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Evidence against the participation of a pharmacokinetic interaction in the protective effect of single-dose curcumin against gastrointestinal damage induced by indomethacin in rats

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Journal of Integrative Medicine 2017年第2期15卷 151-157页

作者： liliana zazueta-beltran Lorena Medina-Aymerich Nadia Estela Diaz-Triste Aracely Evangelina Chavez-Pina GUberto Castaneda-Hernandez Leticia Cruz-Antonio Department of Pharmacology Center for Research and Advanced Studies of the National Polytechnic Institute 07360 Mexico City Mexico Laboratory of Pharmacology Institutional Program in Molecular Biomedicine National School of Medicine and Homeopathy of the National Polytechnic Institute Academic Area of Medicine of the Institute of Health Sciences 07320 Mexico City Mexico Superior Studies Faculty of Zaragoza Universidad National Autonomous of Mexico 09230 Mexico City Mexico

OBJECTIVE： To determine the role of a pharmacokinetic interaction in the protective effect of curcumin against the gastric damage induced by indomethacin administration as such or as its prodrug acemetacin. METHODS： Wistar rats orally received single dose of indomethacin （30 mg/kg） with and without curcumin （30 mg/kg）; gastric injury was evaluated by determining the total damaged area. Additional groups of rats received an oral single dose of indomethacin （30 mg/kg） or its prodrug acemetacin （34.86 mg/kg） in the presence or absence of curcumin （30 mg/kg）. Indomethacin and acemetacin concentrations in plasma from blood draws were determined by high-performance liquid chromatography Plasma concentration-against-time curves were constructed, and bioavailability parameters, maximal concentration （Cmax） and area under the curve to the last sampling time （AUC0_t） were estimated. RESULTS： Concomitant administration of indomethacin and curcumin resulted in a significantly reduced gastric damage compared to indomethacin alone. However, co-administration of curcumin did not produce any significant alteration in the bioavailability parameters of indomethacin and acemetacin after administration of either the active compound or the prodrug. CONCLUSION： Curcumin exhibits a protective effect against indomethacin-induced gastric damage, but does not produce a reduction of the bioavailability of this nonsteroidal anti-inflammatory drug, indomethacin. Data thus suggest that a pharmacokinetic mechanism of action is not involved in curcumin gastroprotection.

关键词： indomethacin curcumin acemetacin bioavailability damage, ggastrointestinal side effect drugs, Chinese herbal

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Dynamic analysis of a predator-prey model of Gause type with Allee effect and non-Lipschitzian hyperbolic-type functional response

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International Journal of Biomathematics 2024年第1期17卷 81-112页

作者： liliana Puchuri Orestes Bueno Pontificia Universidad Catolica del Peri Av.Universitaria 1801 San MiguelLima 15088Peru Universidad del Pacifico Jr.Gral Luis Sanchez Cerro 2141 Jesus MariaLima 15072Peru

In this work,we study a predator-prey model of Gause type,in which the prey growth rate is subject to an Allee effect and the action of the predator over the prey is determined by a generalized hyperbolic-type functional response,which is neither differentiable nor locally Lipschitz at the predator axis.This kind of functional response is an extension of the so-called square root functional response,used to model systems in which the prey have a strong herd structure.We study the behavior of the solutions in the first quadrant and the existence of limit cycles.We prove that,for a wide choice of parameters,the solutions arrive at the predator axis in finite time.We also characterize the existence of an equilibrium point and,when it exists,we provide necessary and sufficient conditions for it to be a center-type equilibrium.In fact,we show that the set of parameters that yield a center-type equilibrium,is the graph of a function with an open domain.We also prove that any center-type equilibrium is stable and it always possesses a supercritical Hopf bifurcation.In particular,we guarantee the existence of a unique limit cycle,for small perturbations of the system.

关键词： Predator-prey models Gause models Allee effect non-differentiable functional response

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Sol-gel derived B_(2)O_(3)-CaO borate bioactive glasses with hemostatic,antibacterial and pro-angiogenic activities

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Regenerative Biomaterials 2024年第1期3卷 108-118页

作者： Kai Zheng Faina Bider Mahshid Monavari Zhiyan Xu Christina Janko Christoph Alexiou Ana M.beltran Aldo R.Boccaccini Jiangsu Province Engineering Research Center of Stomatological Translational Medicine College of StomatologyNanjing Medical UniversityNanjing 210029China Jiangsu Key Laboratory of Oral Diseases Nanjing Medical UniversityNanjing 210029China Institute of Biomaterials University of Erlangen-Nuremberg91058 ErlangenGermany Department of Oto-Rhino-Laryngology Head and Neck SurgerySection of Experimental Oncology and Nanomedicine(SEON)Else Kroener-Fresenius-Stiftung ProfessorshipUniversitaetsklinikum Erlangen91058 ErlangenGermany Departamento de Ingenier�ıa y Ciencia de los Materiales y del Transporte Escuela Politecnica

