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Chinese Journal of Natural Medicines 2018年第8期16卷 599-609页

作者： lin qing-hua QU Wei XU Jian FENG Feng HE Ming-Fang Department of Natural Medicinal Chemistry China Pharmaceutical University Key Laboratory of Biomedical Functional Materials China Pharmaceutical University Institute of Translational Medicine College of Biotechnology and Pharmaceutical EngineeringNanjing Tech University

Angiogenesis is a crucial process in the development of inflammatory diseases,including cancer,psoriasis and rheumatoid ***,several alkaloids from Picrasma quassioides had been screened for angiogenic activity in the zebrafish model,and the results indicated that 1-methoxycarbony-β-carboline(MCC) could effectively inhibit blood vessel *** this study,we further confirmed that MCC can inhibit,in a concentration-dependent manner,the viability,migration,invasion,and tube formation of human umbilical vein endothelial cells(HUVECs) in vitro,as well as the regenerative vascular outgrowth of zebrafish caudal fin in *** the zebrafish xenograft assay,MCC inhibited the growth of tumor masses and the metastatic transplanted DU145 tumor *** proteome profile array of the MCC-treated HUVECs showed that MCC could down-regulate several angiogenesis-related self-secreted proteins,including ANG,EGF,b FGF,GRO,IGF-1,PLG and *** addition,the expression of two key membrane receptor proteins in angiogenesis,TIE-2 and u PAR,were also down-regulated after MCC *** together,these results shed light on the potential therapeutic application of MCC as a potent natural angiogenesis inhibitor via multiple molecular targets.

关键词： 1-Methoxycarbony-β-carboline Angiogenesis inhibitor HUVEC Zebrafish Anti-angiogenic index

Identification and characterization of three new flavonoids from Rhododendron dauricum

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Chinese Journal of Natural Medicines 2015年第8期13卷 628-633页

作者： LOU Xin-Wei lin qing-hua ZHANG Guan-Yu LIU Wen-Yuan FENG Feng QU Wei Department of Natural Medicinal Chemistry China Pharmaceutical University Department of Pharmaceutical Analysis China Pharmaceutical University Key Laboratory of Drug Quality Control and Pharmacovigilance China Pharmaceutical UniversityMinistry of Education Key Laboratory of Carcinogenesis and Intervention China Pharmaceutical University

The present study was designed to determine the major chemical constituents of the leaves of Rhododendron dauricum L. Compounds were isolated and purified by various chromatographic methods, and their structures were elucidated by physicochemical properties and spectral data. The present study identified two new C-methyl flavanones, 5, 7, 3', 5'-tetrahydroxy-6, 8-di-C-methyl flavanone(1) and 5, 4'-dihydroxy-8-C-methylflavanone-7-O-β-D-glucopyranoside(2), and one new flavonoid glycoside, quercetin-3-O-β-D-(6''-O-cinnamoyl)-galactoside(3), along with seven known compounds, including syzalterin(4), poriolin(5), farrerol-7-O-β-D-glucopyranoside(6), myrciacetin(7), quercetin-3-O-β-D-(6-p-hydroxy-benzoyl)-galactoside(8), quercetin-3-O-β-D-(6-p-coumaroyl)-galactoside(9), and 5, 7, 3', 5'-tetrahydroxyl flavanone(10). Compounds 1-3 were determined to be new flavonoids; compounds 4-6 were isolated from this species for the first time; and compounds 7-10 were reported for the first time from this genus.

关键词： Rhododendron dauricum L Flavonoids Spectroscopic identification

Reduction of self-heating effect in SOI MOSFET by forming a new buried layer structure

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Nuclear Science and Techniques 2003年第2期14卷 119-122页

作者： ZHU Ming, lin qing, LIU Xiang-hua, lin Zi-Xin, ZHANG Zheng-Xuan, lin Cheng-Lu(State Key Laboratory of Functional Materials for Informatics, Shanghal Institute of Microsystem and Information Technology,the Chinese Academy of Sciences, Shanghai 200050) Shanghai Institute of Microsystem and Information Technology the Chinese Academy of Sciences State Key Laboratory of Functional Materials for Informatics 上海 200050

An inherent self-heating effect of the silicon-on-insulator (SOI) devices limits their application at high current levels. In this paper a novel solution to reduce the self-heating effect is proposed, based on N+ and O+ co-implantation into silicon wafer to form a new buried layer structure. This new structure was simulated using Medici program, and the temperature distribution and output characteristics were compared with those of the conventional SOI counterparts. As expected, a reduction of self-heating effect in the novel SOI device was observed.

