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Nicotinic acetylcholine receptor subtypes and dentate gyrus long term potentiation in anaesthetized rats

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Nicotinic acetylcholine receptor subtypes and dentate gyrus ...

小鼠T细胞淋巴瘤在同基因鼠内传代的遗传学分析

中国神经科学学会第四次会员代表大会暨第七届全国学术会议

作者： Yun WANG Institutes of Brain Science and State Key Laboratory of medical Neurobiology,Fudan University,Shanghai 200032, China lilly Research Centre,Eli lilly Company,Erl Wood manor,Windlesham,Surrey GU20 6PH,UK.

＜正＞Nicotine has been shown to improve cognition in humans and in animal *** long term potentiation（LTP） is a useful synaptic model of learning and *** in vitro and in vivo studies have shown nicotine facilitates the induction of LTP in CA1 and dentate gyrus（DG） of *** current study,we used selective nicotinic ligands for alpha4beta2（TC-2559 and DHbE） and alpha7（LY2070029,LY2129285 and mLA） subtypes to look more carefully of the role of nAChR subtypes in hippocampal neuronal *** were performed on urethane anaesthetized（1.2 g/kg,i.p.） adult male Sprague *** were made using 2%Pontamine Sky Blue in 2m NaCl filled glass electrode with tip impedance of 2-3 mOme implanted in the DG（3.5-4.0 mm caudal and 1.8-2.2 mm lateral to bregma）.Granual cell responses were evoked by a concentratic bipolar metal electrode implanted in the medio-dorsal perforant pathway（0.5-1.0 mm rostral and 4.0-4.5 mm lateral to lambda）.LTP was induced by 3 trains of high frequency stimulation,each train consisting of 15 pulses at 200 Hz with an inter-train interval of 10s.3 trains of high frequency stimulation induced an un-saturated LTP in DG,an additional 10 trains stimulation evoked larger ***-2559（2 mg/kg,i.v.）, a selective alpha4beta2 agonist,attenuated this LTP,which is DHbE,an alpha4 preferring competitive antagonist,sensitive. In addition,LY2070029 and LY2129285（1 -30 mg kg-1,s.c.2h）,two selective alpha7 receptor modulator,does dependently blocked DG LTP induction,and co-application of mLA（2.5 mg/kg,i.v.）,a selective alpha7 antagonist,prevented LY2070029 and LY2129285 *** conclusion,our results demonstrated selective stimulation of alpha4beta2 and alpha7 nAChR subtypes impairs dentate gyrus long term *** modulator role of nAChRs is in contrast to previous findings that used broad spectrum agonists,highlighting the complex actions of nicotine.

关键词： nAChRs nicotine dentate gyrus long term potentiation rat

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上海实验动物科学 1996年第3期16卷 137-141页

作者：张义读 m.Kaelbling U.B.Dasgupta F.lilly H.P.Klinger 山东医科大学组胚教研室济南250012 美国纽约爱因斯坦医学院遗传系

作者研究了甲基亚硝基脲(methylnitrosourea,mNU)诱发RF/J系小鼠T细胞淋巴瘤及肿瘤细胞在同基因小鼠体内连续传代后的染色体变化。胸腺肿瘤细胞及其传代培养细胞染色体异常,皆发生在15、14、X、1、5、6、3号染色体,说明这些染色体含有... 详细信息

作者研究了甲基亚硝基脲(methylnitrosourea,mNU)诱发RF/J系小鼠T细胞淋巴瘤及肿瘤细胞在同基因小鼠体内连续传代后的染色体变化。胸腺肿瘤细胞及其传代培养细胞染色体异常,皆发生在15、14、X、1、5、6、3号染色体,说明这些染色体含有促进肿瘤多步发生过程的基因即癌基因及抑癌基因。mNU不仅具有组织特异性而且累及特异染色体,结果也说明相同组织病理类型的肿瘤可产生于不同的特定位点的基因变化。

