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Fine-tuning the spatial allocation of phytohormones for smart canopy, smart breeding, and smart agriculture

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Science China life Sciences 2025年第1期 309-310页

作者： Tao Zhou lin li National Key Laboratory of Crop Genetic Improvement Huazhong Agricultural University HuBei HongShan Laboratory

The dual challenges of global climate change and population growth have increased demand for higher crop yields per unit area. The innovative technology of smart agriculture aims to synergize breeding, cultivation, and production through the application of biological and informatics technologies. Historically, the “Green Revolution” introduced semidwarf varieties of certain key crops by utilizing mutations affecting gibberellin pathways, which significantly increased planting densities and yields.

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Mechanism of action of linggui Zhugan Decoction in treating non-alcoholic fatty liver disease using untargeted metabolomics approach

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Traditional Medicine Research 2025年第2期10卷 65-76页

作者： Huan Pei Ren-lin li Xin-Ran Song Qian-Qian Wan Yu-Ming Wang Han-Zhou li Wei-Quan Xu Jia-Bao liao Wei-Bo Wen Jing Miao Huan-Tian Cui School of Basic Medicine Yunnan University of Chinese MedicineKunming 650599China School Clinical Medical College Yunnan University of Chinese MedicineKunming 650599China First School of Clinical Medicine Yunnan University of Chinese MedicineKunming 650599China School of Integrative Chinese and Western Medicine Tianjin University of Traditional Chinese MedicineTianjin 301617China Department of Pharmacy Tianjin Second People's HospitalTianjin 300192China

Background:Non-alcoholic fatty liver disease(NAFLD)is a liver disorder characterized by the accumulation and degeneration of fat in the liver cells,a condition that may further deteriorate and lead to cirrhosis and liver *** studies showed that metabolic dysfunction can promote NAFLD *** Zhugan Decoction(LGZGD)has therapeutic effects on *** mechanism of LGZGD still remains *** study was to examine the impact of LGZGD on the metabolic processes involved in the development of ***:A mice model of NAFLD was treated with *** therapeutic potential of LGZGD was evaluated by assessing the activity of transaminases,lipids levels of blood,and pathological changes in the liver of the mice model of ***,this study also evaluated the influence of LGZGD on liver inflammation and oxidative ***:The results of untargeted metabolomics analysis showed that LGZGD reduced the disordered lipid metabolism in NAFLD *** improved the oxidative stress and also reduced the levels of pro-inflammatory cytokines in the *** metabolomics analysis of liver samples revealed that LGZGD treatment improved metabolic disorders,including alanine,aspartate,glutamate,glycerophospholipid metabolism,and citrate *** RT-qPCR and Western blot results showed that LGZGD could regulate the expression of key enzymes in the metabolic pathway of the citrate cycle,including ATP-citrate lyase(ACLY),alanine-glyoxylate aminotransferase-2(AGXT2),phosphatidylethanolamine N-methyltransferase(PEMT),and succinate dehydrogenase(SDH).Conclusion:We found that LGZGD can treat NAFLD by reducing inflammatory responses,inhibiting oxidative stress,regulating alanine,aspartate,glutamate,and glycerophospholipid metabolism,and citrate cycle pathways.

关键词： NAFLD LGZGD untargeted metabolomics glycerophospholipid metabolism citrate cycle

Deciphering the role of mtH2O2 in hepatic ischemia-reperfusion injury mechanisms with low-background super-resolution fluorogenic probe

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Science China Chemistry 2025年第1期 297-307页

作者： Bin Fang limin Wang Haoqin li Jiaxin Zhang Yang Ding Pan Pan li Bo Peng Hua Bai lin li Frontiers Science Center for Flexible Electronics Xi'an Institute of Flexible Electronics (IFE) and Xi'an Institute of Biomedical Materials &Engineering Northwestern Polytechnical University Institute of Flexible Electronics (IFE Future Technologies) Xiamen University

Hepatic ischemia-reperfusion injury（HIRI） is characterized by mitochondrial dysfunction and oxidative stress. Monitoring mitochondrial hydrogen peroxide（mtH2O2） levels in real-time through super-resolution imaging is crucial for elucidating its distribution in live cells and its mechanism of action during HIRI. However, low-background fluorogenic probes have been overlooked in the context of super-resolution imaging. In this study, we developed a low-background fluorogenic probe（MitoWG） with the potential for super-resolution morphology-correlated mitochondrial identification to track the fluctuates of mtH2O2in HIRI. Activation of the desirable fluorescence properties of the probe by mtH2O2was confirmed using structural illumination microscopy（SIM）, enabling high-quality mitochondrial imaging with exceptional specificity and *** in mtH2O2levels were successfully observed in both cellular and rat models of HIRI. Furthermore, we associated the decline in mitochondrial redox homeostasis with accelerated mtH2O2production during HIRI, which triggered mitophagy deficiency and led to cell death. In conclusion, Mito-WG possesses excellent photophysical and low-background properties for SIM imaging, making it a promising tool for mtH2O2tracking in HIRI research and clinical diagnosis.

