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Diagnosis and treatment of Gardner syndrome with gastric polyposis: A case report and review of the literature

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World Journal of Gastroenterology 2008年第13期14卷 2121-2123页

作者： Guo-Li Gu shi-lin Wang Xue-Ming Wei Li Bai Department of General Surgery the General Hospital of Chinese PLA Air Force Beijing 100036 China Department of Digestive Disease the General Hospital of Chinese PLA Air Force Beijing 100036 China

Gardner syndrome (GS) is an autosomal dominant disease characterized by the presence of colonic polyposis, osteoma and soft tissue tumors. It is regarded as a clinical subgroup of familial adenomatous polyposis (FAP) and may present at any age from 2 mo to 70 years with a variety of symptoms, either colonic or extracolonic. We present a case of a 23-year-old female patient with GS who presented with gastric polyposis and was successively treated with restorative proctocolectomy in combination with ileal pouch anal anastomosis (RPC/ IPAA), ileostomy, ileostomy closure operation, snare polypectomy during 8 mo. After operation, the patient took oral traditional Chinese medicine pills made of Fructus mume and Bombyx batryticatu for about 6 mo. The innutrition and anaemia of this patient were gradually improved. Gastroscopy showed that the remnant gastric polypi gradually decreased and finally disappeared 19 mo after the first operation. The patient had 2-3 times of solid stool per day at the time we wrote this paper.

关键词： Gardner syndrome Familial adenomatous polyposis Colectomy Ileal pouch anal anastomosis Stomach polyposis Hereditary nonpolyposis colorectalcancer

Effects of tachyplesin and n-sodium butyrate on proliferation and gene expression of human gastric adenocarcinoma cell line BGC-823

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World Journal of Gastroenterology 2006年第11期12卷 1694-1698页

作者： Song-lin shi Yong-Ye Wang Ying Liang Qi-Fu Li Laboratory of Cell Biology School of Life Science Xiamen University Xiamen361005 Fujian Province China The Key Laboratory of Chinese Ministry of Education for Cell Biology & Tumor Cell Engineering School of Life Science Xiamen University Xiamen 361005 Fujian ProvinceChina

AIM： To investigate the effects of tachyplesin and n-sodium butyrate on proliferation and gene expression of human gastric adenocarcinoma cell line BGC-823. METHODS： Effects of tachyplesin and n-sodium butyrate on proliferation of BGC-823 cells were determined with trypan blue dye exclusion test and HE staining. Effects of tachyplesin and n-sodium butyrate on cell cycle were detected by flow cytometry. Protein levels of c-erbB-2, c-myc, p53 and p16 were examined by immunocytochemistry. RESULTS： The inhibiting effects were similar after 2.0 mg/L tachyplesin and 2.0 mmol/L n-sodium butyrate treatment, the inhibitory rate of cellular growth was 62.66% and 60.19% respectively, and the respective maximum mitotic index was decreased by 49.35% and 51.69% respectively. Tachyplesin and n-sodium buD/rate treatment could markedly increase the proportion of cells at G0/G1 phase and decrease the proportion at S phase. The expression levels of oncogene c-erbB-2, c-myc, and mtp53 proteins were down-regulated while the expression level of tumor suppressor gene p16 protein was up-regulated after the treatment with tachyplesin or n-sodium buD/rate. The effects of 1.0 mg/L tachyplesin in combination with 1.0 mmol/L n-sodium butyrate were obviously superior to their individual treatment in changing cell cycle distribution and expression of c-erbB-2, c-myc, mtp53 and p16 protein. The inhibitory rate of cellular growth of BGC-823 cells after combination treatment was 62.29% and the maximum mitotic index wasdecreased by 51.95%. CONCLUSION： Tachyplesin as a differentiation inducer of tumor cells has similar effects as n-sodium butyrate on proliferation of tumor cells, expression of correlative oncogene and tumor suppressor gene. It also has a synergistic effect on differentiation of tumor cells.

关键词： Tachyplesin n-sodium butyrate Gastric adenocarcinoma cell Cell differentiation

New triterpenoid sapoin from Ardisia gigantifolia Stapf.

