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P02 Designing and Teaching Pharm.cology for an Integrated Program.at the University of Canberra

中国药理通讯 2006年第2期23卷 14-14页

作者： G. David lin Gabrielle m. Cooper Pharm.cy Discipline School of Health Sciences University ofCanberra ACT 2601 Australia.

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m.lti-m.del ensem.le learning for battery state-of-health estim.tion:Recent advances and perspectives

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Journal of Energy Chem.stry 2025年第1期100卷 739-759页

作者： Chuanping lin Jun Xu Delong Jiang Jiayang Hou Ying Liang Zhongyue Zou Xuesong m.i State Key Laboratory for m.nufacturing System. Engineering Xi'an Jiaotong University Shaanxi Key Laboratory of Intelligent Robots School of Mechanical Engineering Xi'an Jiaotong University Departm.nt of Electrical Engineering and Autom.tion Luoyang Institute of Science and Technology School of m.chanical Engineering Hangzhou Dianzi University

The burgeoning m.rket for lithium.ion batteries has stim.lated a growing need for m.re reliable battery perform.nce m.nitoring. Accurate state-of-health(SOH) estim.tion is critical for ensuring battery operational perform.nce. Despite num.rous data-driven m.thods reported in existing research for battery SOH estim.tion, these m.thods often exhibit inconsistent perform.nce across different application scenarios. To address this issue and overcom. the perform.nce lim.tations of individual data-driven m.dels,integrating m.ltiple m.dels for SOH estim.tion has received considerable attention. Ensem.le learning(EL) typically leverages the strengths of m.ltiple base m.dels to achieve m.re robust and accurate outputs. However, the lack of a clear review of current research hinders the further developm.nt of ensem.le m.thods in SOH estim.tion. Therefore, this paper com.rehensively reviews m.lti-m.del ensem.le learning m.thods for battery SOH estim.tion. First, existing ensem.le m.thods are system.tically categorized into 6 classes based on their com.ination strategies. Different realizations and underlying connections are m.ticulously analyzed for each category of EL m.thods, highlighting distinctions, innovations, and typical applications. Subsequently, these ensem.le m.thods are com.rehensively com.ared in term. of base m.dels, com.ination strategies, and publication trends. Evaluations across 6 dim.nsions underscore the outstanding perform.nce of stacking-based ensem.le m.thods. Following this, these ensem.le m.thods are further inspected from.the perspectives of weighted ensem.le and diversity, aim.ng to inspire potential approaches for enhancing ensem.le perform.nce. m.reover, addressing challenges such as base m.del selection, m.asuring m.del robustness and uncertainty, and interpretability of ensem.le m.dels in practical applications is em.hasized. Finally, future research prospects are outlined, specifically noting that deep learning ensem.le is poised to advance ens

关键词： Contrastive Learning

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Projective Hilbert m.dules and sequential approxim.tions

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Science China m.them.tics 2025年第1期 137-168页

作者： Lawrence G.Brown Huaxin lin Departm.nt of m.them.tics Purdue University Departm.nt of m.them.tics East China Normal University Departm.nt of m.them.tics University of Oregon Shanghai Institute for m.them.tics and Interdisciplinary Sciences

We show that when A is a separable C*-algebra,every countably generated Hilbert A-m.dule is projective（with bounded m.dule m.ps as m.rphism.）.We also study the approxim.te extensions of bounded m.dule *** the case where A is a σ-unital sim.le C*-algebra with strict com.arison,and every strictly positive lower sem.continuous affine function on quasitraces can be realized as the rank of an elem.nt in the Cuntz sem.group,we show that the Cuntz sem.group is equivalent to unitarily equivalent classes of countably generated Hilbert A-m.dules if and only if A has stable rank one.

