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Prevalence and incidence of heart failure among community in China during a three-year follow-up

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Journal of Geriatric Cardiology 2023年第4期20卷 284-292页

作者： Lu FU Jun-Rong JIANG Wei-dong lin Hui-Yi LIU Shu-Yu JIN Xing-dong YE Yan-lin CHEN Si-Jia PU Yang LIU Shang-Fei HE Shu-lin WU Hai DENG Yu-Mei XUE Department of Cardiology Guangdong Cardiovascular InstituteGuangdong Provincial People’s HospitalGuangdong Academy of Medical SciencesGuangzhouChina The Second School of Clinical Medicine Southern Medical UniversityGuangzhouChina School of Medicine South China University of TechnologyGuangzhouChina Department of Cardiology the First Affiliated Hospital of Guangzhou Medical UniversityGuangzhouChina Guangdong Provincial Key Laboratory of Clinical Pharmacology Research Center of Medical SciencesGuangdong Provincial People’s HospitalGuangdong Academy of Medical SciencesGuangzhouChina Qinghai Province Cardio Cerebrovascular Disease Specialist Hospital XiningChina

BACKGROUND Epidemiological surveys on heart failure(HF)in Chinese community are relatively *** study aimed to estimate the prevalence and incidence of HF among community residents in southern *** Baseline data of this prospective study was collected from 2015 to 2017 among 12,013 permanent residents aged≥35years in Guangzhou,*** same survey process was carried out for individuals aged≥65 years after a three-year *** The overall prevalence of HF in community residents aged≥35 years was 1.06%.Male had significantly higher risk of HF prevalence[odds ratio(OR)=1.50,P=0.027].The gender-adjusted risk of HF was 1.48 times higher per 10 years *** prevalence was statistically associated with atrial fibrillation,valvular heart disease,hypertension and chronic obstructive pulmonary disease after adjusting for age and gender(OR=8.30,5.17,1.11,2.28,respectively;all P<0.05).HF incidence in individuals aged≥65 years were 847 per 100,000 *** atrial fibrillation,valvular heart disease,and diabetes mellitus were risk factors for HF incidence for individuals aged≥65 years adjusting for age and gender(OR=5.05,3.99,2.11,respectively;all P<0.05).Besides,residents with new-onset atrial fibrillation and myocardial infarction were at significantly higher risk of progression to HF(OR=14.41,8.54,respectively;all P<0.05).CONCLUSIONS Both pre-existing and new-onset cardiovascular diseases were associated with HF incidence in southern *** of related cardiovascular diseases may be helpful to reduce the incidence of HF.

关键词： prevalence cardiovascular incidence

CRISPR/Cas9-mediated PBP1 and PBP3 mutagenesis induced significant reduction in electrophysiological response to sex pheromones in male Chilo suppressalis

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Insect Science 2019年第3期26卷 388-399页

作者： Xiao-Tong dong Hui Liao Guan-Heng Zhu Sajjad Ali Khuhro Zhan-Feng Ye Qi Yan Shuang-lin dong College of Plant Protection Nanjing Agricultural University/Key Laboratory of Integrated Management of Crop Diseases and Pests Ministry of Education Nanjing China

Pheromone-binding proteins (PBPs) are thought to bind and transport sex pheromones onto the olfactory receptors on the dendrite membrane of olfactory neurons, and thus play a vital role in sex pheromone perception. However, the function of PBPs has rarely been demonstrated in *** this study, two PBPs (PBP1 and PBP3) of Chilo suppressalis, one of the most notorious pyralid pests, were in vivo functionally characterized using insects with the PBP gene knocked out by the CRISPR/Cas9 system. First, through direct injection of PBP-single guide RNA (sgRNA)/Cas9 messenger RNA into newly laid eggs, a high rate of target-gene editing (checked with polled eggs) was induced at 24 h after injection, 21.3% for PBPl-sgRNA injected eggs and 19.5% for PBP3-sgRNA injected eggs. Second, by an in-crossing strategy, insects with mutant PBP1 or PBP3 (both with a premature stop codon) were screened and homozygous mutants were obtained in the G3 generation. Third, the mutant insects were measured for electroantennogram (EAG) response to female sex pheromones. As a result, both PBP mutant males displayed significant reduction in EAG response, and this reduction in PBP1 mutants was higher than that in PBP3 mutants, indicating a more important role of PBP1. Finally, the relative importance of two PBPs and the possible off target effect induced by sgRNA-injection are discussed. Taken together, our study provides a deeper insight into the function of and interaction between different PBP genes in sex pheromone perception of C. suppressalis, as well as a valuable reference in methodology for gene functional study in other genes and other moth species.

