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基于自噬途径探讨补阳还五汤合抵挡汤改善尿酸性肾病大鼠肾脏损伤的作用机制

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中华中医药杂志 2024年第8期39卷 3989-3995页

作者：范丽妃郭玉琴林敏翁曼华鲁玉辉福建中医药大学中医学院福州350122

目的:探讨补阳还五汤合抵挡汤对尿酸性肾病(UAN)大鼠肾脏纤维化的治疗效果及相关作用机制。方法:48只雄性SPF级SD大鼠适应喂养1周后,随机分为空白对照组,模型组,别嘌醇组,补阳还五汤合抵挡汤高、中、低剂量组,每组8只。采用腺嘌呤(100 m... 详细信息

目的:探讨补阳还五汤合抵挡汤对尿酸性肾病(UAN)大鼠肾脏纤维化的治疗效果及相关作用机制。方法:48只雄性SPF级SD大鼠适应喂养1周后,随机分为空白对照组,模型组,别嘌醇组,补阳还五汤合抵挡汤高、中、低剂量组,每组8只。采用腺嘌呤(100 mg/kg)联合氧嗪酸钾(300 mg/kg)混悬液灌胃建立UAN大鼠模型,造模同时各给药组分别给予别嘌醇(5 mg/kg)和补阳还五汤合抵当汤高、中、低剂量(3.46、1.73、0.87 g/kg)灌胃,连续21 d。观察各组大鼠体质量、肾脏质量及肾脏指数等;检测血尿酸(SUA)、血肌酐(Scr)、尿素氮(BUN)及24 h尿微量白蛋白(24h mAlb)水平;HE染色观察肾组织病理变化,Masson染色观察肾脏胶原阳性面积占比情况,免疫组织化学染色检测肾组织CD68、α-平滑肌肌动蛋白(α-SMA)表达情况;实时荧光定量PCR检测肾组织自噬标志蛋白LC3-Ⅱ、Beclin-1、P62基因表达;Western Blot检测自噬标志蛋白LC3-Ⅱ/LC3-Ⅰ比值、Beclin-1、P62蛋白表达。结果:与空白对照组比较,模型组大鼠体质量显著降低(Plin-1基因与蛋白表达显著升高(Plin-1基因与蛋白表达显著降低(Plin-1、P62异常表达有关。

关键词：补阳还五汤合抵挡汤尿酸性肾病肾脏损伤自噬途径机制

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高原含氧柴油燃料研究现状

现代化工 2024年第2期44卷 62-66页

作者：杨修政夏鑫蔺建民杨鹤赵杰李妍中石化石油化工科学研究院有限公司北京100083

高原的低压条件造成柴油燃烧性能下降,导致柴油机出现动力性不足等问题。在柴油中加入醇类燃料、醚类燃料、酯类燃料等含氧燃料,可以在不改变柴油机结构的情况下改善柴油机在高原环境下的使用性能。对上述含氧柴油燃料在柴油发动机中的... 详细信息

高原的低压条件造成柴油燃烧性能下降,导致柴油机出现动力性不足等问题。在柴油中加入醇类燃料、醚类燃料、酯类燃料等含氧燃料,可以在不改变柴油机结构的情况下改善柴油机在高原环境下的使用性能。对上述含氧柴油燃料在柴油发动机中的燃烧特性、动力性和经济性等方面进行对比,结果表明,在高原环境下,含醇柴油会导致发动机滞燃期延长,且脂肪醇的碳数越少影响越严重;含醚柴油缩短滞燃期,但热值较低;含酯柴油凝点较高,难以在高原的低温环境条件下应用;复合型含氧柴油燃料或许能够综合含氧燃料的优点。新型高原含氧柴油燃料应关注聚醚、短链酯以及少量长链醇复合组分。

关键词：高原环境柴油机含氧柴油燃烧性能动力性经济性

Combined adaptive beamforming with space-time block coding for multi-antenna communications

