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Colorectal cancer screening in an academic center compared to the national average

World Journal of Gastrointestinal Oncology 2015年第11期7卷 356-360页

作者： Manuel O Gonzalez lilly M Sadri Alfred B Leong Smruti R Mohanty Parag Mehta Department of Gastroenterology New York Methodist Hospital Department of Medicine Stony Brook University Hospital Department of Medicine New York Methodist Hospital

AIM: To investigate if the increased emphases on training and education on current colorectal cancer(CRC) screening guidelines has resulted in improved national CRC screening rates in an internal medicine training program,and to determine if the doctor's post graduate year(PGY) level of training affected CRC screening ***: We conducted a cross sectional study of every patient who presented to the outpatient clinic of New York Methodist Hospital,Brooklyn,NY,over the span of six continuous weeks in 2011.A questionnaire was integrated into every patient's medical interview that helped determine that patient's current CRC screening status,screening mammography status if applicable,Papanicolaou smear status if applicable,and current pneumococcal vaccination *** the same time,patient demographics were also *** of the questionnaire data was collected at the end of each medical visit and was compiled by a designated *** all the data points were collected,it was ensured that the patient has been seen by his or her continuity care resident at least twice in the *** was then compiled into a secure,encrypted database to then be analyzed by our ***: Data from 547 consecutive clinic visits were *** these,we reviewed 483 charts that met all of the inclusion criteria and did not meet the exclusion *** data was then analyzed for differences between PGY levels,patient's sex,race,and educational *** study population consisted of 138 men and 345 women.35 patients were white(7.40%),174 were black(39.79%) and 264 were Hispanic(55.81%).Our CRC screening rates were: 66% for PGY-1's,72% for PGY-2's and 77% for PGY-3'*** was no statistical difference noted between the three groups(P ≤ 0.05) or was there any difference sex,insurance status or educational *** CRC screening rate was 72% which was not different from the New York State average(P < 0.05).There was a statistically significant higher ra

关键词： Screening Colorectal cancer Post graduate year Res

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Early testing of insulin resistance: a tale of two lipid ratios in a group of 5th graders screened by the Coronary Artery Risk Detection in Appalachian Communities Project (CARDIAC Project)

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World Journal of Pediatrics 2019年第4期15卷 398-404页

作者： Charles Ituka Mosimah Christa lilly Awung-Njia Forbin Pamela J.Murray Lee Pyles Elloise Elliot William Neal West Virginia University MorgantownUSA University of Yaounde I YaoundeCameroon

Background In West Virginia (WV),47% of fifth-grade children are either overweight or *** is no clear consensus regarding the definition of insulin resistance in children,and directly measuring insulin on the population level is *** proposed measures examined further in this study include triglyceride (TRIG)/high-density lipoprotein cholesterol (HDL-C) ratio and TRIG/low-density lipoprotein (LDL-C) *** purpose of this study is to examine the relationship between TRIG/HDL-C ratio,TRIG/LDL-C ratio and insulin resistance in fifth-graders with acanthosis nigricans (AN).Methods Between 2007 and 2016,52,545 fifth-grade students in WV were assessed for *** glucose and insulin levels were collected only for a sub-group of students who were AN-positive and was used to determine insulin resistance using the Homeostatic Model for Insulin Resistance (HOMA-IR) *** analysis included t tests and logistic regression with receiver operating characteristic *** Of the students assessed for AN,4.5% (n =2360) tested *** prevalence of insulin resistance was 79% (n =814) among 1030 with AN and complete ***/HDL-C ratio and TRIG/LDL-C ratio were significantly associated with insulin resistance (TRIG/HDL-C:Est.=0.36,P < 0.0001,AUC =0.68;TRIG/LDL-C:Est.=0.87,P < 0.0001,AUC =0.69).Multivariate analysis showed that increased body mass index (Est.=0.05,P < 0.0001),gender (Est.=0.49,p < 0.0001) and TRIG/HDL-C ratio (Est.=0.21,P < 0.0001) were significantly associated with insulin *** TRIG/HDL-C is a better surrogate marker of insulin resistance in AN-positive children compared to TRIG/ LDL-C ratio;so,on a population-level,cholesterol rather than insulin may be obtained for preliminary testing of early insulin resistance in children.