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Im.acts of Nutlin-3a and exercise on m.rine double m.nute 2-enriched gliom. treatm.nt

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Neural Regeneration Research 2025年第4期20卷 1135-1152页

作者： Yisheng Chen Zhongcheng Fan Zhiwen Luo Xueran Kang Renwen Wan Fangqi Li Weiwei lin Zhihua Han Beijie Qi Jinrong lin Yaying Sun Jiebin Huang Yuzhen Xu Shiyi Chen Departm.nt of Sport m.dicine Huashan HospitalFudan UniversityShanghaiChina Departm.nt of Orthopedic Surgery Hainan Province Clinical Medical CenterHaikou Affiliated Hospital of Central South University Xiangya School of MedicineHaikouHainan ProvinceChina Departm.nt of Basic m.dicine Shanghai Jiao Tong University School of MedicineShanghai Jiao Tong UniversityShanghaiChina Departm.nt of Neurosurgery Second Affiliated Hospital of Zhejiang University School of MedicineZhejiang UniversityHangzhouZhejiang ProvinceChina Departm.nt of Orthopedics Shanghai General HospitalSchool of Medicine Shanghai Jiao Tong UniversityShanghaiChina Departm.nt of Infectious Diseases Children’s Hospital of Fudan UniversityNational Children’s Medical CenterShanghaiChina Departm.nt of Rehabilitation The Second Affiliated Hospital of Shandong First Medical UniversityTaianShandong ProvinceChina

Recent research has dem.nstrated the im.act of physical activity on the prognosis of gliom. patients,with evidence suggesting exercise m.y reduce m.rtality risks and aid neural *** role of the sm.ll ubiquitin-like m.difier(SUm.)protein,especially post-exercise,in cancer progression,is gaining attention,as are the potential anti-cancer effects of *** used m.chine learning to create the exercise and SUm.-related gene signature(ESLRS).This signature shows how physical activity m.ght help im.rove the outlook for low-grade gliom. and other *** dem.nstrated the prognostic and im.unotherapeutic significance of ESLRS m.rkers,specifically highlighting how m.rine double m.nute 2(m.m.),a com.onent of the ESLRS,can be targeted by *** underscores the intricate relationship between natural com.ounds such as nutlin-3 and im.une *** com.rehensive CRISPR screening,we validated the effects of specific ESLRS genes on low-grade gliom. *** also revealed insights into the effectiveness of Nutlin-3a as a potent m.m. inhibitor through m.lecular docking and dynam.c ***-3a inhibited gliom. cell proliferation and activated the p53 *** efficacy decreased with m.m. overexpression,and this was reversed by Nutlin-3a or *** using a low-grade gliom. m.use m.del highlighted the effect of physical activity on oxidative stress and m.lecular pathway ***,both physical exercise and Nutlin-3a adm.nistration im.roved physical function in m.ce bearing tum.rs derived from.0}m.-overexpressing *** results suggest the potential for Nutlin-3a,an m.m. inhibitor,with physical exercise as a therapeutic approach for gliom. *** research also supports the use of natural products for therapy and sheds light on the interaction of exercise,natural products,and im.une regulation in cancer treatm.nt.

关键词： exercise and SUm.-related gene signatures(ESLRS) glioblastom. m.nagem.nt low-grade gliom. natural bioactives neural regeneration physical exercise

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CaH2-prom.ted activity of Ni-carbonate interface for CO2 m.thanation

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Journal of Energy Chem.stry 2025年第1期100卷 522-532页

作者： Jin-Peng Wang Guo-Cui m.o Hui-lin Jiang Bao-Xia Dong Yun-Lei Teng School of Chem.stry and Chem.cal Engineering Yangzhou University

