检索结果-南通市图书馆

Liver transplantation as an alternative for the treatment of perihilar cholangiocarcinoma: A critical review

Hepatobiliary & Pancreatic diseases International 2024年第2期23卷 139-145页

作者： Wellington Andraus Francisco Tustumi Alexandre Chagas Santana Rafael Soares Nunes Pinheiro daniel Reis Waisberg liliana d.catti lopes Rubens Macedo Arantes Vinicius Rocha Santos Rodrigo Bronze de Martino Luiz Augusto Carneiro d’Albuquerque department of Gastroenterology Transplantation UnitUniversidade de São PauloSão PauloBrazil

Background:Perihilar cholangiocarcinoma(phCCC)is a dismal *** is no consensus regard-ing the best treatment for patients with unresectable *** present review aimed to gather the current pieces of evidence for liver transplantation and liver resection as a treatment for phCCC and to build better guidance for clinical *** sources:The search was conducted in PubMed,Embase,Cochrane,and *** related references were searched *** criteria were:reports in English or Portuguese literature that a)patients with confirmed diagnosis of phCCC;b)patients treated with a curative intent;c)patients with the outcomes of liver resection and liver *** reports,reviews,letters,editorials,conference abstracts and papers with full-text unavailability were excluded from the ***:Most of the current literature is based on observational retrospective studies with low grades of *** resection has better long-term outcomes than systemic chemotherapy or palliation ther-apy and liver transplantation is a good alternative for selected patients with unresectable *** candidates for resection or transplantation should be medically fit and free of intrahepatic or extrahep-atic *** a general rule,patients presenting with a tumor having a longitudinal size>3 cm or extending below the cystic duct,lymph node disease,confirmed extrahepatic dissemination;intraoper-atively diagnosed metastatic disease;a history of other malignancies within the last five years,and did not complete chemoradiation regimen and were medically unfit should not be considered for *** of these criteria should be individually *** transplantation or resection should only be considered in highly experienced hepatobiliary centers,and any decision-making must be based on a multidisciplinary ***:phCCC is a complex condition with high *** therapies,including hepatec-tomy and liv

关键词： Liver transplantation Cholangiocarcinoma Liver neoplasms

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

A novel neuroprotective method against ischemic stroke by accelerating the drainage of brain interstitial fluid

引用

Science China(Life Sciences) 2024年第10期67卷 2213-2223页

作者： Jingge Lian Liu Yang Hanbo Tan Shaoyi Su Leonor Serrano lopes Fangxiao Cheng Junhao Yan Yu Fu Wanyi Fu Zhaoheng Xie Jianfei Sun Jicong Zhang Zhiqian Tong Yajuan Gao Hongbin Han department of Radiology Peking University Third HospitalBeijing 100191China Beijing Key Laboratory of Magnetic Resonance Imaging Technology Beijing 100191China Institute of Medical Technology Peking University Health Science CenterBeijing 100191China department of Informatics Technical University of MunichGarching 80539Germany department of Anatomy and Histology School of Basic Medical SciencesPeking UniversityBeijing 100191China department of Neurology Peking University Third HospitalBeijing 100191China department of Electronic Engineering Tsinghua UniversityBeijing 100084China State Key Laboratory of Bioelectronics School of Biological Science and Medical EngineeringSoutheast UniversityNanjing 210096China School of Biological Science and Medical Engineering Beihang UniversityBeijing 100191China Key Laboratory of Alzheimer’s disease of Zhejiang Province Institute of AgingSchool of Mental HealthWenzhou Medical UniversityWenzhou 325035China NMPA Key Laboratory for Evaluation of Medical Imaging Equipment and Technique Beijing 100191China

Ischemic stroke is a leading cause of death and disability *** response after stroke determines the outcome of ischemic injury.A recent study has reported an efficient method,epidural arterial implantation(EAI),for accelerating interstitial fluid(ISF)drainage,which provides a promising strategy to clear pro-inflammatory cytokines in the brain extracellular space(ECS).In this study,the method of EAI was modified(m-EAI)to control its function of accelerating the ISF drainage at different time points following ischemic *** neuroprotective effect of m-EAI on ischemic stroke was evaluated with the transient middle cerebral artery occlusion(tMCAO)rat *** results demonstrated the accumulation of IL-1β,IL-6,and TNF-αwas significantly decreased by activating m-EAI at 7 d before and immediately after ischemic attack in tMCAO rats,accompanied with decreased infarct volume and improved neurological *** study consolidates the hypothesis of exacerbated ischemic damage by inflammatory response and provides a new perspective to treat encephalopathy via brain *** research is essential to investigate whether m-EAI combined with neuroprotective drugs could enhance the therapeutic effect on ischemic stroke.