关键词： Acanthosis nigricans CARDIAC Project High-density lipoprotein cholesterol Insulin resistance Low-density lipoprotein cholesterol

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Lenalidomide downregulates ACE2 protein abundance to alleviate infection by SARS-CoV-2 spike protein conditioned pseudoviruses

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Signal Transduction and Targeted Therapy 2021年第6期6卷 1664-1667页

作者： Siyuan Su Jianfeng Chen Ying Wang lilly M.Wong Zhichuan Zhu Guochun Jiang Pengda Liu Lineberger Comprehensive Cancer Center The University of North Carolina at Chapel HillChapel HillNCUSA Department of Biochemistry and Biophysics The University of North Carolina at Chapel HillChapel HillNCUSA UNC HIV Cure Center Institute of Global Health and Infectious DiseasesThe University of North Carolina at Chapel HillChapel HillNCUSA

Dear Editor,The recent health emergency caused by SARS-CoV-2 created a global *** to other CoVs,SARS-CoV-2 utilizes its Spike(S)protein to specifically recognize the human angiotensin converting enzyme 2(ACE2)membrane... 详细信息

关键词： ACE2 infection utilize

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Population-standardized genetic risk score： the SNP-based method of choice for inherited risk assessment of prostate cancer

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Asian Journal of Andrology 2016年第4期18卷 520-524页

作者： Carly A Conran Rong Na Haitao Chen Deke Jiang Xiaoling Lin S lilly Zheng Charles B Brendler Jianfeng Xu NorthShore University HealthSystem Program for Personalized Cancer Care 1001 University Place Evanston IL 60201 USA Fudan Institute of Urology Huashan Hospital Fudan University 12 Mid-Wulumuqi Road Shanghai 200040 P.R. China Center for Genomic Translational Medicine and Prevention School of Public Health Fudan University 138 Yixueyuan Road Shanghai 200032 RR. China.

Several different approaches are available to clinicians for determining prostate cancer （PCa） risk. The clinical validity of various PCa risk assessment methods utilizing single nucleotide polymorphisms （SNPs） has been established; however, these SNP-based methods have not been compared. The objective of this study was to compare the three most commonly used SNP-based methods for PCa risk assessment. Participants were men （n = 1654） enrolled in a prospective study of PCa development. Genotypes of 59 PCa risk-associated SNPs were available in this cohort. Three methods of calculating SNP-based genetic risk scores （GRSs） were used for the evaluation of individual disease risk such as risk allele count （GRS-RAC）, weighted risk allele count （GRS-wRAC）, and population-standardized genetic risk score （GRS-PS）. Mean GRSs were calculated, and performances were compared using area under the receiver operating characteristic curve （AUC） and positive predictive value （PPV）. All SNP-based methods were found to be independently associated with PCa （all P 〈 0.05; hence their clinical validity）. The mean GRSs in men with or without PCa using GRS-RAC were 55.15 and 53.46, respectively, using GRS-wRAC were 7.42 and 6.97, respectively, and using GRS-PS were 1.12 and 0.84, respectively （all P 〈 0.05 for differences between patients with or without PCa）. All three SNP-based methods performed similarly in discriminating PCa from non-PCa based on AUC and in predicting PCa risk based on PPV （all P 〉 0.05 for comparisons between the three methods）, and all three SNP-based methods had a significantly higher AUC than family history （all P 〈 0.05）. Results from this study suggest that while the three most commonly used SNP-based methods performed similarly in discriminating PCa from non-PCa at the population level, GRS-PS is the method of choice for risk assessment at the individual level because its value （where 1.0 represents average population risk） can be easily interpreted regardless of

关键词： genetic risk score prostate cancer single nucleotide polymorphisms

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Face up to challenge of virology world

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World Journal of Virology 2012年第1期1卷 1-3页

作者： Xiaoli lilly Pang Department of Laboratory Medicine and Pathology University of Alberta and Alberta Provincial Laboratory for Public Health (Microbiology)WMC 2B4.58 8440-112 Street Edmonton Alberta T6G 1B1 Canada

