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Tranylcypromine upregulates Sestrin 2 expression to ameliorate NLRP3-related noise-induced hearing loss

Neural Regeneration Research 2025年第5期20卷 1483-1494页

作者： Xihang che. Zhifeng che. Menghua Li Weiwei Guo Shuolong Yuan Liangwei Xu Chang lin Xi Shi Wei che. Shiming Yang Senior Department of Otolaryngology Head and Neck Surgery Chinese PLA General HospitalChinese PLA Medical SchoolBeijingChina State Key Laboratory of Hearing and Balance Science BeijingChina National Clinical Research Center for Otolaryngologic Diseases BeijingChina Key Laboratory of Hearing Science Ministry of EducationBeijingChina Beijing Key Laboratory of Hearing Impairment Prevention and Treatment BeijingChina Department of Otorhinolaryngology Head and Neck Surgery The First Affiliated Hospital of Fujian Medical UniversityFuzhouFujian ProvinceChina Department of Otolaryngology Head and Neck Surgery The 940th Hospital of Joint Logistics Support Force of Chinese PLALanzhouGansu ProvinceChina Key Laboratory of Tropical Biological Resources of Ministry of Education School of Pharmaceutical SciencesHainan UniversityHaikouHainan ProvinceChina Academician Workstation of Hainan University School of Pharmaceutical SciencesYazhou BaySanyaHainan ProvinceChina

Noise-induced hearing loss is the primary non-genetic factor contributing to auditory ***,there are currently no effective pharmacological interventions for patients with noise-induced hearing ***,we present evidence suggesting that the lysine-specific demethylase 1 inhibitor–tranylcypromine is an otoprotective agent that could be used to treat noise-induced hearing loss,and elucidate its underlying regulatory *** established a mouse model of permanent threshold shift hearing loss by exposing the mice to white broadband noise at a sound pressure level of 120 d B for 4 *** found that tranylcypromine treatment led to the upregulation of Sestrin2(SESN2)and activation of the autophagy markers light chain 3B and lysosome-associated membrane glycoprotein 1 in the cochleae of mice treated with *** noise exposure group treated with tranylcypromine showed significantly lower average auditory brainstem response hearing thresholds at click,4,8,and 16 k Hz frequencies compared with the noise exposure group treated with *** findings indicate that tranylcypromine treatment resulted in increased SESN2,light chain 3B,and lysosome-associated membrane glycoprotein 1 expression after noise exposure,leading to a reduction in levels of 4-hydroxynonenal and cleaved caspase-3,thereby reducing noise-induced hair cell ***,immunoblot analysis demonstrated that treatment with tranylcypromine upregulated SESN2 expression via the autophagy *** treatment also reduced the production of NOD-like receptor family pyrin domaincontaining 3(NLRP3)*** conclusion,our results showed that tranylcypromine treatment ameliorated cochlear inflammation by promoting the expression of SESN2,which induced autophagy,thereby restricting NLRP3-related inflammasome signaling,alleviating cochlear hair cell loss,and protecting hearing *** findings suggest that inhibiting lysine-specific demethylase 1 is a

关键词： 4-hydroxynonenal apoptosis autophagy cleaved caspase-3 inflammation NOD-like receptor family pyrin domain-containing 3(NLRP3) noise-induced hearing loss oxidative stress Sestrin2 tranylcypromine

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Clinical value of combining epirubicin with mindfulness intervention in patients with urinary system tumors and depression

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World Journal of Psychiatry 2025年第1期15卷 54-62页

作者： Juan Liu Yan-Ping Guo Yan-Mei Lu Bei-lin Wang Department of Urology Surgery Zhumadian Central HospitalZhumadian 463000Henan ProvinceChina Department of Psychiatry Zhumadian Mental HospitalZhumadian 463000Henan ProvinceChina

