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Reality-Virtuality Fusional Campus Environment:An Online 3D Platform Based on OpenSimulator

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Geo-Spatial Information Science 2011年第2期14卷 144-149页

作者： che.Weitao lin Hui HU Mingyuan Institute of Space and Earth Information Science The Chinese University of Hong Kong Shatin NT Hong Kong China

This paper presents a reality-virtual fusional campus *** is an online 3D platform with some aspects of real information merged *** whole platform is based on OpenSimulator with detailed geo-models to represent the university *** preliminary experiments were done to integrate the realistic information with the virtual campus for making the geo-environment not only with detailed indoor and outdoor models,but also with the real representations of the physical *** overall motivation is to provide a framework with strong support for reality-virtuality fusional modeling in a collaborative 3D online platform for research purposes.

关键词： collaborative 3D modeling OpenSimulator virtual geographic environment fusion of reality and virtuality

An Inequality for the Perron Pair of an Irreducible and Symmetric Nonnegative Tensor with Application

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Journal of the Operations Research Society of China 2017年第1期5卷 65-82页

作者： Mao-lin che.Yi-Min Wei School of Mathematical Sciences Fudan UniversityShanghai 200433China School of Mathematical Sciences and Shanghai Key Laboratory of Contemporary Applied Mathematics Fudan UniversityShanghai 200433China

The main purpose of this paper is to consider the Perron pair of an irreducible and symmetric nonnegative tensor and the smallest eigenvalue of an irreducible and symmetric nonsingular *** analyze the analytical property of an algebraic simple eigenvalue of symmetric *** also derive an inequality about the Perron pair of nonnegative tensors based on plane stochastic *** finally consider the perturbation of the smallest eigenvalue of nonsingular M-tensors and design a strategy to compute its smallest *** verify our results via random numerical examples.

关键词： Nonnegative tensor Symmetric tensor Irreducible tensor M-Tensor H-Eigenpair An algebraic simple eigenvalue The Perron pair The smallest eigenvalue Perturbation

Synthesis of Anisotropic Silica Nanoparticles

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che.ical Research in Chinese Universities 2024年第6期40卷 1220-1226页

作者： WEI Lili FAN Yuanqing lin Haifeng che.Shunai School of che.istry and che.ical Engineering Frontiers Science Center for Transformative MoleculesState Key Laboratory of Metal Matrix CompositesShanghai Key Laboratory for Molecular Engineering of Chiral DrugsShanghai Jiao Tong UniversityShanghai 200240P.R.China

Anisotropic silica nanoparticles (AISNPs) are appealing for various applications due to their greater effective surface area and increased active sites compared to isotropic silica nanoparticles (ISNPs).Herein,we employed a sol-gel method to synthesize AISNPs utilizing the mixture of ethylenediamine (EDA);1,3-diaminopropane (1,3-DAP) as both structure-directing agents and *** increasing EDA:1,3-DAP molar ratio,the samples transitioned from isotropic spherical particles to anisotropic particles with increasing *** synthesis of AISNP with a particle size of ca.40 nm,average circularity (e) of 0.83,fitting ellipse aspect ratio (ar) of 1.18 and percentage of deformed particles of 83.3% was achieved with a molar ratio of EDA:1,3-DAP=7:*** is speculated that the close proximity of EDA's amine groups facilitates their adsorption on the same primary particle through electrostatic interaction,inhibiting primary particle connections and resulting in spherical seeds that grow into small isotropic particles;the long-distance amine groups of 1,3-DAP connect adjacent particles anisotropically due to the steric hindrance,leading to large anisotropic particles;the mixtures with different EDA/1,3-DAP molar ratios result in different morphologies and sizes by their cooperative effect.