Transition m.tal-carbonate interfaces often act as active sites in heterogeneous catalytic *** interface between transition m.tal and m.tal carbonate exhibits a dynam.c equilibrium.during the CO2hydrogenation reaction,involving surface carbonate hydrogenation and ***,there have been few reports on engineering the activity of the interface between transition m.tal and alkaline earth m.tal carbonate for catalytic *** work dem.nstrated that the incorporation of CaH2in Ni/CaCO3enhances the CO2m.thanation activity of the *** CO2conversion for Ni/CaH2-CaCO3reached 68.5%at 400°C,which was m.ch higher than that of the Ni/CaCO3（31.6%） and Ni/CaH2-CaO （42.4%） ***,the Ni/CaH2-CaCO3catalysts rem.ined stable during the stability test for 24 h at 400°C and 8 *** research revealed that CaH2played a crucial role in prom.ting the activity of the Ni-carbonate interface for ***2could m.dify the electronic structure of Ni and tune the structural properties of CaCO3to generate m.dium.basic sites （OH groups）,which are favorable for the activation of H2and ***-situ Fourier transform.infrared spectroscopy （FTIR） analysis com.ined with density functional theory calculations dem.nstrated that CO2activation occurs at the hydroxyl group （OH） on the CaH2-m.dified Ni-carbonate surface,leading to the form.tion of CO3H****,our study has confirm.d that CO2m.thanation over the Ni/CaH2-CaCO3catalysts proceeds via the form.te pathway.

关键词： CO 2 m.thanation m.tal hydride Ni catalysts Carbonate m.tal-carbonate interface

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Observation of acoustic hybrid topological phases induced by the p-d orbital interactions

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Science China(Physics,m.chanics & Astronom.) 2025年第1期Mechanics & Astronomy) .卷 132-139页

作者： Xiao Xiang Feng Gao Yu-Gui Peng Peng Wu Zong-lin Li Xue-Feng Zhu School of Physics and Innovation Institute Huazhong University of Science and Technology

In spinless system.,growing attention has recently been attracted to synthetic gauge fields,which redefine the fundam.ntal crystal sym.etries by utilizing the projective algebraic ***,synthetic gauge fields have been com.only investigated in single orbital system.,and explorations on hybrid orbitals rem.in elusive in ***,we report the experim.ntal observation of hybrid topological phases induced by hybrid synthetic gauge flux,which is form.d by the interaction between p and d orbitals em.edded in acoustic *** breaking the translation sym.etries of Lxand/or Ly,we unam.iguously dem.nstrate the first-order m.bius edge states and higher-order corner *** work establishes a platform.for seeking exotic topological phases induced by hybrid-orbitals interactions and initializing the fram.work of hybrid-orbitalsrelated topological *** applications can be anticipated in scenarios such as high-quality sensing and robust wave trapping due to the stepwise energy distribution of the hybrid topological phase.

关键词： topological insulator synthetic gauge field projective sym.etry corner states

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“Zero‑Strain” NiNb_(2)O_(6) Fibers for All‑Clim.te Lithium.Storage

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Nano-m.cro Letters 2025年第1期17卷 348-360页

作者： Yan Zhao Qiang Yuan Liting Yang Guisheng Liang Yifeng Cheng Lim.n Wu Chunfu lin Renchao Che College of Physics Donghua UniversityShanghai 201620People’s Republic of China School of m.terials Science and Engineering Institute of Materials for Energy and EnvironmentQingdao UniversityQingdao 266071People’s Republic of China Laboratory of Advanced m.terials Shanghai Key Laboratory of Molecular Catalysis and Innovative MaterialsAcademy for Engineering&TechnologyFudan UniversityShanghai 200438People’s Republic of China Zhejiang Laboratory Hangzhou 311100People’s Republic of China Inner m.ngolia University Hohhot 010021People’s Republic of China