关键词： CRISPR/Cas9 system electroantennogram pheromone binding protein sex pheromone striped stem borer

Structures and Properties of 1,2,3-Triazoles and 1,2,4-Triazoles

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Chinese Journal of Structural Chemistry 2006年第5期25卷 582-588页

作者： LU Ya-lin GONG Xue-dong JU Xue-Hai JI Guang-Fu XIAO He-Ming School of Chemical Engineering Nanjing University of Science and Technology Nanjing 210094 China

In this paper, the fully optimized molecular geometries and electronic structures of six 1,2,3- and 1,2,4-triazoles were calculated using density functional theory B3LYP/6-311G^＊＊ method. The salvation energies were obtained by SCRF in THF. The results show that the total energies of F are the lowest both in gas and liquid phases, and the order of thermodynamic stabilities of the title compounds is F〉D〉C〉B〉E〉A. Their frontier orbital energy gaps and electron delocalization also support that F is the most stable. All the computed conclusions are in good agreement with the experiments. Vibrational frequencies of the title compounds were computed. The thermodynamic properties and their temperature curves of six compounds were obtained by using the statistical thermodynamic method with the temperature ranging from 200 to 1000 K.

关键词： triazoles DFT stabilities IR thermodynamic properties

Theoretical Studies on Intermolecular Interactions of 4-Amino-5-nitro-1,2,3-triazole Dimers

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Chinese Journal of Structural Chemistry 2006年第8期25卷 1004-1010页

作者： LU Ya-lin GONG Xue-dong JU Xue-Hai MA Xiu-Fang XIAO He-Ming School of Chemical Engineering Nanjing Universityof Science and Technology Nanjing 210094 China

Seven optimized configurations and their electronic structures of 4-amino-5-nitro- 1,2,3-triazole dimers on their potential energy surface have been obtained by using density functional theory （DPT） method at the B3LYP/6-311＋＋G＊＊ level. The maximum intermolecular interaction energy is -35.42 kJ/mol via the basis set superposition error-correction （BSSE） and zero point energy-correction （ZPE）. Charge transfers between the two subsystems are small. The vibration analysis of optimized configurations was performed, and the thermodynamic property changes from monomer to dimer have been obtained with the temperature ranging from 200 to 800 K on the basis of statistical thermodynamics. It is found that the hydrogen bonds contribute to the dimers dominantly, and the extent of intermolecular interaction is mainly determined by the hydrogen bonds＇ strength rather than their number. The dimerization processes of Ⅳ, Ⅴand Ⅵ can occur spontaneously at 200 K.

关键词： 4-amino-5-nitro-1,2,3-triazole intermolecular interaction density functional theory thermodynamic properties

Extended Power Law Nonlinear Response and Amplitude-Dependent ac Susceptibility of High-To Superconductors

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Chinese Physics Letters 2004年第7期21卷 1340-1343页

作者： NINGZhen-Hua CHENKai-Xuan YINLan LUGuo XUXiao-lin GUOjian-dong WANGFu-Ren YINDao-Le DepartmentofPhysics PekingUniversityBelting100871

We show a nonlinear materials equation of superconductors in the form of an extended power law which can be derived from the Ginzburg–Landau (GL) functional. The critical current Jc and ac susceptibility χ are analysed by using this equation, and the puzzling question of the increasing height of the out-of-phase susceptibility peak χ''peak with increasing amplitude hac is explained.

关键词： Magnetic susceptibility

Experimental studies on oxidizing removal of Cyclops of zooplankton

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High Technology Letters 2006年第1期12卷 86-90页

作者：刘冬梅 Cui Fuyi lin Tao An dong Zhang Min School of Municipal ＆ Environmental Engineering Harbin Institute of Technology Harbin 150090 P.R. China

The inactivation of Cyclops with currently available oxidants such as chlorine, chlorine dioxide, ozone and potassium permanganate was investigated and reported under various working conditions of different oxidant dosage, organic substance content and pH value. The removal efficiency of Cyclops by predosing chlorine dioxide in water treatment process was comprehensively compared with that of the conventional prechlorination process. The results showed that chlorine dioxide might be most effective to inactivate Cyclops than other oxidants and its effect was less influenced by external conditions. Cyclops could be effectively inactivated by chlorine dioxide preoxidation and be thoroughly removed from water by chlorine dioxide preoxidation cooperating with routine clarification process, i.e. flocculation, sedimentation and filtration.

