检索结果-南通市图书馆

Unraveling brain aging through the lens of oral microbiota

Neural Regeneration Research 2025年第7期20卷 1930-1943页

作者： Qinchao Hu Si Wang Weiqi Zhang Jing qu Guang-Hui Liu State Key Laboratory of Membrane Biology Institute of ZoologyChinese Academy of SciencesBeijingChina Hospital of Stomatology Guanghua School of StomatologyGuangdong Provincial Key Laboratory of StomatologySun Yat-sen UniversityGuangzhouGuangdong ProvinceChina Advanced Innovation Center for Human Brain Protection and National Clinical Research Center for Geriatric Disorders Xuanwu HospitalCapital Medical UniversityBeijingChina Aging Translational Medicine Center International Center for Aging and CancerBeijing Municipal Geriatric Medical Research CenterXuanwu HospitalCapital Medical UniversityBeijingChina CAS Key Laboratory of Genomic and Precision Medicine Beijing Institute of GenomicsChinese Academy of Sciences and China National Center for BioinformationBeijingChina University of Chinese Academy of Sciences BeijingChina Institute for Stem Cell and Regeneration Chinese Academy of SciencesBeijingChina Aging Biomarker Consortium BeijingChina State Key Laboratory of Stem Cell and Reproductive Biology Institute of ZoologyChinese Academy of SciencesBeijingChina Beijing Institute for Stem Cell and Regenerative Medicine BeijingChina

The oral cavity is a complex physiological community encompassing a wide range of *** of oral microbiota can lead to various oral infectious diseases,such as periodontitis and tooth decay,and even affect systemic health,including brain aging and neurodegenerative *** studies have highlighted how oral microbes might be involved in brain aging and neurodegeneration,indicating potential avenues for intervention *** this review,we summarize clinical evidence demonstrating a link between oral microbes/oral infectious diseases and brain aging/neurodegenerative diseases,and dissect potential mechanisms by which oral microbes contribute to brain aging and *** also highlight advances in therapeutic development grounded in the realm of oral microbes,with the goal of advancing brain health and promoting healthy aging.

关键词： Alzheimer's disease brain aging multiple sclerosis neurodegeneration neurodegenerative diseases oral microbiota Parkinson's disease periodontitis bacteria Porphyromonas gingivalis

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

变压器油纸绝缘非线性介电弛豫模型构建方法研究

引用

绝缘材料 2024年第3期57卷 72-81页

作者：曲利民张健孟繁昊张亮张朋宫铭辰于沐禾国网黑龙江电力有限公司电力科学研究院黑龙江哈尔滨150030 哈尔滨理工大学工程电介质及其应用教育部重点实验室黑龙江哈尔滨150080

基于频域介电响应(FDS)对变压器油纸绝缘状态进行检测时,油纸绝缘频域介电响应的非线性变化会影响绝缘评估的准确性,因此亟须开展不同老化程度油纸绝缘材料FDS非线性变化规律的研究。在实验室环境下制备了多组不同老化程度的油纸绝缘模... 详细信息

基于频域介电响应(FDS)对变压器油纸绝缘状态进行检测时,油纸绝缘频域介电响应的非线性变化会影响绝缘评估的准确性,因此亟须开展不同老化程度油纸绝缘材料FDS非线性变化规律的研究。在实验室环境下制备了多组不同老化程度的油纸绝缘模型,并在不同温度下对油纸绝缘非线性FDS进行测试。结果表明:测试激励幅值越大,FDS曲线在低频段降低越明显,且随着测试温度的升高及老化程度的增加,介质损耗因数曲线出现非线变化的特征频段向高频方向移动;本文基于修正的Davidson-Cole模型,通过曲线拟合计算得到模型中的形状参数,并以此建立基于传递函数的等效电路模型,仿真计算得到了油纸绝缘阻抗模值非线性的变化规律。根据仿真结果可知,各阶阻抗模型的电路参数与油纸绝缘介电特性非线性的变化规律密切相关,而阻抗的改变使得曲线在相应频段发生变化。