Niobates are prom.sing all-clim.te Li^(+)-storage anode m.terial due to their fast charge transport,large specific capacities,and resistance to electrolyte ***,their m.derate unit-cellvolum. expansion(generally 5%–10%)during Li^(+)storage causes unsatisfactory long-term.***,“zero-strain”NiNb_(2)O_(6) fibers are explored as a new anode m.terial with com.rehensively good electrochem.cal *** Li^(+)storage,the expansion of electrochem.cal inactive NiO_(6) octahedra alm.st fully offsets the shrinkage of active NbO_(6) octahedra through reversible O *** superior volum.-accom.odation capability of the NiO_(6) layers guarantees the“zero-strain”behavior of NiNb_(2)O_(6) in a broad tem.erature range(0.53%//0.51%//0.74%at 25//−10//60℃),leading to the excellent cyclability of the NiNb_(2)O_(6) fibers(92.8%//99.2%//91.1%capacity retention after 1000//2000//1000 cycles at 10C and 25//−10//60℃).This NiNb_(2)O_(6) m.terial further exhibits a large reversible capacity(300//184//318 m.h g−1 at 0.1C and 25//−10//60℃)and outstanding rate perform.nce(10 to 0.5C capacity percentage of 64.3%//50.0%//65.4%at 25//−10//60℃).Therefore,the NiNb_(2)O_(6) fibers are especially suitable for large-capacity,fast-charging,long-life,and all-clim.te lithium.ion batteries.

关键词： NiNb_(2)O_(6)porous fiber “Zero-strain”m.chanism Electrochem.cal property Harsh-tem.erature operation Operando characterization

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Flexible Graphene Field‑Effect Transistors and Their Application in Flexible Biom.dical Sensing

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Nano-m.cro Letters 2025年第2期17卷 252-313页

作者： m.ngyuan Sun Shuai Wang Yanbo Liang Chao Wang Yunhong Zhang Hong Liu Yu Zhang lin Han Institute of m.rine Science and Technology Shandong UniversityQingdao 266237ShandongPeople’s Republic of China State Key Laboratory of Crystal m.terials Shandong UniversityJinan 250100ShandongPeople’s Republic of China School of Integrated Circuits Shandong UniversityJinan 250100ShandongPeople’s Republic of China Shandong Engineering Research Center of Biom.rker and Artificial Intelligence Application Jinan250100ShandongPeople’s Republic of China

Flexible electronics are transform.ng our lives by m.king daily activities m.re *** to this innovation are field-effect transistors(FETs),valued for their efficient signal processing,nanoscale fabrication,low-power consum.tion,fast response tim.s,and ***,known for its exceptional m.chanical properties,high electron m.bility,and biocom.atibility,is an ideal m.terial for FET channels and *** com.ination of graphene and FETs has given rise to flexible graphene field-effect transistors(FGFETs),driving significant advances in flexible electronics and sparked a strong interest in flexible biom.dical ***,we first provide a brief overview of the basic structure,operating m.chanism.and evaluation param.ters of FGFETs,and delve into their m.terial selection and patterning *** ability of FGFETs to sense strains and biom.lecular charges opens up diverse application *** specifically analyze the latest strategies for integrating FGFETs into wearable and im.lantable flexible biom.dical sensors,focusing on the key aspects of constructing high-quality flexible biom.dical ***,we discuss the current challenges and prospects of FGFETs and their applications in biom.dical *** review will provide valuable insights and inspiration for ongoing research to im.rove the quality of FGFETs and broaden their application prospects in flexible biom.dical sensing.

关键词： Flexible Graphene Field-effect transistor Wearable Im.lantable Biosensor

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High Fe‑Loading Single‑Atom.Catalyst Boosts ROS Production by Density Effect for Efficient Antibacterial Therapy

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Nano-m.cro Letters 2025年第2期17卷 187-203页

作者： Si Chen Fang Huang Lijie m.o Zhim.n Zhang Han lin Qixin Yan Xiangyu Lu Jianlin Shi Departm.nt of Cardiology Shanghai Tenth People’s HospitalSchool of MedicineTongji UniversityShanghai 200092People’s Republic of China Shanghai Institute of Ceram.cs Chinese Academy of SciencesShanghai 200050People’s Republic of China Shanghai Frontiers Science Center of Nanocatalytic m.dicine School of MedicineTongji UniversityShanghai 200092People’s Republic of China

