检索结果-南通市图书馆

Chinese Chemical Letters 2024年第7期35卷 247-252页

作者： xiao xiao Biao Chen Jia-Wei Li jun-Bo Zheng Xu Wang Hang Zhao Fen-Er Chen Institute of Pharmaceutical Science and Technology Collaborative Innovation Center of Yangtze River Delta Region Green PharmaceuticalsZhejiang University of TechnologyHangzhou 310014China College of Chemistry and Chemical Engineering Jiangxi Normal UniversityNanchang 330022China Engineering Center of Catalysis and Synthesis for Chiral Molecules Department of ChemistryFudan UniversityShanghai 200433China Shanghai Engineering Center of Industrial Asymmetric Catalysis for Chiral Drugs Shanghai 200433China

A highly efficient and concise bromocyclization has been successfully achieved,in which tryptamine/tryptophol derivates can be transformed to valuable HPI/TFI scaffolds with economic and green ***,a controllable cascade transformation of bromocyclization and aromatic bromination has also been smoothly achieved to form dibrominated HPIs and *** could be successfully scaled up under both the batch process and a continuous flow *** most remarkable peculiarity of our process over all previous methods is that the generated water is the major ***,successful application of this new protocol has been demonstrated by the pharmaceutical and natural products syntheses.

关键词： Tryptamines and tryptophols Nitrite Economic and sustainable bromocyclization HPI and TFI structures Bath and flow

A Fluorine-Functionalized 3D Covalent Organic Framework with Entangled 2D Layers

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Polymer Science 2024年第8期42卷 1210-1216页

作者： Li-Bang xiao Zi-Han Wu jun-Jie Xin Yuan-Peng Cheng Bo Gui jun-Liang Sun Cheng Wang College of Chemistry and Molecular Sciences Wuhan UniversityWuhan 430072China College of Chemistry and Molecular Engineering Beijing National Laboratory for Molecular SciencesPeking UniversityBeijing 100871China

Constructing three dimensional(3D)covalent organic frameworks(COFs)through the entanglement of two dimensional(2D)nets is a promising but underdeveloped ***,we report the design and synthesis of a fluorine functionalized 3DCOF(3D-An-COF-F)formed by entangled 2D sql *** structure of 3D-An-COF-F was determined by the combination of continuous rotation electron diffraction technique and modelling based on the chemical information from real ***,compared to the isostructural 3D-An-COF without F atom s,3DAn-COF-F showed an improved CO_(2)sorption ability and higher CO_(2)/N_(2)*** study not only demonstrated the generality of constructing 3D COFs with entangled 2D nets by introducing bulky groups vertically in planar building blocks,but also will expand the diversity of 3D COFs for various applications.

关键词： 3D covalent organic frameworks Fluorine Entangled 2D layers Electron diffraction CO_(2)adsorption

在线全文

学校读者我要写书评

暂无评论

开式整体叶盘叶片型面数控抛光编程技术

计算机集成制造系统 2014年第2期20卷 379-384页

作者：蔺小军杨阔吴广董婷西北工业大学现代设计与集成制造技术教育部重点实验室陕西西安710072

为了实现整体叶盘叶片型面数控抛光,针对五坐标数控抛光机,研究开式整体叶盘叶片型面数控抛光轨迹规划与编程技术。通过分析多坐标数控抛光系统结构及开式整体叶盘抛光工艺方法,提出面向抛光加工的路径规划方法,选择分段直纹面拟合逼近... 详细信息

为了实现整体叶盘叶片型面数控抛光,针对五坐标数控抛光机,研究开式整体叶盘叶片型面数控抛光轨迹规划与编程技术。通过分析多坐标数控抛光系统结构及开式整体叶盘抛光工艺方法,提出面向抛光加工的路径规划方法,选择分段直纹面拟合逼近叶片型面,利用分段直纹面的直母线直接生成刀位轨迹。最后进行了数控抛光实验验证,实现了整体叶盘叶片型面抛光的机械化和自动化,极大地提高了整体叶盘的抛光效率,为航空发动机整体叶盘的使用性能和安全可靠性提供了保障。

关键词：数控抛光柱形磨头叶片型面抛光轨迹规划编程

在线全文

学校读者我要写书评

暂无评论

广州市植保新技术新方法推广现状分析

广东农业科学 2013年第14期40卷 103-104,108页

作者：林小军广州市农业环境与植物保护总站广东广州510405

论述了2003年以来广州市主要农区推广使用频振式杀虫灯控害等新技术,以及推广数量、应用面积和新技术的防治效果等。但在新技术推广过程中发现农民接受程度不高、宣传力度不足、后续管理跟不上等一系列问题,由此提出了转变思路、发挥主... 详细信息