Welcome to the World Journal of Virology(WJV), a new member of the World Journal Series. The World Journal Series was first launched as a peer-reviewed scientific journal covering aspects of research, diagnostics and clinical practice in biomedicine in 1995. WJV is an online and open-access peer-reviewed periodical focusing on virology. WJV covers a variety of topics in different areas of virology, including advances in basic research, updates in nomenclature, the development of novel diagnostic assays, the epidemiology of viral disorders and, new developments in the clinical management of viral diseases, including new vaccines and antiviral therapeutics. The purpose in launching the WJV is to promote knowledge exchange related to the classic human viruses as well as newly emerging viruses and their associated clinical disorders. Continually updating knowledge in a timely manner in this field where information related to the unceasing evolution of viruses is becoming available at a rapid pace is challenging. Thanks to the World-Wide-Web we are able to provide a podium for all authors and readers of WJV to address this challenge. I would like to acknowledge the Baishideng publisher, the members of the editorial board, and all contributing authors involved in this inaugural issue of the WJV. I sincerely hope all readers,i.e. future contributing authors, will like WJV and we look forward to your input in assisting WJV to grow and mature.

关键词： Viruses Viral disorders Knowledge exchange Fast-paced communication Peer-reviewed Open-access

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Hepatitis C virus-associated pruritus: Etiopathogenesis and therapeutic strategies

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World Journal of Gastroenterology 2017年第5期23卷 743-750页

作者： Youssef Alhmada Denis Selimovic Fadi Murad Sarah-lilly Hassan Youssef Haikel Mossaad Megahed Matthias Hannig Mohamed Hassan Department of Pathology University of Mississippi Medical Center Graduate School of Dental Medicine Depart-ment of Restorative DentistryDivision of Oral Health ScienceHokkaido University Clinic of Operative Dentistry Periodontology and Preventive DentistrySaarland University Department of Surgery Tulane University School of Medicine Clinic of Dermatology University Hospital of Aachen Institut National de la Santéet de la RecherchéMédicale Department of Operative Dentistry and Endodontics Dental FacultyUniversity of Strasbourg

In addition to its contributing role in the development of chronic liver diseases, chronic hepatitis C virus (HCV) infection is associated with extrahepatic manifestations, particularly, cutaneous-based disorders including those with pruritus as a symptom. Pruritus is frequently associated with the development of chronic liver diseases such as cholestasis and chronic viral infection, and the accumulation of bile acids in patients’ sera and tissues as a consequence of liver damage is considered the main cause of pruritus. In addition to their role in dietary lipid absorption, bile acids can trigger the activation of specific receptors, such as the G protein-coupled bile acid receptor (GPBA/ TGR5). These types of receptors are known to play a crucial role in the modulation of the systemic actions of bile acids. TGR5 expression in primary sensory neurons triggers the activation of the transient receptor potential vanilloid 1 (TRPV1) leading to the induction of pruritus by an unknown mechanism. Although the pathologic phenomenon of pruritus is common, there is no uniformly effective therapy available. Understanding the mechanisms regulating the occurrence of pruritus together with the conduction of large-scale clinical and evidence-based studies, may help to create a standard treatment protocol. This review focuses on the etiopathogenesis and treatment strategies of pruritus associated with chronic HCV infection.

关键词： Hepatitis C virus Pruritus Cholestasis Autotoxin Lysophosphatidic acid PI3 kinase

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International Dream Vacation Destinations

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空中英语教室（高级版．彭蒙惠英语） 2022年第7期 22-25,45,46页

作者： lilly LeClair 陈信宏(译) 不详

在西方文化中,新婚夫妇去度假的习俗起源于19世纪初的英国。传统上,蜜月开始的方式是新婚夫妇于宴席中途离开,赶搭晚班火车或船只,前往天气较晴朗、气候较温暖的地方。现在,新婚夫妇有更多的弹性和选择。所以,以下是全世界的首选蜜月景... 详细信息

在西方文化中,新婚夫妇去度假的习俗起源于19世纪初的英国。传统上,蜜月开始的方式是新婚夫妇于宴席中途离开,赶搭晚班火车或船只,前往天气较晴朗、气候较温暖的地方。现在,新婚夫妇有更多的弹性和选择。所以,以下是全世界的首选蜜月景点:巴黎就算排除非凡的酒店、餐厅、购物与文艺活动,巴黎也仍然可以说是全世界最浪漫的城市。

关键词：新婚夫妇文艺活动蜜月 19世纪初

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到了进行雷暴数值预报的时候了吗?

