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Journal of Otology 2023年第1期18卷 26-32页

作者： Francisco Javier Gonzalez Eslait Paola Andrea Escudero Trivino Yaidy Viviana giraldo Vergara Monica Andrea Morales Garcia Vanessa Fernanda Lucero Gutierrez Universidad del Valle Audiological and Otological Balance CenterImbanaco Clinic-Grupo Quiron SaludCaliColombia Research Institute.Imbanaco Clinic-Grupo Quiron Salud CaliColombia

Objective:We describe the first-year implementation experience of an Instrumented Sensory Integration Therapy Program in Audiological&Balance Center ***:This is a retrospective descriptive *** included Seventy-three adults with diagnoses of acute,episodic,or chronic vestibular *** were classified into the following two groups:group 1 included 46 individuals treated with ISIT plus VRT,and group 2 included 27 individuals treated only with ***:The Sensory Organization Test(SOT)for both groups showed a statistical significance for all three sensory inputs;visual systems(G1:p=0.0003;G2:p=0.0337),vestibular system(G1:p<0.0001;G2:p=0.0003),and balance as demonstrated by compound balance score(G1:p<0.0001;G2:p=0.0035),and balance percentage deficit(G1:p<0.0001;G2:p=0.0078).Conclusions:The severity and complexity of functional neurological disorders in the context of vestibular syndromes seem to require between 10 and 20 therapy sessions,and combined ISIT plus VRT appears to be more effective than ISIT as a monotherapy.

关键词： Posturography Vestibular rehabilitation therapy Dizziness handicap inventory

Nanoparticle-Mediated Genetic Engineering of Plants

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Molecular Plant 2019年第8期12卷 1037-1040页

作者： Jeffrey W.Wang Eduardo G.Grand io Gregory M.Newkirk Gozde S.Demirer Salwan Butrus Juan Pablo giraldo Markita P.Landry Department of Chemical and Biomolecular Engineering University of CaliforniaBerkeleyCA 94720USA Department of Chemical Engineering University of MichiganAnn ArborMI 48103USA Department of Botany and Plant Sciences University of CaliforniaRiversideCA 92521USA Institute of Integrative Genome Biology (IIGB) RiversideCA 92521USA Innovative Genomics Institute (IGI) BerkeleyCA 94720USA California Institute for Quantitative Biosciences QB3University of CaliforniaBerkeleyCA 94720USA Chan-Zuckerberg Biohub San FranciscoCA 94158USA

Genetic engineering of plants is at the core of sustainability efforts,natural product synthesis,and agricultural crop *** past several decades have brought remarkable progress in biotechnology with the improvement of genome editing and sequencing tools,which stand to advance plant synthetic biology and *** agriculture,genetic engineering can be employed to create crops that have in creased yields and nu tritio nal value,are resista nt to herbicides,in sects,diseases,and abiotic stresses,in cludi ng drought and heat .In pharmaceuticals and therapeutics,genetically engineered plants can be used to synthesize valuable small-molecule drugs and recombinant proteins.

关键词： Nanoparticle-Mediated Genetic Engineering Plants biotechnology

Temporal Evolution of Anodization Current of Porous Silicon Samples

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Materials Sciences and Applications 2013年第8期4卷 43-47页

作者： Adriana Gutiérrez Jairo giraldo Mario Enrique Rodríguez-García Centro de Física Aplicada y Tecnología Avanzada Universidad Nacional Autónoma de México Querétaro México Departamento de Física Universidad Nacional de Colombia-Sede Bogotá Ciudad Universitaria Bogotá DC Colombia Departamento de Física Universidad Nacional de Colombia-Sede Bogotá Ciudad Universitaria Bogotá DC Colombia Departamento de Física Universidad Militar Nueva Granada Bogotá DC Colombia

Temporal evolution of the anodization current of porous silicon samples was studied by means of a model of resistances connected in series that represented the temporal changes of the substrate and of the interface between the substrate and the electrolyte during the porous sample formation process. The porous samples were obtained by means of photoelectrochemical etching of (100) n-type silicon wafers with different resistivity values, all in the range of 1 - 25 Wcm. The samples were formed at room temperature in an electrolytic bath composed by a mixture of hydrofluoric acid (48%) and ethanol having a composition ratio of 1:1 in volume under potentiostatic condition (10 V and 20 V) and an etching time of 2 minutes using back illumination provided by a laser beam with a wavelength of 808 nm.

关键词： Porous Silicon Electrochemical Etching Anodization Current

Green Gold—Dirty Gold, Tadó, Dept. Chocó, Colombia

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Natural Resources 2015年第11期6卷 534-542页

作者： William E. Brooks Julio Andrés Sierra-giraldo Franciso Mena Palacios Geologist Reston VA USA Herbario FAUC Universidad de Caldas Manizales Colombia Joyero William Chin Quibdó Colombia

In place of mercury, small-scale alluvial gold miners in Tadó, Dept. Chocó, Colombia produce “green gold” (oroverde) using locally available plant extracts. The leaves of Balso (Ochroma pyramidale) and Malva (Hibiscus furcellatus) are crushed by hand and are mixed with water to make a foamy liquid that is added to the gold pan (batea) instead of mercury. After the plant extract is added, the gold, magnetite, and other heavy minerals sink and the lighter minerals are floated out of the gold pan. For final clean-up, a combination of other methods may be used. However, ICP (Inductively Coupled Plasma) analyses indicate that even green gold contains 208 - 4530 ppm Hg—this mercury may have been released from dragas or other small-scale gold mining operations that continue to use mercury;coal burning;volcanism;or native mercury released from cinnabar occurrences. ICP also indicates 308 - 106,000 ppm Ag and 452 - 585 ppm Pt.