论述了2003年以来广州市主要农区推广使用频振式杀虫灯控害等新技术,以及推广数量、应用面积和新技术的防治效果等。但在新技术推广过程中发现农民接受程度不高、宣传力度不足、后续管理跟不上等一系列问题,由此提出了转变思路、发挥主动性、加大杀虫灯等新技术宣传力度、提高新技术覆盖率等对策。

关键词：植保新技术杀虫灯对策广州

Diagnostic Value of GDF10 for the Tumorigenesis and Immune Infiltration in Lung Squamous Cell Carcinoma

在线全文

学校读者我要写书评

暂无评论

Current Medical Science 2024年第2期44卷 309-327页

作者： xiao-jun WANG Jia-ping CHEN Xin-wei QIAO Wang-yang MENG Yang-wei WANG Yun-chong MENG Rong ZHAO Wei lin Yong-de LIAO Han xiao Pei-yuan MEI Department of Thoracic Surgery Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022China Department of Thoracic Surgery Shandong Provincial Hospital Affiliated to Shandong First Medical UniversityJinan 250021China

Objective:Lung squamous cell carcinoma(LUSC)is associated with a low survival *** suggests that bone morphogenetic proteins(BMPs)and their receptors(BMPRs)play crucial roles in tumorigenesis and ***,a comprehensive analysis of their role in LUSC is *** study aimed to explore the relationship between BMPs/BMPRs expression levels and the tumorigenesis and prognosis of ***:The“R/Limma”package was utilized to analyze the differential expression characteristics of BMPs/BMPRs in LUSC,using data from TCGA,GTEx,and GEO ***,the“survminer”packages were employed to investigate their prognostic value and correlation with clinical features in *** core gene associated with LUSC progression was further explored through weighted gene correlation network analysis(WGCNA).LASSO analysis was conducted to construct a prognostic risk model for *** specimens were examined by immunohistochemical analysis to confirm the diagnostic value in ***,based on the tumor immune estimation resource database and tumor-immune system interaction database,the role of the core gene in the tumor microenvironment of LUSC was ***:GDF10 had a significant correlation only with the pathological T stage of LUSC,and the protein expression level of GDF10 decreased with the tumorigenesis of LUSC.A prognostic risk model was constructed with GDF10 as the core gene and 5 hub genes(HRASLS,HIST1H2BH,FLRT3,CHEK2,and ALPL)for ***10 showed a significant positive correlation with immune cell infiltration and immune checkpoint ***:GDF10 might serve as a diagnostic biomarker reflecting the tumorigenesis of LUSC and regulating the tumor immune microenvironment to guide more effective treatment for LUSC.

关键词： lung squamous cell carcinoma tumorigenesis bone morphogenetic protein GDF10 tumor immune microenvironment

Evaluating effectiveness and safety of combined percutaneous transhepatic gallbladder drainage and laparoscopic cholecystectomy in acute cholecystitis patients:Meta-analysis

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastrointestinal Surgery 2024年第5期16卷 1407-1419页

作者： Yu Li Wei-Ke xiao xiao-jun Li Hui-Yuan Dong Department of General Surgery No.942 Hospital of PLAYinchuan 750004Ningxia Hui Autonomous RegionChina

BACKGROUND Acute cholecystitis(AC)is a common disease in general *** cholecystectomy(LC)is widely recognized as the"gold standard"surgical procedure for treating *** low-risk patients without complications,LC is the recommended treatment plan,but there is still controversy regarding the treatment strategy for moderate AC patients,which relies more on the surgeon's experience and the medical platform of the visiting *** transhepatic gallbladder puncture drainage(PTGBD)can effectively alleviate gallbladder inflammation,reduce gallbladder wall edema and adhesion around the gallbladder,and create a"time window"for elective *** To compare the clinical efficacy and safety of LC or PTGBD combined with LC for treating AC patients,providing a theoretical basis for choosing reasonable surgical methods for AC *** In this study,we conducted a clinical investigation regarding the combined use of PTGBD tubes for the treatment of gastric cancer patients with *** performed searches in the following databases:PubMed,Web of Science,EMBASE,Cochrane Library,China National Knowledge Infrastructure,and Wanfang *** search encompassed literature published from the inception of these databases to the ***,relevant data were extracted,and a meta-analysis was conducted using RevMan 5.3 *** A comprehensive analysis was conducted,encompassing 24 studies involving a total of 2564 *** patients were categorized into two groups:1371 in the LC group and 1193 in the PTGBD+LC *** outcomes of the meta-analysis revealed noteworthy disparities between the PTGBD+LC group and the LC group in multiple dimensions:(1)Operative time:Mean difference(MD)=17.51,95%CI:9.53-25.49,P<0.01;(2)Conversion to open surgery rate:Odds ratio(OR)=2.95,95%CI:1.90-4.58,P<0.01;(3)Intraoperative bleeding loss:MD=32.27,95%CI:23.03-41.50,P<0.01;(4)Postoperative hospital stay:MD=1.44,95%CI:0.14-2.73,P=0.03;(5)Overall posto