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Science in China(Series F) 2008年第12期51卷 2062-2073页

作者： lin min LI min YANG LuXi LI Bin School of Information Science and Engineering Southeast University Nanjing 210096 China Nanjing Institute of Telecommunication Technology Nanjing 210007 China Huawei Technologies Co. Ltd. Shenzhen 518129 China

Aiming at the multi-antenna communication systems, a downlink transmit scheme combining adaptive beamforming （ABF） with space-time block coding （STBC） is first presented, which utilizes the maximization of the output mean signal-to-noise ratio （SNR） and the minimization of the symbol error rate （SER） upper bound of the three widely used modulations as the design criteria. Then, based on the moment generating function （MGF） and the Gauss-Chebyshev integration, a simple and accurate numerical method is presented to analyze the SER performance of the system with the new transmit scheme under the three commonly used modulations. Finally, computer simulation results demonstrate the effectiveness and superiority of the proposed strategy.

关键词： adaptive beamforming space-time block coding transmit scheme multi-antenna communication

锆/铪氧簇中硫原子导向的金属-配体协同高效催化胺氧化反应

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Science Bulletin 2024年第4期69卷 492-501页

作者：孙胜男牛倩林焦敏何莉玲石景文黄青刘江兰亚乾 School of Chemistry South China Normal UniversityGuangzhou 510006China College of Materials Science and Engineering Nanjing Forestry UniversityNanjing 210037China School of Chemistry and Materials Science Nanjing Normal UniversityNanjing 210023China

The performance applications(e.g.,photocatalysis)of zirconium(Zr)and hafnium(Hf)based complexes are greatly hindered by the limited development of their structures and the relatively inert metal *** this work,we constructed two ultrastable Zr/Hf-based clusters(Zr_(9)-TC4A and Hf_(9)-TC4A)using hydrophobic 4-tert-butylthiacalix[4]arene(H4TC4A)ligands,in which unsaturated coordinated sulfur(S)atoms on the TC4A^(4-)ligand can generate strong metal–ligand synergy with nearby active metal Zr/Hf *** a result,these two functionalized H4TC4A ligands modified Zr/Hf-oxo clusters,as catalysts for the amine oxidation reaction,exhibited excellent catalytic activity,achieving very high substrate conversion(>99%)and product selectivity(>90%).Combining comparative experiments and theoretical calculations,we found that these Zr/Hf-based cluster catalysts accomplish efficient amine oxidation reactions through synergistic effect between metals and ligands:(i)The photocatalytic benzylamine(BA)oxidation reaction was achieved by the synergistic effect of the dual active sites,in which,the naked S sites on the TC4A^(4-)ligand oxidize the BA by photogenerated hole and oxygen molecules are reduced by photogenerated electrons on the metal active sites;(ii)in the aniline oxidation reaction,aniline was adsorbed by the bare S sites on ligands to be closer to metal active sites and then oxidized by the oxygen-containing radicals activated by the metal sites,thus completing the catalytic reaction under the synergistic catalytic effect of the proximity metal–*** this work,the Zr/Hf-based complexes applied in the oxidation of organic amines have been realized using active S atom-directed metal–ligand synergistic catalysis and have demonstrated very high reactivity.

关键词： Zirconium/hafnium-oxo clusters Amine oxidation reaction Photocatalytic reaction Synergistic catalysis

Entanglement Capacity of Two-Qubit Unitary Operator with the Help of Auxiliary System

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Communications in Theoretical Physics 2007年第6期47卷 1029-1032页

作者： HU Bao-lin DI Yao-min Department of Physics Xuzhou Normal University Xuzhou 221116 China

The＇entanglement capacity of general two-qubit unitary operators is studied when auxiliary systems are allowed, and the analytical results based on linear entropy when input states are disentangled are given. From the results the condition for perfect entangler, α1 = α2 = π/4, is obtained. Contrary to the case without auxiliary system, the parameter α3 may play active role to the entanglement capacity when auxiliary systems are allowed.