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Chinese Chemical Letters 2010年第4期21卷 449-452页

作者： Gong, Qiang Qiang Mu, Li Hua Liu, Ping Yang, shi lin Wang, Bo Feng, Yu lin Gen Hosp PLA Dept Clin Pharmacol Beijing 100853 Peoples R China JiangXi Univ Tradit Chinese Med Nanchang 330006 Peoples R China

One new triterpenoid sapoin with two known triterpenoid sapoins:3β-O-{α-L-rhamnopyranosyl-(1→3)-[β-D-xylopyranose-(1→2)]-β-D-glucopyranosyl-(1→4)-α-L-arabinopyranosyl}-3β-hydroxy-13β,28-epoxy-oleanan-16-oxo-30-al(1),3β-O-{α-L-rhamnopyranosyl-(1→3)-[(β-D-xylopyranosyl-(1→2)]-β-D-galactopyranosyl-(1→4)-[(β-D-glucopyranosyl-(1→2)]-α-L-ara-binopyranoside}-16α-hydroxy-13,28-epoxy-oleanane(2) and cyclamiretin A 3β-O-α-L-rhamnopyranosyl-(l→3)-[P-D-xylopyranosyl-(1→2)]-β-D-glucopyranosyl-(1→4)-[β-D-glucopyranosyl-(...

关键词： Ardisia gigantifolia Stapf. Myrsinaceae Triterpenoid sapoin

Doubly heavy tetraquarks in an extended chromomagnetic model

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Chinese Physics C 2022年第1期46卷 43-66页

作者： Xin-Zhen Weng Wei-Zhen Deng shi-lin Zhu Center of High Energy Physics Peking UniversityBeijing 100871China School of Physics and Astronomy Tel Aviv UniversityTel Aviv 69978Israel School of Physics and State Key Laboratory of Nuclear Physics and Technology Peking UniversityBeijing 100871China Collaborative Innovation Center of Quantum Matter Beijing 100871China

Using an extended chromomagnetic model,we perform a systematic study of the masses of doubly heavy *** find that the ground states of the doubly heavy tetraquarks are dominated by the color-triplet ■configuration,which is opposite to that of fully heavy *** combined results suggest that the color-triplet configuration becomes more important when the mass difference between the quarks and antiquarks *** find three stable states that lie below the thresholds of two pseudoscalar *** are the I^(P)=01^(+)nnbb tetraquark,I^(P)=1^(+)nncb tetraquark,and J^(P)=1^(+)nsbb tetraquark.

关键词： extended chromomagnetic model doubly heavy tetraquarks mass spectrum

Complete chloroplast genome of Salvia plebeia:organization, specific barcode and phylogenetic analysis

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Chinese Journal of Natural Medicines 2020年第8期18卷 563-572页

作者： CUI Ning LIAO Bao-Sheng LIANG Cong-Lian LI shi-Feng ZHANG Hao XU Jiang LI Xi-Wen Chen shi-lin College of Pharmacy Shandong University of Traditional Chinese MedicineJi’nan 250300China Institute of Chinese Materia Medica China Academy of Chinese Medical SciencesBeijing 100700China Central Laboratory Shandong Academy of Chinese MedicineJi’nan 250014China

Salvia plebeia has been in use as traditional Chinese medicine(TCM)for more than 500 *** this study,the complete chloroplast(cp)genome of *** was sequenced,assembled and compared to those of other five published Salvia cp *** was found that the cp genome structure of *** was well conserved and had a total size of 151062 *** parameters were used to display the usage conditions of the codons of the amino acids in Salvia *** the number of protein-coding genes in each species was the same,the total number of codons was *** for amino acids Trp and Met whose Relative Synonymous Codon Usage(RSCU)value of one condon was equal to 1,the remaining 19 amino acids had 1-3 preferred *** preferred codon names of each amino acid were *** period size for the tandem repeats of six species ranged from 9 to 410 *** cp genomes mainly possessed tandem repeats with a copy number less than or equal to *** sequence length of tandem repeats of the six species ranged from 25 to 824 *** viarable regions including four intergenic spacers and six partial genes were discovered as potential specific barcodes for Salvia species through cp genome-wide ***,we performed phylogenetic analyses based on the complete cp genome and coding sequences *** results provide information to help construct the cp genome library for Salvia,which may support studies of phylogenetics,DNA barcoding,population and transplastomics.

关键词： Simple sequence repeat Chloroplast Tandem repeats Microsatellites Barcode

Synthesis and mesomorphic properties of fluorinated Schiff's base liquid crystals containing vinyl end groups

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Journal of University of Science and Technology Beijing 2007年第4期14卷 373-377页

作者： Qiang Wei Siquan Zhu lin shi Lipei Zhang Xiaotao Yuan Hui Cao Huai Yang Materials Science and Engineering School University of Science and Technology Beijing Bcijing 100083 China Beijing Tongren Hospital Capital Medical University Beijing 100730 China

Three kinds of fluorinated Schiff＇s base esters, 4-allyloxy-2-X-6-X-benzoic acid 4-[（2, 3, 4-trifluorophenylimino）methyl]phenyl ester, where X=H or F, were synthesized and characterized. Their chemical structures were identified by Fourier transform infrared spectroscopy （FTIR） and ^1H nuclear magnetic resonance （^1H NMR）. Their mesomorphic properties were studied by polarized optical microscopy （POM） and differential scanning calorimetry （DSC）. It was found that all the three compounds exhibited enantiotropic nematic phases only. And their cleating point temperature and thermal range of mesophase decreased with the number of fluorine atoms on the rigid core of the compounds; while their melting point temperature showed no distinct regularity.

