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Conformationally Dynamic Supramolecular Single Chain Nanogels for Mutilscale Biomechanical Regulation of Stem Cells

医用生物力学 2019年第A1期34卷 150-151页

作者： liming bian Department of Biomedical Engineering The Chinese University of Hong Kong

Objective The binding of cell adhesive peptides(such as RGD)to integrins initiates the recruitment of cytoplasmic adaptor proteins(e.g.,vinculin)and the formation of focal adhesion(FA)complexes required for cell *** ability to manipulate this ligand-mediated cell adhesion process is crucial for regulating cell migration,cell differentiation,injury healing,and immune *** recent studies reported the importance of the tether length/mobility of the cell adhesive ligands in regulating the traction force development of *** the native cellular microenvironment,such a dynamic change in the nanoscale tether length of bioactive ligands is often mediated by conformational changes of the structural proteins due to protein folding or ***,no prior studies have demonstrated the modulation of the ligand tether mobility by controlling the intramolecular folding of polymeric *** synthetic macromolecules with easy synthetic routes and controllable structures,such as supramolecular host-guest single chain nanogels(SCNGs),are ideal candidates for mimicking the changes in the tether mobility of bioactive ligands via biorthogonal *** S,S’-bis(a’a’-dimethyl-a’’-propargyl acetate)trithiocarbonate was first used to mediate the RAFT polymerization of N,N-dimethyl acrylamide,vinyl-adamantane and vinyl-β-cyclodextrin to yield the ADA@*** preparation of the unfoldable host-guest SCNGs was evidenced by the by gel permeation chromatography,proton nuclear magnetic resonance spectroscopy,atomic force microscopy and dynamic light *** the RGD peptide was conjugated to the alkynyl group on one end of the SCNGs before immobilizing the material on the substrate,which was confirmed by scanning electron microscopy(SEM).The regulation of cell behaviours by unfolding of the SCNG-RGD was confirmed by immunofluorescence staining of vinculin and Yes-associated protein(YAP).Results The preparation of ADA@CD-SCNGs was confirm

关键词： Single Chain Nanogels Mutilscale Biomechanical Regulation Stem Cells

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Energy-Dissipative Hydrogels:A Promising Material for Tissue Regeneration

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Chinese Journal of Chemistry 2023年第20期41卷 2697-2714页

作者： Mingrui Li Youshi Lin Yuxiao Zhang liming bian Kunyu Zhang School of Biomedical Sciences and Engineering South China University of TechnologyGuangzhou International CampusGuangzhouGuangdong511442 China National Engineering Research Center for Tissue Restoration and Reconstruction South China University of TechnologyGuangzhouGuangdong510006 China Guangdong Provincial Key Laboratory of Biomedical Engineering South China University of TechnologyGuangzhouGuangdong510006 China Key Laboratory of Biomedical Materials and Engineering of the Ministry of Education South China University of TechnologyGuangzhouGuangdong510006 China

Hydrogels are promising candidates for mimicking native extracellular matrix(ECM)and are therefore widely adopted as scaffolds in tissue ***,conventional hydrogels composed of static networks are prone to permanent structural damages and lack the ability to provide the time-dependent mechanical cues,which are essential for cell development,ECM remodeling,and tissue *** recent substantial development in the structurally dynamic hydrogels with energy-dissipative ability has demonstrated the unique capability of such viscoelastic hydrogels to withstand extreme biomechanical loads and regulate cellular behaviors not present in classical *** review starts with the general design principles for energy-dissipative hydrogels,followed by recent advancements in fabrication approaches for energy-dissipative *** then highlight some applications of energy-dissipative hydrogels in tissue engineering,including bone and cartilage regeneration,vessel regeneration,nerve regeneration,and wound ***,we discuss about the key current challenges and future development of energy-dissipative hydrogels for biomedical applications.

