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No association between low-dose reserpine use and depression in older hypertensive patient: result of a multicenter, cross-sectional study

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Journal of Geriatric Cardiology 2019年第8期16卷 608-613页

作者： Guo-Hua ZHU Xi-Peng SUN Jing LI lin pi Hai-Qin TANG Hai-Qing GAO Hong-Liang CONG Peng QU Xin-Zheng LU Xin-Jun ZHANG Luo-Sha ZHAO Yi-Fang GUO Dong-Xia LIU Liang-Qing ZHANG Hua TANG Yi-Xin HU Li FAN Qi HUA Department of Cardiology Xuanwu Hospital Capital Medical UniversityBeijingChina Department of Geriatrics Hebei General HospitalShijiazhuangChina Department of Cardiology Hebei General HospitalShijiazhuangChina Department of Cardiology Shanxi Cardiovascular HospitalXianChina Department of Geriatrics Chinese PLA General HospitalBeijingChina Department of Cardiology Chuiyangliu Hospital affiliated to Tsinghua UniversityBeijingChina Department of Cardiology the First Affiliated Hospital of Anhui Medical UniversityHefeiChina Department of Cadre Health Care Qilu Hospital of Shandong UniversityJinanChina Department of Cardiology Tianjin Chest HospitalTianjinChina Department of Cardiology the Second Hospital of Dalian Medical UniversityDalianChina Department of Cardiology Jiangsu Provincial HospitalNanjingChina Department of Geriatrics West China HospitalSichuan UniversityChengduChina Department of Cardiology the First Affiliated Hospital of Zhengzhou UniversityZhengzhouChina

Background Reserpine is currently used by millions of Chinese hypertensive patients, in spite of the continued concern of its depressogenic effect, even when used in low dose. This study aimed to investigate the association between low-dose reserpine use and depression in older Chinese hypertensive patient. Methods In this cross-sectional, case-control study, we recruited patient aged 60 years or over who had regularly taken one or two tables of “compound reserpine and triamterene tablets (CRTTs)” for more than one year (reserpine user) from 26 community health centers located in 10 provinces in China. For each patient who took CRTTs, we selected an age (within five years) and sex matched hypertensive patient who had never taken any drugs containing reserpine (non-reserpine user) as control. Depressive symptoms were evaluated using a Chinese depression scale adapted from the Zung Self-Rating Depression Scale. Demographic, clinical data and laboratory examination results within six months were collected. Results From August 2018 to December 2018, 787 reserpine user and 787 non-reserpine user were recruited. The mean age of all study subjects was 70.3 years, with about equal numbers of males and females. The mean depression score was 40.4 in reserpine users and 40.6 in non-reserpine users (P = 0.7). The majority of study subject had a depression score pine users and 88.2% in non-reserpine users, respectively). There were no significant differences in the prevalence of mild, moderate or severe depression in reserpine users and non-reserpine users. Conclusions There is no association between low-dose reserpine use and depression in older hypertensive patient. The role of reserpine in the treatment and control of hypertension should be reconsidered;and further studies, especially randomized, controlled clinical trials to compare efficacy and safety of reserpine and other widely recommended anti-hypertensive agents are needed.

关键词： Depression Hypertension Reserpine

Chinese expert consensus on the management of hypertension in the very elderly

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Journal of Geriatric Cardiology 2016年第12期13卷 945-953页