关键词： Cyclops of zooplankton water treatment oxidant removal

Clinical efficacy of ultrasound-guided pulsed radiofrequency combined with ganglion impar block for treatment of perineal pain

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World Journal of Clinical Cases 2021年第9期9卷 2153-2159页

作者： Shui-Qing Li ling Jiang Li-Gang Cui dong-lin Jia Department of Algology Peking University Third HospitalBeijing 100191China Department of Ultrasound Peking University Third HospitalBeijing 100191China

BACKGROUND Ganglion impar block alone or pulsed radiofrequency alone are effective options for treating perineal ***,ganglion impar block combined with pulsed radiofrequency(GIB-PRF)for treating perineal pain is rare and the puncture is usually performed with X-ray or computed tomography *** To evaluate the safety and clinical efficacy of real-time ultrasound-guided GIBPRF in treating perineal *** Thirty patients with perineal pain were included and were treated by GIB-PRF guided by real-time ultrasound imaging between January 2015 and December *** were recorded to observe the safety of the ultrasound-guided GIB-PRF procedure,and visual analogue scale(VAS)scores at 24 h before and after treatment and 1,3,and 6 mo later were analyzed to evaluate clinical *** Ultrasound-guided GIB-PRF was performed successfully in all patients,and no complications *** with pretreatment scores,the VAS scores were significantly lower(P0.05)and were significantly lower at 6 mo after treatment(P0.05).CONCLUSION Ultrasound-guided GIB-PRF was a safe and effective way to treat perineal *** 6-mo short-term clinical efficacy was favorable,but the long-term outcomes need future study.

关键词： Ganglion impar Perineal pain Pulsed radiofrequency Real-time ultrasound guidance

Continuous Cooling Transformation Behavior and Kinetic Models of Transformations for an Ultra-Low Carbon Bainitic Steel

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Journal of Iron and Steel Research International 2012年第12期19卷 73-78页

作者： ZHANG Zhi-min CAI Qing-wu YU Wei LIXiao-lin WANG Li-dong Metallurgical Engineering Research Institute University of Science and Technology Beijing Beijing 100083 China

The aim was to investigate transformation behavior and transformation kinetics of an ultra-low carbon bai- nitic steel during continuous cooling. Continuous cooling transformation （CCT） curves of tested steel were measured by thermal dilatometer and metallographic structures at room temperature were observed by optical microscope. Then transformation kinetic equation of austenite to ferrite as well as austenite to bainite was established by analyzing the relationship of lnln]-l/（1--f）] and lnt in the kinetic equation on the basis of processed experimental data. Finally, the measured and calculated kinetic behaviors of the steel during continuous cooling were compared and growth pat- terns of transformed ferrite and bainite were analyzed. Results showed that calculated result was in reasonable agree- ment with the experimental data. It could be concluded that the growth modes of transformed ferrite and bainite were mainly one dimension as the Avrami exponents were between 1 and 2.

关键词： ultra low carbon bainitic steel continuous cooling transformation kinetics Avrami equation

Two novel aconane-type diterpenes derived from C-nor-C_(19)-diterpenoid alkaloid

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Chinese Chemical Letters 2009年第4期20卷 431-434页

作者： Xiang Li Shen Qiao Hong Chen dong lin Chen Feng Peng Wang Department of Chemistry of Medicinal Natural Products West China College of Pharmacy Sichuan University Chengdu 610041 China Second Hospital of Sichuan University Chengdu 610041 China

Two novel C-nor-B-homo aconane-type diterpenes 4 and 5, featuring a unique eight-membered ring system, were obtained by the treatment of C-nor-C19-diterpenoid alkaloid 3 with HNO2 in 8% and 21% yields, respectively. Structures of these two compounds were established based on the combination of spectroscopic data, including HRESIMS, 1D and 2D NMR data. A olausible mechanism for the formation of 4 and 5 is also presented.

关键词： C19-diterpenoid alkaloid C-nor-B-homo-aconane Rearrangement Imine