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Geoscience Frontiers 2022年第2期13卷 333-350页

作者： Bradley Cave William Perkins Richard lilly Department of Earth Sciences University of AdelaideAdelaideSAAustralia Geological Survey of Queensland BrisbaneQLDAustralia

The subeconomic mount Novit Zn-Pb-Ag deposit is located approximately 20 km south of mount Isa,*** contrast to the nearby mount Isa,Hilton and George Fisher Zn-Pb-Ag deposits,mineralisation at mount Novit is situated to the west of the regional-scale mount Isa Fault and is hosted in the moondarra Siltstone as opposed to the Urquhart ***-grade(mineralisation primarily replaces pre-existing carbonate alteration and veining and consists of pyrrhotite,pyrite and sphalerite with lesser ***-grade(>10 wt.%Zn+Pb)mineralisation occurs as a matrix supported breccia dominated by sphalerite and pyrrhotite with galena,pyrite,and ***-situ U-Pb geochronology was completed on apatite and two textural varieties of ***-grained(m)subhedral to anhedral monazite is located within highly foliated biotite alteration directly adjacent Zn-Pb-Ag mineralisation and yields a mean weighted^(207)Pb/^(206)Pb age of 1527±18 ma(mSWD=1.06).This age is consistent with the formation of highly foliated biotite alteration during D;deformation of the Isan *** from the same fabric yields a lower intercept age of1443±29 ma(mSWD=1.30).Consistent with previous studies,this age is interpreted to represent the age of a major thrusting event along the mount Isa Fault that resulted in the cooling of the mount Novit area below~375℃.Coarse-grained monazite is coeval with Zn-Pb-Ag mineralisation and yields a mean weighted^(207)Pb/^(206)Pb age of 1457±11 ma(mSWD=0.28).Sphalerite from mount Novit has low concentrations(m)of Ge and Ga and a relatively high concentration of In(5 to>10 ppm),possibly reflecting the leaching of the metals from an underlying basement *** GGImFis geothermometer(Frenzel et al.,2016)produced a mean formation temperature of 345±52℃.The timing and temperature of Zn-Pb-Ag mineralisation is consistent with the age and cooling temperature of apatite presented in this *** on these correlations,we

关键词： mount Isa mount Novit Zn-Pb-Ag mineralisation monazite Apatite Geochronology

Lenalidomide downregulates ACE2 protein abundance to alleviate infection by SARS-CoV-2 spike protein conditioned pseudoviruses

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Signal Transduction and Targeted Therapy 2021年第6期6卷 1664-1667页

作者： Siyuan Su Jianfeng Chen Ying Wang lilly m.Wong Zhichuan Zhu Guochun Jiang Pengda Liu Lineberger Comprehensive Cancer Center The University of North Carolina at Chapel HillChapel HillNCUSA Department of Biochemistry and Biophysics The University of North Carolina at Chapel HillChapel HillNCUSA UNC HIV Cure Center Institute of Global Health and Infectious DiseasesThe University of North Carolina at Chapel HillChapel HillNCUSA

Dear Editor,The recent health emergency caused by SARS-CoV-2 created a global *** to other CoVs,SARS-CoV-2 utilizes its Spike(S)protein to specifically recognize the human angiotensin converting enzyme 2(ACE2)membrane... 详细信息

关键词： ACE2 infection utilize

Hepatitis C virus-associated pruritus: Etiopathogenesis and therapeutic strategies

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World Journal of Gastroenterology 2017年第5期23卷 743-750页

作者： Youssef Alhmada Denis Selimovic Fadi murad Sarah-lilly Hassan Youssef Haikel mossaad megahed matthias Hannig mohamed Hassan Department of Pathology University of Mississippi Medical Center Graduate School of Dental medicine Depart-ment of Restorative DentistryDivision of Oral Health ScienceHokkaido University Clinic of Operative Dentistry Periodontology and Preventive DentistrySaarland University Department of Surgery Tulane University School of Medicine Clinic of Dermatology University Hospital of Aachen Institut National de la Santéet de la Recherchémédicale Department of Operative Dentistry and Endodontics Dental FacultyUniversity of Strasbourg

In addition to its contributing role in the development of chronic liver diseases, chronic hepatitis C virus (HCV) infection is associated with extrahepatic manifestations, particularly, cutaneous-based disorders including those with pruritus as a symptom. Pruritus is frequently associated with the development of chronic liver diseases such as cholestasis and chronic viral infection, and the accumulation of bile acids in patients’ sera and tissues as a consequence of liver damage is considered the main cause of pruritus. In addition to their role in dietary lipid absorption, bile acids can trigger the activation of specific receptors, such as the G protein-coupled bile acid receptor (GPBA/ TGR5). These types of receptors are known to play a crucial role in the modulation of the systemic actions of bile acids. TGR5 expression in primary sensory neurons triggers the activation of the transient receptor potential vanilloid 1 (TRPV1) leading to the induction of pruritus by an unknown mechanism. Although the pathologic phenomenon of pruritus is common, there is no uniformly effective therapy available. Understanding the mechanisms regulating the occurrence of pruritus together with the conduction of large-scale clinical and evidence-based studies, may help to create a standard treatment protocol. This review focuses on the etiopathogenesis and treatment strategies of pruritus associated with chronic HCV infection.