关键词： T细胞淋巴瘤同基因鼠遗传学小鼠肿瘤模型

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甲基亚硝基脲致癌机理探讨

中国实验动物学杂志 1996年第3期6卷 154-156页

作者：张义读 m．Kaelbling U．B．Dsgupta F．lilly H．P．Klinger 山东医科大学组胚教研室美国纽约爱因斯坦医学院遗传系

本文报道了甲基亚硝基脲（ｍｅｔｈｙｌｎｉｔｒｏｓｏｕｒｅａ，ＭＮＵ）诱发ＲＦ／Ｊ系小鼠Ｔ细胞淋巴瘤在裸小鼠（ｎｕｄｅｍｉｃｅ）体内连续传代的染色体变化。我们选用４个Ｔ细胞淋巴瘤接种６只裸小鼠而建立６个细胞系，每系连续... 详细信息

本文报道了甲基亚硝基脲（ｍｅｔｈｙｌｎｉｔｒｏｓｏｕｒｅａ，ＭＮＵ）诱发ＲＦ／Ｊ系小鼠Ｔ细胞淋巴瘤在裸小鼠（ｎｕｄｅｍｉｃｅ）体内连续传代的染色体变化。我们选用４个Ｔ细胞淋巴瘤接种６只裸小鼠而建立６个细胞系，每系连续传代５～７次。其核型分析结果九有１１种异常染色体的发生率比预计的要高，按递减的顺序分别为１０、Ｘ、３、１２、６、１、４、１９、１５、１８、１４。染色体异常发生率随传代培养逐渐增加。如果ＭＮＵ只是选择性地作用于某些特定的基因位点，这对解释其致癌机理有重要意义。

关键词：发生率裸小鼠致癌机理 T细胞淋巴瘤体内染色体异常诱发位点连续传代接种

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饲料添加剂对家禽生产性能和生理机能的影响

中国家禽 2011年第6期33卷 35-37页

作者： A.murakami C.Eyng J.Torrent K.R.Perryman C.K.Gehring W.A.Dozier E.J.Kim A.Corzo C.A.RuizFeria E.Larrison m.Davis L.K.Shires S.A.Loop K.G.S.lilly 巴西马林加州立大学美国奥本大学美国农业部密西西比州立大学德克萨斯A&m大学美国西弗吉尼亚大学

1功能性油脂能提高肉鸡生产性能、改善肠道形态本研究的目的旨在评价市售功能性油脂复合物(有效成分为腰果壳油脂和蓖麻油)对肉鸡生产性能参数、表观代谢能(AmE)、氮校正表观代谢能(AmEn)以及肠道形态的影响。将594只1日龄雏鸡随机分为1... 详细信息

1功能性油脂能提高肉鸡生产性能、改善肠道形态本研究的目的旨在评价市售功能性油脂复合物(有效成分为腰果壳油脂和蓖麻油)对肉鸡生产性能参数、表观代谢能(AmE)、氮校正表观代谢能(AmEn)以及肠道形态的影响。将594只1日龄雏鸡随机分为18组,每组33只,其中9组为对照组,饲喂普通日粮,另9组为试验组,饲喂添加功能性油脂的日粮,试验为期42d。

关键词：肉鸡生产氮校正表观代谢能基础日粮试验鸡硫酸氢钠饲喂饲养屠体重胴体重饲料转化率垫料绒毛高度日龄

脉搏波反射幅度对死亡率的预测作用:动脉粥样硬化多种族研究

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中华高血压杂志 2014年第11期22卷 1042-1042页

作者：刘莉叶鹏 Zamani P Jacobs DR Jr Segers P Duprez DA Brumback L Kronmal RA lilly Sm Townsend RR Budoff m Lima JA Hannan P Chirinos JA

研究表明,纯亚裔人群中脉搏波反射与死亡率相关。但是,多种族人群中是否存在这样的关系,以及其是否独立于亚临床动脉粥样硬化,尚未确定。该研究人员假设,以社区为基础的多种族成人样本中,脉搏波反射幅度（定义为后向波振幅Pb与前向波振... 详细信息

研究表明,纯亚裔人群中脉搏波反射与死亡率相关。但是,多种族人群中是否存在这样的关系,以及其是否独立于亚临床动脉粥样硬化,尚未确定。该研究人员假设,以社区为基础的多种族成人样本中,脉搏波反射幅度（定义为后向波振幅Pb与前向波振幅Pf的比值）与全因死亡率相关。方法与结果：纳入多种族动脉粥样硬化研究中,行动脉张力波形分析的5984名受试者作为研究对象。

关键词：亚临床动脉粥样硬化全因死亡率种族人群波反射预测作用脉搏社区为基础研究人员

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Primary tumor location and survival in colorectal cancer: A retrospective cohort study

