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Methodology of Care Humanitude Implementation at an Integrated Continuing Care Unit: Benefits for the Individuals Receiving Care

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Open Journal of Nursing 2020年第10期10卷 960-972页

作者： liliana henriques Marília Dourado Rosa Melo João Araújo Mafalda Inácio Instituto Gineste-Marescotti Portugal Via Hominis Leiria Portugal Faculdade de Medicina Universidade de Coimbra Coimbra Portugal Escola Superior de Enfermagem de Coimbra Coimbra Portugal Centro de Solidariedade e Cultura de Peniche Leiria Portugal

The increasing number of elderly people with behavioral changes, agitation, aggressiveness, and refusal to receive care imposes new challenges to caregivers, who need to take ownership of innovative care methodologies to better take care of this group of people. Objective: To evaluate the benefits of the Humanitude Care Methodology (HCM) in order to improve the health condition of people admitted in a Portuguese Integrated Continuing Care Unit (UCCI). Methods: An action research study was conducted between September and December 2016. The sample consisted of 33 people who were admitted in this UCCI for at least 90 days. Monthly data collection, during four periods, using the Braden Scale, Morse Scale, Barthel Index and Mini Mental State Examination. The data was processed using the Statistical Package for Social Science, version 17.0. Results: The following decreases were observed: in individuals with cognitive deficit (93.94 percent to 81.82 percent);in individuals considered totally dependent (60.61 percent to 30.30 percent);at risk developing pressure ulcers (PU) (84.85 percent to 51.52 percent);in individuals who had PU (24.24 percent to 15.15 percent);in people with high risk of fall (45.45 percent to 39.39 percent);in the number of individuals with two antipsychotic prescriptions (27.27 percent to 9.09 percent). Conclusions: These results allowed to understand the positive benefits, of implementing the HCM, on the people receiving care, specifically at cognitive level, dependency level in activities of daily living, and the avoidance of physical and mental deterioration.

关键词： Healthcare Quality Humanization of Care Patient-Centered Care Elderly Care Dementia

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A Use Case of Patent Classification Using Deep Learning with Transfer Learning

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Journal of Data and Information Science 2022年第3期7卷 49-70页

作者： Roberto henriques Adria Ferreira Mauro Castelli Campus de Campolide Lisboa 1070-312Portugal

Purpose:Patent classification is one of the areas in Intellectual Property Analytics(IPA),and a growing use case since the number of patent applications has been increasing *** propose using machine learning algorithms to classify Portuguese patents and evaluate the performance of transfer learning methodologies to solve this ***/methodology/approach:We applied three different approaches in this ***,we used a dataset available by INPI to explore traditional machine learning algorithms and ensemble *** preprocessing data by applying TF-IDF,FastText and Doc2Vec,the models were evaluated by cross-validation in 5 *** a second approach,we used two different Neural Networks architectures,a Convolutional Neural Network(CNN)and a bi-directional Long Short-Term Memory(BiLSTM).Finally,we used pre-trained BERT,DistilBERT,and ULMFiT models in the third ***:BERTTimbau,a BERT architecture model pre-trained on a large Portuguese corpus,presented the best results for the task,even though with a performance of only 4%superior to a LinearSVC model using TF-IDF feature *** limitations:The dataset was highly imbalanced,as usual in patent applications,so the classes with the lowest samples were expected to present the worst *** result happened in some cases,especially in classes with less than 60 training *** implications:Patent classification is challenging because of the hierarchical classification system,the context overlap,and the underrepresentation of the ***,the final model presented an acceptable performance given the size of the dataset and the task *** model can support the decision and improve the time by proposing a category in the second level of ICP,which is one of the critical phases of the grant patent ***/value:To our knowledge,the proposed models were never implemented for Portuguese patent classification.

关键词： Natural Language Processing(NLP) Patent classification Transfer Learning Bi-directional Encoder Representations for Transformers(BERT)

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Deterioration of Early Holocene coral reef due to sea level rise along west coast of India:Benthic foraminiferal testimony

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Geoscience Frontiers 2012年第5期3卷 697-705页

作者： Abhijit Mazumder Rajiv Nigam Pravin J.henriques Birbal Sahni Institute of Palaeobotany 53 University RoadLucknow 226 007India National Institute of Oceanography Dona PaulaGoa 403 004India Department St.Xavier's CollegeMahapalika MargMumbai 400 001India

A total of 103 surface sediment samples collected from the water depth range of 15-3300 m along Vijaydurg-Karwar stretch of central west coast of India were analyzed for foraminiferal content. Relict benthic foraminiferal assemblage was noted within 50--135 m water depth. The relict benthic foraminiferal assemblage that includes Amphistegina, Operculina and Alveolinella in sediment samples within the water depth of 85-- 135 m indicates presence of coral reef at this depth during Early Holocene. The presence of barnacle fouling on Relict foraminifera at 60--90 m confirms the paleo-shoreline. The shallow depth zone is characterized by presence of agglutinated relict foraminifera. The agglutinated forms indicate freshwater influx, which eventually increased the sea level and subsequently deteriorated the paleo-coral reef.