关键词： Hepatitis C virus Pruritus Cholestasis Autotoxin Lysophosphatidic acid PI3 kinase

Hydrological model to Simulate Daily Flow in a Basin with the Help of a GIS

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Open Journal of modern Hydrology 2015年第3期5卷 58-67页

作者： Vitali Diaz mercado Khalidou m. Ba Emmanuelle Quentin Febe Helia Ortiz madrid lilly Gama UNESCO-IHE Institute for Water Education Delft Netherlands Centro Interamericano de Recursos del Agua Universidad Autónoma del Estado de México Toluca México Instituto Nacional de Investigación en Salud Pública Quito Ecuador División Académica de Ciencias Biológicas Universidad Juárez Autónoma de Tabasco México

Hydrological modeling is an essential tool to evaluate water resources in hydrological basins. The time invested in it depends on the structure of the hydrological model chosen, the amount and quality of information required and the efforts invested in calibration. CEQUEAU is a distributed hydrological model developed at the INRS-ETE, Quebec, Canada. The basin is divided into cells and the rainfall-runoff process is simulated cell by cell until the outlet. Recent advances in geomatics make it possible to develop modules integrated in geographic information systems (GIS) to facilitate the processing of information required by hydrological models. The objective of the present investigation is to implement the CEQUEAU model in Idrisi GIS for the hydrological modeling of basins, thereby reducing information processing time and improving limitations in the original version, such as the number of discretization cells and methods to calculate evapotranspiration. This document presents the results from the implementation of the CEQUEAU model, including evapotranspiration, water levels (in reservoirs, soil and aquifers) and hydrographs. These results show that these new changes provide more hydrology options to the user and with better results.

关键词： Hydrological modeling Flow Simulation GIS Cequeau Idrisi

Colorectal cancer screening in an academic center compared to the national average

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World Journal of Gastrointestinal Oncology 2015年第11期7卷 356-360页

作者： manuel O Gonzalez lilly m Sadri Alfred B Leong Smruti R mohanty Parag mehta Department of Gastroenterology New York Methodist Hospital Department of medicine Stony Brook University Hospital Department of medicine New York Methodist Hospital

AIm: To investigate if the increased emphases on training and education on current colorectal cancer(CRC) screening guidelines has resulted in improved national CRC screening rates in an internal medicine training program,and to determine if the doctor's post graduate year(PGY) level of training affected CRC screening ***: We conducted a cross sectional study of every patient who presented to the outpatient clinic of New York methodist Hospital,Brooklyn,NY,over the span of six continuous weeks in 2011.A questionnaire was integrated into every patient's medical interview that helped determine that patient's current CRC screening status,screening mammography status if applicable,Papanicolaou smear status if applicable,and current pneumococcal vaccination *** the same time,patient demographics were also *** of the questionnaire data was collected at the end of each medical visit and was compiled by a designated *** all the data points were collected,it was ensured that the patient has been seen by his or her continuity care resident at least twice in the *** was then compiled into a secure,encrypted database to then be analyzed by our ***: Data from 547 consecutive clinic visits were *** these,we reviewed 483 charts that met all of the inclusion criteria and did not meet the exclusion *** data was then analyzed for differences between PGY levels,patient's sex,race,and educational *** study population consisted of 138 men and 345 women.35 patients were white(7.40%),174 were black(39.79%) and 264 were Hispanic(55.81%).Our CRC screening rates were: 66% for PGY-1's,72% for PGY-2's and 77% for PGY-3'*** was no statistical difference noted between the three groups(P ≤ 0.05) or was there any difference sex,insurance status or educational *** CRC screening rate was 72% which was not different from the New York State average(P < 0.05).There was a statistically significant higher ra

关键词： Screening Colorectal cancer Post graduate year Res

Divergent trajectories of lean vs obese non-alcoholic steatohepatitis patients from listing to post-transplant:A retrospective cohort study

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World Journal of Gastroenterology 2022年第26期28卷 3218-3231页

作者： Fakhar Ali Qazi-Arisar Raj Uchila Catherine Chen Cathy Yang Shi-Yi Chen Ravikiran Sindhuvalada Karnam Amirhossein Azhie Wei Xu Zita Galvin Nazia Selzner Leslie lilly mamatha Bhat Ajmera Transplant Program Toronto General HospitalUniversity Health NetworkToronto M5G 2N2OntarioCanada Division of Gastroenterology and Hepatology Department of MedicineUniversity of TorontoToronto M5G 2N2OntarioCanada National Institute of Liver and GI Diseases Dow University of Health SciencesKarachi 75330Pakistan Department of Biostatistics Princess Margaret Cancer CenterUniversity Health NetworkToronto M5G 2C1OntarioCanada Division of Biostatistics Dalla Lana School of Public HealthUniversity of TorontoToronto M5G 2C1OntarioCanada