作者： Jing LI Yi-Xin HU Wen WANG Ning-Yuan FANG Xin-Zheng LU lin pi Mei-lin LIU Wei-Min LI Yan-Fang LI Peng QU Qi HUA Qing HE Hai-Ying WU Yuan-Ming ZHANG Xiao-ping CHEN Lu-Yuan CHEN Li FAN Xing-Sheng ZHAO Zhi-Ming ZHU Yi-Nong JIANG Yi-Fang GUO Hong YUAN ping-Jin GAO Xin-Juan XU Jun CAI Liang-Di XIE Xuan Wu Hospital Capital Medical University Beijing China Chinese PLA General Hospital Beijing China Chinese Academy of Medical Science Fuwai Hospital Beijing China Renji Hospital Medical College of Shanghai Jiao Tong University ShanghaL China Jiang Su Province People's Hospital Jiangsu China Beijing Chui Yang Liu Hospital Beijing China Peking University First Hospital Beijing China First Affiliated Hospital of Harbin Medical University Heilongjiang China Beijing An Zhen Hospital Capital Medical University Beijing China The Second Affiliated Hospital of Dalian Medical University Liaoning China Beijing Hospital Beijing China The First Hospital of Xinjiang Medical University Xinjiang Uygur Autonomous Region China West China Hospital Sichuan University Sichuan China The People's Hospital of Guangdong Province Guangdong China Inner Mongolia Autonomous Region People's Hospital Inner Mongolia Autonomous Region China Daping Hospital the Third Military Medical University Chongqing China The First Affiliated Hospital of Dalian Medical University Liaoning China Hebei Province People's Hospital Hebei China Xiangya Third Hospital Central South University Hunan China Shanghai Hypertension Research Institute Shanghai China The First Hospital of Fujian Medical University Fujian China

Population aging has become a major challenge for the healthcare in China. More than 23 million Chinese are currently > 80 years,with an annual increase of 5%. The Chinese population of 80 years or older is expected t... 详细信息

关键词：一致衰老老人高血压 Octogenarians

Suppression of matrix metalloproteinase-2 via RNA interference inhibits pancreatic carcinoma cell invasiveness and adhesion

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World Journal of Gastroenterology 2009年第9期15卷 1072-1078页

作者： Ying-Hui Zhi Mao-Min Song pi-lin Wang Tie Zhang Zi-Yi Yin Department of General Surgery Affiliated Beijing Tiantan Hospital Capital Medical University Beijing 100050 China

AIM:To investigate the inhibitory effects of RNA interference (RNAi) on expression of matrix metalloproteinase-2 (MMP-2) gene and invasiveness and adhesion of human pancreatic cancer cell line,BxPC-3.METHODS:RNAi was performed using the vector (pGPU6)-based small interference RNA (siRNA) plasmid gene silence system to specifically knock down MMP-2 expression in pancreatic cancer cell line,BxPC-3. Four groups of different specific target sequence in coding region of MMP-2 and one non-specific sequence were chosen to construct four experimental siRNA plasmids of pGPU6-1,pGPU6-2,pGPU6-3 and pGPU6-4,and one negative control siRNA plasmid of pGPU6 (-). MMP-2 expression was measured by reverse transcription polymerase chain reaction (RT-PCR) and Western blot. Cell proliferation and apoptosis were examined by methyl thiazolyl tetrazolium (MTT) and flow cytometry,respectively. The abilities of adhesion and invasion were detected by cell adhesion assay and cell invasion assay using Transwell chambers.RESULTS:The expression of MMP-2 was inhibited and the inhibitory effects of different sequence varied. pGPU6-1 group had the most efficient inhibitory effect,followed by pGPU6-2 and pGPU6-3 groups.Invasiveness and adhesion were more significantly reduced in pGPU6-1,pGPU6-2 and pGPU6-3 groups as compared with pGPU6 (-) and blank control groups. However,no difference concerning cell proliferation and apoptosis was observed after transfection between experiment groups and control groups.CONCLUSION:RNAi against MMP-2 successfully inhibited the mRNA and protein expression of MMP-2 in the pancreatic cancer cell line,BxPC-3,leading to a potent suppression of tumor cell adhesion and invasion without affecting cell proliferation and apoptosis. These findings suggest that the RNAi approach towards MMP-2 may be an effective therapeutic strategy for the clinical management of pancreatic tumor.

关键词：基质金属蛋白酶-2 人胰腺癌细胞系肿瘤细胞粘附 RNAi技术癌细胞侵袭干扰抑制逆转录聚合酶链反应 Transwell

Multi-surrogate framework with an adaptive selection mechanism for production optimization

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Petroleum Science 2024年第1期21卷 366-383页

作者： Jia-lin Wang Li-Ming Zhang Kai Zhang Jian Wang Jian-ping Zhou Wen-Feng Peng Fa-Liang Yin Chao Zhong Xia Yan pi-Yang Liu Hua-Qing Zhang Yong-Fei Yang Hai Sun School of Petroleum Engineering China University of Petroleum(East China)Qingdao266580ShandongChina Qingdao University of Technology Qingdao266580ShandongChina College of Science China University of PetroleumQingdao266580ShandongChina Zepu Oil and Gas Development Department PetroChina Tarim Oilfield CompanyKorla841000XinjiangChina Hainan Branch of CNOOC Ltd Haikou70311HainanChina

