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Acta Pharmaceutica Sinica B 2019年第5期9卷 923-936页

作者： Huanmin Niu lilin qian Bin Sun Wenjian Liu Fang Wang qian Wang Xiaotian Ji Yanhai Luo Effat Un Nesa Hongxiang Lou Huiqing Yuan Institute of Medical Sciences/Department of Biochemistry and Molecular Biology the Second Hospital of Shandong UniversityJinan250033China Key Laboratory of Natural Products&Chemical Biology Ministry of EducationDepartment of Natural ProductsChemistrySchool of Pharmaceutical SciencesShandong UniversityJinan250012China Department of Radiation Oncology Qilu Hospital of Shandong UniversityJinan250012China

It is critical to regulate the senescence-associated secretory phenotype(SASP) due to its effect on promoting malignant phenotypes and limiting the efficiency of cancer therapy. In this study, we demonstrated that marchantin M(Mar-M, a naturally occurring bisbibenzyl) suppressed proinflammatory SASP components which were elevated in chemotherapy-resistant cells. Mar-M treatment attenuated the pro-tumorigenic effects of SASP and enhanced survival in drug-resistant mouse *** toxicity was detected on normal fibroblast cells or in animals following this treatment. Inactivation of transcription factor EB(TFEB) and nuclear factor-k B(NF-k B) by Mar-M significantly accounted for its suppression on the components of SASP. Furthermore, inhibition of SASP by Mar-M contributed to a synergistic effect during co-treatment with doxorubicin to lower toxicity and enhance antitumor efficacy. Thus, chemotherapy-driven pro-inflammatory activity, seen to contribute to drug-resistance, is an important target for Mar-M. By decreasing SASP, Mar-M may be a potential approach to overcome tumor malignancy.

关键词： SASP Marchantin M TFEB NF-kB Drug resistance

Targeting of VPS 18 by the lysosomotropic agent RDN reverses TFE3-mediated drug resistance

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Signal Transduction and Targeted Therapy 2021年第7期6卷 1979-1981页

作者： Huanmin Niu lilin qian Yanhai Luo Fang Wang Hongbo Zheng Yanhui Gao Hanbo Wang Xuelei Hu Huiqing Yuan Hongxiang Lou Key Laboratory of Natural Products&Chemical Biology of Ministry of Education Institute of Medical SciencesThe Second HospitalCheeloo College of MedicineShandong UniversityJinanChina Department of Natural Product Chemistry School of Pharmaceutical SciencesCheeloo College of MedicineShandong UniversityJinanChina Minimally Invasive Urology Center Shandong Provincial HospitalJinanChina Department of Thoracic Surgery Qilu HospitalCheeloo College of MedicineShandong UniversityQingdaoChina

Dear Editor,Multidrug resistance(MDR)is still a major challenge for successful cancer *** mechanisms that confer therapy-induced drug resistance have been extensively investigated to explore how to combat the *** this regard,lysosomal sequestration has demonstrated to be a mechanism contributing to drug resistance via an/,off-target,/effect in which hydrophobic and weakly basic chemotherapeutic agents are trapped in lysosomes,sequestering them from their targets.

关键词： drug resistance agent

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基于声波传播时间估计的气流速度测量方法

航空学报 2015年第4期36卷 1285-1298页

作者：虞飞陶建武钱立林海军航空工程学院控制工程系烟台264001 空军航空大学飞行器控制系长春130022

为实现对亚声速和超声速气流速度的统一测量,提出了一种基于声传感器的新型测量方法。首先,根据声波在亚声速和超声速气流中的传播特性,利用特定的测量装置建立了声波传播时间与气流速度之间的数学模型,从而将气流速度的测量问题转化为... 详细信息

为实现对亚声速和超声速气流速度的统一测量,提出了一种基于声传感器的新型测量方法。首先,根据声波在亚声速和超声速气流中的传播特性,利用特定的测量装置建立了声波传播时间与气流速度之间的数学模型,从而将气流速度的测量问题转化为声波传播时间的测量问题。然后,在此基础上,利用计时法和最大似然估计(MLE)方法来估计声波传播时间;其中,计时法在实时性上优势明显,而MLE方法则在可靠性上优于前者。最后,分别从阵元位置扰动性、计时误差和克拉美-罗界(CRB)3个方面对所提算法的性能进行了分析与仿真验证。结果表明,该算法能够实现对亚声速和超声速气流速度的精确测量。

关键词：气流速度测量声传感器嵌入式大气数据传感最大似然估计克拉美-罗界信号处理

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基于钝头球体绕流速度的大气参数估计

空气动力学学报 2015年第6期33卷 772-779页

作者：钱立林陶建武杨越明虞飞空军航空大学吉林长春130022 海军航空工程学院山东烟台264001

提出了一种新型基于气流绕钝头球体速度模型的大气参数估计方法,主要解决大气参数中的攻角、侧滑角、自由流速度的求解问题。首先,根据势流模型推导了可压缩流下的速度模型,利用气体热力学公式和可压缩性系数对模型进行了校正。其次,通... 详细信息