关键词： Anisotropic Silica nanoparticle Synthesis

Non-coding RNAs in acute ische.ic stroke:from brain to periphery

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Neural Regeneration Research 2025年第1期20卷 116-129页

作者： Shuo Li Zhaohan Xu Shiyao Zhang Huiling Sun Xiaodan Qin lin Zhu Teng Jiang Junshan Zhou Fuling Yan Qiwen Deng Department of Neurology Nanjing First HospitalNanjing Medical UniversityNanjingJiangsu ProvinceChina Department of Neurology Zhongda HospitalSchool of MedicineSoutheast UniversityNanjingJiangsu ProvinceChina General Clinical Research Center Nanjing First HospitalNanjing Medical UniversityNanjingJiangsu ProvinceChina

Acute ische.ic stroke is a clinical emergency and a condition with high morbidity,mortality,and *** predictive,diagnostic,and prognostic biomarkers and effective therapeutic targets for acute ische.ic stroke remain *** innovations in high-throughput gene sequencing analysis,many aberrantly expressed non-coding RNAs(ncRNAs)in the brain and peripheral blood after acute ische.ic stroke have been found in clinical samples and experimental *** expressed ncRNAs in the post-stroke brain were demonstrated to play vital roles in pathological processes,leading to neuroprotection or deterioration,thus ncRNAs can serve as therapeutic targets in acute ische.ic ***,distinctly expressed ncRNAs in the peripheral blood can be used as biomarkers for acute ische.ic stroke prediction,diagnosis,and *** particular,ncRNAs in peripheral immune cells were recently shown to be involved in the peripheral and brain immune response after acute ische.ic *** this review,we consolidate the latest progress of research into the roles of ncRNAs(microRNAs,long ncRNAs,and circular RNAs)in the pathological processes of acute ische.ic stroke–induced brain damage,as well as the potential of these ncRNAs to act as biomarkers for acute ische.ic stroke prediction,diagnosis,and *** from this review will provide novel ideas for the clinical application of ncRNAs in acute ische.ic stroke.

关键词： acute ische.ic stroke apoptosis blood–brain barrier damage circular RNAs excitatory toxicity long non-coding RNAs microRNAs neuroinflammation non-coding RNAs oxidative stress

Impacts of Nutlin-3a and exercise on murine double minute 2-enriche. glioma treatment

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Neural Regeneration Research 2025年第4期20卷 1135-1152页

作者： Yisheng che. Zhongche.g Fan Zhiwen Luo Xueran Kang Renwen Wan Fangqi Li Weiwei lin Zhihua Han Beijie Qi Jinrong lin Yaying Sun Jiebin Huang Yuzhen Xu Shiyi che. Department of Sport Medicine Huashan HospitalFudan UniversityShanghaiChina Department of Orthopedic Surgery Hainan Province Clinical Medical CenterHaikou Affiliated Hospital of Central South University Xiangya School of MedicineHaikouHainan ProvinceChina Department of Basic Medicine Shanghai Jiao Tong University School of MedicineShanghai Jiao Tong UniversityShanghaiChina Department of Neurosurgery Second Affiliated Hospital of Zhejiang University School of MedicineZhejiang UniversityHangzhouZhejiang ProvinceChina Department of Orthopedics Shanghai General HospitalSchool of Medicine Shanghai Jiao Tong UniversityShanghaiChina Department of Infectious Diseases Children’s Hospital of Fudan UniversityNational Children’s Medical CenterShanghaiChina Department of Rehabilitation The Second Affiliated Hospital of Shandong First Medical UniversityTaianShandong ProvinceChina