关键词： ischemic stroke brain extracellular space interstitial fluid modified epidural arterial implantation

来源：

维普期刊数据库

同方期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Physico-chemical characterization of acid base disorders in patients with COVId-19:A cohort study

引用

World Journal of Nephrology 2024年第2期13卷 16-23页

作者： Sergio Pinto de Souza Juliana R Caldas Marcelo Barreto lopes Marcelo Augusto duarte Silveira Fernanda Oliveira Coelho Igor Oliveira Queiroz Pedro domingues Cury Rogério da Hora Passos department of Nephrology Hospital São RafaelSalvadorBA 41253190Brazil department of Nephrology D’Or Institute for Research and Education(IDOR)SalvadorBA 41253190Brazil Faculty of Medicine Escola Bahiana de Medicina e Saúde Pública-EBMSPSalvadorBA 40290000Brazil department of Intensive Care D’Or Institute for Research and Education(IDOR)SalvadorBA 41253190Brazil Hospital São Rafael D’Or Institute for Research and Education(IDOR)SalvadorBA 41253190Brazil department of Intensive Care Unit Hospital Israelita Albert EinsteinSao PauloSP 05652900Brazil

BACKGROUNd Acid-base imbalance has been poorly described in patients with coronavirus disease 2019(COVId-19).Study by the quantitative acid-base approach may be able to account for minor changes in ion distribution that may have been over-looked using traditional acid-base analysis *** a cohort of critically ill COVId-19 patients,we looked for an association between metabolic acidosis surrogates and worse clinical outcomes,such as mortality,renal dialysis,and length of hospital *** To describe the acid-base disorders of critically ill COVId-19 patients using Stewart’s approach,associating its variables with poor *** This study pertained to a retrospective cohort comprised of adult patients who experienced an intensive care unit stay exceeding 4 days and who were diagnosed with severe acute respiratory syndrome coronavirus 2 infection through a positive polymerase chain reaction analysis of a nasal swab and typical pulmonary involvement observed in chest computed tomography *** and clinical data were obtained from electronic *** variables were compared using Fisher’s exact *** data were presented as median and interquartile *** Mann-Whitney U test was used for *** In total,211 patients were *** mortality rate was 13.7%.Overall,149 patients(70.6%)presented with alkalosis,28 patients(13.3%)had acidosis,and the remaining 34 patients(16.2%)had a normal arterial pondus *** those presenting with acidosis,most had a low apparent strong ion difference(SId)(20 patients,9.5%).Within the group with alkalosis,128 patients(61.0%)had respiratory *** non-survivors were older,had more comorbidities,and had higher Charlson’s and simplified acute physiology score *** did not find severe acid-base imbalance in this *** analyzed Stewart’s variables(effective SId,apparent SId,and strong ion gap and the effect of albumin,lactate,phosphorus,and chloride)were not d

关键词： COVId-19 Physicochemical approach Acid-base status Critically ill patients Acute respiratory syndrome

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Influence of PVd-duplex-treated, Bionic Surface Structures on the Wetting Behavior for Sheet-Bulk Metal Forming Tools

引用

Journal of Bionic Engineering 2017年第3期14卷 520-531页

作者： Wolfgang Tiilmann dominic Stangier Nelson Filipe lopes dias Institute of Materials Engineering TU Dortmund 44227 Dortmund Germany Leonhard-Euler-Strafle 2