关键词：自动加热效应埋存层状结构绝缘硅片 SOI 二氧化硅

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电磁轨道炮瞬态温度场的数值模拟

工程热物理学报 2017年第1期38卷 149-154页

作者：林庆华栗保明南京理工大学瞬态物理国家重点实验室南京210094

为了研究电磁轨道炮的热生成机理及其温度分布特点,本文建立了三维瞬态电磁场和温度场的耦合计算模型,用有限元方法模拟了发射时身管和一体化发射单元温度分布的时空演化过程,以及发射后的身管散热过程,讨论了温度对射速的影响。数值模... 详细信息

为了研究电磁轨道炮的热生成机理及其温度分布特点,本文建立了三维瞬态电磁场和温度场的耦合计算模型,用有限元方法模拟了发射时身管和一体化发射单元温度分布的时空演化过程,以及发射后的身管散热过程,讨论了温度对射速的影响。数值模拟结果表明,发射过程中电枢产生熔化波效应,临近炮尾的轨道温升较大,在发射后的散热过程初期,轨道热传导起主要作用。通过该模型建立了身管结构、材料参数、电流激励条件与温度变化的关系,指明了炮尾轨道为热管理的关键部位,为电磁轨道炮的热设计提供了理论依据。

关键词：动力机械工程电磁轨道炮温度场有限元数值模拟

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电磁轨道炮瞬态磁场测量与数值模拟

兵工学报 2016年第10期37卷 1788-1794页

作者：林庆华栗保明南京理工大学瞬态物理国家重点实验室江苏南京210094

为研究电磁轨道炮的磁场特性,建立三维瞬态电磁场计算模型,采用时域有限元/边界元耦合方法进行求解,获得了电枢的膛内运动过程,以及电流密度和磁通密度的时空分布,讨论电枢与轨道间的滑动电接触在电流扩散过程中产生的速度趋肤效应。在... 详细信息

为研究电磁轨道炮的磁场特性,建立三维瞬态电磁场计算模型,采用时域有限元/边界元耦合方法进行求解,获得了电枢的膛内运动过程,以及电流密度和磁通密度的时空分布,讨论电枢与轨道间的滑动电接触在电流扩散过程中产生的速度趋肤效应。在发射实验中,用B探针测量电枢运动及磁场,分析了发射过程中的瞬态磁场变化特点,与数值模拟结果进行对比,验证了电磁轨道炮三维瞬态电磁场计算模型的有效性。

关键词：兵器科学与技术轨道炮电磁场 B探针有限元数值计算

Effect of Exogenous Ammonium on GlutamineSynthetase, Glutamate Synthase, and Glutamate Dehydrogenase in the Root of Rice Seedling

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Wuhan University Journal of Natural Sciences 1999年第3期4卷 358-362页

作者： Li Ze-song Zhang Chu-fu lin qing-hua Peng Jin Li Chang-jian He Guang-cun Peng Shao-bing John Bennett College of Life Sciences Wuhan University Wuhan China International Rice Research Institute Makati City Philippines

Root biomass of rice seedlings was increased at lower concentration of exogenous NH 4 + , but it was decreased at higher concentration of exogenous NH 4 + . The level of free NH 4 + in the roots was accumulated gradually with the increase of NH 4 + concentration in the nutrient solution. The content of the soluble proteins was essentially constant at higher NH 4 + . The activities of glutamine synthetase (GS), NADH-dependent glutamate synthase (NADH-GOGAT), and NADH-dependent glutamate dehydrogenase (NADH-GDH) were risen with exogenous NH 4 + concentration at the lower NH 4 + concentration range. But the activities of GS and NADH-GOGAT were declined, and the level of NADH-GDH activity was kept constant under higher NH 4 + concentration. The GS/GDH ratio suggested that NH 4 + was assimilated by GS-GOGAT cycle under lower NH 4 + concentration, but NADH-GDH was more important for NH 4 + assimilation and detoxifying NH 4 + to the tissue cells at the higher NH 4 + level. According to the growth and the activity changes of these ammonium-assimilating enzymes of rice seedling roots, 10. 0 μg/mL NH 4 + -N in nutrient solution was more suitable to the rice growth.