关键词： Relict benthicforaminifera Early Holocene coral reefPaleo-shoreline West coast of India Sea level rise

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How to manage inflammatory bowel disease during the COVID-19 pandemic:A guide for the practicing clinician

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World Journal of Gastroenterology 2021年第11期27卷 1022-1042页

作者： Júlio Maria Fonseca Chebli Natália Sousa Freitas Queiroz Adérson Omar Mourão Cintra Damião liliana Andrade Chebli Márcia henriques de Magalhães Costa Rogério Serafim Parra Division of Gastroenterology Department of MedicineInflammatory Bowel Disease CenterFederal University of Juiz de ForaJuiz de Fora 36036-900MGBrazil Department of Gastroenterology University of São Paulo School of MedicineSão Paulo 05403-000SPBrazil Department of Clinical Medicine Fluminense Federal UniversityRio de Janeiro 24210-200RJBrazil Department of Surgery and Anatomy Ribeirão Preto Medical SchoolUniversity of São PauloRibeirão Preto 14048-900SPBrazil

Managing inflammatory bowel disease(IBD)during the coronavirus disease 2019(COVID-19)pandemic has been a challenge faced by clinicians and their patients,especially concerning whether to proceed with biologics and immunosuppressive agents in the background of a global outbreak of a highly contagious new coronavirus(severe acute respiratory syndrome coronavirus 2,SARS-CoV-2).The knowledge about the impact of this virus on patients with IBD,although it is still scarce,is rapidly *** particular,concerns surrounding medications’impact for IBD on the risk of acquiring SARS-CoV-2 infection or developing COVID-19,and potentially exacerbate viral replication and the COVID-19 course,are a current thinking of both practicing clinicians and providers caring for patients with *** patients with IBD infected with SARS-CoV-2 depends on both the clinical activity of the IBD and the occasional development and severity of *** this review,we summarize the current data regarding gastrointestinal involvement by SARS-CoV-2 and pharmacologic and surgical management for IBD concerning this infection,and the COVID-19 impact on both the patient's psychological functioning and endoscopy services,and we concisely summarize the telemedicine roles during the COVID-19 pandemic.

关键词： Inflammatory bowel disease SARS-CoV-2 COVID-19 Crohn disease Colitis ulcerative Biological therapy

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Infections Following Kidney Transplant in Children: A Single-Center Study

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Open Journal of Nephrology 2014年第3期4卷 117-124页

作者： Alexandre Fernandes liliana Rocha Teresa Costa Paula Matos Maria Sameiro Faria Laura Marques Conceicao Mota Antonio Castro henriques Pediatric Infectious Diseases and Immunodeficiency Department Centro Hospitalar do PortoOportoPortugal Pediatric Nephrology Department Centro Hospitalar do PortoOportoPortugal Kidney Transplant Department Centro Hospitalar do PortoOportoPortugal

Introduction: Infections are a major cause of morbidity and mortality in pediatric patients undergoing kidney transplantation (KT). Aim and Methods: To determine the patterns of infectious complications during the first 6 months post transplantation, we report our single center experience with data from pediatric kidney recipients transplanted between 2006 and 2011. Results: Thirty-two children (20 males) were submitted to KT. The most common cause of end-stage renal disease (ESRD) was congenital anomalies of the kidney and urinary tract (CAKUT) accounting for 62%. Over the first 6 months post-transplant period, twenty-eight (87.5%) children developed a total of 77 infections, mainly urinary tract infections (UTI) (64.9%). CAKUT etiology of ESRD and UTI before KT increased the risk to develop more than one episode of UTI [71.4% vs. 14.3% and 81.8% vs. 18.2%, respectively;p < 0.05]. Twenty-three (29.9%) viral infections occurred. Cytomegalovirus (CMV) was the most common opportunistic pathogen, occurred in 11 patients and was more frequently in those with a donor (D)+/recipient (R)- CMV sero-status [74.5% vs. 25.5% (p < 0.05)]. A polyomaviruses (BKV) disease with nephropathy and meningitis was registered. The majority of infectious episodes had mild or moderate severity. No deaths occurred. Conclusion: A significant number of patients presented infectious complications during the first 6 months post transplantation. UTI are the most common type of infection, followed by viral infections, particularly CMV. Recognition, prevention and early treatment of infections are of major importance.

