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The landscape of investigator‐initiated oncology trials conducted in China's Mainland during the past decade(2010–2019)

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Cancer Innovation 2023年第1期2卷 79-90页

作者： ye Cao lin‐miao ye Zhong Fan Wei Yang Li‐Ying Chen Yun Mei De‐Ying He Wen‐Jin Mo Department of Clinical Research State Key Laboratory of Oncology in South ChinaCollaborative Innovation Center for Cancer MedicineSun Yat‐sen University Cancer CenterGuangzhouChina Department of Clinical Research Jieyang People's HospitalJieyangChina Department of Pediatrics the First Affiliated HospitalSun Yat‐sen UniversityGuangzhouChina Department of Clinical Trials AI Innovations Yidu Tech Inc.BeijingChina Information Service Department Guangzhou Yushi Medicinal Technology Co.Ltd.GuangzhouChina

The number of clinical trials conducted in China's Mainland,including investigator‐initiated trials(IITs),has increased rapidly in recent ***,there are few data on the characteristics of cancer‐related *** performed a comprehensive analysis of the landscape of cancer‐related IITs in China's Mainland in the past *** cancer‐related IITs registered on two clinical trial registries in the United States(***,***)and China's Mainland(***,ChiCTR)from 2010 to 2019 were *** were reviewed manually to validate classification,subcategorized by cancer type,and stratified by design characteristics to facilitate comparison across cancer types and with other specialties.A total of 8199 cancer‐related IITs were *** number of trials registered annually increased over time,especially in the last 5 *** interventional studies were predominant,randomized double‐blind studies accounted for only 8%of *** the past decade,the trend for interventional studies conducted with different drugs increased year on year,although the increase in hormonal therapy IITs was not ***,cancerrelated IITs were unevenly geographically distributed,with half concentrated in the economically developed cities Shanghai,Beijing,and *** also found an increase in registration before participant enrollment(64.9%for trials in conducted in 2015–2019 vs.40.2%in 2010–2014,p<0.001)and data monitoring committee use(44.5%vs.40.0%,p=0.001)and a decrease in randomization(51.5%vs.62.7%,p<0.001)and funding(36.4%vs.56.3%,p<0.001)between these *** also observed changes in intervention type(decrease in cytotoxic drug therapy[34.8%vs.48.9%,p<0.001];increase in targeted therapy[17.8%vs.14.2%,p=0.004],immune checkpoint inhibitor therapy[6.6%vs.0.0%,p<0.001],and immune cell therapy[9.6%vs.4.5%,p<0.001]).Details of cancer‐related IITs conducted during the past decade illustrate the merits of oncology research

关键词： cancer investigator‐initiated trials landscape clinicaltrials.gov ***

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基于亲景度和竞争态的福建省入境客源市场分析及对策

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三明学院学报 2009年第2期26卷 222-228页

作者：缪琳烨张启贤三明学院数学与计算机科学系福建三明365004

分析研究福建省入境客源市场,有利于福建省旅游业健康、持续与快速发展。本文运用亲景度和市场竞争态对福建省1997-2008年的入境客源市场进行量化分析,发现福建省入境客源市场亲景度存在高位振荡、中位波动和低位平稳三种变化,亲景度和... 详细信息

分析研究福建省入境客源市场,有利于福建省旅游业健康、持续与快速发展。本文运用亲景度和市场竞争态对福建省1997-2008年的入境客源市场进行量化分析,发现福建省入境客源市场亲景度存在高位振荡、中位波动和低位平稳三种变化,亲景度和竞争态的相关性并不显著;提出了福建省未来拓展入境客源市场的方向和对策。

关键词：亲景度市场竞争态福建省入境客源市场

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Development of a new high resolution waveform migration location method and its applications to induced seismicity

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Earth and Planetary Physics 2021年第6期5卷 520-531页

作者： SiYu miao HaiJiang Zhang YuYang Tan ye lin Laboratory of Seismology and Earth’s Interior School of Earth and Space SciencesUniversity of Science and Technology of ChinaHefei 230026China Mengcheng National Geophysical Observatory University of Science and Technology of ChinaHefei 230026China Key Lab of Submarine Geosciences and Prospecting Techniques MOE Institute for Advanced Ocean StudyOcean University of ChinaQingdao 266100China Laboratory for Marine Mineral Resources Qingdao National Laboratory for Marine Science and TechnologyQingdao 266100China

Locating seismic events is a central task for earthquake *** to arrival-based location methods,waveformbased location methods do not require picking phase arrivals and are more suitable for locating seismic events with noisy *** waveform-based location methods,one approach is to stack different attributes of P and S waveforms around arrival times corresponding to potential event locations and origin times,and the maximum stacking values are assumed to indicate the correct event location and origin *** this study,to obtain a high-resolution location image,we improve the waveform-based location method by applying a hybrid multiplicative imaging condition to characteristic functions of seismic *** our new stacking method,stations are divided into groups;characteristic functions of seismic waveforms recorded at stations in the same group are summed,and then multiplied among *** find that this approach can largely eliminate the cumulative effects of noise in the summation process and thus improve the resolution of location *** test the new method and compare it to three other stacking methods,using both synthetic and real datasets that are related to induced seismicity occurring in petroleum/gas *** test results confirm that the new stacking method can provide higher-resolution location images than those derived from currently used methods.

