences Minzu University of ChinaBeijing 100081China State Key Joint Laboratory of Environment Simulation and Pollution Control School of EnvironmentTsinghua UniversityBeijing 100084China Yangtze Ecology and Environment Co. Ltd.Wuhan 430062China

H_(2)O_(2) was produced at an appreciable rate in microbial reverse-electrodialysis cells(MRCs)coupled with thermolytic solutions,which can simultaneously capture waste heat as electrical *** determine the optimal cathode and membrane stack configurations for H_(2)O_(2) production,different catalysts,catalyst loadings and numbers of membrane cell pairs were *** black(CB)outperformed activated carbon(AC)for H_(2)O_(2) production,although AC showed higher catalytic activity for oxygen *** optimum CB loading was 10 mg/cm^(2) in terms of both the H_(2)O_(2) production rate and power *** optimum number of cell pairs was determined to be three based on a tradeoff between H_(2)O_(2) production and capital costs.A H_(2)O_(2) production rate as high as 0.99±0.10 mmol/(L·h)was achieved with 10 mg/cm^(2) CB loading and 3 cell pairs,where the H_(2)O_(2) recovery efficiency was 52±2%and the maximum power density was 780±37 mW/m^(2).Increasing the number of cell pairs to five resulted in an increase in maximum power density(980±21 mW/m^(2))but showed limited effects on H_(2)O_(2) *** results indicated that MRCs can be an efficient method for sustainable H_(2)O_(2) production.

关键词： Microbial reverse-electrodialysis cell Hydrogen peroxide production Ammonium bicarbonate Electrolysis cell Optimization

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Cosmological Dynamics of de Sitter Gravity

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Chinese Physics Letters 2011年第4期28卷 36-39页

作者： ao xi-Chen LI xin-Zhou xi Ping Shanghai United Center for Astrophysics(SUCA) Shanghai Normal University100 Guilin RoadShanghai 200234

A new cosmological model based on the de Sitter gravity is investigated by dynamical analysis and numerical *** some transformations,the evolution equations of this model can form an autonomous system with 8 physical critical *** these critical points there exist one positive attractor and one negative *** positive attractor describes the asymptotic behavior of late-time universe,which indicates that the universe will enter the exponential expansion phase,*** numerical calculations are also carried out,which convince us of this conclusion derived from the dynamical analysis.

关键词： attractor dynamical Sitter

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