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Treatment and survival in a population-based sample of patients diagnosed with gastroesophageal adenocarcinoma

World Journal of Gastroenterology 2008年第20期14卷 3165-3173页

作者： Deirdre P Cronin-Fenton Margaret M Mooney limin x clegg Linda C Harlan Surveillance Research Program DCCPS National Cancer Institute CTEP DCTD National Cancer Institute Applied Research Program DCCPS National Cancer Institute

AIM： TO examine the extent of use of specific therapies in clinical practice, and their relationship to therapies validated in clinical trials. METHODS： The US National Cancer Institutes＇ Patterns of Care study was used to examine therapies and survival of patients diagnosed in 2001 with histologically-confirmed gastroesophageal adenocarcinoma （/7 = 1356）. The study re-abstracted data and verified therapy with treating physicians for a population-based stratified random sample. RESULTS： Approximately 62% of patients had stomach adenocarcinoma （SAC）, while 22% had gastric-cardia adenocarcinoma （GCA）, and 16% lower esophageal adenocarcinoma （EAC）. Stage 1V/ unstaged esophageal cancer patients were most likely and stage Ⅰ -Ⅲ stomach cancer patients least likely to receive chemotherapy as all or part of their therapy; gastric-cardia patients received chemotherapy at a rate between these two. In multivariable analysis by anatomic site, patients 70 years and older were significantly less likely than younger patients to receive chemotherapy alone or chemoradiation for all three anatomic sites. Among esophageal and stomach cancer patients, receipt of chemotherapy was associated with lower mortality; but no association was found among gastric-cardia patients. CONCLUSION： This study highlights the relatively low use of clinical trials-validated anti-cancer therapies in community practice. Use of chemotherapy-based treatment was associated with lower mortality, dependent on anatomic site. Findings suggest that physicians treat lower esophageal and SAC as two distinct entities, while gastric-cardia patients receive a mix of the treatment strategies employed for the two other sites.

关键词： Adenocarcinoma Esophageal adeno-carcinoma Gastroesophageal Gastric adenocarcinoma Survival Chemotherapy Radiotherapy

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THE CREDIBILITY MODELS WITH EQUAL CORRELATION RISKS

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Journal of Systems Science & Complexity 2011年第3期24卷 532-539页

作者： limin WEN Wenli DENG Institute of Mathematics and Information Science Jiangxi Normal University Nanehang 330022 China Department of Statistics and Actuarial Science East China Normal University Shanghai 200241 China Institute of Mathematics and Information Science Jiangxi Normal University Nanchang 330022 China.

In almost all credibility estimators considered previously, the claims are assumed to be independent over risks. However, from practical point of view, this paper investigates the credibility premium when risks are dependent on each other. The authors build the Biihlmann＇s credibility models to account for an equal correlation structure over risks, and parameter estimations are also considered. Some desired results are derived.

关键词： Credibility premium dependence equal correlation projection.

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Experimental Data-Driven Flow Field Prediction for Compressor Cascade based on Deep Learning and l_(1)Regularization

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Journal of Thermal Science 2024年第5期33卷 1867-1882页

作者： LIU Tantao GAO limin LI Ruiyu School of Power and Energy Northwestern Polytechnical UniversityXi'an 710012China School of Aerospace Engineering Xi'an Jiaotong UniversityXi'an 710049China

For complex flows in compressors containing flow separations and adverse pressure gradients,the numerical simulation results based on Reynolds-averaged Navier-Stokes(RANS)models often deviate from experimental measurements more or *** improve the prediction accuracy and reduce the difference between the RANS prediction results and experimental measurements,an experimental data-driven flow field prediction method based on deep learning and l_(1)regularization is proposed and applied to a compressor cascade flow *** inlet boundary conditions and turbulence model parameters are calibrated to obtain the high-fidelity flow *** Saplart-Allmaras and SST turbulence models are used independently for mutual *** contributions of key modified parameters are also analyzed via sensitivity *** results show that the prediction error can be reduced by nearly 70%based on the proposed *** flow fields predicted by the two calibrated turbulence models are almost the same and nearly independent of the turbulence *** corrections of the inlet boundary conditions reduce the error in the first half of the *** turbulence model calibrations fix the overprediction of flow separation on the suction surface near the tail edge.

关键词： experimental data-driven compressor cascade deep learning l_(1)regularization

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RNA Imaging in Live Cells

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Chinese Journal of Chemistry 2023年第19期41卷 2531-2535页

作者： Jingfang Zhao limin xiang College of Chemistry and Molecular Sciences&TaiKang Center for Life and Medical Sciences Wuhan UniversityWuhanHubei430072 China

Traditional molecular biology tools have elucidated the identities and functions of RNA molecules,which are essential to the understanding of gene transcription and protein *** this research field would further require the direct visualization of RNA dynamics such as the DNA-RNA interactions and RNA-protein *** this goal,the rise of RNA imaging tools over the past 15 years has reformed how we looked at these *** this Emerging Topic,we first highlighted recent advances on three main RNA imaging tools based on the species of interacting molecules:RNA-RNA pairing,RNA-protein binding,and small molecule-RNA *** introduced the advantages of these tools from a technical viewpoint,including binding affinity,fluorescent turn-on ratio,stability,and impacts on targeted ***,we discussed new rising opportunities and future directions,echoing the state-of-the-art imaging tools in the fields of fluorescent proteins and small fluorescent ***,we believe this emerging field will bring new insights on how we study RNA biology in living systems.