关键词： Hydrogels Energy dissipation Interchain interactions Tissue engineering Crosslinking Supramolecular chemistry Viscoelasticity

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High-throughput phenotyping of plant leaf morphological, physiological,and biochemical traits on multiple scales using optical sensing

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The Crop Journal 2023年第5期11卷 1303-1318页

作者： Huichun Zhang Lu Wang Xiuliang Jin liming bian Yufeng Ge College of Mechanical and Electronic Engineering Nanjing Forestry UniversityNanjing 210037JiangsuChina Jiangsu Co-Innovation Center of Efficient Processing and Utilization of Forest Resources Nanjing Forestry UniversityNanjing 210037JiangsuChina Institute of Crop Sciences Chinese Academy of Agricultural Sciences/Key Laboratory of Crop Physiology and EcologyMinistry of AgricultureBeijing 100081China College of Forestry Nanjing Forestry UniversityNanjing 210037JiangsuChina Co-Innovation Center for Sustainable Forestry in Southern China and Key Laboratory of Forest Genetics&Biotechnology of the Ministry of Education Nanjing Forestry UniversityNanjing 210037JiangsuChina Department of Biological Systems Engineering University of Nebraska-LincolnNE 68583USA

Acquisition of plant phenotypic information facilitates plant breeding, sheds light on gene action, and can be applied to optimize the quality of agricultural and forestry products. Because leaves often show the fastest responses to external environmental stimuli, leaf phenotypic traits are indicators of plant growth,health, and stress levels. Combination of new imaging sensors, image processing, and data analytics permits measurement over the full life span of plants at high temporal resolution and at several organizational levels from organs to individual plants to field populations of plants. We review the optical sensors and associated data analytics used for measuring morphological, physiological, and biochemical traits of plant leaves on multiple scales. We summarize the characteristics, advantages and limitations of optical sensing and data-processing methods applied in various plant phenotyping scenarios. Finally, we discuss the future prospects of plant leaf phenotyping research. This review aims to help researchers choose appropriate optical sensors and data processing methods to acquire plant leaf phenotypes rapidly,accurately, and cost-effectively.

关键词： Leaf traits Optical sensing Image processing Machine learning Artificial intelligence

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Bisphosphonate-based nanocomposite hydrogels for biomedical applications

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Bioactive Materials 2020年第4期5卷 819-831页

作者： Weihao Yuan Zhuo Li Xian Xie Zhi-Yong Zhang liming bian Department of Biomedical Engineering The Chinese University of Hong KongShatinHong Kong999077PR China Shenzhen Research Institute The Chinese University of Hong KongShenzhen518172PR China Translational Research Centre of Regenerative Medicine and 3D Printing of Guangzhou Medical University Guangdong Province Engineering Research Center for Biomedical EngineeringState Key Laboratory of Respiratory DiseaseThe Third Affiliated Hospital of Guangzhou Medical UniversityNo.63 Duobao RoadLiwan DistrictGuangzhou CityGuangdong Province510150PR China China Orthopedic Regenerative Medicine Group(CORMed) HangzhouZhejiang310058PR China

Nanocomposite hydrogels consist of polymeric network embedded with functional nanoparticles or nanostructures,which not only contribute to the enhanced mechanical properties but also exhibit the bioactivities for regulating cell ***(BPs)are capable of coordinating with various metal ions and modulating bone *** to the inherent dynamic properties of metal–ligand coordination bonds,BPbased nanocomposite hydrogels possess tunable mechanical properties,highly dynamic structures,and the capability to mediate controlled release of encapsulated therapeutic agents,thereby making them highly versatile for various biomedical *** review presents the comprehensive overview of recent developments in BP-based nanocomposite hydrogels with an emphasis on the properties of embedded nanoparticles(NPs)and interactions between hydrogel network and ***,various challenges in the biomedical applications of these hydrogels are discussed to provide an outlook of potential clinical translation.

关键词： Bisphosphonates Metal-ligand coordination Nanocomposite hydrogels

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A sandwiched patch toward leakage-free and anti-postoperative tissue adhesion sealing of intestinal injuries

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Bioactive Materials 2023年第6期24卷 112-123页

作者： Wei Yang Chengkai Xuan Xuemin Liu Qiang Zhang Kai Wu liming bian Xuetao Shi National Engineering Research Centre for Tissue Restoration and Reconstruction South China University of TechnologyGuangzhou510006China School of Materials Science and Engineering South China University of TechnologyGuangzhou510640China Key Laboratory of Biomedical Engineering of Guangdong Province South China University of TechnologyGuangzhou510006China Key Laboratory of Biomedical Materials and Engineering of the Ministry of Education South China University of TechnologyGuangzhou510006China School of Biomedical Sciences and Engineering South China University of TechnologyGuangzhou International CampusGuangzhou511442China Guangzhou Soonheal Medical Technology.Co LtdGuangzhou510230China