BACKGROUND Non-alcoholic steatohepatitis(NASH)cirrhosis is the second most common indication for liver transplantation(LT).The role of body mass index(BmI)on outcomes of NASH cirrhosis has been *** To compare the longitudinal trajectories of patients with lean vs obese NASH cirrhosis,from listing up to post-transplant,having adjusted their BmI for *** We retrospectively reviewed all adult NASH patients listed for LT in our program from 2012 to ***-Gray Competing Risk analyses and Cox Proportional-Hazard models were performed to examine the cumulative incidence of transplant and survival outcomes *** Out of 265 NASH cirrhosis listed patients,176 were *** age was 61.0 years;46%were females.111 patients underwent *** robust patients had better waitlist survival[hazard ratio(HR):0.12;95%CI:0.05–0.29,Pmore benign than obese NASH,our study suggests a paradoxical correlation of lean NASH with waitlist outcomes,and graft and patient survival post-LT.

关键词： Outcomes Frailty Waitlist Liver transplant Survival

DEVELOPmENT AND PRODUCTION OF FeAl BASED INTERmET ALLICALLOYS

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中国有色金属学会会刊：英文版 1999年第S1期9卷 309-317页

作者： S.D.Deevi, m.R.Hajaligol, A.Cliff lilly and G.S.Fleischhauer Research Center, Philip morris USA, 4201 Commerce Road, Richmond, VA 23234, U.S.A.

Intermetallic materials have long been considered as potential candidates for high temperature applications due to their high strength/weight ratio, oxidation resistance, and corrosion resistance. The recent alloy design approaches undertaken by many researchers around the world allowed design of intermetallics for high strength application. Environmental embrittlement, solidification porosity, and low ductility of FeAl alloys necessitated innovative ways of processing FeAl sheets based on powder metallurgical route as opposed to an ingot route. Excellent sheets of FeAl have been processed by roll compaction followed by sintering technique using water atomized FeAl powder. Gas atomized FeAl powder was used to obtain sheets of FeAl by tape casting technique. Plasma spray technique was employed to obtain coating of FeAl alloy.

关键词： intermetallics FeAl based development production

Vibration monitoring of Rotating Systems

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Engineering（科研） 2010年第1期2卷 46-54页

作者： K. N. EDE E. A. OGBONNAYA m. T. lilly S. O. T. OGAJI S. D. PROBERT 不详

most energy-conversion machines (e.g. vehicle engines and electric motors) involve rotating components (e.g. roller bearings and gears), which generate vibrations. The behavior of a pump which includes a deliberate fault was chosen to illustrate this assertion. The test bearing at the driven end of the pump’s motor was deliberately damaged using a 1.5mm wire-cutting method and an adjustable coupling disk introduced to impose a shaft misalignment of 40. The resulting undesirable behavior of the pump was observed. Experimental data were measured at various speeds of the rotor. The sample period at various operating frequencies were 0.9, 0.6 and 0.45s respectively. The ball-passage frequency was observed at 4.4, 8.8, 13.2 and 17.6Hz. A computer-based analytical model was developed, in visual basic, for monitoring the machine failures: this led to an integrated system-process algorithm for diagnosis of faults in rotating components.

关键词： Vibration measurement Rotating Component Ball-Passage Frequency Alarm Limit

美国冬季最美城镇想要找冬季旅游景点吗?以下是几个值得考虑的选项

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空中英语教室（高级版．彭蒙惠英语） 2019年第12期 6-7,38页

作者： lilly LeClair 陈信宏(译) 不详

冬天就要到了,美国各地许多迷人的城镇都懂得如何迎接冬天。以下是六个在美景排行榜上名列前茅的城镇,还有许多有趣的事物,让你玩转整个冬季。沙勒沃伊,密歇根州位于密歇根州北部的沙勒沃伊四周环绕着三座淡水湖,在游艇季节总会涌人大... 详细信息

冬天就要到了,美国各地许多迷人的城镇都懂得如何迎接冬天。以下是六个在美景排行榜上名列前茅的城镇,还有许多有趣的事物,让你玩转整个冬季。沙勒沃伊,密歇根州位于密歇根州北部的沙勒沃伊四周环绕着三座淡水湖,在游艇季节总会涌人大量的夏季游客。不过,敢冒着寒冬前来的人,就能享受这里清新的环境,这里的冬天经常降雪。在沙勒沃伊景色别致的市区里,就以主要街道布里吉街最引人注目,街上的树木都装点着圣诞灯饰。逛过当地的商店与画廊之后,把自己包紧一点,到码头去造访灯塔吧。在那里你有机会看到密歇根湖猛烈拍岸的冬浪。

关键词：密歇根州旅游景点淡水湖密歇根湖排行榜勒沃美国