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World Journal of Gastrointestinal Oncology 2020年第4期12卷 405-423页

作者： Himani Aggarwal Kristin m Sheffield Li Li David Lenis Rachael Sorg Afsaneh Barzi Rebecca miksad Eli lilly and Company IndianapolisIN 46225United States Flatiron Health New YorkNY 10013United States Keck School of medicine University of Southern CaliforniaLos AngelesCA 90033United States

BACKGROUND Primary tumor location is a prognostic factor for metastatic colorectal cancer(m CRC).Post hoc analyses of m CRC clinical trials,including FIRE-3,CALGB/SWOG 80405,suggest that primary tumor location is also predictive of survival benefit with cetuximab or bevacizumab in combination with 5-fluorouracil-based *** Evaluate prognostic/predictive roles of primary tumor location in real-world m CRC patients treated with cetuximab or bevacizumab plus 5-fluorouracil-based *** This retrospective cohort study selected patients with KRAS wild-type m CRC who initiated first-line therapy with cetuximab or bevacizumab in combination with 5-fluorouracil/leucovorin/irinotecan(FOLFIRI)or 5-fluorouracil/leucovorin/oxaliplatin(FOLFOX)between January 2013 and April 2017 from the Flatiron Health electronic health record-derived database of de-identified patientlevel data in the United *** tumor location was abstracted from patients’***-sided primary tumor location(LPTL)was defined as tumors that originated in the splenic flexure,descending colon,sigmoid colon,or rectum;right-sided primary tumor location(RPTL)was defined as tumors that originated from the appendix,cecum,ascending colon,hepatic flexure,or transverse *** score matching was used to balance the baseline demographic and clinical characteristics between patients treated with cetuximab and patientstreated with ***-meier and Cox regression methods were used for survival *** A total of 1312 patients met the selection *** 248 cetuximab plus FOLFIRI or FOLFOX patients,164 had LPTL and 84 had RPTL;of 1064 bevacizumab plus FOLFIRI or FOLFOX patients,679 had LPTL and 385 had *** LPTL and RPTL patients were more likely to receive FOLFIRI vs bevacizumab patients(LPTL:64.0%vs 24.3%;RPTL:76.2%vs 24.9%,Pmab RPTL vs bevacizumab RPTL patients(Pmab

关键词： Bevacizumab Cetuximab Cohort study Colorectal neoplasms Electronic health records Prognosis Retrospective studies Survival

migraine Pathogenesis

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中国临床神经科学 2000年第Z1期8卷 29-33页

作者： Nabih m. m.D. Ramadan Research Advisor Eli Lilly & Co. Adjunct Professor of Neurology Department of Neurology Indiana University Medical Center

　　Introduction Various theories of migraine pathogenesis have been developed over the years. To this date, none fully explains all the migraine phenomena. A complete description of each proposed theory is beyond the scope of this chapter. Nonetheless, a brief description of the arguments for and against the leading theories is noteworthy　　……

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Secondary Lysosomal Changes in Liver in Preclinical Drug Development

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毒理学杂志 2005年第S1期 243-244页

作者： Vincent P. meador,D.V.m.,Diplomate ACVP Eli lilly and Co. 2001 West main Street Greenfield Indiana U.S.A. 46140 Eli lilly and Co. 2001 West main Street Greenfield Indiana U.S.A. 46140 Ph.D. Eli lilly and Co. 2001 West main Street Greenfield Indiana U.S.A. 46140

Secondary Lysosomal Changes in Liver in Preclinical Drug Development

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毒理学杂志 2005年第A3期19卷 243-244页

作者： Vincent P. meador D.V.m. Diplomate ACVP Eli lilly and Co. 2001 West Main StreetGreenfieldIndianaU.S.A.46140Eli Lilly and Co.2001 West Main StreetGreenfieldIndianaU.S.A.46140 Ph.D.Eli Lilly and Co.2001 West Main StreetGreenfieldIndianaU.S.A.46140

Lysosomes are intracytoplasmic membrane-bound organelles that function to degrade intracellular substances by enzymatic digestion. They occur normally in all cells, being especially prominent in phagocytic cells of th... 详细信息

关键词：肝脏代谢药物治疗血药浓度潜伏期