Ideal repair of intestinal injury requires a combination of leakage-free sealing and postoperative ***,neither conventional hand-sewn closures nor existing bioglues/patches can achieve such a *** this end,we develop a sandwiched patch composed of an inner adhesive and an outer antiadhesive layer that are topologically linked together through a reinforced *** inner adhesive layer tightly and instantly adheres to the wound sites via-NHS chemistry;the outer antiadhesive layer can inhibit cell and protein fouling based on the zwitterion structure;and the interlayer enhances the bulk resilience of the patch under excessive *** complementary trilayer patch(TLP)possesses a unique combination of instant wet adhesion,high mechanical strength,and biological *** rat and pig models demonstrate that the sandwiched TLP can effectively seal intestinal injuries and inhibit undesired postoperative tissue *** study provides valuable insight into the design of multifunctional bioadhesives to enhance the treatment efficacy of intestinal injuries.

关键词： Trilayer patch Bioadhesives Preventing postoperative adhesion Antiadhesion Intestinal injuries

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Spatial analysis increases efficiency of progeny testing of Chinese fir

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Journal of Forestry Research 2017年第3期28卷 445-452页

作者： liming bian Renhua Zheng Shunde Su Huazhong Lin Hui Xiao Harry Xiaming Wu Jisen Shi South China Forestry Multidisciplinary Collaborative Innovation Center College of ForestryNanjing Forestry University159 Longpan RoadNanjing 210037People'sRepublic of China Fujian Academy of Forestry 35 ShangchiqiaoFuzhou 350012People's Republic of China Jiangle Forest Farm Jiangle 353300People's Republic of China Department of Forest Genetics and Plant Physiology Umea Plant Science CentreSwedish University of Agricultural Sciences90183 UmeaSweden College of Forestry Nanjing Forestry University159 Longpan RoadNanjing 210037People's Republic of China

We used spatial, global trend and post-blocking analysis to examine the effectiveness of a progeny trial in a tree breeding program for Chinese fir （Cunninghamia lanceolata （Lamb.） Hook） on a hilly site with an environmental gradient from hill top to bottom. Diameter at breast height （DBH） and tree height data had significant spatial auto-correlations among rows and columns. Adding a firstorder separable autoregressive term more effectively modelled the spatial variation than did the incomplete block （IB） model used for the experimental design. The spatial model also accounted for effects of experimental design factors and greatly reduced residual variances. The spatial analysis rel- ative to the IB analysis improved estimation of genetic parameters with the residual variance reduced 13 and 19% for DBH and tree height, respectively; heritability increased 35 and 51% for DBH and tree height, respectively; and genetic gain improved 3-5%. Fitting global trend and postblocking did not improve the analyses under IB model. The use of a spatial model or combined with a design model is recommended for forest genetic trials, particularly with global trend and local spatial variation of hilly sites.

关键词： Chinese fir Genetic variance Heritabilities Progeny testing Spatial analysis

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Inheritance of growth and survival in two 9-year-old, open-pollinated progenies of an advanced breeding population of Chinese firs in southeastern China

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Journal of Forestry Research 2016年第5期27卷 1067-1075页

作者： Renhua Zheng Zhou Hong Shunde Su liming bian Hui Xiao Jisen Shi Harry X. Wu Fujian Academy of Forestry Fuzhou 350012 People's Republic of China The Key Laboratory of Timber Forest Breeding and Cultivation for Mountainous Areas in Southern China Fuzhou 350012 People's Republic of China State Forestry Administration Engineering Research Center of Chinese Fir Fuzhou 350012 People's Republic of China The Key Laboratory of Forest Culture and Forest Product Processing Utilization of Fujian Province Fuzhou 350012People's Republic of China Research Institute of Tropical Forestry Chinese Academy of Forestry No. 682 Guangshan 1 Rd. Guangzhou 510520People's Republic of China The Key Laboratory of Forest Genetics and Biotechnology Nanjing Forestry University Nanjing 210037 People's Republic of China Department of Forest Genetics and Plant Physiology Umea Plant Science Centre Swedish University of Agricultural Sciences 90183 Umea Sweden CSIRO NRCA Black Mountain GPO Box 1600 CanberraACT 2601 Australia

Tree growth traits （tree height, DBH and stem volume） and survival from two 9-year-old, open-pollinated progeny tests of Chinese fir were investigated for heri- tability, genotype × environment interaction, age-age genetic correlation and selection efficiency. The 97 and 79 families planted at two sites were collected from the thirdcycle seed orchard. Individual heritability was estimated between 0.05 and 0.21 for tree height, DBH, and volume and between 0.45 and 1.0 for survival. Family heritability was between 0.20 and 1.14. Significant genotype x envi- ronment interaction was observed for the three growth traits. Type B genetic correlation was between 0.41 and 0.67 with an increasing trend as tree grows. High age-age genetic correlation was observed with correlation reaching 0.9 after age 4 for height, DBH, and volume. The genetic gains were estimated at 3.26, 3.39 and 5.98 % for tree height, DBH, and volume with 10 % selection intensity. The implication for advanced tree breeding in Chinese fir is discussed.