提出了一种新型基于气流绕钝头球体速度模型的大气参数估计方法,主要解决大气参数中的攻角、侧滑角、自由流速度的求解问题。首先,根据势流模型推导了可压缩流下的速度模型,利用气体热力学公式和可压缩性系数对模型进行了校正。其次,通过传感器策略组合,根据修正的模型推导了基于气流速度值求解大气参数的公式。最后,利用Fluent软件仿真并采样了气流绕钝头球体速度分布情况,通过仿真数据验证了各公式的有效性,表明基于气流速度值的大气参数估计方法是可行的。该方法能够实现较大的攻角和速度的测量并且明显提高大气参数估计的实时性。

关键词：钝头体 Fluent 气流速度大气参数

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基于机翼前缘绕流速度的大气参数测量方法

系统仿真学报 2017年第4期29卷 723-729页

作者：钱立林陶建武杨越明虞飞空军航空大学飞行器控制系长春130022 空军航空大学航空理论系长春130022

利用安装在机翼前缘的声矢量传感器,给出了一种新型大气参数的估计方法。基于声矢量传感器敏感翼部绕流分布,建立大气参数求解模型。根据机翼后掠、对称的特点,对速度矢量进行分解来对模型的非线性方程进行解耦,从而求解了侧滑角、攻角... 详细信息

利用安装在机翼前缘的声矢量传感器,给出了一种新型大气参数的估计方法。基于声矢量传感器敏感翼部绕流分布,建立大气参数求解模型。根据机翼后掠、对称的特点,对速度矢量进行分解来对模型的非线性方程进行解耦,从而求解了侧滑角、攻角和自由流速度的表达式。通过Fluent对机翼绕流进行仿真,验证了方法的可行性。

关键词：机翼前缘气流速度大气参数 Fluent 流分离

Estimation of Incidence of Herpes Zoster in Three Cities of China,2019-2020

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Biomedical and Environmental Sciences 2024年第9期37卷 1091-1094页

作者： qian Zhang Wei Qin Zhenshui Huang lilin Liang qianqian Hu Yao Wang Fan Pan Feng Cui Xinli Liu Lin Tang Xiaoqi Wang Chao Ma Fuzhen Wang Zundong Yin National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Disease Beijing 102206China National Immunization Program Chinese Center for Disease Control and PreventionBeijing 100050China Lu’an Center for Disease Control and Prevention Lu’an 23700Anhui China Zibo Center for Disease Control and Prevention Zibo 255026ShandongChina Tongchuan Center for Disease Control and Prevention Tongchuan 727031ShaanxiChina

Herpes zoster(HZ)is a painful condition resulting from reactivation of dormant varicella-zoster virus(VZV)in a previously VZV-infected person[1].Typical clinical manifestation of HZ are unilateral radicular pain and a vesicular rash limited to one side of the body in the distribution of a nerve[2].The most common complication of HZ postherpetic neuralgia(PHN).

关键词： zoster Herpes clinical

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陶瓷防护结构对引信抗破片冲击性能影响研究

兵器装备工程学报 2024年第6期45卷 159-165页

作者：吴立林钱晨晨陆静南京理工大学机械工程学院南京210094

针对引信受破片撞击时的安全性问题,提出了一种引信防护结构,通过在引信传爆管壳和引信壳体之间增加一层防护陶瓷,使得引信在受到破片撞击时能够通过陶瓷吸收部分动能,从而提升引信的安全性能。通过仿真与试验对比的方法,分析了无防护... 详细信息

针对引信受破片撞击时的安全性问题,提出了一种引信防护结构,通过在引信传爆管壳和引信壳体之间增加一层防护陶瓷,使得引信在受到破片撞击时能够通过陶瓷吸收部分动能,从而提升引信的安全性能。通过仿真与试验对比的方法,分析了无防护、氧化铝陶瓷和碳化硅陶瓷防护结构的抗破片撞击性能。结果表明:增加碳化硅陶瓷防护结构可使引信在破片撞击下的传爆药峰值压力降低82.6%,见证板凹痕直径降低4.8%,优于氧化铝陶瓷防护时的81.8%和2.58%。陶瓷防护能够有效提升引信抗破片冲击能力,碳化硅陶瓷的抗冲击效果优于氧化铝陶瓷。

关键词：爆炸力学破片撞击陶瓷防护不敏感引信数值模拟

Peroxyoxalate Chemiluminescence Based on Fluorescent Conjugated Polymer for the Determination of Triton X-IO0

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Chinese Journal of Chemistry 2011年第3期29卷 575-580页