Data-driven surrogate models that assist with efficient evolutionary algorithms to find the optimal development scheme have been widely used to solve reservoir production optimization problems.However,existing research suggests that the effectiveness of a surrogate model can vary depending on the complexity of the design problem.A surrogate model that has demonstrated success in one scenario may not perform as well in others.In the absence of prior knowledge,finding a promising surrogate model that performs well for an unknown reservoir is challenging.Moreover,the optimization process often relies on a single evolutionary algorithm,which can yield varying results across different cases.To address these limitations,this paper introduces a novel approach called the multi-surrogate framework with an adaptive selection mechanism(MSFASM)to tackle production optimization problems.MSFASM consists of two stages.In the first stage,a reduced-dimensional broad learning system(BLS)is used to adaptively select the evolutionary algorithm with the best performance during the current optimization period.In the second stage,the multi-objective algorithm,non-dominated sorting genetic algorithm II(NSGA-II),is used as an optimizer to find a set of Pareto solutions with good performance on multiple surrogate models.A novel optimal point criterion is utilized in this stage to select the Pareto solutions,thereby obtaining the desired development schemes without increasing the computational load of the numerical simulator.The two stages are combined using sequential transfer learning.From the two most important perspectives of an evolutionary algorithm and a surrogate model,the proposed method improves adaptability to optimization problems of various reservoir types.To verify the effectiveness of the proposed method,four 100-dimensional benchmark functions and two reservoir models are tested,and the results are compared with those obtained by six other surrogate-model-based methods.The results demonstrate that our approach can obtain th

关键词： Production optimization Multi-surrogate models Multi-evolutionary algorithms Dimension reduction Broad learning system

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生物填料在废水处理中的研究进展

化工环保 2023年第1期43卷 25-29页

作者：皮林郦和生王珺中石化(北京)化工研究院有限公司北京100013

综述了生物膜废水处理工艺中常用生物填料的研究进展。针对无机生物填料和有机生物填料的不同特点,分别介绍了二者在生物膜反应器中的应用现状。重点介绍了有机生物填料在亲水改性、表面带电改性、生物亲和改性和磁改性方面的研究进展... 详细信息

综述了生物膜废水处理工艺中常用生物填料的研究进展。针对无机生物填料和有机生物填料的不同特点,分别介绍了二者在生物膜反应器中的应用现状。重点介绍了有机生物填料在亲水改性、表面带电改性、生物亲和改性和磁改性方面的研究进展。在此基础上,结合生物填料的使用现状,提出了未来生物填料的研究方向和发展趋势。

关键词：生物填料生物膜废水处理改性

Gas-phase photocatalytic oxidation of benzene over titanium dioxide loaded on Bi_(12)TiO_(20)

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Chinese Chemical Letters 2007年第2期18卷 241-243页

作者： Tao lin, Zhan pi, Mao Chu Gong, Jun Bo Zhong, Jian Li Wang, Yao Qiang Chen College of Chemistry, Sichuan University, Chengdu 610064, China College of Chemistry Sichuan University Chengdu 610064 China

TiO2 was prepared by sol-gel method using tetrabutyl titanate as precursor. TiO2 was loaded on Bi12TiO20. The photocatalyst with different TiO2 loading was calcined at 723 K. The photocatalytic activity of decomposition gaseous benzene was investigated in a batch reactor. The prepared photocatalyst was characterized by UV-vis diffuse reflectance. The result showed that TiO2/Bi12TiO20 absorbed much more ultraviolet light than Ti02 in the ultraviolet light region and showed red shift. The results indicated that the prepared photocatalyst can greatly promote the photocatalytic activity. The 2.0% TiO2/Bi12TiO20 system exhibited the highest photocatalytic activity.