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气象科技 1991年第3期19卷 10-22页

作者： Douglas K.lilly 胡圣昌俄克拉何马大学

本文简述了未来10年研究开发对流风暴环境数值预报的一条途径。描述了主要的科学问题,以及早期解决其中一些问题所取得的进展。

关键词：数值预报可预报性对流风暴平均气流数值天气预报多普勒雷达预报模式半球模式大气运动涡度

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Risk assessment of venous thromboembolism in inflammatory bowel disease by inherited risk in a population-based incident cohort

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World Journal of Gastroenterology 2023年第39期29卷 5494-5502页

作者： Andrew S Rifkin Zhuqing Shi Jun Wei Siqun lilly Zheng Brian T Helfand Jonathan S Cordova Vincent F Biank Alfonso J Tafur Omar Khan Jianfeng Xu Program for Personalized Cancer Care NorthShore University HealthSystemEvanstonIL 60201United States Department of Surgery NorthShore University HealthSystemEvanstonIL 60201United States Pritzker School of Medicine University of ChicagoChicagoIL 60637United States Department of Pediatrics NorthShore University HealthSystemEvanstonIL 60201United States Cardiovascular Institute NorthShore University HealthSystemEvanstonIL 60201United States Department of Medicine NorthShore University HealthSystemEvanstonIL 60201United States

Inflammatory bowel disease(IBD),including Crohn’s disease(CD)and ulcerative colitis(UC),is a chronic inflammatory disease of the digestive tract with increasing prevalence *** venous thromboembolism(VTE)is a major complication in IBD patients,it is often underappreciated with limited tools for risk *** To estimate the proportion of VTE among IBD patients and assess genetic risk factors(monogenic and polygenic)for *** Incident VTE was followed for 8465 IBD patients in the UK Biobank(UKB).The associations of VTE with F5 factor V leiden(FVL)mutation,F2 G20210A prothrombin gene mutation(PGM),and polygenic score(PGS003332)were tested using Cox hazards regression analysis,adjusting for age at IBD diagnosis,gender,and genetic background(top 10 principal components).The performance of genetic risk factors for discriminating VTE diagnosis was estimated using the area under the receiver operating characteristic curve(AUC).RESULTS The overall proportion of incident VTE was 4.70%in IBD patients and was similar for CD(4.46%),UC(4.49%),and unclassified(6.42%),and comparable to that of cancer patients(4.66%)who are well-known at increased risk for *** carriers of F5/F2 had a significantly increased risk for VTE compared to non-mutation carriers,hazard ratio(HR)was 1.94,95%confidence interval(CI):*** contrast,patients with the top PGS decile had a considerably higher risk for VTE compared to those with intermediate scores(middle 8 deciles),HR was 2.06(95%CI:1.57-2.71).The AUC for differentiating VTE diagnosis was 0.64(95%CI:0.61-0.67),0.68(95%CI:0.66-0.71),and 0.69(95%CI:0.66-0.71),respectively,for F5/F2 mutation carriers,PGS,and *** Similar to cancer patients,VTE complications are common in IBD *** provides more informative risk information than F5/F2 mutations(FVL and PGM)for personalized thromboprophylaxis.

关键词： Inflammatory bowel disease Venous thromboembolism Polygenic score Factor V leiden Prothrombin gene mutation

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三亚十大最浪漫摄影地榜单揭晓

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中国国家旅游 2012年第2期 64-75页

作者： lilly

持续数月，官方微博互动专题有6000多位网友直接参与，相关信息转发二十多万次；其中一位网友发贴3天内被转发六千余次，网友发表评论近200条，这个数量已接近微博人气王最高的单条微博转发纪录……

关键词：摄影浪漫三亚信息转发网友

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