Bionic surface structures, inspired by the flora, were developed for Sheet-Bulk Metal Forming （SBMF） in order to locally control the friction condition by adjusting the wetting behavior. Five bionic structures were micromilled on ASP 2023 in annealed as well as hardened and tempered conditions. Subsequently, the structured surfaces were plasma-nitrided and coated with a CrA1N thin film. The influence of the treatment method on the structural geometry was investigated with the aid of a scanning electron microscope and 3d-profilometer. The wetting behaviors of water and deep drawing oil （Berufluid ST6007） on bionic surfaces were evaluated using contact angle measurements. The resulting micro-milled structures exhibit an almost identical shape as their bionic models. However, the roughness of the structured surfaces is influenced by the microstructure. The combination of plasma-nitriding and Physical Vapor deposition （PVd） leads to an increase in roughness. All bionic struc- tures possess higher contact angles than that of the unstructured surfaces when wetted by water. This can be explained by the fact that the structural elevations block the spreading. When the bionic surfaces are wetted by deep drawing oil, the lubricant spreads in the structural cavities, leading to smaller contact angles. Furthermore, the anisotropy of the structure has an influence on the wetting behavior.

关键词： bionic structures sheet-bulk metal forming CrA1N PVd-duplex treatment wetting behavior

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Solar-stellar astrophysics and dark matter

引用

Research in Astronomy and Astrophysics 2012年第8期12卷 1107-1138页

作者： Sylvaine Turck-Chize Ilídio lopes CEA/IRFU/Service d'Astrophysique AIMCE Saclay91191 Gif sur YvetteFrance Centro Multidisciplinar de Astrofísica Instituto Superior TcnicoUniversidade Tcnica de LisboaAv.Rovisco Pais1049-001 LisboaPortugal departamento de Física Escola de Ciência e TecnologiaUniversidade de vora Colgio Luis António Verney7002-554 voraPortugal

In this review, we recall how stars contribute to the search for dark matter and the specific role of the Sun. We describe a more complete picture of the solar interior that emerges from neutrino detections, gravity and acoustic mode measurements of the Solar and Heliospheric Observatory （SOHO） satellite, becoming a reference for the most common stars in the Universe. The Sun is a unique star in that we can observe directly the effect of dark matter. The absence of a signature related to Weakly Interacting Massive Particles （WIMPs） in its core disfavors a WIMP mass range below 12 GeV. We give arguments to continue this search on the Sun and other promising cases. We also examine another dark matter candidate, the sterile neutrino, and infer the limitations of the classical structural equations. Open questions on the young Sun, when planets formed, and on its present internal dynamics are finally dis- cussed. Future directions are proposed for the next decade： a better description of the solar core, a generalization to stars coming from seismic missions and a better under- standing of the dynamics of our galaxy which are all crucial keys for understanding dark matter.

关键词： stellar evolution: theory -- elementary particles -- helioseismology --dark matter -- early solar-planet relationship

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

In vitro toxicity of particulate matter emissions from residential pellet combustion

引用

Journal of Environmental Sciences 2022年第5期34卷 215-226页

作者： Estela d.Vicente daniela Figueiredo Catia Goncalves Isabel lopes Helena Oliveira Nora Kovats Teresa Pinheiro Celia A.Alves department of Environment and Planning and CESAM-Centre for Environmental and Marine Studies University of Aveiro3810-193 AveiroPortugal department of Biology and CESAM-Centre for Environmental and Marine Studies University of Aveiro3810-193 AveiroPortugal Centre of Natural Environmental Sciences University of PannoniaEgyetem str.108200 VeszpremHungary Instituto de Bioengenharia e Biociencias Departamento de Engenharia e Ciencias NuclearesInstituto Superior TecnicoUniversidade de LisboaAv.Rovisco Pais 11049-001 LisboaPortugal

Particulate matter emissions(PM10)from the combustion,in a residential stove,of two com-mercial brands of certified(ENplus A1)pellets,a non-certified brand and laboratory made pellets of acacia were tested for their ability to induce ecotoxic,cytotoxic,and mutagenic re-sponses in unicellular organisms and a human cell *** was evaluated through the Vibrio fischeri bioluminescence inhibition ***,cytotoxicity was assessed at two time points(24-and 48-hr)through two complementary techniques in order to evaluate the cellular metabolic activity and membrane integrity of human lung epithelial cells *** Ames test using two Salmonella typhimurium strains(TA100 and TA98)was employed to assess the mutagenic potential of the polycyclic aromatic hydrocarbon fraction extracted from the PM10 *** obtained with the bioluminescent bacteria indicated that only particles from the combustion of acacia pellets were *** samples induced im-pairment on the A549 cells metabolic activity,while no significant release of lactate dehy-drogenase was ***10 emissions from acacia pellets were the most cytotoxic,while samples from both certified pellets evoked significant cytotoxicity at lower ***-icity time-dependency was only observed for PM10 from the combustion of acacia pellets and one of the brands of certified *** activity was not detected in both *** murium *** study emphasises the role of the raw material for pellet manu-facturing on the toxicological profile of PM *** raw materials should be deeply investigated before their use in pelletisation and combustion in residential appli-ances.