关键词： Fluorescent imaging RNA imaging Fluorogenic RNA RNA Fluorescent probes RNA recognition

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Chemical Design of Nuclear-Targeting Mesoporous Silica Nanoparticles for Intra-nuclear Drug Delivery

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Chinese Journal of Chemistry 2018年第6期36卷 481-486页

作者： limin Pan Jianlin Shi Shanghai Institute of Ceramics Chines Academy of Sciences Shanghai 200050 China

Targeted drug delivery has been widely explored for efficient tumor therapy with desired efficacy but minimized side effects. It is widely known that large numbers of DNA-toxins, such as doxorubicin, genes, reactive oxygen species, serving as therapeutic agents, can result in maximized therapeutic effects via the interaction directly with DNA helix. So after cellular uptake, these agents should be further delivered into cell nuclei to play their essential roles in damaging the DNA helix in cancer ceils. Here, we demonstrate the first paradigm estabJished in our laboratory in developing nucle- ar-targeted drug delivery systems （DDSs） based on MSNs for enhanced therapeutic efficiency in the hope of speeding their translation into the ctinics. Firstly, nuclear-targeting DDSs based on MSNs, capable of intranuclear accumulation and drug release therein, were designed and constructed for the first time, resulting in much enhanced anticancer effects both in vitro and in vivo. Such an MSNs-based and nuclear-targeted drug/agent delivery strategy was further applied to overcome multidrug resistance （MDR） of malignant tumors, intra-nuclearly deliver therapeutic genes, photosensitizers, radio-enhancement agents and photothermal agents to realize efficient gene therapy, photodynamic therapy, radiation therapy and photothermal therapy, respectively.

关键词： nuclear targeting mesoporous silica nanoparticles drug delivery cancer therapy nanomedicine

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Spatially mapping the diffusivity of proteins in live cells based on cumulative area analysis

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Science China Chemistry 2023年第11期66卷 3307-3313页

作者： Huihui Gao Chu Han limin xiang College of Chemistry and Molecular Sciences&Taikang Center for Life and Medical Sciences Wuhan UniversityWuhan 430072China

Molecular motion provides a way for biomolecules to mix and interact in living *** their motion is critical to the understanding of how biomolecules perform its ***,it has been a challenged task to spatially map the fast diffusion of unbound proteins in the heterogenous intracellular *** we reported a new imaging technique named cumulative area based on single-molecule diffusivity mapping(CA-SMdM).The strategy is based on the comparison of singlemolecule images between a shorter and longer exposure *** longer exposure time,molecules will travel further,thus giving more blurred single-molecule images,hence implying its local diffusion *** validated our technique through measuring the fast diffusion rates(10–40μm~2/s)of fluorescent dye in glycerol-water mixture,and found the values fit well with Stokes-Einstein *** further showed that the spatially mapping of diffusivity in live cells is plausible through CA-SMdM,and it faithfully reported the local diffusivity heterogeneity in cytosol and ***-SMdM provides an efficient way to mapping the local molecular motion,and therefore will have profound applications in probing the biomolecular interactions for living systems.

关键词： single molecule diffusivity cumulative area single-molecule diffusivity mapping

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Effects of carrier and Mn loading on supported manganese oxide catalysts for catalytic combustion of methane

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Journal of Natural Gas Chemistry 2008年第2期17卷 159-164页

作者： Jinyan Hu Wei Chu limin Shi Department of Environmental Science and Engineering Sichuan University Chengdu 610065 Sichuan China Department of Chemical Engineering Sichuan University Chengdu 610065 Sichuan China

Supported manganese oxide catalysts were prepared by incipient wetness impregnation method for methane catalytic combustion, and effects of the support （Al2O3, SiO2 and TiO2） and Mn loading were investigated. These catalysts were characterized with N2 adsorption, x-ray diffraction, x-ray photoelectron spectroscopy and temperature-programmed reduction techniques. Methane conversion varied in a large range depending on supports or Mn loading. Al2O3 supported 15% Mn catalyst exhibited better activity toward methane catalytic oxidation. The manganese state and oxygen species played an important role in the catalytic performance,

关键词： methane catalytic combustion manganese oxide catalyst support effect alumina

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A Robust Blade Design Method based on Non-Intrusive Polynomial Chaos Considering Profile Error

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Journal of Thermal Science 2019年第5期28卷 875-885页