BACKGROUND Urinary system tumors often cause negative psychological symptoms,such as depression and dysphoria which significantly impact immune function and indirectly affect cancer *** epirubicin(EPI)is recommended by the European Association of Urology and can improve prognosis,its long-term use can cause toxic side effects,reduce treatment compliance,and increase psycho-logical ***,an appropriate intervention mode is *** This was a retrospective study including 110 patients with urinary system tumors and depression admitted to Zhumadian Central Hospital between March 2021 and July *** were divided into conventional(n=55)and joint inter-vention(n=55)*** conventional group received mitomycin and routine nursing,while the joint intervention group received EPI and mindfulness *** groups underwent three cycles of *** function(CD4+cells,CD8+cells,CD4+/CD8+ratio),tumor marker levels[urinary bladder cancer antigen(UBC),bladder tumor antigen(BTA)and nuclear matrix protein 22(NMP22)],quality of life questionnaire-core 30(QLQ-C30),17-item Hamilton depression scale(HAMD-17),and cancer-related fatigue[cancer fatigue scale(CFS)]were *** reactions and nursing satisfaction were recorded and *** Post-intervention,CD4+,CD8+,and CD4+/CD8+levels increased in both groups,with the joint intervention group showing more significant improvement(Plinical outcomes in patients with urinar

关键词： Urinary system tumor Bladder cancer Prostate cancer Depression Epirubicin

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Comparison of in vitro digestion methods for determining bioaccessibility of Hg in rice of China

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Journal of Environmental Sciences 2018年第6期30卷 185-193页

作者： Ze Wu Xinbin Feng Ping Li che.Jen lin Guangle Qiu Xun Wang Huifang Zhao Hui Dong State Key Laboratory of Environmental Geoche.istry Institute of Geochemistry Chinese Academy of Sciences Guiyang 550081 China University of Chinese Academy of Sciences Beijing 100049 China Center for Advances in Water and Air Quality Lamar University Beaumont TX USA

Rice consumption can be a major pathway for mercury（Hg） exposure, which can cause health hazards to Chinese residents. To accurately assess the potential health risks, the bioaccessibility of Hg in rice samples collected at background and Hg-contamination sites was examined using four in vitro methods. The results showed that 〈 50% of the total mercury（THg） was bioaccessible in the studied rice samples. The THg bioaccessibility in the rice samples collected at the Hg-contaminated site was higher than that observed at the background area. The bioaccessibility of arsenic（As） and cadmium（Cd） was also evaluated for comparison of the four in vitro methods used in this study. The Physiologically Based Extraction Test was found to be the most accurate method based on the consistency of the results compared to those reported in previous studies. The estimated daily intakes of THg via rice consumption using the bioaccessibility data were found to meet the recommendation value set by the JECFA and the WHO in both sites. However, the potential health risk was not negligible at the Hg-contaminated sites, due to the high THg concentration and bioaccessibility in the rice samples.

关键词： Mercury Bioaccessibility Rice Health-risks

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Protective electrode/electrolyte interphases for high energy lithium-ion batteries with p-toluenesulfonyl fluoride electrolyte additive

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Journal of Energy che.istry 2021年第1期30卷 361-371,I0012页

作者： Yanxia che.Xiuyi lin Lidan Xing Xiongcong Guan Rude Guo Guangyuan Lan Qinfeng Zheng Wenguang Zhang Weishan Li School of che.istry South China Normal UniversityGuangzhou 510006GuangdongChina National and Local Joint Engineering Research Center of MPTES in High Energy and Safety LIBs Engineering Research Center of MTEES(Ministry of Education)and Key Lab.of ETESPG(GHEI)South China Normal UniversityGuangzhou 510006GuangdongChina

High energy density lithium-ion batteries using Ni-rich cathode(such as lini0.6Co0.2Mn0.2O2) suffer from severe capacity decay.P-toluenesulfonyl fluoride(pTSF) has been investigated as a novel film-forming electrolyte additive to enhance the cycling performances of graphite/lini0.6Co0.2Mn0.2O2 pouch *** comparison with the baseline electrolyte,a small dose of pTSF can significantly improve the cyclic stability of the *** calculations together with experimental results indicate that pTSF would be oxidized and reduced to construct protective interphase film on the surfaces of lini0.6Co0.2Mn0.2O2 cathode and graphite anode,*** S-containing surface films derived from pTSF effectively mitigate the decomposition of electrolyte,reduce the interphasial impedance,as well as prevent the dissolution of transition metal ions from Ni-rich cathode upon cycling at high *** finding is beneficial for the practical application of high energy density graphite/lini0.6Co0.2Mn0.2O2 cells.