关键词： induced earthquake seismic location seismic monitoring

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Effect of dissolved-oxygen on the flotation behavior of pyrite at high altitude area

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International Journal of Minerals,Metallurgy and Materials 2024年第10期31卷 2148-2158页

作者： Yan miao Guangke ye Guofan Zhang School of Minerals Processing and Bio-engineering Central South UniversityChangsha 410083China

With the continuous development of mineral resources to high altitude areas,the study of sulfide ore flotation in unconventional systems has been *** is a consensus that moderate oxidation of sulfide ore is beneficial to flotation,but the specific suitable dissolved oxygen value is inconclusive,and there are few studies on sulfide ore flotation under low dissolved oxygen environment at high *** this paper,we designed and assembled an atmosphere simulation flotation equipment to simulate the flotation of pyrite at high altitude by controlling the partial pressure of N_(2)/O_(2) and dissolved oxygen under atmospheric conditions.X-ray photoelectron spec-troscopy(XPS),atomic force microscope(AFM),Fourier transform infrared spectrometer(FT-IR),UV-vis spectrophotometer,zeta po-tential,and contact angle measurements were used to reveal the effects of surface oxidation and agent adsorption on pyrite at high altitude(4600 m dissolved oxygen(DO)=4.0 mg/L).The results of pure mineral flotation indicated that the high altitude and low dissolved oxy-gen environment is favorable for pyrite *** angle measurements and XPS analysis showed that the high altitude atmosphere nslows down the oxidation of pyrite surface,facilitates S_(n)^(2-)/S^(0) production and enhances surface *** calcula-tions and zeta potential analysis showed that the influence of atmosphere on the form of pyrite adsorption is small,and the different atmo-spheric conditions are consistent with dixanthogen electrochemical adsorption,with lower Zeta potential under high altitude atmosphere and significant potential shift after sodium isobutyl xanthate(SIBX)*** results of FT-IR,UV-vis,and AFM analysis showed that SIBX adsorbed more on the surface of pyrite under high altitude atmosphere and adsorbed on the surface in a mesh structure com-posed of column/*** results of the experimental study revealed the reasons for the easy flotation of sul

关键词： high altitude dissolved-oxygen pyrite flotation oxidation

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Clinical observation of Kuntai capsule combined with Fenmotong in treatment of decline of ovarian reserve function

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World Journal of Clinical Cases 2021年第28期9卷 8349-8357页

作者： Xin-miao lin miao Chen Qiao-ling Wang Xiao-Min ye Hao-Fan Chen Department of Reproductive Health and Infertility Zhanjiang Central People’s HospitalZhanjiang 524037Guangdong ProvinceChina

BACKGROUND Decreased ovarian reserve function is an ovarian hypofunction disease that occurs in women before 40 years of age,leading to a decline in fertility and perimeno-pausal symptoms,such as irregular menstruation,amenorrhea,infertility,de-creased libido,and autonomic nervous ***(FMT)is a com-pound mixture of estradiol tablets and estradiol didroxyprogesterone tablets,which can improve ovarian reserve function by supplementation of exogenous ***,this treatment has also been shown to cause breast pain,gastrointestinal discomfort,irregular vaginal bleeding,and changes in sexual *** severe cases,FMT can promote the development of breast cancer,endometrial cancer,and venous embolic *** To observe the effects of Kuntai capsules and FMT on endocrine indexes and uterine artery blood circulation in patients with decreased ovarian reserve *** Patients(130)with decreased ovarian reserve function,who were treated in our hospital from May 2018 to May 2020,were divided into two groups:The FMT group,in which patients were treated with FMT,and the observation group,in which patients were treated with Kuntai *** medicine symptom scores,uterine artery blood flow parameters,ovarian ultrasound test indexes,pictorial blood loss assessment chart(PBAC)scores,and hormone levels were recorded,and total effective rates were calculated for both *** The total effective rate in the observation group was higher than that in the FMT group(Pyed menstruation,red color and thick consistency of menses,di-zziness,palpitation,weakness at the waist and knee,insomnia and excessive dreaming,irritability,and dryness and astringency of the pudendal canal in the observation group decreased,and scores for primary and secondary symptoms in the observation group were significantly lower than those in the FMT group(P<0.05).The systolic peak flow rate(

关键词： Kuntai capsule Fenmatong Ovarian reserve function decline Endocrine index Blood circulation

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Stability/Instability of Solitary waves with Nonzero Asymptotic Value for a PDE in Microstructural Solid Materials

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Acta Mathematicae Applicatae Sinica 2015年第3期31卷 693-700页

作者： ye ZHAO miao-chao CHEN Department of Mathematics and Physics Beijing Institute of Petrolchemical Technology Department of Mathematics Chaohu University

The present paper deals with results of stability/instability of solitary waves with nonzero asymptotic value for a microstructure PDE. By the exact solitary wave solutions and detailed computations, we set up the explicit expression for the discrimination d′′（c）. Finally, a complete study of orbital stablity/instablity for the explicit exact solutions is given.