关键词： synthesis Schiff's base fluorinated liquid crystal vinyl end group

Two New Saponins from Lysimachia capillipes Hemsl.

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Journal of Integrative Plant Biology 2005年第10期47卷 1271-1275页

作者： Jing-Kui TIAN Zhong-Mei ZOU Li-Zhen XU shi-lin YANG Department of Chinese Medicine Sciences and Engineering Zhejiang University Hangzhou 310027 China Institute of Medicinal Plants Development Chinese Academy of Medical Sciences and Peking Union Medical College Beijing 100094 China

To investigate the saponins from whole plants of Lysimachia capilUpes Hemsl., two new saponins, named capilliposide E （1） and capilliposide F （2）, were isolated. The structures of the new saponins were elucidated as 3β, 22α-dihydroxy-16α-acetat-28→ 13-lactone-oleanane-3-O- [β-D-glucopyranosyl- （1 →2）-α-L-arabinpyranoyl]-22-O-β-D-glucopyranoside （1） and 3β, 22α-dihydroxy- 16α-acetat-28→ 13-lactone-oleanane-3-O-{ [β-D-glucopyranosyl-（1→2）-β-D-glucopyranosyl-（1→4）]-α-L-arabinpyranoyl}-22-O-β- D-glucopyranoside （2）. The structures of these compounds were determined by 1D- and 2D-NMR, MS techniques, and chemical methods.

关键词： capilliposide E and F, Lysimachia capillipes triterpene saponin.

New Cytotoxic Saponins from Lysimachia davurica Ledeb.

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Journal of Integrative Plant Biology 2006年第2期48卷 232-235页

作者： Jing-Kui Tian Zhong-Mei Zou Li-Zhen Xu shi-lin Yang Department of Chinese Medicine Sciences and Engineering Zhejiang University Hangzhou 310028 China Institute of Medicinal Plants Development Chinese Academy of Medical Sciences and Peking Union Medical College Beijing 100094 China

To investigate the saponins from whole plants of Lysimachia davurica Ledeb., two new saponins named davuricoside I （compound 1） and E （compound 2） were isolated. Their chemical structures were elucidated as 3β, 16α, 28, 29-tetrihydroxy-olean-12-en-3-O-β-D-glucopyranosyl-（1→2）-β-D-glucuronopyranoside （compound 1） and 3β, 16α, 29-trihydroxy-13, 28-epoxy-oleanane-3-O-β-D-glucopyranosyl-（1→2）-β-D-glucuronopyranoside （compound 2） on the basis of their one- and two-dimensional nuclear magnetic resonance and mass spectrometry data, and chemical methods. Compound 1 showed significant cytotoxic activity against human A2780 cells.

关键词： davuricoside I and E Lysimachia davurica triterpene saponin.

DNA barcoding and rapid identification of the precious herb Herba Anoectochili

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Chinese Journal of Natural Medicines 2019年第10期17卷 738-745页

作者： HU Shuai-Jun HU Hao-Yu GAO Han LIU Xia CHEN shi-lin School of Chemistry Chemical Engineering and Life SciencesWuhan University of TechnologyWuhan 430070China Institute of Chinese Materia Medica China Academy of Chinese Medical SciencesBeijing 100700China

Herba Anoectochili is a commonly used medicinal material. However, its adulteration is a serious concern. Due to the similar morphological characteristics of Herba Anoectochili and its adulterants, traditional identification techniques often fail to distinguish between them accurately, which is not conducive to the circulation management and safety of the medicinal materials. To improve the distinction between Herba Anoectochili and its adulterants accurately, this study identified 41 Herba Anoectochili and its adulterant samples based on the ITS2 sequence. Sequence characteristics, Basic Local Alignment Search Tool(BLAST) application, genetic distance, construction of phylogenetic tree, secondary structure prediction, and other methods showed the ITS2 sequence to accurately identify Herba Anoectochili from its adulterants. Furthermore, in this study, we designed a specific primer, based on the ITS2 sequence, and established a real-time PCR detection system for the rapid, sensitive, and specific identification of the original plant of Herba Anoectochili. Compared to DNA barcoding technology, this method has shorter detection time, stronger specificity, and higher sensitivity, which lays the foundation for the rapid identification of Herba Anoectochili.

关键词： Herba Anoectochili ITS2 DNA barcode Real-time PCR Rapid identification