Recent research has demonstrated the impact of physical activity on the prognosis of glioma patients,with evidence suggesting exercise may reduce mortality risks and aid neural *** role of the small ubiquitin-like modifier(SUMO)protein,especially post-exercise,in cancer progression,is gaining attention,as are the potential anti-cancer effects of *** used machine learning to create the exercise and SUMO-related gene signature(ESLRS).This signature shows how physical activity might help improve the outlook for low-grade glioma and other *** demonstrated the prognostic and immunotherapeutic significance of ESLRS markers,specifically highlighting how murine double minute 2(MDM2),a component of the ESLRS,can be targeted by *** underscores the intricate relationship between natural compounds such as nutlin-3 and immune *** comprehensive CRISPR screening,we validated the effects of specific ESLRS genes on low-grade glioma *** also revealed insights into the effectiveness of Nutlin-3a as a potent MDM2 inhibitor through molecular docking and dynamic ***-3a inhibited glioma cell proliferation and activated the p53 *** efficacy decreased with MDM2 overexpression,and this was reversed by Nutlin-3a or *** using a low-grade glioma mouse model highlighted the effect of physical activity on oxidative stress and molecular pathway ***,both physical exercise and Nutlin-3a administration improved physical function in mice bearing tumors derived from MDM2-overexpressing *** results suggest the potential for Nutlin-3a,an MDM2 inhibitor,with physical exercise as a therapeutic approach for glioma *** research also supports the use of natural products for therapy and sheds light on the interaction of exercise,natural products,and immune regulation in cancer treatment.

关键词： exercise and SUMO-related gene signatures(ESLRS) glioblastoma management low-grade glioma natural bioactives neural regeneration physical exercise

Experiments on Channel Evolution due to Dam Removal in Taiwan

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Journal of Mountain Science 2014年第6期11卷 1396-1405页

作者： WANG Hsiao-Wen che.G Ying-che.lin Chung-Yi Department of Hydraulic and Ocean Engineering National Cheng Kung University

Due to safety concerns and habitat restoration for landlocked salmon,a 13-m high che.k dam on Chijiawan Creek was removed in late May 2011 in *** conducted experiments to understand channel evolution of different *** further compared our experimental results of riverbed elevation changes with the analytical solutions derived from the diffusion equation and field dynamics as well after the creek experienced the first flood *** results indicated that magnitude of discharges and notch size are dominant factors in resulting channel *** the largest differences between grain size distribution are associated with discharge,the largest differences in net change in upstream volume are associated with notch *** the theoretical equation could help understand the channel change after dam removal,it only explained the evolution closer to the *** physical experiments,on the other hand,provided insights especially with regard to comparing alternative proposed management *** discrepancies between predicted and actual outcome highlight more needed inputs for future dam-removal assessments.

关键词： Dam removal Physical Experiments Channel Evolution Grain size distribution Riverbed elevation

Synthesis and Crystal Structure of Glycin·3,5-Dihydroxybenzoic Acid

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Chinese Journal of Structural che.istry 2006年第2期25卷 229-231页

作者： che. Hao XUE lin che.Yun-Xia ZHENG Ji-Min Department of che.istry Nankai University Tianjin 300071 China

The title compound glycin.3,5-dihydroxybenzoic acid （GDB） has been synthesized and characterized by single-crystal X-ray analysis. It crystallizes in orthorhombic, space group Pca21 with a = 25.513（10）, b = 4.668（2）, c = 9.150（4） A°, Z= 4, V= 1089.8（8） A°^3, C9H13NO7, Mr= 247.20, Dc = 1.507 g/m^3,/z（MoKa） = 0.132 mm^-1, F（000） = 520, R1 = 0.0322 and wR2 = 0.0611 for 885 observed reflections （I 〉 2σ（I））. The title compound is a 1：1 molecular complex of glycin and 3,5-dihydroxybenzoic acid, which is linked by O-H…O and N-H…O hydrogen bonds to form a three-dimensional framework. Test of SHG （second harmonic generation） indicates that NLO generation of the crystal is higher than that of KDP.