作者： Jin, Yingqiong Sun, lilin Hao, Dan Yu, Rui qian, Zhangsheng Zhu, Changqing Anhui Key Laboratory of Chemo-Biosensing College of Chemistry and Materials Science Anhui Normal University Wuhu Anhui 241000 China

A novel peroxyoxalate chemiluminescence system has been designed for the determination of Triton X-100 （TX-100）, in which a hydrophobic fluorescent conjugated polymer, poly[2,5-bisnonyloxy-1,4-phenyleneethynylene-9,10-anthrylene] （PPEA） was employed as a fluorophor. A strong enhanced intensity of chemiluminescence （CL） was observed in the presence of TX-100, due to the improved emission efficiency of PPEA in the presence of TX-100. Under optimum conditions, the detection range of Triton X-100 is between 1.0 ×10 ^-7 and 1.0 ×10 ^-4 mol·L ^-1, with a detection limit at 6.0×10 ^-8 moloL 1. The relative standard deviation is 2.4% （n=6） for 1.0×10 ^-6 mol·L ^-1Triton X-100. This method provides satisfying results in the detection of TX-100 in nature water and biological samples with high sensitivity and wide linear range.

关键词： peroxyoxalate chemiluminescence triton X-100 fluorescent conjugated polymers

咪唑和吡啶类两类含氮杂环功能化合物对稀有金属铼的吸附性能研究进展

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乐山师范学院学报 2024年第8期39卷 19-29页

作者：程倩罗文正罗恩明甘立霖李硕陈稼轩重庆理工大学化学化工学院重庆巴南区400054 乐山师范学院新能源材料与化学学院四川乐山614004

铼是一种极稀有分散金属,在自然界中难以独立存在且需求量较大,亟需开发高效的铼分离吸附材料。开发具有应用前景的铼吸附材料的关键在于构建特异性吸附位点,氮杂环类化合物是一类可作为金属配体的化合物,季铵化后可有效吸附铼。论文介... 详细信息

铼是一种极稀有分散金属,在自然界中难以独立存在且需求量较大,亟需开发高效的铼分离吸附材料。开发具有应用前景的铼吸附材料的关键在于构建特异性吸附位点,氮杂环类化合物是一类可作为金属配体的化合物,季铵化后可有效吸附铼。论文介绍了近年来以咪唑和吡啶两类氮杂环化合物作为吸附位点的材料,比较了二者的构效关系、结构设计、耐酸碱性和选择性能力,并提出了设计性能优异的铼吸附剂的建议。总体来看,这两类化合物作为铼吸附位点在耐酸碱性和选择性分离方面各具优势,但理论支撑较欠缺且评价指标不够全面。

关键词：氮杂环功能基团咪唑吡啶铼选择性吸附

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Aged hematopoietic stem cells entrap regulatory T cells to create a prosurvival microenvironment

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Cellular & Molecular Immunology 2023年第10期20卷 1216-1231页

作者： Weinian Liao Chaonan Liu Ke Yang Jun Chen Yiding Wu Shuzhen Zhang Kuan Yu Lisha Wang Li Ran Mo Chen Fang Chen Yang Xu Song Wang Fengchao Wang qian Zhang Jinghong Zhao lilin Ye Changhong Du Junping Wang State Key Laboratory of Trauma Burnsand Combined InjuryInstitute of Combined InjuryChongqing Engineering Research Center for NanomedicineCollege of Preventive MedicineArmy Medical University(Third Military Medical University)400038ChongqingChina Department of Nephrology The Key Laboratory for the Prevention and Treatment of Chronic Kidney Disease of ChongqingKidney Center of PLAXinqiao HospitalArmy Medical University(Third Military Medical University)400037ChongqingChina Institute of Immunology Army Medical University(Third Military Medical University)400038ChongqingChina National Key Laboratory of Medical Immunology Institute of ImmunologyNaval Medical University200433ShanghaiChina

Although DNA mutation drives stem cell aging,how mutation-accumulated stem cells obtain clonal advantage during aging remains poorly ***,using a mouse model of irradiation-induced premature aging and middle-aged mice,we show that DNA mutation accumulation in hematopoietic stem cells(HSCs)during aging upregulates their surface expression of major histocompatibility complex class II(MHCII).MHCII upregulation increases the chance for recognition by bone marrow(BM)-resident regulatory T cells(Tregs),resulting in their clonal expansion and accumulation in the HSC *** the basis of the establishment of connexin 43(Cx43)-mediated gap junctions,BM Tregs transfer cyclic adenosine monophosphate(cAMP)to aged HSCs to diminish apoptotic priming and promote their survival via activation of protein kinase A(PKA)***,targeting the HSC–Treg interaction or depleting Tregs effectively prevents the premature/physiological aging of *** findings show that aged HSCs use an active self-protective mechanism by entrapping local Tregs to construct a prosurvival niche and obtain a clonal advantage.

关键词： Hematopoietic stem cell regulatory T cell Aging