关键词：油纸绝缘老化非线性介电特性扩展Davidson-Cole模型

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

黑龙江电网资产统一身份编码建设及应用

引用

黑龙江电力 2020年第5期42卷 385-392页

作者：曲利民张弘鲲孙巍王超张航国网黑龙江省电力有限公司电力科学研究院哈尔滨150030 国网黑龙江省电力有限公司哈尔滨150090

针对电网企业在资产全寿命周期管理中存在实物与资产对应混乱、业务流转操作不规范、账卡物不一致等问题,国家电网有限公司提出了电网资产统一身份编码的概念,有效解决了信息贯通断与乱的问题。通过黑龙江电网在资产统一身份编码建设和... 详细信息

针对电网企业在资产全寿命周期管理中存在实物与资产对应混乱、业务流转操作不规范、账卡物不一致等问题,国家电网有限公司提出了电网资产统一身份编码的概念,有效解决了信息贯通断与乱的问题。通过黑龙江电网在资产统一身份编码建设和应用过程中的经验,详细阐述了其建设的背景意义、内涵、实施方法、具体应用以及实践成效。

关键词：资产全寿命管理实物ID 赋码贴签数据追溯

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Dynamic Regulation of Hydrogen Bonding Networks and Solvation Structures for Synergistic Solar‑Thermal Desalination of Seawater and Catalytic Degradation of Organic Pollutants

引用

Nano-Micro Letters 2025年第2期17卷 548-565页

作者： Ming‑Yuan Yu Jing Wu Guang Yin Fan‑Zhen Jiao Zhong‑Zhen Yu Jin qu Beijing Key Laboratory of Advanced Functional Polymer Composites Beijing University of Chemical TechnologyBeijing 100029People’s Republic of China State Key Laboratory of Organic‑Inorganic Composites College of Materials Science and EngineeringBeijing University of Chemical TechnologyBeijing 100029People’s Republic of China

Although solar steam generation strategy is efficient in desalinating seawater,it is still challenging to achieve continuous solar-thermal desalination of seawater and catalytic degradation of organic ***,dynamic regulations of hydrogen bonding networks and solvation structures are realized by designing an asymmetric bilayer membrane consisting of a bacterial cellulose/carbon nanotube/Co_(2)(OH)_(2)CO_(3)nanorod top layer and a bacterial cellulose/Co_(2)(OH)_(2)CO_(3)nanorod(BCH)bottom ***,the hydrogen bonding networks inside the membrane can be tuned by the rich surface–OH groups of the bacterial cellulose and Co_(2)(OH)_(2)CO_(3)as well as the ions and radicals in situ generated during the catalysis ***,both SO_(4)^(2−)and HSO_(5)−can regulate the solvation structure of Na^(+)and be adsorbed more preferentially on the evaporation surface than Cl^(−),thus hindering the de-solvation of the solvated Na^(+)and subsequent nucleation/growth of ***,the heat generated by the solar-thermal energy conversion can accelerate the reaction kinetics and enhance the catalytic degradation *** work provides a flow-bed water purification system with an asymmetric solar-thermal and catalytic membrane for synergistic solar thermal desalination of seawater/brine and catalytic degradation of organic pollutants.

关键词： Solar steam generation Seawater desalination Catalytic degradation Bacterial cellulose Cobalt hydroxycarbonate nanorods

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

创伤骨科患者护理分级模式的应用研究

引用

国际护理学杂志 2017年第1期36卷 90-94页

作者：李芸香成丽敏曲玲玲王烁烟台市烟台山医院创一科 264000 烟台市烟台山医院创三科 264000 烟台市烟台山医院创四科 264000 烟台市烟台山医院肝胆外科 264000

目的：探讨并制定创伤骨科患者护理分级模式,提高护理分级合格率。方法成立专家组,对2015年1月20日创伤科所有在院患者208例进行护理分级合格率的横断面调查,针对原因制定新的护理分级模式,即医生根据专科病情评估表确定病情等级,护士... 详细信息

目的：探讨并制定创伤骨科患者护理分级模式,提高护理分级合格率。方法成立专家组,对2015年1月20日创伤科所有在院患者208例进行护理分级合格率的横断面调查,针对原因制定新的护理分级模式,即医生根据专科病情评估表确定病情等级,护士根据情况进行Barthel指数（ BL）评分,医护沟通按修订的护理分级流程决定患者的护理等级,模式运行后,再由前述专家对2015年7月4日创伤科所有在院患者266例进行横断面调查,比较模式运行前后护理分级合格率；运行模式后对医护人员进行半结构式访谈,评价医护人员对运行模式的看法。结果模式运行后护理分级合格率明显高于运行前,差异有统计学意义（χ2=15.93, P〈0.05）；半结构式访谈结果：访谈医护人员均对分级模式给予肯定,表示运行后护理级别更加符合患者的病情和护理需求。结论新护理分级模式能明显提高创伤骨科患者护理分级的合格率,具有一定的临床意义。