关键词： unitary operator entanglement capacity linear entropy auxiliary system

Modified DM Models for Aging Networks Based on Neighborhood Connectivity

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Communications in Theoretical Physics 2008年第1期49卷 243-248页

作者： lin min WANG Gang CHEN Tian-Lun Department of Mathematics Ocean University of China Qingdao 266071 China First Institute of Oceanography State Oceanic Administration Qingdao 266061 China Department of Physics Nankai University Tianjin 300071 China

Two modified Dorogovtsev-Mendes （DM） models of aging networks based on the dynamics of connecting nearest-neighbors are introduced. One edge of the new site is connected to the old site with probability - kt^-α as in the DM＇s model, where the degree and age of the old site are k and t, respectively. We consider two cases, i.e. the other edges of the new site attaching to the nearest-neighbors of the old site with uniform and degree connectivity probability, respectively. The network structure changes with an increase of aging exponent α It is found that the networks can produce scale-free degree distributions with small-world properties. And the different connectivity probabilities lead to the different properties of the networks.

关键词： evolving networks aging neighborhood connectivity

Self-organized Criticality in an Integrate-and-Fire Neuron Model Based on Modified Aging Networks

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Communications in Theoretical Physics 2007年第4期47卷 759-764页

Based on an integrate-and-fire mechanism, we investigate self-organized criticality of a simple neuron model on a modified BA scale-free network with aging nodes. In our model, we find that the distribution of avalanche size follows power-law behavior. The critical exponent τ depends on the aging exponent α. The structures of the network with aging of nodes change with an increase of α. The different topological structures lead to different behaviors in models of integrate-and-fire neurons.

关键词： self-organized criticality avalanche aging

A Modified Earthquake Model Based on Generalized Barabási-Albert Scale-Free Networks

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Communications in Theoretical Physics 2006年第6X期46卷 1011-1016页

作者： lin min WANG Gang CHEN Tian-Lun Department of Mathematics Ocean University of China Qingdao 266071 China Institute of Oceanology the Chinese Academy of Sciences Qingdao 266071 China Graduate School the Chinese Academy of Sciences Beijing 100049 China Department of Physics Nankai University Tianjin 300071 China

A modified Olami-Feder-Christenaen model of self-organized criticality on generalized Barabási-Albert （GBA） scale-flee networks is investigated. We find that our mode/ displays power-law behavior and the avalanche dynamical behavior is sensitive to the topological structure of networks. Furthermore, the exponent ~ of the model depends on b, which weights the distance in comparison with the degree in the GBA network evolution.

关键词： self-organized criticality avalanche GBA scale-free networks

Identification of Eye Movements from Non-frontal Face Images for Eye-controlled Systems

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International Journal of Automation and computing 2014年第5期11卷 543-554页

作者： min lin Bin Li Qiao-Hong Liu School of Mechatronic Engineering and Automation Shanghai University Shanghai Medical Instrumentation College University of Shanghai Science and Technology

The novel eye-based human-computer interaction(HCI) system aims to provide people, especially, disabled persons,a new way of communication with surroundings. It adopts a series of continual eye movements as input to perform simple control activities. Identification of eye movements is the crucial technology in these eye-based HCI systems. At present, researches on eye movement identification mainly focus on frontal face images. In fact, acquisition of non-frontal face images is more reasonable in real applications. In this paper, we discuss the identification process of eye movements from non-frontal face images. Firstly, the original head-shoulder images of 0?–±60?azimuths are sampled without any auxiliary light source. Secondly, the non-frontal face region is detected by using the Adaboost cascade classifiers. After that, we roughly extract eye windows by the integral projection ***, we propose a new method to calculate the x- y coordinates of the pupil center point by searching the minimal intensity value in the eye windows. According to the trajectory of the pupil center points, different eye movements(eye moving left, right, up or down)are successfully identified. A set of experiments is presented.

关键词： Eye movement identification non-frontal face images pupil center localization human-computer interaction eye-based system