Sol-gel borate bioactive glasses(BGs)are promising ion-releasing biomaterials for wound healing applications.Here,we report the synthesis of a series of binary B_(2)O_(3)-CaO borate BGs(CaO ranging from 50 to 90mol%)using a sol-gel-based method.The influence of CaO content in B_(2)O_(3)-CaO borate BG on morphology,structure and ion release behavior was investigated in detail.Reduced dissolution(ion release)and crystallization could be observed in borate BGs when CaO content increased,while the morphology was not significantly altered by increasing CaO content.Our results evidenced that the ion release behavior of borate BGs could be tailored by tuning the B_(2)O_(3)/CaO molar ratio.We also evaluated the in vitro cytotoxicity,hemostatic,antibacterial and angiogenic activities of borate BGs.Cytocompatibility was validated for all borate BGs.However,borate BGs exhibited composition-dependent hemostatic,antibacterial and angiogenic activities.Generally,higher contents of Ca in borate BGs facilitated hemostatic activity,while higher contents of B_(2)O_(3) were beneficial for pro-angiogenic activity.The synthesized sol-gel-derived borate BGs are promising materials for developing advanced wound healing dressings,given their fast ion release behavior and favorable hemostatic,antibacterial and angiogenic activities.

关键词： borate glasses sol-gel processing glass composition wound healing

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Fractal Fractional Order Operators in Computational Techniques for Mathematical Models in Epidemiology

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Computer Modeling in Engineering & Sciences 2024年第2期138卷 1385-1403页

作者： Muhammad Farman Ali Akgül Mir Sajjad Hashemi liliana Guran Amelia Bucur Institue of Mathematics Khwaja Fareed University of Enginnering and Information TechnologyRaheem Yar KhanPakistan Department of Computer Science and Mathematics Lebanese American UniversityBeirutLebanon Department of Mathematics Art and Science FacultySiirt UniversitySiirt56100Turkey Department of Mathematics Mathematics Research CenterNear East UniversityNicosiaTurkey Department of Computer Engineering Biruni UniversityIstanbul34010Turkey Department of Hospitality Services Babes-Bolyai UniversityCluj-Napoca400174Romania Department of Pharmaceutical Sciences Vasile Goldi竤Western University of AradArad310025Romania Department of Mathematics and Informatics Faculty of SciencesLucian Blaga University of SibiuSibiu550012Romania Department of Electronics and Communication Engineering Saveetha School of EngineeringSIMATSChennaiTamilnaduIndia

New fractional operators, the COVID-19 model has been studied in this paper. By using different numericaltechniques and the time fractional parameters, the mechanical characteristics of the fractional order model areidentified. The uniqueness and existence have been established. Themodel’sUlam-Hyers stability analysis has beenfound. In order to justify the theoretical results, numerical simulations are carried out for the presented methodin the range of fractional order to show the implications of fractional and fractal orders.We applied very effectivenumerical techniques to obtain the solutions of themodel and simulations. Also, we present conditions of existencefor a solution to the proposed epidemicmodel and to calculate the reproduction number in certain state conditionsof the analyzed dynamic system. COVID-19 fractional order model for the case of Wuhan, China, is offered foranalysis with simulations in order to determine the possible efficacy of Coronavirus disease transmission in theCommunity. For this reason, we employed the COVID-19 fractal fractional derivative model in the example ofWuhan, China, with the given beginning conditions. In conclusion, again the mathematical models with fractionaloperators can facilitate the improvement of decision-making for measures to be taken in the management of anepidemic situation.

关键词： COVID-19 model fractal-fractional operator Ulam-Hyers stability existence and uniqueness numerical simulation

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Surgical management of tegmen defects of the temporal bone and meningoencephalic herniation: our experience

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Journal of Otology 2024年第1期19卷 30-34页

作者： Giuseppe De Donato Emanuela Fuccillo Alberto Maria Saibene Elena Ferrari Giorgia Carlotta Pipolo Antonia Pisani liliana Colletti Anastasia Urbanelli Luigi De Donato Giovanni Felisati Otorhinolaryngology Unit Head and Neck DepartmentASST Santi Paolo e Carlo HospitalVia Antonio di Rudinì820142MilanItaly Department of Health Sciences University of MilanVia Festa del Perdono720122MilanItaly Department of Biomedical Surgical and Dental SciencesUniversity of MilanVia Festa del Perdono720122MilanItaly ENT Unit Department of Surgical SciencesUniversity of TurinVia Verdi810124TurinItaly

1. Introduction The tegmental wall of the tympanic cavity is a thin plate of the temporal bone that separates the middle cranial fossa(MCF) from the ear. This anatomical region consists of two areas: an anterior one, comprised of the tegmen tympani(To′th et al., 2007), and a posterior one, formed by the tegmen antri and the tegmen mastoideum(Makki et al., 2011). In some patients, the tegmental region of the temporal bone can be interrupted, causing a tegmen defect(TD). A TD is sometimes associated with a meningoencephalic herniation(MEH), in which brain tissue herniates through a TD.