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Stabilization for Discrete-Time Stochastic Systems with Multiple Input Delays

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Journal of Systems Science & Complexity 2023年第5期36卷 1961-1980页

作者： li lin ZHANG Huanshui College of Mechanical and Electronic Engineering Shandong Agricultural UniversityTaian 271018China School of Information Science and Engineering Shandong Agricultural UniversityTaian 271018China College of Electrical Engineering and Automation Shandong University of Science and TechnologyQingdao 266590China

A stabilization problem for stochastic systems with multiple input delays is investigated herein.A new method to construct an optimal control problem with input constraints is adopted.A sufficient stabilization condition is established via Riccati-type equations,whose verification is computationally simple because the variable dimension of the equations does not increase with regard to the delay.A stabilization controller is proposed,and it is a feedback of the state and a history *** controller uses less history information than those with distributed *** numerical examples illustrate the effectiveness of the obtained results.

关键词： Riccati-type equations stabilization stochastic systems time-delay systems

VOC emitted by biopharmaceutical industries:Source profiles,health risks,and secondary pollution

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Journal of Environmental Sciences 2024年第1期135卷 570-584页

作者： Jiawei Ma lin li State Key Laboratory of Environmental Aquatic Chemistry Research Center for Eco-Environmental SciencesChinese Academy of SciencesBeijing 100085China University of Chinese Academy of Sciences Beijing 100049China National Engineering Laboratory for VOCs Pollution Control Material&Technology University of Chinese Academy of SciencesBeijing 101408China

The biopharmaceutical industry contributes substantially to volatile organic compounds(VOCs)emissions,causing growing concerns and social developmental *** study conducted an on-site investigation of the process-based emission of VOCs from three biopharmaceutical *** the workshops of the three enterprises,26 VOCs were detected,which could be sorted into 4 classes:hydrocarbons,aromatic hydrocarbons,oxygen-containing compounds,and nitrogen-containing *** were the main components of waste gases,accounting for 44.13%-77.85%of the overall ***-based source profiles were compiled for each process unit,with the fermentation and extraction units of tiamulin fumarate being the main source of VOC *** heptanone,vinyl acetate,diethylamine,propylene glycol methyl ether(PGME),and benzene were screened as priority pollutants through a fuzzy comprehensive evaluation *** level concentration simulation results of the Gauss plume diffusion model demonstrated that the diffusivity of VOCs in the atmosphere was relatively high,indicating potential non-carcinogenic and carcinogenic risks 1.5-2 km ***,the process-based formation potentials of ozone and secondary organic aerosols(SOAs)were determined and indicated that N-methyl-2-pyrrolidone,dimethyl heptanone,and PGME should be preferentially controlled to reduce the ozone formation potential,whereas the control of benzene and chlorobenzene should be prioritized to reduce the generation of *** results provide a basis for understanding the characteristics of VOC emission by biopharmaceutical industries and their diffusion,potentially allowing the development of measures to reduce health risks and secondary pollution.

关键词： Biopharmaceutical Volatile organic compound Priority pollutant Exposure risk Secondary pollution

Adaptive Leader-Follower Consensus Control of Multiple Flexible Manipulators With Actuator Failures and Parameter Uncertainties

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IEEE/CAA Journal of Automatica Sinica 2023年第4期10卷 1020-1031页

作者： Yu liu lin li School of Automation Science and Engineering South China University of TechnologyGuangzhou 510640 Research and Development Center of Precision Electronic Manufacturing Technology Guangzhou Institute of Modern Industrial TechnologyGuangzhou 511458China

In this paper,the leader-follower consensus problem for a multiple flexible manipulator network with actuator failures,parameter uncertainties,and unknown time-varying boundary disturbances is *** purpose of this study is to develop distributed controllers utilizing local interactive protocols that not only suppress the vibration of each flexible manipulator but also achieve consensus on joint angle position between actual followers and the virtual *** the accomplishment of the reconstruction of the fault terms and parameter uncertainties,the adaptive neural network method and parameter estimation technique are employed to compensate for unknown items and bounded ***,the Lyapunov stability theory is used to demonstrate that followers’angle consensus errors and vibration deflections in closed-loop systems are uniformly ultimately ***,the numerical simulation results confirm the efficacy of the proposed controllers.