关键词： Titanium Bi_(12)TiO_(20) Benzene Photocatalytic oxidation

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一起刀闸操作引起开关跳闸事故的分析

电力系统保护与控制 2009年第8期37卷 102-103,106页

作者：郑宁敏林匹福建省厦门超高压输变电局福建厦门361004

通过对福建省500kV福州变的一起500kV线路刀闸操作引起联变220kV侧开关跳闸的事故调查,指出一些进口的刀闸设备在辅助触点的设计上存在重大隐患,而且这些隐患在变电所电气设计中极易被忽视。就此问题也提出预防和整改的措施。同时希望... 详细信息

通过对福建省500kV福州变的一起500kV线路刀闸操作引起联变220kV侧开关跳闸的事故调查,指出一些进口的刀闸设备在辅助触点的设计上存在重大隐患,而且这些隐患在变电所电气设计中极易被忽视。就此问题也提出预防和整改的措施。同时希望籍此文提醒继电保护同行在采用同类设备时注意检查,避免类似事故的发生。

关键词：刀闸辅助触点交流干扰跳闸

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刀闸操作电弧对载波通道的干扰

电力系统保护与控制 2009年第17期37卷 128-131页

作者：郑宁敏林匹福建省厦门超高压输变电局福建厦门361004

通过对一起220kV线路刀闸操作引起保护收发信机烧毁事故的调查,以及对现场实验拍录的干扰波形进行的频谱分析,初步了解刀闸操作电弧给附近设备造成的干扰量的幅频特性,并提出一些尚未解决的疑问。

关键词：刀闸操作载波通道干扰收发信机载波机

Predictive value of serum uric acid on cardiovascular disease and all-cause mortality in urban Chinese patients

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Chinese Medical Journal 2010年第11期123卷 1387-1391页

作者： WU Yong-quan LI Jue XU Yuan-xi WANG Yong-liang LUO Ying-yi HU Da-yi LIU Wei-jing YANG Ming pi lin WANG Ming-sheng WANG Ji-yun ZHAO Shu-mei LI Mei-jing Department of Cardiology Beijing Friendship Hospital affiliated toCapital Medical University Beijing 100050 China Heart Lung and Blood Vessel Centre Medical School of TongjiUniversity Shanghai 200065 China Department of Cardiology Tongji Hospital of Tongji UniversityShanghai 200065 China Department of Cardiology Shanghai 10th Hospital Shanghai200072 China Department of Cardiology Beijing Fuxing Hospital affiliated toCapital Medical University Beijing 100038 China Department of Cardiology - B-eijing Chuiyangliu HospitalBeijing100022 China Department of cardiology Beijing Shijingshan HospitalBeijing100043 China Department of Cardiology Beijing Tongren Hospital Affiliated toCapital Medical University Beijing 100005 China Department of Cardiology Shanghai Oriental Hospital Shanghai200120 China

Background The association between increased serum uric acid （SUA） levels and cardiovascular risk has been debated for decades. Several large studies have provided conflicting results regarding the clinical significance of elevated SUA levels in cardiovascular disease （CVD） or cerebrovascular disease. The aim of this study was to investigate the relationship between SUA and CVD and all-cause mortality and their potential diagnostic value. Methods A total of 3570 in-patients ranging in age from 56 to 95 years （mean （67.36_＋11.36） years） were selected from 20 hospitals in Beijing and Shanghai. A carefully designed questionnaire was used to gather baseline data of each patient All patients were divided into two main groups according to their SUA levels： high SUA and normal SUA groups. Serum indices and other important parameters were measured. Results Compared with normal SUA group, high SUA group had significant difference in systolic blood pressure （SBP）, total cholesterol （TC）, triglyceride （TG）, high density lipoprotein cholesterol （HDL-C）, body mass index （BMI）, and age （P 〈0.05 or P 〈0.01）. High SUA prevailed in female and patients with history of essential hypertension, while history of smoking and diabetes showed no significant difference between two groups. All-cause and CVD mortality occurred more frequently in high SUA group than in normal SUA group. In the accumulative survival analysis, high SUA group had lower survival rate than normal SUA group both in CVD and all-cause mortality. COX regression analysis indicated that the history of smoking, age and high SUA were independent risk factors for the development of CVD. Conclusions These preliminary observations suggest that patients with high SUA levels would face higher risk of mortality. SUA measurement may be applied as a routine predictor for clinical assessment.

关键词： serum uric acid, cardiovascular disease mortality