关键词： Green Gold Mercury Geochemistry Plants Colombia

An interactive tool for visualization and prediction of solar radiation and photovoltaic generation in Colombia

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Big Earth Data 2023年第3期7卷 904-929页

作者： Gabriel Narvaez Luis Felipe giraldo Michael Bressan Camilo A.Guillen María A.Pabón Nicolás Díaz Manuel Felipe Porras Brayan Herney Medina Fernando Jiménez Guillermo Jiménez-Estévez Andres Pantoja Corinne Alonso Department of Electrical and Electronic Engineering Universidad de Los AndesBogotáColombia Laboratory for Analysis and Architecture of Systems ToulouseFrance Department of BiomedicalEngineering Universidad de Los AndesBogotáColombia Department of Systems Engineering Corporacion Universitaria del HuilaNeivaColombia Department of Electronic Engineering Universidad deNariñoPastoColombia

This paper presents the building process of an interactive instrument called the Colombian Solar Atlas able to easily visualize meteorological data but also assess the current and future potentials of solar photovoltaic generation throughout the whole territory of Colombia,South *** new tool is based on two different meteorological *** first one is done with historical data extracted from satellite imagery information,and the other one corresponds to data issues from regional-scale climate change projection *** satellite database was validated with different in-situ *** Colombian Solar Atlas uses basic and advanced photovoltaic generation models to estimate the generation of a custom solar *** this tool,a user selects a point on the map and can have directly pertinent information to search for an optimal location with a spatial resolution of 4 *** tool is the first open interactive online tool particularly adapted to study the photovoltaic power potential in Colombia,considering the country’s needs and native language.

关键词： Solar atlas PV power potential climate change Colombia data validation

Conversion disorder in a neurological emergency department:Restrospective series

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Journal of Acute Disease 2017年第5期6卷 218-221页

作者： Alejandro Cardozo Maria-Alejandra Rubiano Giovanny Garces Jaime-Andres giraldo Jose Bareno Emergency Medicine Physician Emergency DepartmentInstituto Neurologico de Colombia General physician Emergency Department Instituto Neurologico de Colombia Emergency Medicine Resident Universidad CES Research and Teaching Instituto Neurologico de Colombia

Objective: To observe the conversion disorder in a neurological emergency department. Methods: It is common that the initial approach to this patients include the use of various diagnostic exams. In this series we reviewed 94 patients that arrived a neurological emergency room in a 3 year period. Results: 72 patients were females (76%), and the initial presumptive diagnosis were: neurovascular syndrome in 36 patients (38.3%), convulsive disorder in 20 patients (21.28%), and conversive disorder in 8 patients (8.51%). 82 patients had motor symptoms and 61 sensitive symptoms. 88 patients (93%) required neuroimaging studies, 77 (81%) patients underwent through basic biochemical panels. Other tests performed were:electroencephalogram in 12 patients (12.77%), electromyography in 11 patients (11.7%), lumbar punction in 8 patients (8.04%) and regarding the medical consult in the care of these patients 11 were evaluated by 1 specialists, 35 (37.2%) by 2 different specialties, 42 (44.63%) patients required evaluation by 3, and 6 patients (6.38%) required evaluation by 4 different specialties. Conclusions: Based on this data, we conclude that conversion disorders require a lot of resources in the emergency room and that the similarities with neurological diseases demands a complete workup including expensive diagnostic tools. However, this patients can be discharged safely without requiring hospitalization.

关键词： Conversion disorder Neurological symptoms Clinical

Relation between Gastrointestinal Adverse Effects in Gaucher Disease Patients and Intestinal Disaccharidases Activity Evaluated by Methane Hydrogen Breath Test

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Journal of Pharmacy and Pharmacology 2017年第2期5卷 85-97页

作者： Blanca Medrano-Engay Marcio Andrade-Campos Maria Pilar Irun Miguel Pocovi Pilaf giraldo Unidad de Investigacion Traslacional Hospital Universitario Miguel Servet Zaragoza 50009 Spain Instituto de Investigacion Sanitaria Aragon (IIS Aragon) Zaragoza 50009 Spain Centro de lnvestigacion Biomedica en Red de Enfermedades Raras (CIBERER) ISCIII Zaragoza 50009 Spain Departamento de Bioquimica y Biologia Molecular y Celular Universidad de Zaragoza Zaragoza 50009 Spain Fundacion Espanola para el Estudio y Terapeutica de la Enfermedad de Gaucher (FEETEG) Zaragoza 50008 Spain