关键词： CMV Infection Immunosuppression Kidney Transplantation Urinary Tract Infections

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Fecal calprotectin and endoscopic scores: The cornerstones in clinical practice for evaluating mucosal healing in inflammatory bowel disease

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World Journal of Gastroenterology 2024年第24期30卷 3022-3035页

作者： Marcia henriques de Magalhães Costa Ligia Yukie Sassaki Júlio Maria Fonseca Chebli Department of Clinical Medicine Fluminense Federal UniversityRio de Janeiro 24210-200Brazil Department of Internal Medicine Medical SchoolSão Paulo State University(Unesp)Botucatu 18618-686São PauloBrazil Division of Gastroenterology Department of MedicineUniversity Hospital of The Federal University of Juiz de ForaUniversity of Juiz de Fora School of MedicineJuiz de Fora 36036-247Minas GeraisBrazil

Managing inflammatory bowel disease(IBD)is becoming increasingly complex and personalized,considering the advent of new advanced therapies with distinct mechanisms of *** mucosal healing(MH)is a pivotal therapeutic goal in IBD management and can prevent IBD progression and reduce flares,hospitalization,surgery,intestinal damage,and colorectal *** proactive disease and therapy assessment is essential to achieve better control of intestinal inflammation,even if subclinical,to alter the natural course of *** monitoring of fecal calprotectin(FC)levels and interval endoscopic evaluations are cornerstones for evaluating response/remission to advanced therapies targeting IBD,assessing MH,and detecting subclinical ***,we comment on the article by Ishida et al Moreover,this editorial aimed to review the role of FC and endoscopic scores in predicting MH in patients with ***,we intend to present some evidence on the role of these markers in future targets,such as histological and transmural *** prospective multicenter studies with a stricter MH criterion,standardized endoscopic and histopathological analyses,and virtual chromoscopy,potentially including artificial intelligence and other biomarkers,are desired.

关键词： Fecal calprotectin Endoscopic scores Mucosal healing Histological healing Ulcerative colitis Inflammatory bowel diseases

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A discussion about the limitations of the Eurocode’s high-speed load model for railway bridges

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Railway Engineering Science 2024年第2期32卷 211-228页

作者： Gonçalo Ferreira Pedro Montenegro JoséRui Pinto António Abel henriques Rui Calçada CONSTRUCT-LESE Faculty of EngineeringUniversity of PortoRua Dr.Roberto Frias4200-465 PortoPortugal CONSTRUCT-LABEST Faculty of EngineeringUniversity of PortoRua Dr.Roberto Frias4200-465 PortoPortugal

High-speed railway bridges are subjected to normative limitations concerning maximum permissible deck *** the design of these structures,the European norm EN 1991-2 introduces the high-speed load model(HSLM)—a set of point loads intended to include the effects of existing high-speed ***,the evolution of current trains and the recent development of new load models motivate a discussion regarding the limits of validity of the *** this study,a large number of randomly generated load models of articulated,conventional,and regular trains are tested and compared with the envelope of HSLM *** each type of train,two sets of 100,000 load models are considered:one abiding by the limits of the EN 1991-2 and another considering wider *** comparison is achieved using both a bridge-independent metric(train signatures)and dynamic analyses on a case study bridge(the Canelas bridge of the Portuguese Railway Network).For the latter,a methodology to decrease the computational cost of moving loads analysis is *** show that some theoretical load models constructed within the stipulated limits of the norm can lead to effects not covered by the *** is especially noted in conventional trains,where there is a relation with larger distances between centres of adjacent vehicle bogies.

关键词： High-speed load model Dynamic analysis High-speed railways Train signature Railway bridges Deck acceleration

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Sudden cardiac death and valvular pathology

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Forensic Sciences Research 2019年第3期4卷 280-286页

作者： Rosa H.A.M.henriques de Gouveia Francisco M.A.Corte Real Goncalves Forensic Clinical and Pathology Service Central Branch of the National Institute of Legal Medicine and Forensic SciencesCoimbraPortugal

Sudden death due to valvular heart disease is reported to range from 1% to 5% in native valves and around 0.2%-0.9%/year in *** nature of the diseases is varied,from heritable,congenital to *** may affect both genders in multiple age *** authors show and comment examples of the major nosologic aetiologies underlying unexpected exitus letalis of valvular nature.