关键词： Chinese fir - Progeny test Heritability -Genetic gain

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Surface decoration of development-inspired synthetic N-cadherin motif via Ac-BP promotes osseointegration of metal implants

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Bioactive Materials 2021年第5期6卷 1353-1364页

作者： Meiling Zhu Kunyu Zhang Lu Feng Sien Lin Qi Pan liming bian Gang Li Department of Orthopaedics&Traumatology Faculty of MedicineThe Chinese University of Hong KongPrince of Wales HospitalShatinHong KongSARPR China Stem Cells and Regenerative Medicine Laboratory Li Ka Shing Institute of Health SciencesThe Chinese University of Hong KongPrince of Wales HospitalShatinSARHong KongPR China The Eighth Affiliated Hospital Sun Yat-Sen UniversityShenzhenPR China Department of Biomedical Engineering The Chinese University of Hong KongHong KongSARPR China Shenzhen Research Institute The Chinese University of Hong KongShenzhenPR China Centre of Novel Biomaterials The Chinese University of Hong KongHong KongSARPR China

Research works on the synergistic effect of surface modified bioactive molecules and bone metal implants have been highlighted.N-cadherin is regarded as a key factor in directing cell-cell interactions during the mesenchymal condensation preceding the osteogenesis in the musculoskeletal *** this study,the N-cadherin mimetic peptide(Cad)was biofunctionalized on the titanium metal surface via the acryloyl bisphosphonate(Ac-BP).To learn the synergistic effect of N-cadherin mimetic peptide,when tethered with titanium substrates,on promoting osteogenic differentiation of the seeded human mesenchymal stem cells(hMSCs)and the osseointegration at the bone-implant *** show that the conjugation of N-cadherin mimetic peptide with Ac-BP promoted the osteogenic gene markers expression in the *** biofunctionalized biomaterial surfaces promote the expression of the Wnt/β-catenin downstream axis in the attached hMSCs,and then enhance the in-situ bone formation and osseointegration at the bone-implant *** conclude that this N-cadherin mimetic peptide tethered on Ti surface promote osteogenic differentiation of hMSCs and osseointegration of biomaterial implants in vitro and in *** findings demonstrate the importance of the development-inspired surface bioactivation of metal implants and shed light on the possible cellular mechanisms of the enhanced osseointegration.

关键词： N-cadherin mimetic peptide Mesenchymal condensation Osseointegration Wnt/β-catenin signaling Titanium dioxide(TiO2)

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Building Osteogenic Microenvironments with a Double-Network Composite Hydrogel for Bone Repair

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Research 2023年第3期6卷 319-333页

作者： Jiaying Li Jinjin Ma Qian Feng En Xie Qingchen Meng Wenmiao Shu Junxi Wu liming bian Fengxuan Han Bin Li State Key Laboratory of Radiation Medicine and Protection School of Radiation Medicine and Protection and Interdisciplinary Sciences(RAD-X)Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education InstitutionsThe First Affiliated HospitalSuzhou Medical CollegeSoochow UniversitySuzhouJiangsu 215006China Orthopedic Institute Department of Orthopaedic SurgeryThe First Affiliated HospitalSuzhou Medical CollegeSoochow UniversitySuzhouJiangsuChina Key Laboratory of Biorheological Science and Technology Ministry of EducationCollege of BioengineeringChongqing UniversityChongqing 400044China Department of Biomedical Engineering University of StrathclydeGlasgowG11QEUK School of Biomedical Sciences and Engineering South China University of TechnologyGuangzhou International CampusGuangzhou 511442China National Engineering Research Center for Tissue Restoration and Reconstruction South China University of TechnologyGuangzhou 510006China Guangdong Provincial Key Laboratory of Biomedical Engineering South China University of TechnologyGuangzhou 510006 China Key Laboratory of Biomedical Materials and Engineering of the Ministry of Education South China University of TechnologyGuangzhou 510006 China