The aim of this paper is to study the disaccharidase profile in GD （Gaucher disease） patients treated or not with miglustat and compare it with a healthy control group. Miglustat is an iminosugar used as substrate inhibitor in the therapy of some lysosomal disorders, its main side effects resembling carbohydrate maldigestion symptoms and cause more than 50% of medication discontinuation among GD patients. In-vitro studies have revealed that miglustat can act as an inhibitor of some digestive enzymes. An exploratory non-interventional study was designed to compare the disaccharidase profile assessed by MHBT （methane hydrogen breath test） and to analyze the correlation with the reported gastrointestinal symptoms in GD patients （40） and healthy subjects （20）. MHBT was performed following the ingestion of lactose, sucrose and maltose on different days. Each participant completed two detailed surveys about dietary habits, medications and gastrointestinal symptoms previous and during the test. Twenty-one GD were receiving miglustat, 10 （47.6%） of them reported gastrointestinal side effects, and 7/10 （70%） recorded a positive MHBT （lactose 5, maltose 2, and sucrose 1）. In 6/19 （31.6%） patients that never been exposed to miglustat and 7/20 （35%） controls a positive MHBT were detected. The comparison of the malabsorption phenotype between GD patients exposed and not exposed to miglustat （p = 0.028） and control group （p 〈 0.04） showed high statistical significance for the group of patients treated with miglustat. These results suggest that miglustat therapy induces persistent changes in digestive enzyme activity in GD patients.

关键词： Methane hydrogen breath test lactose intolerance sucrose intolerance maltose intolerance gastrointestinal disorders Gaucher disease miglustat.

Comparison of Different Models for the Simulation of Photovoltaic Panels

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Energy and Power Engineering 2016年第8期8卷 283-295页

作者： Luisa Fernanda Herrera giraldo Jeison Alexander Rodríguez Cruz Johann Alexander Hernández Mora Electric Engineering Distrital Francisco José de Caldas University Bogotá Colombia

This article contains the description of a circuital model, which was developed to represent the energy production of a photovoltaic panel in a more accurate way, taking into consideration the decrease of its operational time. Furthermore, a comparison among the experimental, the posed simulated model in PSIM and the results obtained by a piece of software developed by some students of the Universidad Distrital is performed in order to verify the values provided by the software and demonstrate the optimal operation of the developed model.

关键词： Photovoltaic Panels (PVP) Simulation PSIM Circuital Model

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中国:拉丁美洲的同盟或对手

消费导刊 2008年第4期 28-29页

作者： Mildred Torres giraldo 上海大学国际工商与管理学院

中国和拉丁美洲之间到底在发生着什么?中国对拉美而言到底意味着机遇还是挑战。这个问题很难回答清楚,但有一点是肯定的,这一主题对于中国和拉美的利益同样息息相关。当然,对于拉丁美洲更为重要,因为该地区居住着占世界512 million的人... 详细信息

中国和拉丁美洲之间到底在发生着什么?中国对拉美而言到底意味着机遇还是挑战。这个问题很难回答清楚,但有一点是肯定的,这一主题对于中国和拉美的利益同样息息相关。当然,对于拉丁美洲更为重要,因为该地区居住着占世界512 million的人口。它在世界贸易中所占比重很低,但也拥有众多发展优势。现在,中国已经成为拉丁美洲的重要经济合作伙伴之一,对拉美的出口额也有进一步增长。中国是否会成为拉美的主要同盟?从另一方面看,中国视美国为其第一贸易同盟。该文章试图通过对拉丁美洲与加勒比海地区问题的分析来看到拉丁美洲的希望,并包括分析拉丁美洲与如中国这样有着广阔经济发展前景国家间的关系。

关键词：贸易同盟

Economic Impact of a Dispensing Analog Insulin Strategy to Diabetic Patients

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Journal of Pharmacy and Pharmacology 2017年第8期5卷 531-535页

作者： Jose Jaime giraldo Rojas Zoraida Andrea Oeampo Saldarriaga Luis Carlos Sanchez Rojo Edwin Alejandro Ospina Marulanda Department of Plannin Cooperativa de Hospitales de Antioquia Medellin 050021 Colombia Department of Plannin Cooperativa de Hospitales de Antioquia Medellin 050021 Colombia

Objective： Assess the economic impact of the dispensing control strategy implementation on analogue insulin dosage indiabetic patients of the subsidized system of Antioquia. Methodology： A retrospective cohort study compares the units of analogueinsulin consumed with the expense per patient during the periods of December/l 4-May/15 versus December/15-May/16. Statisticaltreatment is applied to data obtained and the results are analyzed. Results： The expense per patient during the period ofDecember/15-May/16 was statistically less than the one during the same period on the year before （December/14-May/15）, having astate dispensing saving per patient of US$ 1.34 per month. And a saving per patient in the pharmaceutical care is approximatelyUS$ 2.82 per month. Conclusions： Cost savings in care of insulin-dependent diabetic population enrolled in the subsidized plan waspossible due to the development of cost/effective dispensing strategies that allowed access and safety of insulin therapy.

关键词： Dispensing, insulin, dosage, cost.