关键词： Forensic sciences forensic pathology sudden death cardiac valvular pathology

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Competition among rare earth elements on sorption onto six seaweeds

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Journal of Rare Earths 2021年第6期39卷 734-741,I0005页

作者： Joāo Pinto Marcelo Costa Bruno henriques JoséSoares Mariana Dias Thainara Viana Nicole Ferreira Carlos Vale JoséPinheiro-Torres Eduarda Pereira Department of Chemistry University of Aveiro3810-193 AveiroPortugal CESAM Department of ChemistryUniversity of Aveiro3810-193 AveiroPortugal LAQV-REQUIMTE Department of Chemistry&Central Laboratory of AnalysisUniversity of Aveiro3810-193 AveiroPortugal CIIMAR一Interdisciplinary Centre of Marine and Environmental Research MatosinhosPortugal N9VE-Nature Ocean and ValueLdaPortoPortugal Central Laboratory of Analysis University of Aveiro3810-193 AveiroPortugal

Sorption has been proposed as a promising approach towards a sustainable water decontamination and recently to the recycling of rare earth elements(REE).Although living seaweed have been shown to be capable of removing REE from contaminated solutions,no studies have yet compared the effects of REE competition on sorption onto different groups of *** effects were analysed in the present study by exposing six living seaweeds(Ulva lactuca,Ulva intestinalis,Fucus spiralis,Fucus vesiculosus,Gracilaria *** Osmundea pinnatifida)(3 g/L,fresh weight) to mono-element and multi-element solutions of Y,La,Ce,Pr,Nd,Eu,Gd,Tb and Dy(1 μmol/L).Results show a preference towards light REE in mono-element solutions,which is reduced when in competition with other *** competitive effect is less pronounced in heavy REE indicating that these are still able to bind to the macroalgae despite the presence of competing *** to water content(%),seaweed specific surface area(cm^(2)/g) shows to be an important factor in the sorption of REE,since larger surface area is associated with higher removal and larger competitive effect.

关键词： Bioaccumulation Wastewater e-waste Recovery Removal Marine macroalgae

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An Update on the Clinical Pipelines of New Antibacterial Drugs Developed in China

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Engineering 2024年第7期38卷 52-68页

作者： Xinyi Yang Congran Li Xiukun Wang Zhonghui Zheng Peiyi Sun Chunjie Xu Luni Chen Jiandong Jiang Staffan Normark Birgitta henriques-Normark Xuefu You Beijing Key Laboratory of Antimicrobial Agents/Laboratory of Pharmacology Institute of Medicinal BiotechnologyChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100050China Division for Medicinal Microorganism-Related Strains CAMS Collection Center of Pathogenic MicroorganismsChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100050China State Key Laboratory of Bioactive Substances and Functions of Natural Medicines Institute of Medicinal BiotechnologyChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100050China Shandong Xinhua Pharmaceutical Co. Ltd.Zibo 255005China Department of Microbiology Tumor and Cell BiologyKarolinska InstitutetStockholm SE-17177Sweden State Key Laboratory of Bioactive Substances and Function of Natural Medicines Institute of Materia MedicaChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100050China Institute of Medicinal Biotechnology Chinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100050China Clinical Microbiology Karolinska University HospitalBioclinicumStockholm SE-17176Sweden

Antibacterial resistance is a global health threat that requires further concrete action on the part of all *** this context,one of the biggest concerns is whether enough new antibacterial drugs are being discovered and *** several high-quality reviews on clinical antibacterial drug pipelines from a global perspective were published recently,none provides comprehensive information on original antibacterial drugs at clinical stages in *** this review,we summarize the latest progress of novel antibacterial drugs approved for marketing and under clinical evaluation in China since *** was obtained by consulting official websites,searching commercial databases,retrieving literature,asking personnel from institutions or companies,and other means,and a considerable part of the data covered here has not been included in other *** of June 30,2023,a total of 20 antibacterial projects from 17 Chinese pharmaceutical companies or developers were identified and *** them,two new antibacterial drugs that belong to traditional antibiotic classes were approved by the National Medical Products Administration(NMPA)in China in 2019 and 2021,respectively,and 18 antibacterial agents are in clinical development,with one under regulatory evaluation,five in phase-3,six in phase-2,and six in *** of the clinical candidates are new analogs or monocomponents of traditional antibacterial pharmacophore types,including two dual-acting hybrid antibiotics and a recombinant antibacterial ***,despite there being 17 antibacterial clinical candidates,our analysis indicates that there are still relatively few clinically differentiated antibacterial agents in stages of clinical development in ***,Chinese pharmaceutical companies and institutions will develop more innovative and clinically differentiated candidates with good market potential in the future research and development(R&D)of original antibacterial drugs.

关键词： Antimicrobial resistance New antibiotics Clinical pipelines WHO priority pathogens National Mega-Project for Innovative Drugs

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