关键词： Ecotoxicity Cytotoxicity Mutagenicity Fuel quality Pellet combustion PM10 emissions

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Rainfall partitioning in young clonal plantations Eucalyptus species in a subtropical environment,and implications for water and forest management

引用

International Soil and Water Conservation Research 2021年第3期9卷 474-484页

作者： decio Oscar Cardoso Ferreto JoséMiguel Reichert Rosane Barbosa lopes Cavalcante Raghavan Srinivasan Soils department Universidade Federal de Santa Maria(UFSM).Avenida Romima 1000Santa MariaRSBrazil Instituto Tecnoldgico Vale.Rua Boaventura da Silva 955UmarizalBelemPABrazil department of Ecology and Conservation Biology Texas A&M University(TAMU)534 John Kimbrough Blvd.Room 305College StationTXUSA

different canopy characteristics of industrial eucalyptus may lead to differences in water evaporation and availability to *** study aims to understand rainfall partitioning in a young clonal plantation(age of 2-4.5 years)of three eucalyptus species by relating tree parameters:diameter at breast height,total height,and leaf area *** measured rainfall,throughfall,stemflow and litter interception,along with the tree *** eucalyptus trees had rainfall interception varying between 22 mm(for 178 mm of rainfall)and 42 mm(for 87 mm of te rainfall),throughfall between 106 mm(for 186 mm of rainfall)and 44 mm(for 74 mm of rainfall),and stemflow between 0.5 mm(for 92 mm of rainfall)and 1.4 mm(for 24 mm of rainfall).For the three species,rainfall interception varied between 12 and 48%,throughfall between 57 and 90%,and stemflow between 0.3 and 5.4%.The coefficient of determination between interception and rainfall was 0.76,indicating interception depends on other variables,possibly including antecedent rainfall,rainfall intensity,and *** decreased with a reduction in leaf area index caused by eucalyptus *** *** had 0.75 mm of throughfall per 1 mm of rainfall,whereas in *** and E saligna,these ratios were 0.71 and 0.68,*** in *** and *** had a higher positive relationship with the diameter at breast height of the trees,whereas in *** the highest relationship was with the *** results contribute to establishing management strategies,such as choosing suitable eucalyptus species to local climate,and to improve the synchronization of crop-demand versus soil-water-supply while maintaining streamflow to fulfill ecological and production needs.

关键词： Water balance Blue-green water Forest hydrology Rainfall interception Rainfall throughfall

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Kinetics of Hydrogen Molecules in MAGNUM-PSI

引用

Plasma Science and Technology 2008年第2期10卷 162-169页

作者： M.BAEVA W.J.GOEdHEER N.J.lopes CARdOZO Leibniz Institute for Plasma Science and Technology Felix-Hausdorf-Str. 2 D-17489 Greifswald Germany FOM-Institute for Plasma Physics Rijnhuizen Association EURATOM-FOM Trilateral Euregio Cluster P. O. Box 1207 3430 BE Nieuwegein The Netherlands

Results from simulations of plasma and neutrals under conditions predictively characterizing the detached plasma regime in the linear machine MAGNUM-PSI are presented. The relaxation of the vibrationally excited hydrogen molecules is investigated in order to establish a relation between their relaxation and dwell times, and the role of the varions mechanisms of the molecular vibrational kinetics. Tile results obtained show that the individual vibrational states have to be inclllded in the transport code for neutrals as distinct species, since the relaxation time of tile vibrational states is sufficiently longer than the typical dwell time of hydrogen molecules in the detached plasma region. The parameters of plasma and neutrals are affected by the transport of the vibrationally excited hydrogen lnolecnles. Furthermore. the rate of molecular reconlbination is overestimated by a factor of - 5 provided that the transport of ilydrogen molecules only in their ground vibrational state is considered. The role of the various processes of vibrational kinetics is studied. The vibrational excitation through singlet electronic states ires a strong influence on the molecular densities for levels with vibrational quantum numbers v≥ 5. Vibration-vibration （V-V） collisions between vibrationally excited hydrogen molecules and vibration-translation （V-T） collisions between vibrationally excited hydrogen molecules and ground state molecules and atoms are of nlinor importance in MAGNUM-PSI.