关键词： ammonium glutamine synthetase glutamate synthase glutamate dehydrogenase rice root

高装填密度钝感发射装药的内弹道遗传算法优化

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弹道学报 2008年第3期20卷 29-32页

作者：林庆华栗保明南京理工大学瞬态物理国家重点实验室南京210094

在对高装填密度钝感发射药燃烧规律研究的基础上,运用现代优化设计方法,建立了基于遗传算法的内弹道多目标优化模型,对利用遗传算法求解内弹道优化问题中的约束处理方法和遗传搜索策略进行了研究.探讨和分析了钝感发射装药技术提高火炮... 详细信息

在对高装填密度钝感发射药燃烧规律研究的基础上,运用现代优化设计方法,建立了基于遗传算法的内弹道多目标优化模型,对利用遗传算法求解内弹道优化问题中的约束处理方法和遗传搜索策略进行了研究.探讨和分析了钝感发射装药技术提高火炮初速的潜力,针对制约这种装药技术应用的点火困难问题,讨论了用电热化学发射技术实现该装药优化方案的可能性.研究表明,遗传算法是一种求解枪炮内弹道多目标优化问题的有效方法,可作为内弹道设计方案的优化工具.

关键词：内弹道遗传算法参量优化

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电热化学炮内弹道过程的势平衡分析

兵工学报 2008年第4期29卷 487-490页

作者：林庆华栗保明南京理工大学瞬态物理国家重点实验室江苏南京210094

通过对电能作火药当量化假设,将势平衡理论用于电热化学炮的内弹道分析。根据常规和电热化学发射的试验结果,初步探讨了势平衡理论在电热化学炮内弹道数据分析中的应用。该方法可以用于确定弹丸运动的阻力系数,确定实际火药力和电能利... 详细信息

通过对电能作火药当量化假设,将势平衡理论用于电热化学炮的内弹道分析。根据常规和电热化学发射的试验结果,初步探讨了势平衡理论在电热化学炮内弹道数据分析中的应用。该方法可以用于确定弹丸运动的阻力系数,确定实际火药力和电能利用系数,评价脉冲放电的作用效能。根据势平衡点参数的变化,可以检测膛内火药燃烧是否有异常现象。

关键词：流体力学势平衡理论电热化学炮内弹道压力

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黄梅戏电影在香港及台湾的发展

中央音乐学院学报 2009年第2期115卷 74-82,120页

作者：林青华香港浸会大学音乐研究部

中国戏曲在二十世纪经历了前所未有的变化,其中影响颇为深远的是戏曲电影的诞生。通过对两部在香港及台湾风行一时的黄梅调电影《江山美人》及《白蛇传》的分析,可以看到:受到中国内地于1955年后陆续公演的黄梅戏电影《天仙配》《女驸... 详细信息

中国戏曲在二十世纪经历了前所未有的变化,其中影响颇为深远的是戏曲电影的诞生。通过对两部在香港及台湾风行一时的黄梅调电影《江山美人》及《白蛇传》的分析,可以看到:受到中国内地于1955年后陆续公演的黄梅戏电影《天仙配》《女驸马》《牛郎织女》的影响而产生的香港黄梅调电影,也为黄梅戏这种地方戏剧的发展及其在香港和台湾的传播做出过独特的贡献。

关键词：黄梅戏黄梅调电影《江山美人》《白蛇传》《天仙配》《女驸马》《牛郎织女》

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论当代西方天主教新自然法理论

复旦学报（社会科学版） 2008年第2期50卷 76-82页

作者：林庆华四川大学道教与宗教文化研究所成都610064

新自然法理论是当代西方天主教最重要、最有影响的伦理学思潮之一。新自然法理论的主要内容包括其关于实践理性的第一原则、基本人类善、道德第一原则和居间原则(责任模式或实践理性的基本要求)以及道德规范等方面。新自然法理论是建立... 详细信息

新自然法理论是当代西方天主教最重要、最有影响的伦理学思潮之一。新自然法理论的主要内容包括其关于实践理性的第一原则、基本人类善、道德第一原则和居间原则(责任模式或实践理性的基本要求)以及道德规范等方面。新自然法理论是建立在阿奎那的自然法学说之上的,是对阿奎那有关观念的重新解读与具体的阐发。

关键词：新自然法理论实践理性基本人类善道德第一原则道德规范