关键词： Lithium-ion batteries Electrolyte additive P-toluenesulfonyl fluoride Electrode/electrolyte interphase Graphite/lini0.6Co0.2Mn0.2O2

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Cross-border electronic commerce’s new path:from literature review to AI text generation

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Data Science and Management 2023年第1期6卷 21-33页

作者： Qing Zhu Yinglin Ruan Shan Liu Sung-Byung Yang lin Wang Jianhua che International Business School Shaanxi Normal UniversityXi’an710061China School of Management Xi’an Jiaotong UniversityXi’an710049China School of Management Kyung Hee University26 Kyungheedae-roDongdaemun-guSeoul02447South Korea School of Management Huazhong University of Science&TechnologyWuhan430074China

Digitization,informatization,and Internet penetration have led to a significant rise in cross-border e-commerce(CBEC),attracting considerable interest from academia,government,and *** study employed a novel method combining automatic text generation technology and traditional bibliometric analysis to summarize and categorize the research on CBEC evolution from 2000 to *** were selected and examined with a focus on four dimensions:customer,risk,supply chain,and *** in these dimensions were found to result in two major obstacles to CBEC development,namely,dataset sharing and platform *** obstacles prevent research on cross-border platforms from moving beyond theory-based *** research needs to examine how soft computing can be used to accelerate and remodel the global trade ecosystem.

关键词： Cross-border e-commerce Literature review Platform Risk management Text generation

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Silicone oil as a corneal lubricant to reduce corneal edema and improve visualization during

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International Journal of Ophthalmology(English edition) 2024年第1期17卷 92-96页

作者： Dan-Yang che.Zhu-lin Chan Ji-Bo Zhou Dong-Qing Zhu Department of Ophthalmology Ninth People’s HospitalShanghai Jiao Tong University School of MedicineShanghai 200011China College of Health Science and Technology Shanghai Jiao Tong University School of MedicineShanghai 200011China The PLA Navy Anqing Hospital Anqing 246004Anhui ProvinceChina

AIM:To evaluate the efficacy and safety of silicone oil(SO)as a corneal lubricant to improve visualization during ***:Patients who underwent vitreoretinal surgery were divided into two *** 1 was operated on with initial SO(Oxane 5700)as a corneal *** 2 was operated on with initial lactated ringer’s solution(LRS)and then replaced with SO as *** clarity was scored during the *** staining was performed to determine the damage to corneal ***:Totally 114 eyes of 114 patients were *** SO use maintained a clear cornea and provided excellent visualization of surgical *** group 1,the fundus clarity was grade 3 in 41/45 eyes and grade 2 in 4/45 *** group 2,corneal edema frequently occurred after initial LRS *** fundus clarity was grade 3 in 19/69 eyes,2 in 37/69 eyes and 1 in 13/69 eyes(P0.05).CONCLUSION:The use of SO as a corneal lubricant is effective and safe for preserving and improving corneal clarity and providing clear surgical field during vitrectomy.

关键词： silicone oil corneal lubricant corneal edema vitrectomy

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A Comparative Study About the Neuroprotective Effects of EPA-Enriche. Phosphoethanolamine Plasmalogen and Phosphatidylethanolamine Against Oxidative Damage in Primary Hippocampal Neurons

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Journal of Ocean University of China 2021年第5期20卷 1207-1214页