关键词： vibrational relaxation hydrogen molecules. B2-Eirene simulation detached plasma

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Factors determining the occupancy of nest-boxes by Great Tits(Parus major)in eucalypt plantations

引用

Avian Research 2023年第2期14卷 200-205页

作者： Ricardo S.Ceia Pedro B.lopes Luís Pda Silva Centre for Functional Ecology–Science for People&the Planet Department of Life SciencesUniversity of Coimbra3000-456CoimbraPortugal CIBIO Centro de Investigaçao em Biodiversidade e Recursos GeneticosInBIO Laboratorio AssociadoCampus de Vair aoUniversidade do Porto4485-661VairaoPortugal BIOPOLIS Program in Genomics Biodiversity and Land PlanningCIBIOCampus de Vai~ao4485-661VairaoPortugal

Providing nest-boxes as surrogate tree cavities can be of great importance to increase the breeding populations of cavity-nesting birds in managed ***,the exact placement of nest-boxes should be taken into consideration to enhance their occupancy according to species-specific *** this study,we investigated which factors can better predict nest-box occupancy by the Great Tit(Parus major)in eucalypt *** used generalised linear mixed-effects models to analyse the influence of topography,nest-box positioning,vegetation cover and landscape variables on three-year occupancy records from 80 newly provided ***-random patterns of nest-box occupancy were found with respect to all categories except *** suggest that Great Tits prefer to occupy high-placed nest-boxes,close to areas that can provide them with supplementary resources either within or in the vicinity of the stand(i.e.,trees other than eucalypts,riparian vegetation,and large patches of adjacent habitats).Overall,this study provides important recommendations for nest-box placement and spatial distribution in managed forests and enhances the potential of nest-box interventions as a biodiversity offset and management tool.

关键词： Eucalyptus globulus Managed forest Nest-site attributes Secondary cavity-nester Species-specific preferences Tit

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Therapeutic Properties of Flavonoids in Treatment of Cancer through Autophagic Modulation:A Systematic Review

引用

Chinese Journal of Integrative Medicine 2023年第3期29卷 268-279页

作者： Guilherme Vinicio de Sousa Silva Ana Luiza Vieira Ferreira Guimaraes lopes Isis Carolina Viali Lucas Zannini Medeiros Lima Matheus Ribeiro Bizuti Fabiana Brum Haag débora Tavares de Resende e Silva department of Medicine Federal University of Fronteira SulChapecóSanta CatarinaBrazil department of Nursing Federal University of Fronteira SulChapecóSanta CatarinaBrazil department of Graduate Studies in Biomedical Sciences Federal University of Fronteira SulChapecóSanta CatarinaBrazil

Cancers have high morbidity and mortality rates *** anticancer therapies have demonstrated specific signaling pathways as a target in the involvement of *** is a quality control system for proteins and plays a fundamental role in cancer carcinogenesis,exerting an anticarcinogenic role in normal cells and can inhibit the transformation of malignant ***,drugs aimed at autophagy can function as antitumor *** are a class of polyphenolic secondary metabolites commonly found in plants and,consequently,consumed in *** this review,the systematic search strategy was used,which included the search for descriptors"flavonoids"ANd"mTOR pathway"ANd"cancer"ANd"autophagy",in the electronic databases of PubMed,Cochrane Library,Web of Science and Scopus,from January 2011 to January *** current literature demonstrates that flavonoids have anticarcinogenic properties,including inhibition of cell proliferation,induction of apoptosis,autophagy,necrosis,cell cycle arrest,senescence,impaired cell migration,invasion,tumor angiogenesis and reduced resistance to multiple drugs in tumor *** demonstrate the available evidence on the roles of flavonoids and autophagy in cancer progression and inhibition.(Registration ***42021243071 at PROSPERO)

关键词： anti-cancer effects apoptosis cell proliferation cell survival flavonoids

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：