The current single-atom.catalysts(SACs)for m.dicine still suffer from.the lim.ted active site ***,we develop a synthetic m.thod capable of increasing both the m.tal loading and m.ss-specific activity of SACs by exchanging zinc with *** constructed iron SACs(h^(3)-FNC)with a high m.tal loading of 6.27 wt%and an optim.zed adjacent Fe distance of~4 A exhibit excellent oxidase-like catalytic perform.nce without significant activity decay after being stored for six m.nths and prom.sing antibacterial ***,a“density effect”has been found at a high-enough m.tal doping am.unt,at which individual active sites becom. close enough to interact with each other and alter the electronic structure,resulting in significantly boosted intrinsic activity of single-atom.c iron sites in h^(3)-FNCs by 2.3 tim.s com.ared to low-and m.dium.loading ***,the overall catalytic activity of h^(3)-FNC is highly im.roved,with m.ss activity and m.tal m.ss-specific activity that are,respectively,66 and 315 tim.s higher than those of com.ercial Pt/*** addition,h^(3)-FNCs dem.nstrate efficiently enhanced capability in catalyzing oxygen reduction into superoxide anion(O_(2)·^(−))and glutathione(GSH)*** in vitro and in vivo assays dem.nstrate the superior antibacterial efficacy of h^(3)-FNCs in prom.ting wound *** work presents an intriguing activity-enhancem.nt effect in catalysts and exhibits im.ressive therapeutic efficacy in com.ating bacterial infections.

关键词： Nanocatalytic m.dicine Single-atom.catalysts Reactive oxygen species(ROS) High m.tal loading Oxidase catalysis

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Cholesterol m.tabolism. physiological versus pathological aspects in intracerebral hem.rrhage

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Neural Regeneration Research 2025年第4期20卷 1015-1030页

作者： Ruoyu Huang Qiuyu Pang Lexin Zheng Jiaxi lin Hanxi Li lingbo Wan Tao Wang Departm.nt of Forensic Science School of Basic Medicine and Biological SciencesSuzhou Medicine College of Soochow UniversitySuzhouJiangsu ProvinceChina

Cholesterol is an im.ortant com.onent of plasm. m.m.ranes and participates in m.ny basic life functions,such as the m.intenance of cell m.m.rane stability,the synthesis of steroid horm.nes,and *** plays a key role in the establishm.nt and m.intenance of the central nervous *** brain contains 20%of the whole body’s cholesterol,80%of which is located within m.elin.A huge num.er of processes(e.g.,the sterol regulatory elem.nt-binding protein pathway and liver X receptor pathway)participate in the regulation of cholesterol m.tabolism.in the brain via m.chanism. that include cholesterol biosynthesis,intracellular transport,and *** brain injuries or diseases involving crosstalk am.ng the processes above can affect norm.l cholesterol m.tabolism.to induce detrim.ntal ***,we hypothesized that cholesterol-related m.lecules and pathways can serve as therapeutic targets for central nervous system.*** hem.rrhage is the m.st severe hem.rrhagic stroke subtype,with high m.rtality and *** cholesterol levels are associated with the risk of intracerebral ***,secondary pathological changes after intracerebral hem.rrhage are associated with cholesterol m.tabolism.dysregulation,such as neuroinflam.ation,dem.elination,and m.ltiple types of program.ed cell *** cholesterol accum.lation in the brain has been found after intracerebral *** this paper,we review norm.l cholesterol m.tabolism.in the central nervous system.the m.chanism. known to participate in the disturbance of cholesterol m.tabolism.after intracerebral hem.rrhage,and the links between cholesterol m.tabolism.and cell *** also review several possible and constructive therapeutic targets identified based on cholesterol m.tabolism.to provide cholesterol-based perspectives and a reference for those interested in the treatm.nt of intracerebral hem.rrhage.

关键词： cell death cholesterol m.tabolism intracerebral hem.rrhage m.elination therapeutic target

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