关键词： al. herniation bone

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Wood anatomy chronologies of Scots pine in the foothills of the Western Sayan(Siberia)

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Journal of Forestry Research 2024年第3期35卷 13-27页

作者： Elena A.Babushkina Dmitry R.Dergunov Mikhail S.Zharkov liliana V.Belokopytova Dina F.Zhirnova Bao Yang Jingjing Liu Xiaomei Peng ·Eugene A.Vaganoy Khakass Technical Institute Siberian Federal UniversityAbakan 655017Russia Institute of Ecology and Geography Siberian Federal UniversityKrasnoyarsk 660036Russia Mathematical Methods and IT Department Siberian Federal UniversityKrasnoyarsk 660036Russia Key Laboratory of Desert and Desertification Northwest Institute of Eco-Environment and ResourcesChinese Academy of SciencesLanzhou 730000People's Republic of China School of Geographic and Oceanographic Sciences Nanjing UniversityNanjing 210093People's Republic of China Department of Dendroecology V.N.Sukachev Institute of ForestSiberian Branch of the Russian Academy of ScienceKrasnoyarsk 660036Russia

Recent methodological advances in quantitative wood anatomy have provided new insights into the climatic responses of radial growth at the scale of cell structure of tree rings.This study considered long-term chronologies of tracheid measurements,indexed by a novel approach to separate their specific climatic responses from signal recorded in cell production(closely reflected in tree-ring width).To fll gaps in understanding the impact of climate on conifer xylem structure,Scots pine(Pinus sylvestris L.)trees>200 years old were selected within the forest-steppe zone in southern Siberia.Such habitats undergo mild moisture deficits and the resulting climatic regulation of growth processes.Mean and maximum values of cell radial diameter and cell wall thickness were recorded for each tree ring.Despite a low level of climatogenic stress,components of cell chronologies independent of cambial activity were separated to obtain significant climatic signals revealing the timing of the specific stages of tracheid differentiation.Cell expansion lasted from mid-April to July and was impacted similarly to tree-ring width(stimulated by precipitation and stressed by heat),maximum cell size formed late June.A switch in the climatic responses of mean anatomical traits indicated transition to latewood in mid-July.Secondary wall deposition lasted until mid-September,suppressed by end of season temperatures.Generally,anatomical climatic responses were modulated by a less dry May and September compared with summer months.

关键词： Quantitative wood anatomy Cell radial size Cell wall thickness Pinus sylvestris Climatic response

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Liver transplantation as an alternative for the treatment of perihilar cholangiocarcinoma: A critical review

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Hepatobiliary & Pancreatic Diseases International 2024年第2期23卷 139-145页

作者： Wellington Andraus Francisco Tustumi Alexandre Chagas Santana Rafael Soares Nunes Pinheiro Daniel Reis Waisberg liliana Ducatti Lopes Rubens Macedo Arantes Vinicius Rocha Santos Rodrigo Bronze de Martino Luiz Augusto Carneiro D’Albuquerque Department of Gastroenterology Transplantation UnitUniversidade de São PauloSão PauloBrazil

Background:Perihilar cholangiocarcinoma(phCCC)is a dismal malignancy.There is no consensus regard-ing the best treatment for patients with unresectable phCCC.The present review aimed to gather the current pieces of evidence for liver transplantation and liver resection as a treatment for phCCC and to build better guidance for clinical practice.Data sources:The search was conducted in PubMed,Embase,Cochrane,and LILACS.The related references were searched manually.Inclusion criteria were:reports in English or Portuguese literature that a)patients with confirmed diagnosis of phCCC;b)patients treated with a curative intent;c)patients with the outcomes of liver resection and liver transplantation.Case reports,reviews,letters,editorials,conference abstracts and papers with full-text unavailability were excluded from the analysis.Results:Most of the current literature is based on observational retrospective studies with low grades of evidence.Liver resection has better long-term outcomes than systemic chemotherapy or palliation ther-apy and liver transplantation is a good alternative for selected patients with unresectable phCCC.All candidates for resection or transplantation should be medically fit and free of intrahepatic or extrahep-atic diseases.As a general rule,patients presenting with a tumor having a longitudinal size>3 cm or extending below the cystic duct,lymph node disease,confirmed extrahepatic dissemination;intraoper-atively diagnosed metastatic disease;a history of other malignancies within the last five years,and did not complete chemoradiation regimen and were medically unfit should not be considered for transplan-tation.Some of these criteria should be individually assessed.Liver transplantation or resection should only be considered in highly experienced hepatobiliary centers,and any decision-making must be based on a multidisciplinary evaluation.Conclusions:phCCC is a complex condition with high morbidity.Surgical therapies,including hepatec-tomy and liver transplantation,are the best option for bette