关键词： Acute cholecystitis Laparoscopic cholecystectomy Percutaneous transhepatic gallbladder drainage Metaanalysis Efficacy

fas介导系统性红斑狼疮患者Foxp3+CD4+CD25+Treg细胞凋亡的研究

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

中华医学杂志 2011年第9期91卷 586-590页

作者：林小军罗敏蔡小燕广州医学院附属广州市第一人民医院风湿科

目的探讨fas凋亡信号传导途径在系统性红斑狼疮(SLE)患者Foxp3+CD4+CD25+Treg凋亡异常中的作用。方法选取活动期SLE患者25例、缓解期SLE患者20例及健康对照25名为研究对象,检测所有研究对象外周血Foxp3+CD4+CD25+Treg表面fas的表达,同... 详细信息

目的探讨fas凋亡信号传导途径在系统性红斑狼疮(SLE)患者Foxp3+CD4+CD25+Treg凋亡异常中的作用。方法选取活动期SLE患者25例、缓解期SLE患者20例及健康对照25名为研究对象,检测所有研究对象外周血Foxp3+CD4+CD25+Treg表面fas的表达,同时分析CD4+CD25+T细胞Foxp3表达。并分别将fas表达率及Foxp3表达率与病情活动性(SLEDAI评分)进行相关分析。结果 (1)外周血Foxp3+CD4+CD25+Treg上fas的表达:活动期SLE组为(23.72±2.35)%,缓解期SLE组为(14.0±2.1)%,对照组为(10.1±1.2)%,在活动期SLE组明显高于缓解期SLE组(P0.05),fas在Foxp3+CD4+CD25+Treg上的表达与SLEDAI评分呈正相关(r=0.336,P<0.05)。(2)外周血CD4+CD25+T细胞Foxp3的表达:活动期SLE组为(2.83±0.30)%,缓解期SLE组为(5.38±0.63)%,对照组为(8.12±0.70)%。活动期SLE组外周血CD4+CD25+T细胞Foxp3表达明显低于缓解期SLE组(P<0.01)和对照组(P<0.01);而缓解期SLE组亦低于对照组(P<0.05)。外周血Foxp3表达与SLEDAI评分呈负相关(r=-0.581,P<0.01)。(3)Foxp3与fas的表达呈负相关(r=-0.349,P<0.01)。结论 SLE患者中存在由fas介导的Foxp3+CD4+CD25+Treg的过度凋亡,这可能是导致SLE病情活动的机制之一。

关键词：红斑狼疮,系统性 Foxp3+CD4+CD25+调节性T细胞细胞凋亡 fas

Clinical characteristics and risk factors of post-operative intestinal flora disorder following laparoscopic colonic surgery:A propensityscore-matching analysis

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastrointestinal Surgery 2024年第5期16卷 1259-1270页

作者： Gan-Bin Li Chen-Tong Wang xiao Zhang xiao-Yuan Qiu Wei-Jie Chen jun-Yang Lu Lai Xu Bin Wu Yixiao Guo-Le lin Department of General Surgery Peking Union Medical College HospitalPeking Union Medical CollegeBeijing 100730China

BACKGROUND Intestinal flora disorder(IFD)poses a significant challenge after laparoscopic colonic surgery,and no standard criteria exists for its diagnosis and *** To analyze the clinical features and risk factors of *** Patients with colon cancer receiving laparoscopic surgery were included using propensity-score-matching(PSM)*** on the occurrence of IFD,patients were categorized into IFD and non-IFD *** clinical characteristics and treatment approaches for patients with IFD were *** regression analysis was performed to identify the risk factors of *** The IFD incidence after laparoscopic surgery was 9.0%(97 of 1073 patients).After PSM,97 and 194 patients were identified in the IFD and non-IFD groups,*** most common symptoms of IFD were diarrhea and abdominal,typically occurring on post-operative days 3 and *** patients were managed conservatively,including modulation of the intestinal flora(90.7%),oral/intravenous application of vancomycin(74.2%),and insertion of a gastric/ileus tube for decompression(23.7%).Multivariate regression analysis identified that preoperative intestinal obstruction[odds ratio(OR)=2.79,95%CI:1.04–7.47,P=0.041]and post-operative antibiotics(OR=8.57,95%CI:3.31–23.49,P<0.001)were independent risk factors for IFD,whereas pre-operative parenteral nutrition(OR=0.12,95%CI:0.06–0.26,P<0.001)emerged as a protective *** A stepwise approach of probiotics,vancomycin,and decompression could be an alternative treatment for *** attention is warranted post-operatively for patients with pre-operative obstruction or early use of antibiotics.