作者： GAO limin MA Chi CAI Yutong School of Power and Energy Northwestern Polytechnical University Xi'an 710129 China The National Key Laboratory of Aerodynamic Design and Research Xi'an 710129 China

To weaken the influence of profile error on compressor aerodynamic performance, especially on pressure ratio and efficiency, a robust design method considering profile error is built to improve the robustness of aerodynamic performance of the blade. The characteristics of profile error are random and small-scaled, which means that to evaluate the influence of profile error on blade aerodynamic performance is a time-intensive and high-precision work. For this reason, non-intrusive polynomial chaos(NIPC) and Kriging surrogate model are introduced in this robust design method to improve the efficiency of uncertainty quantification(UQ) and ensure the evaluate accuracy. The profile error satisfies the Gaussian distribution, and NIPC is carried out to do uncertainty quantification since it has advantages in prediction accuracy and efficiency to get statistical behavior of random profile error. In the integrand points of NIPC, several surrogate models are established based on Latin hypercube sampling(LHS)+ Kriging, which further reduces the costs of optimization design by replacing calling computational fluid dynamic(CFD) repeatedly. The results show that this robust design method can significantly improve the performance robustness in shorter time(40 times faster) without losing accuracy, which is meaningful in engineering application to reduce manufacturing cost in the premise of ensuring the aerodynamic performance. Mechanism analysis of the robustness improvement samples carried out in current work can help find out the key parameter dominating the robustness under the disturbance of profile error, which is meaningful to further improvement of compressor robustness.

关键词： robust design non-intrusive polynomial chaos aerodynamic performance random profile error uncertainty quantification

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Impacts of Urban Expansion on the Urban Thermal Environment:A Case Study of Changchun,China

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Chinese Geographical Science 2022年第1期32卷 79-92页

作者： YANG limin LI xiaoyan SHANG Beibei College of Earth Sciences Jilin UniversityChangchun 130012China College of Public Administration Nanjing Agricultural UniversityNanjing 210095China

Urbanization,especially urban land expansion,has a profound influence on the urban thermal *** in Northeast China face remarkably uneven development and environmental issues,and thus it is necessary to strengthen the diagnosis of thermal environmental pressure brought by *** this study,multi remote sensing imageries and statistical approaches,involving piecewise linear regression(PLR),were used to explore urban expansion and its effects on the thermal environment of Changchun City in Jilin Province,*** show that Changchun experienced rapid urban expansion from 2000 to 2020,with urban built-up areas increasing from 171.77 to 525.14 km^(2).The area of the city’s urban heat island(UHI)increased dramatically,during both day and *** PLR,a positive linear correlation of built-up density with land surface temperature(LST)was detected,with critical breakpoints of 70%-80%during the daytime and 40%-50%at *** the thresholds,the magnitude of LST in response to built-up density significantly increased with intensifying urbanization,especially for nighttime *** analysis of the relative frequency distributions(RFDs)of LST reveals that rapid urbanization resulted in a significant increase of mean LST in newly urbanized areas,but had weak effects on daytime LST change in existing urban *** expansion also contributed to a constant decrease of spatial heterogeneity of LST in existing urban area,especially at ***,in newly urbanized areas,the spatial heterogeneity of LST was decreased during the daytime but increased at nighttime due to urbanization.

关键词： urban expansion urban thermal environment urban heat island(UHI) remote sensing Changchun China

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Crystallographic and electrochemical characteristics of melt-spun Ti-Zr-Ni-Cu alloys

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Rare Metals 2007年第5期26卷 440-444页

作者： LIU Baozhong WU Yaoming WANG limin State Key Laboratory for Application of the Rare Earth Resources Changchun Institute of Applied Chemistry Chinese Academy of Sciences Changchun 130022 China Graduate School of Chinese Academy of Sciences Beijing 100049 China

Ti44Zr32Ni22Cu2 and Ti41Zr29Ni28Cu2 alloys were prepared by the melt-spinning method. The phase structure was analyzed by x-ray diffraction,and the electrochemical performances of the melt-spun alloys were investigated. The results indicated that the Ti44Zr32Ni22Cu2 alloy was composed of the icosahedral quasicrystals and amorphous phases,and the Ti41Zr29Ni28Cu2 alloy comprised icosahedral quasicrystals,amorphous,and Laves phases. The maximum discharge capacity was 141 mAh/g for the Ti44Zr32Ni22Cu2 alloy and 181 mAh/g for the Ti41Zr29Ni28Cu2 alloy,respectively. The Ti41Zr29Ni28Cu2 alloy also showed a better high-rate dischargeability and cycling stability. The better electrochemical properties should be ascribed to the high content of Ni,which was beneficial to the electrochemical kinetic properties and made the alloy more resistant to oxidation,as well as to the Laves phase in the Ti41Zr29Ni28Cu2 alloy,which could work as the electro-catalyst and the micro-current collector.

关键词： metal-hydride electrodes electrochemical properties icosahedral quasicrystal Ti-Zr-Ni-Cu alloy

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