关键词：专科病情评估表护理分级创伤骨科

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Traditional Chinese medicine in the treatment of Helicobacter pylorirelated gastritis:The mechanisms of signalling pathway regulations

引用

World Journal of Gastroenterology 2025年第3期31卷 11-28页

作者： Pei-Pei Zhang Liang Li Hao-Yu qu Guang-Yu Chen Meng-Zhou Xie Yan-Kun Chen School of Traditional Chinese Medicine Hunan University of Chinese MedicineChangsha 410200Hunan ProvinceChina Hunan Engineering Technology Research Center for Medicinal and Functional Food Hunan University of Chinese MedicineChangsha 410200Hunan ProvinceChina Key Laboratory of Traditional Chinese Medicine Heart and Lung Syndrome Differentiation and Medicated Diet and Dietotherapy Hunan University of Chinese MedicineChangsha 410200Hunan ProvinceChina School of Informatics Hunan University of Chinese MedicineChangsha 410208Hunan ProvinceChina Precision Medicine Research and Development Center Zhuhai Institute of Advanced TechnologyChinese Academy of SciencesZhuhai 519000Guangdong ProvinceChina

Helicobacter pylori-associated gastritis(HPAG)is a common condition of the gastrointestinal ***,extensive and long-term antibiotic use has resulted in numerous adverse effects,including increased resistance,gastrointestinal dysfunction,and increased recurrence *** these concerns develop,traditional Chinese medicine(TCM)may have *** is based on the concept of completeness and aims to eliminate pathogens and strengthen the *** has the potential to prevent this condition while also boosting the rate of Helicobacter pylori *** review elaborates on the mechanism of TCM treatment for HPAG based on cellular signalling pathways,which reflects the flexibility of TCM in treating diseases and the advantages of multi-level,multipathway,and multi-target treatments for HPAG.

关键词： Helicobacter pylori Helicobacter pylori-associated gastritis Traditional Chinese medicine Signalling pathway Eliminate pathogens Strengthen the body

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Exosomes:the next-generation therapeutic platform for ischemic stroke

引用

Neural Regeneration Research 2025年第5期20卷 1221-1235页

作者： Wenjing Yin Hongyin Ma Yang qu Jiaxin Ren Yingying Sun Zhen-Ni Guo Yi Yang Stroke Center Department of NeurologyFirst Hospital of Jilin UniversityChangchunJilin ProvinceChina Neuroscience Research Center Department of NeurologyFirst Hospital of Jilin UniversityChangchunJilin ProvinceChina

Current therapeutic strategies for ischemic stroke fall short of the desired objective of neurological functional ***,there is an urgent need to develop new methods for the treatment of this *** are natural cell-derived vesicles that mediate signal transduction between cells under physiological and pathological *** have low immunogenicity,good stability,high delivery efficiency,and the ability to cross the blood–brain *** physiological properties of exosomes have the potential to lead to new breakthroughs in the treatment of ischemic *** rapid development of nanotechnology has advanced the application of engineered exosomes,which can effectively improve targeting ability,enhance therapeutic efficacy,and minimize the dosages *** in technology have also driven clinical translational research on *** this review,we describe the therapeutic effects of exosomes and their positive roles in current treatment strategies for ischemic stroke,including their antiinflammation,anti-apoptosis,autophagy-regulation,angiogenesis,neurogenesis,and glial scar formation reduction ***,it is worth noting that,despite their significant therapeutic potential,there remains a dearth of standardized characterization methods and efficient isolation techniques capable of producing highly purified *** optimization strategies should prioritize the exploration of suitable isolation techniques and the establishment of unified workflows to effectively harness exosomes for diagnostic or therapeutic applications in ischemic ***,our review aims to summarize our understanding of exosome-based treatment prospects in ischemic stroke and foster innovative ideas for the development of exosome-based therapies.