关键词： Actuator failures leader-follower consensus multiple flexible manipulators neural network parameter uncertainties

Quantifying TiO_2 Abundance of Lunar Soils:Partial Least Squares and Stepwise Multiple Regression Analysis for Determining Causal Effect

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Journal of Earth Science 2011年第5期22卷 549-565页

作者： lin li Department of Earth Sciences Indiana University-Purdue University Indianapolis IN 46202 USA

Partial least squares （PLS） regression was applied to the Lunar Soft Characterization Consortium （LSCC） dataset for spectral estimation of TiO2. The LSCC dataset was split into a number of subsets including the low-Ti, high-Ti, total mare soils, total highland, Apollo 16, and Apollo 14 soils to investigate the effects of interfering minerals and nonlinearity on the PLS performance. The PLS weight loading vectors were analyzed through stepwise multiple regression analysis （SMRA） to identify mineral species driving and interfering the PLS performance. PLS exhibits high performance for estimating TiO2 for the LSCC low-Ti and high-Ti mare samples and both groups analyzed together. The results suggest that while the dominant TiO2-bearing minerals are few, additional PLS factors are required to compensate the effects on the important PLS factors of minerals that are not highly corrected to TiO2, to accommodate nonlinear relationships between reflectance and TiO2, and to correct inconsistent mineral-TiO2 correlations between the high-Ti and iow-Ti mare samples. Analysis of the LSCC highland soil samples indicates that the Apollo 16 soils are responsible for the large errors of TiO2 estimates when the soils are modeled with other subgroups. For the LSCC Apollo 16 samples, the dominant spectral effects of plagioclase over other dark minerals are primarily responsible for large errors of estimated TiO2. For the Apollo 14 soils, more accurate estimation for TiO2 is attributed to the posi- tive correlation between a major TiOe-bearing component and TiO2, explaining why the Apollo 14 soils follow the regression trend when analyzed with other soils groups.

关键词： lunar soils LSCC dataset TiO2 abundance partial least squares stepwise multiple regression.

RAGE on the Toll Road?

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Cellular & Molecular Immunology 2006年第5期3卷 351-358页

作者： li lin Laboratory of Cardiovascular Sciences National Nathan Shock Drive Baltimore Maryland 21224 Institute on Aging 5600 USA Laboratory of Cardiovascular Sciences National Institute on Aging 5600 Nathan Shock Drive Baltimore Maryland 21224 USA

Mammalian Toll-like receptors （TLRs） are cellular pattern-recognizing receptors （PRRs） that recognize the molecular patterns of pathogens. After engaging the pathogenic patterned ligands, the cytosolic portion of the TLRs in monocytes and macrophages, recruits adaptor proteins, via a receptor-driven signaling cascade, activates the transcription factor NF-kB, leading to the expression of proinflammatory cytokines, which trigger inflammation. Such rapid, innate cellular responses serve as the first line of host defense against infection by pathogens, and also stimulate the adaptive immune system to clear the invading microbes. Increasing evidence suggests that TLRs also recognize host-derived ligands, linking this group of PRRs to diseases that may not have an etiology that is associated directly with infections. Advanced glycation end products （AGEs） are nonenzymatically glycated or oxidated proteins, lipids and nucleic acids that are formed in the environment of oxidant stress and hyperglycemia. Binding of AGEs to their receptor RAGE initiates cellular signals that activate NF-kB, which results in transcription of proinflammatory factors. RAGE can also interact with other endogenous ligands generated by cell death and tissue injuries. RAGE has been implicated in chronic diseases such as diabetes, atherosclerosis, neurodisorders, cancers, as well as aging. This review discusses the possible role of RAGE as a PRR that may use signaling mechanisms parallel to TLRs＇, to solicit inflammatory reactions. Thus, in this scenario, RAGE may play a prominent role in the regulation of cellular homeostasis in the context of complex disease progression. Cellular ＆ Molecular Immunology.

关键词： TLR RAGE NF-kB innate immunity inflammation noncanonical toll

Segmentation of the Ventricle Membranes in Short-Axis Sequences by Optical Flow Base on DLSRE Model

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Chinese Journal of Electronics 2021年第3期30卷 460-470页

作者： li lin WU Hengfei li Junhua Department of Electronics and Information Engineering Bozhou University Key Laboratory of Jiangxi Province for Image Processing and Pattern Recognition Nanchang Hangkong University

Recent studies have pointed out that the boundary of the extracted ventricle membranes is unsmooth, and the segmentation of the cardiac papillary muscle and trabecular muscle do inconformity the clinical requirements. To address these issues, this paper proposes an automatic segment algorithm for continuously extracting ventricle membranes boundary, which adopts optical flow field information and sequential images information. The images are cropped by frame difference method, which according to the continuity of adjacent slices of cardiac MRI images. The roughly boundary of epicardium is extracted by the Double level set region evolution(DLSRE) model, which combines image global information, local information and edge information. The ventricle endocardium and epicardial contours are tracked according to the optical flow field information between image sequences. The segmentation results are optimized by Delaunay triangulation algorithm. The experimental results demonstrate that the proposed method can improve the accuracy of segmenting the ventricle endocardium and epicardium contours, and segment the contour of the smooth ventricle membrane edge that meets the clinical definition.

关键词： edge information image sequences automatic segment algorithm sequential images information clinical requirements medical image processing cardiology optical flow base extracted ventricle membranes roughly boundary local information ventricle endocardium trabecular muscle optical flow field information continuously extracting ventricle membranes boundary DLSRE model biomedical MRI smooth ventricle membrane edge image global information mesh generation muscle short-axis sequences cardiac MRI images image segmentation cardiac papillary muscle frame difference method region evolution model