作者： ZHU Yunfang ZHANG Tiantian DING lin SHI Haohao XUE Changhu XIE Wancui che.Hongxia WANG Yuming College of Food Science and Engineering Ocean University of ChinaQingdao 266003China Shandong Provincial Key Laboratory of Bioche.ical Engineering College of Marine Science and Biological EngineeringQingdao University of Science and TechnologyQingdao 266042China Laboratory for Marine Drugs and Bioproducts Pilot National Laboratory for Marine Science and Technology(Qingdao)Qingdao 266237China

s Oxidative stress is involved in the progression of neurodegenerative *** evidences showed that plasma-logens could improve neurodegenerative *** this study,we investigated the function of phosphoethanolamine plasmalogens enriche. with EPA(EPA-pPE)and phosphatidylethanolamine enriche. with EPA(EPA-PE)on oxidative damage prevention after hy-drogen peroxide(H2O2)and tert-butylhydroperoxide(t-BHP)challenge in primary hippocampal *** showed that neurons pretreated with EPA-pPE and EPA-PE demonstrated the ability to alleviate oxidative damage,which was proved by the in-creased cell ***,the shape and number of neurons were more similar to those of the control *** acti-vity,apoptosis,as well as TrkB/ERK/CREB signaling pathway were investigated to explore the *** results suggested that EPA-PE was superior to EPA-pPE in regulating mitochondrial ***-pPE was more prominent than EPA-PE in upre-gulating TrkB/ERK/CREB signaling *** with EPA exerted neuroprotective effects via inhibiting oxidative stress,suppressing apoptosis,and regulating TrkB/ERK/CREB signaling ***,the results provide a scientific basis for utili-zation of phospholipids enriche. with EPA on the treatment of neurodegenerative disease.

关键词： oxidative stress EPA-enriche. phosphoethanolamine plasmalogens EPA-enriche. phosphatidylethanolamine primary hippocampal neurons

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Hypoxia-preconditioned bone marrow-derived mesenchymal stem cells protect neurons from cardiac arrest-induced pyroptosis

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Neural Regeneration Research 2025年第4期20卷 1103-1123页

作者： Xiahong Tang Nan Zheng Qingming lin Yan You Zheng Gong Yangping Zhuang Jiali Wu Yu Wang Hanlin Huang Jun Ke Feng che. Shengli Clinical Medical College of Fujian Medical University Fujian Medical UniversityFuzhouFujian ProvinceChina Department of Emergency Fujian Provincial HospitalFuzhouFujian ProvinceChina Fujian Provincial Key Laboratory of Emergency Medicine FuzhouFujian ProvinceChina The Second Department of Intensive Care Unit Fujian Provincial Hospital South BranchFuzhouFujian ProvinceChina

Cardiac arrest can lead to severe neurological impairment as a result of inflammation,mitochondrial dysfunction,and post-cardiopulmonary resuscitation neurological *** preconditioning has been shown to improve migration and survival of bone marrow–derived mesenchymal stem cells and reduce pyroptosis after cardiac arrest,but the specific mechanisms by which hypoxia-preconditioned bone marrow–derived mesenchymal stem cells protect against brain injury after cardiac arrest are *** this end,we established an in vitro co-culture model of bone marrow–derived mesenchymal stem cells and oxygen–glucose deprived primary neurons and found that hypoxic preconditioning enhanced the protective effect of bone marrow stromal stem cells against neuronal pyroptosis,possibly through inhibition of the MAPK and nuclear factor κB ***,we transplanted hypoxia-preconditioned bone marrow–derived mesenchymal stem cells into the lateral ventricle after the return of spontaneous circulation in an 8-minute cardiac arrest rat model induced by *** results showed that hypoxia-preconditioned bone marrow–derived mesenchymal stem cells significantly reduced cardiac arrest–induced neuronal pyroptosis,oxidative stress,and mitochondrial damage,whereas knockdown of the liver isoform of phosphofructokinase in bone marrow–derived mesenchymal stem cells inhibited these *** conclude,hypoxia-preconditioned bone marrow–derived mesenchymal stem cells offer a promising therapeutic approach for neuronal injury following cardiac arrest,and their beneficial effects are potentially associated with increased expression of the liver isoform of phosphofructokinase following hypoxic preconditioning.