关键词： Colon cancer,Laparoscopy Intestinal flora disorder Clinical characteristics Risk factors

Development review and the prospect of oil shale in-situ catalysis conversion technology

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Petroleum Science 2024年第2期21卷 1385-1395页

作者： Li Wang Chen-Hao Gao Rui-Ying Xiong xiao-jun Zhang Ji-Xiang Guo The Unconventional Oil and Gas Institute China University of Petroleum-BeijingBeijing102200China

As an unconventional resource, oil shale possesses abundant reserves and significant potential for industrial applications. The rational and efficient development of oil shale resources holds immense importance in reducing national energy demand. In-situ catalytic technology, characterized by its high efficiency, low pollution, and minimal energy consumption, represents a key direction for future oil shale development. This paper provides a comprehensive review of research progress in in-situ oil shale mining technology, oil shale pyrolysis catalysts, the pyrolysis mechanism of kerogen, and the compatibility of different heating processes and catalysts. Furthermore, the paper proposes future research directions and prospects for oil shale in-situ catalytic technology, including reservoir modification, highefficiency catalyst synthesis, injection processes, and high-efficiency heating technology. These insights serve as valuable technical references for the advancement of oil shale in-situ catalytic technology.

关键词： Oil shale In-situ catalytic technology Pyrolysis catalyst Kerogen pyrolysis mechanism

High dimensional proteomic mapping of bone marrow immune characteristics in immune thrombocytopenia

在线全文

学校读者我要写书评

暂无评论

Science China(Life Sciences) 2024年第8期67卷 1635-1647页

作者： Feng-Qi Liu Qing-Yuan Qu Ying Lei Qi Chen Yu-Xiu Chen Meng-lin Li Xue-Yan Sun Ye-jun Wu Qiu-Sha Huang Hai-Xia Fu Yuan Kong Yue-Ying Li Qian-Fei Wang xiao-jun Huang xiao-Hui Zhang Peking University People’s Hospital Peking University Institute of HematologyBeijing 100044China Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation Beijing 100044China National Clinical Research Center for Hematologic Disease Beijing 100044China Collaborative Innovation Centre of Hematology Peking UniversityBeijing 100044China CAS Key Laboratory of Genomic and Precision Medicine Beijing Institute of GenomicsChinese Academy of Sciences and China National Center for BioinformationBeijing 100101China University of Chinese Academy of Sciences Beijing 100049China Peking-Tsinghua Center for Life Sciences Academy for Advanced Interdisciplinary StudiesPeking UniversityBeijing 100074China State Key Laboratory of Natural and Biomimetic Drugs Peking UniversityBeijing 100191China

To investigate the role of co-stimulatory and co-inhibitory molecules on immune tolerance in immune thrombocytopenia(ITP),this study mapped the immune cell heterogeneity in the bone marrow of ITP at the single-cell level using Cytometry by Time of Flight(CyTOF).Thirtysix patients with ITP and nine healthy volunteers were enrolled in the *** soluble immunomodulatory molecules,more sCD25 and sGalectin-9 were detected in ITP *** the cell surface,co-stimulatory molecules like ICOS and HVEM were observed to be upregulated in mainly central memory and effector T *** contrast,co-inhibitory molecules such as CTLA-4 were significantly reduced in Th1 and Th17 cell *** a platelet count of 30×10^(9)L^(−1)as the cutoff value,ITP patients with high and low platelet counts showed different T cell immune ***-presenting cells such as monocytes and B cells may regulate the activation of T cells through CTLA-4/CD86 and HVEM/BTLA interactions,respectively,and participate in the pathogenesis of *** conclusion,the proteomic and soluble molecular profiles brought insight into the interaction and modulation of immune cells in the bone marrow of *** may offer novel targets to develop personalized immunotherapies.

关键词： immune thrombocytopenia autoimmune diseases co-stimulatory co-inhibitory immune checkpoint CTLA4 Cytometry by Time of Flight bone marrow