关键词： crystal structure synthesis glycin-3,5-dihydroxybenzoic acid

Bidirectional regulation of the brain-gut-microbiota axis following traumatic brain injury

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Neural Regeneration Research 2025年第8期20卷 2153-2168页

作者： Xinyu You lin Niu Jiafeng Fu Shining Ge Jiangwei Shi Yanjun Zhang Pengwei Zhuang National Key Laboratory of Chinese Medicine Modernization Tianjin University of Traditional Chinese MedicineTianjinChina Haihe Laboratory of Modern Chinese Medicine Tianjin University of Traditional Chinese MedicineTianjinChina First Teaching Hospital of Tianjin University of Traditional Chinese Medicine TianjinChina National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion TianjinChina

Traumatic brain injury is a prevalent disorder of the central nervous *** addition to primary brain parenchymal damage,the enduring biological consequences of traumatic brain injury pose long-term risks for patients with traumatic brain injury;however,the underlying pathogenesis remains unclear,and effective intervention methods are *** dysfunction is a significant consequence of traumatic brain *** the most densely innervated peripheral tissue in the body,the gut possesses multiple pathways for the establishment of a bidirectional“brain-gut axis”with the central nervous *** gut harbors a vast microbial community,and alterations of the gut niche.contribute to the progression of traumatic brain injury and its unfavorable prognosis through neuronal,hormonal,and immune pathways.A comprehensive understanding of microbiota-mediated peripheral neuroimmunomodulation mechanisms is needed to enhance treatment strategies for traumatic brain injury and its associated *** comprehensively reviewed alterations in the gut microecological environment following traumatic brain injury,with a specific focus on the complex biological processes of peripheral nerves,immunity,and microbes triggered by traumatic brain injury,encompassing autonomic dysfunction,neuroendocrine disturbances,peripheral immunosuppression,increased intestinal barrier permeability,compromised responses of sensory nerves to microorganisms,and potential effector nuclei in the central nervous system influenced by gut ***,we reviewed the mechanisms underlying secondary biological injury and the dynamic pathological responses that occur following injury to enhance our current understanding of how peripheral pathways impact the outcome of patients with traumatic brain *** review aimed to propose a conceptual model for future risk assessment of central nervous system-related diseases while elucidating novel insights into the bidirectional effec

关键词： traumatic brain injury brain-gut-microbiome axis gut microbiota neuroimmune immunosuppression host defense vagal afferents bacterial infection dorsal root ganglia nociception neural circuitry

Cholesterol metabolism: physiological versus pathological aspects in intracerebral hemorrhage

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Neural Regeneration Research 2025年第4期20卷 1015-1030页

作者： Ruoyu Huang Qiuyu Pang Lexin Zheng Jiaxi lin Hanxi Li lingbo Wan Tao Wang Department of Forensic Science School of Basic Medicine and Biological SciencesSuzhou Medicine College of Soochow UniversitySuzhouJiangsu ProvinceChina

Cholesterol is an important component of plasma membranes and participates in many basic life functions,such as the maintenance of cell membrane stability,the synthesis of steroid hormones,and *** plays a key role in the establishment and maintenance of the central nervous *** brain contains 20%of the whole body’s cholesterol,80%of which is located within myelin.A huge number of processes(e.g.,the sterol regulatory element-binding protein pathway and liver X receptor pathway)participate in the regulation of cholesterol metabolism in the brain via mechanisms that include cholesterol biosynthesis,intracellular transport,and *** brain injuries or diseases involving crosstalk among the processes above can affect normal cholesterol metabolism to induce detrimental ***,we hypothesized that cholesterol-related molecules and pathways can serve as therapeutic targets for central nervous system *** hemorrhage is the most severe hemorrhagic stroke subtype,with high mortality and *** cholesterol levels are associated with the risk of intracerebral ***,secondary pathological changes after intracerebral hemorrhage are associated with cholesterol metabolism dysregulation,such as neuroinflammation,demyelination,and multiple types of programmed cell *** cholesterol accumulation in the brain has been found after intracerebral *** this paper,we review normal cholesterol metabolism in the central nervous system,the mechanisms known to participate in the disturbance of cholesterol metabolism after intracerebral hemorrhage,and the links between cholesterol metabolism and cell *** also review several possible and constructive therapeutic targets identified based on cholesterol metabolism to provide cholesterol-based perspectives and a reference for those interested in the treatment of intracerebral hemorrhage.

关键词： cell death cholesterol metabolism intracerebral hemorrhage myelination therapeutic target