关键词： solitary waves microstructured solid orbital stability/instability spectral analysis

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Robust adaptive repetitive learning control for a class of time-varying nonlinear systems with unknown control direction

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控制理论与应用（英文版） 2013年第3期11卷 336-342页

作者： miao YU Xudong ye Donglian QI College of Electrical Engineering Zhejiang University

A robust adaptive repetitive learning control method is proposed for a class of time-varying nonlinear systems. Nussbaum-gain method is incorporated into the control design to counteract the lack of a priori knowledge of the control direction which determines the motion direction of the system under any input. It is shown that the system state could converge to the desired trajectory asymptotically along the iteration axis through repetitive learning. Simulation is carried out to show the validity of the proposed control method.

关键词： Repetitive learning control (RLC) Unknown control direction Nussbaum gain

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Radiation graft of acrylamide onto polyethylene separators for lithium-ion batteries

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Nuclear Science and Techniques 2017年第6期28卷 108-114页

作者： Xiao-Li miao Ji-Hao Li Qun Xiang Jia-Qiang Xu lin-Fan Li Jing-ye Li Shanghai Institute of Applied Physics Chinese Academy of Science Department of Chemistry College of ScienceShanghai University

To improve the affinity between separators and electrolyte in lithium-ion battery,microporous polyethylene(PE) separator was grafted of polyacrylamide(PAAm) by *** structure of the PAAmgrafted PE separators(denoted as PE-g-PAAm) was characterized by Fourier transform infrared spectroscopy and X-ray photoelectron *** of the pristine PE and PE-g-PAAm were tested by scanning electron microscope,liquid electrolyte uptake and lithium-ion *** performances of the grafted PE separators(up to 0.76 × 10^(-3) S/cm of ionic conductivity at room temperature) were much better than pristine PE,and performance of the battery with the grafted separator behaved better than with the virgin PE separator,under the same condition(assembled in Ar-filled glove box).

关键词： Lithium-ion battery Polyethylene Acrylamide Irradiation graft Separator

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Structural insight into enhanced calcium indicator GCaMP3 and GCaMPJ to promote further improvement

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Protein & Cell 2013年第4期4卷 299-309页

作者： Yingxiao Chen Xianqiang Song Sheng ye lin miao Yun Zhu Rong-Guang Zhang Guangju Ji National Laboratory of Biomacromolecules Institute of BiophysicsChinese Academy of SciencesBeijing 100101China

Genetically encoded Ca^(2+) indicators(GECI)are important for the measurement of Ca^(2+) in ***2,a widelyused GECI,has recently been iteratively *** the improved variants,GCaMP3 exhibits significantly better fluorescent *** this study,we developed a new GECI called GCaMPJ and determined the crystal structures of GCaMP3 and *** has a 1.5-fold increase in fl uorescence and 1.3-fold increase in calcium affi nity over *** Ca^(2+) binding,GCaMP3 exhibits both monomeric and dimeric *** structural superposition of these two forms reveals the role of Arg-376 in improving monomer ***,GCaMPJ seldom forms dimers under conditions similar to *** ructural and mutagenesis studies on Tyr-380 confi rmed its importance in blocking the cpEGFPβ-barrel *** study proposes an efficient tool for mapping Ca^(2+) signals in intact organs to facilitate the further improvement of GCaMP sensors.

关键词： genetically encoded calcium indicator mu-tants crystal structure fl uorescentintensity dimerization

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GRSA: Service-Aware Flow Scheduling for Cloud Storage Datacenter Networks

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China Communications 2020年第6期17卷 164-179页

作者： Wenlong Ke Yong Wang miao ye School of Information and Communication Guilin University of Electronic TechnologyGuilin 541004China School of Computer Science and Information Security Guilin University of Electronic TechnologyGuilin 541004China Guangxi Engineering Technology Research Center of Cloud Security and Cloud Service Guilin University of Electronic TechnologyGuilin 541004China

The proliferation of the global datasphere has forced cloud storage systems to evolve more complex architectures for different *** emergence of these application session requests and system daemon services has created large persistent flows with diverse performance requirements that need to coexist with other types of *** routing methods such as equal-cost multipath(ECMP)and Hedera do not take into consideration specific traffic characteristics nor performance requirements,which make these methods difficult to meet the quality of service(QoS)for high-priority *** this paper,we tailored the best routing for different kinds of cloud storage flows as an integer programming problem and utilized grey relational analysis(GRA)to solve this optimization *** resulting method is a GRAbased service-aware flow scheduling(GRSA)framework that considers requested flow types and network status to select appropriate routing paths for flows in cloud storage datacenter *** results from experiments carried out on a real traffic trace show that the proposed GRSA method can better balance traffic loads,conserve table space and reduce the average transmission delay for high-priority flows compared to ECMP and Hedera.

关键词： cloud storage datacenter networks flow scheduling grey relational analysis QoS SDN

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