关键词： bone marrow–derived mesenchymal stem cells cardiac arrest cardiac resuscitation hypoxic preconditioning liver isoform of phosphofructokinase mitochondria neuroinflammation oxidative stress pyroptosis reactive oxygen species

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High Bulk Modulus of Nanocrystal γ-Fe2O3 with che.ical Dodecyl Benzene Sulfonic Decoration Under High Pressure

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Chinese Physics Letters 2000年第2期17卷 126-128页

作者： ZHAO Jing GUO lin LIU Jing YANG Yang che.Rong-Zheng ZHOU Lei Beijing Synchrotron Radiation Laboratory Institute of High Energy PhysicsChinese Acaderny of SciencesBeijing 100039 Institute of Physics Chinese Academy of SciencesBeijing 100080

Structural transformation in γ-Fe2O3 nanocrystals (about 1Onm) with dodecyl benzene sulfonic (DBS) coated is studied by using high-pressure energy dispersive x-ray diffraction of synchrotron radiation and high-resolution transmission electron microscopy (HRTEM). Relative to the bulk crystal, the transition pressure showed a decrease while the compressibility increases significantly up to 375 (±9 GPa). HRTEM picture confirmed that there is surface cladding surrounding nanocrystals due to DBS, which formed new special boundaries between nanocrystals and should be different from the ordinary grain boundaries. The experimental results imply that the surface layers of γ-Fe2O3 nanocrystals have strong effect on the compressibility.

关键词： crystal ordinary surface

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Reliable protocols for whole-mount fluorescent in situ hybridization （FISH） in the pea aphid Acyrthosiphon pisum： A comprehensive survey and analysis

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Insect Science 2014年第3期21卷 265-277页

作者： che.-yo Chung Charles E. Cook Gee-way lin Ting-Yu Huang Chun-che.Chang Laboratory for Genetics and Development Department ofEntomologyllnstitute of Biotechnology College ofBioresources andAgriculture National Taiwan University Taipei Taiwan European Molecular Biology Laboratory European Bioinformatics Institute (EMBL-EBI) Wellcome Trust Genome Campus Hinxton Cambridge UK Research Center for Developmental Biology and Regenerative Medicine National Taiwan University Taipei Taiwan Institute of Bioche.ical Sciences College of Life Science National Taiwan University Taipei Taiwan Genome and Systems Biology Degree Program National Taiwan University Taipei Taiwan China

RNA in situ hybridization （ISH）, including chromogenic ISH （CISH） and fluorescent ISH （FISH）, has become a powerful tool for revealing the spatial distribution ofgene transcripts in model organisms. Previously, we developed a robust protocol for wholemount RNA CISH in the pea aphid Acyrthosiphon pisum, an emerging insect genomicmodel. In order to improve the resolving capacity of gene detection, we comprehensively surveyed current protocols of whole-mount RNA-FISH and developed protocols that allow,using confocal microscopy, clearer visualization of target messenger RNAs （mRNAs） - including those subcellularly localized and those with spatially overlapping expression. Wefind that Fast dye-based substrate fluorescence （SF）, tyramide signal amplification （TSA）, and TSA Plus all enable identifying gene expression thanks to multiplex amplificationof fluorescent signals. By contrast, methods of direct fluorescence （DF） do not allow visualizing signals. Detection of a single gene target was achieved with SF and TSA Plusfor most mRNAs, whereas TSA only allowed visualization of abundant transcripts such as Apvasl andAppiwi2 in the germ cells. For detection of multiple gene targets using doubleFISH, we recommend：（i） TSA/TSA, rather than TSA Plus/TSA Plus for colocalized mRNAs abundantly expressed in germ ceils, as proteinase K treatment can be omitted;and （ii） SF/TSA Plus for other gene targets such as Apenl and Apen2 as inactivation of enzyme conjugates is not required. SF/SF is not ideal for double FISH experiments due tosignal blurring. Based on these new conditions for RNA-FISH, we have obtained a better understanding of germline specification and embryonic segmentation in the pea *** anticipate that the RNA-FISH protocols for the pea aphid may also be used for other aphids and possibly other insect species, thus expanding the range of species from whichuseful insights into development and evolution may be obtained.

关键词： aphid fluorescence gene expression in situ hybridization model organism probe detection

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