关键词： blood–brain barrier electroacupuncture engineering exercise exosomes ischemic stroke mesenchymal stem cells microglia neuroprotection stents

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Aptamer-induced in-situ growth of acetylcholinesterase-Cu_(3)(PO_(4))_(2)hybrid nanoflowers for electrochemical detection of organophosphorus inhibitors

引用

Nano Research 2023年第10期16卷 12134-12143页

作者： limin Yang Linjiao qu Xiaolong Zhang Mingming Li Zhen Liu State Key Laboratory of Heavy Oil Processing and Center for Bioengineering and Biotechnology China University of Petroleum(East China)Qingdao 266580China Institute of Biomedical Engineering Shenzhen Bay LaboratoryShenzhen 518055Chin

Enzyme-inorganic hybrid nanoflowers(HNFs)have shown excellent sensing capabilities due to their large specific surface area as well as the simplicity and mildness of the preparation ***,coupling HNFs to electrodes to fabricate a uniform and controllable enzymatic electrochemical sensing interface remains a ***,we proposed an aptamer-induced insitu fabrication strategy for preparing an HNF-based electrochemical sensor with ideal *** to this strategy is the introduction of acetylcholinesterase(AChE)-specific binding aptamer(Apt),which induces the in-situ growth of AChE-copper phosphate(Cu_(3)(PO_(4))_(2))HNFs on the surface of carbon paper(CP).In addition,a dense gold nanoparticle(AuNP)layer was electrodeposited on the CP for anchoring Apt and further extending the electroactive surface *** prepared AChECu_(3)(PO_(4))_(2)HNF/Apt/AuNP/CP biosensor exhibited a wide detection range from 1 to 107 pM for the four organophosphorus inhibitors,including isocarbophos,dichlorvos,methamidophos,and parathion,with detection limits down to 0.016,0.028,0.071,and 0.113 pM,*** the reactivation of pralidoxime chloride,the electrode can still recover 98.1%of the response after five times of repeated *** real sample detection,the biosensor achieved high recoveries from 96.45%to 100.13%.The detection target may be extendable to other AChE inhibitors(e.g.,drugs for Alzheimer’s disease).This study demonstrates for the first time the feasibility of using aptamers as an inducer to fabricate an electrochemical enzyme sensing interface *** strategy can be used to fabricate other enzyme-based biosensors and therefore has broader applications.

关键词： in-situ fabrication aptamer enzyme-inorganic hybrid nanoflowers electrochemical biosensor acetylcholinesterase inhibitors

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

罐式断路器伴热带控制保障系统研究

引用

黑龙江电力 2017年第3期39卷 240-244,264页

作者：柳贡强李岩高颖郭跃男曲利民徐超国网黑龙江省电力有限公司哈尔滨150090 国网黑龙江省电力有限公司电力科学研究院哈尔滨150030

为解决罐式断路器伴热带的控制方式比较简单,运行人员无法直接监控其工作状态的问题,设计了伴热带控制保障系统。该系统可以自动检测每条伴热带的工作电流、环境温度及原有伴热带温控开关工作情况,增加了温控开关的手动功能,实现了上位... 详细信息

为解决罐式断路器伴热带的控制方式比较简单,运行人员无法直接监控其工作状态的问题,设计了伴热带控制保障系统。该系统可以自动检测每条伴热带的工作电流、环境温度及原有伴热带温控开关工作情况,增加了温控开关的手动功能,实现了上位机实时监控功能,提高了伴热带运行的可靠性与稳定性。

关键词：罐式断路器伴热带实时监测 iFIX

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

基于动态相量法的孤岛微电网稳定性分析

引用

黑龙江电力 2017年第4期39卷 290-294,306页

作者：曲利民郭跃男王佳伟兰森宫铭辰王超国网黑龙江省电力有限公司电力科学研究院哈尔滨150030 优视科技(中国)有限公司广州510630

微电网中大量电力电子装置的存在,增加了微电网电磁暂态过程的建模和分析难度。针对这个问题,建立了微电网离网运行时的动态相量模型,并采用奇异值摄动理论对模型进行降阶。采用李雅普诺夫直接法分析微电网孤岛运行时系统参数对系统稳... 详细信息

微电网中大量电力电子装置的存在,增加了微电网电磁暂态过程的建模和分析难度。针对这个问题,建立了微电网离网运行时的动态相量模型,并采用奇异值摄动理论对模型进行降阶。采用李雅普诺夫直接法分析微电网孤岛运行时系统参数对系统稳定性的影响。仿真结果验证了理论分析的正确性。

关键词：微电网动态相量奇异扰动李雅普诺夫稳定性

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：