The critical factor determining the in vivo effect of bone repair materials is the microenvironment,which greatly depends on their abilities to promote vascularization and bone ***,implant materials are far from ideal candidates for guiding bone regeneration due to their deficient angiogenic and osteogenic ***,a double-network composite hydrogel combining vascular endothelial growth factor(VEGF)-mimetic peptide with hydroxyapatite(HA)precursor was developed to build an osteogenic microenvironment for bone *** hydrogel was prepared by mixing acrylatedβ-cyclodextrins and octacalcium phosphate(OCP),an HA precursor,with gelatin solution,followed by ultraviolet *** improve the angiogenic potential of the hydrogel,QK,a VEGF-mimicking peptide,was loaded in acrylatedβ-*** QK-loaded hydrogel promoted tube formation of human umbilical vein endothelial cells and upregulated the expression of angiogenesis-related genes,such as Flt1,Kdr,and VEGF,in bone marrow mesenchymal stem ***,QK could recruit bone marrow mesenchymal stem ***,OCP in the composite hydrogel could be transformed into HA and release calcium ions facilitating bone *** double-network composite hydrogel integrated QK and OCP showed obvious osteoinductive *** results of animal experiments showed that the composite hydrogel enhanced bone regeneration in skull defects of rats,due to perfect synergistic effects of QK and OCP on vascularized bone *** summary,improving the angiogenic and osteogenic microenvironments by our double-network composite hydrogel shows promising prospects for bone repair.

关键词： composite loaded inductive

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Complex coacervate-derived hydrogel with asymmetric and reversible wet bioadhesion for preventing UV light-induced morbidities

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Bioactive Materials 2023年第12期30卷 62-72页

作者： Xin Peng Yuan Li Menghui Liu Zhuo Li Xuemei Wang Kunyu Zhang Xin Zhao Gang Li liming bian Guangdong Provincial Engineering Research Center of Molecular Imaging The Fifth Affiliated HospitalSun Yat-sen UniversityZhuhai519000China Department of Orthopaedics&Traumatology Stem Cells and Regenerative Medicine LaboratoryLi Ka Shing Institute of Health SciencesThe Chinese University ofHong KongPrince of Wales HospitalShatin999077Hong Kong Special Administrative Region School of Biomedical Sciences and Engineering Guangzhou International CampusNational Engineering Research Center for Tissue Restoration and ReconstructionGuangdong Provincial Key Laboratory of Biomedical EngineeringKey Laboratory of Biomedical Materials and Engineering of the Ministry of EducationSouth ChinaUniversity of TechnologyGuangzhou510006PR China Department of Biomedical Engineering The Hong Kong Polytechnic UniversityHong Kong

Protecting the skin from UV light irradiation in wet and underwater environments is challenging due to the weak adhesion of existing sunscreen materials but highly *** we report a polyethyleneimine/thioctic acid/titanium dioxide(PEI/TA/TiO_(2))coacervate-derived hydrogel with robust,asymmetric,and reversible wet bioadhesion and effective UV-light-shielding *** PEI/TA/TiO_(2)complex coacervate can be easily obtained by mixing a PEI solution and TA/TiO_(2)*** fluid PEI/TA/TiO_(2)coacervate deposited on wet skin can spread into surface irregularities and subsequently transform into a hydrogel with increased cohesion,thereby establishing interdigitated contact and adhesion between the bottom surface and ***,the functional groups between the skin and hydrogel can form physical interactions to further enhance bioadhesion,whereas the limited movement of amine and carboxyl groups on the top hydrogel surface leads to low ***,the coacervate-derived hydrogel exhibits asymmetric adhesiveness on the bottom and top ***,the PEI/TA/TiO_(2)hydrogel formed on the skin could be easily removed using a NaHCO3 aqueous solution without inflicting *** importantly,the PEI/TA/TiO_(2)hydrogel can function as an effective sunscreen to block UV light and prevent UV-induced MMP-9 overexpression,inflammation,and DNA damage in animal *** advantages of PEI/TA/TiO_(2)coacervate-derived hydrogels include robust,asymmetric,and reversible wet bioadhesion,effective UV light-shielding ability,excellent biocompatibility,and easy preparation and usage,making them a promising bioadhesive to protect the skin from UV light-associated damage in wet and underwater environments.

关键词： Adhesive hydrogel Coacervate Asymmetric adhesion Reversible adhesion

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