关键词： Liver transplantation Cholangiocarcinoma Liver neoplasms

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Patterns of Interactions of the Complex City System:Emotional Urban Objects as Triggering Agents-A Secondary Publication

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Journal of World Architecture 2024年第1期8卷 45-53页

作者： O.A.Gonzalez liliana Beatriz Sosa Compeán Autonomous University of Nuevo Leon San Nicolás de los Garza 66455Mexico

This article presents an analysis of the patterns of interactions resulting from the positive and negative emotional events that occur in cities,considering them as complex systems.It explores,from the imaginaries,how certain urban objects can act as emotional agents and how these events affect the urban system as a whole.An adaptive complex systems perspective is used to analyze these patterns.The results show patterns in the processes and dynamics that occur in cities based on the objects that affect the emotions of the people who live there.These patterns depend on the characteristics of the emotional charge of urban objects,but they can be generalized in the following process:(1)immediate reaction by some individuals;(2)emotions are generated at the individual level which begins to generalize,permuting to a collective emotion;(3)a process of reflection is detonated in some individuals from the reading of collective emotions;(4)integration/significance in the community both at the individual and collective level,on the concepts,roles and/or functions that give rise to the process in the system.Therefore,it is clear that emotions play a significant role in the development of cities and these aspects should be considered in the design strategies of all kinds of projects for the city.Future extensions of this work could include a deeper analysis of specific emotional events in urban environments,as well as possible implications for urban policy and decision making.

关键词： Emotional events Urban objects Complex adaptive systems Adaptive complex systems City

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幸福的体验 We Are Emma美发沙龙

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室内设计与装修 2024年第1期 144-145页

作者： [西班牙]Masquespacio coco(编译) Luis beltran(摄影) Masquespacio

西班牙设计公司Masquespacio为美发沙龙品牌We Are Emma米兰新店设计了一个充满欢乐和俏皮氛围的环境。设计师主要是通过色彩和有机形状的运用来实现这一想法的。充满活力的色调和异想天开的形式装饰着整个空间,增添了室内的魅力,营造... 详细信息

西班牙设计公司Masquespacio为美发沙龙品牌We Are Emma米兰新店设计了一个充满欢乐和俏皮氛围的环境。设计师主要是通过色彩和有机形状的运用来实现这一想法的。充满活力的色调和异想天开的形式装饰着整个空间,增添了室内的魅力,营造出轻松愉快的氛围。并且,这种俏皮的氛围并不以牺牲精致为代价。

关键词：美发异想天开愉快的氛围沙龙

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Bloom-forming cyanobacteria and dinoflagellates in five Argentinian reservoirs:Multi-year sampling

Water Biology and Security

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Water Biology and Security 2024年第1期3卷 28-36页

作者： Florencia Soledad Alvarez Dalinger Borja Claudia Nidia Veronica Laura Lozano liliana Beatriz Morana María Monica Salusso Facultad de Ciencias Naturales Universidad Nacional de SaltaAvenida Bolivia 5150Salta4400Argentina Consejo Nacional de Investigaciones Científicas y T'ecnicas(CONICET) Godoy Cruz 2290Ciudad Autonoma de Buenos AiresArgentina

Harmful algal blooms are important threats to reservoir condition.Over a 15-year period,we sampled five Argentinian reservoirs to identify the responsible species for harmful algal blooms and determine the water quality factors driving their occurrence.These reservoirs exhibit diverse morphological and hydrological characteristics and are distributed across varying climatic zones.Cyanobacterial blooms included an array of species,including toxin producers such as Raphidiopsis raciborskii,Aphanizomenon gracile,and Microcystis aeruginosa.In contrast,dinoflagellate blooms were predominantly characterized by Ceratium.The cyanobacterial blooms primarily occurred in the shallower reservoirs located in warmer regions,whereas dinoflagellate blooms occurred where temperatures were lower.The most intense blooms occurred during the summer,and although cyanobacterial and chlorophyte blooms co-occurred,they never coexisted with dinoflagellate blooms.We identified cyanotoxins in the reservoirs over the past three years,a phenomenon previously unreported in the region.Given that these reservoirs are drinking water sources for human populations,ongoing and systematic monitoring is needed to protect public health.Controlling the proliferation of algae and cyanobacteria in reservoirs requires resource management at the watershed level,and in the case of the Itiyuro and El Limon,requires binational management with Bolivia.

关键词： HABs Freshwater South America Toxins

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