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Tibolone Reverses NAFLD in Ovariectomised Rats by Reducing Adiposity and Insulin Resistance

Journal of Pharmacy and Pharmacology 2019年第4期7卷 148-164页

作者： lilian brites campos-shimada Eduardo Hideo Gilglioni Danielle Aparecida Munhos Hermoso Ana Julia dos Reis Buzzo Rosangela Fernandes Garcia Elismari Rizato Martins-Maciel Emy Luiza Ishii-Iwamoto Clairce Luzia Salgueiro-Pagadigorria Laboratory of Experimental Steatosis Department of BiochemistryState University of MaringáMaringá87020900Brazil Department of Physiological Sciences State University of MaringáMaringá87020900Brazil Department of Biomedicine Centro Universitario IntegradoCampo Mourao 87300970Brazil

This study aimed to investigate the effects of tibolone,a synthetic steroid,on several metabolic dysfunctions induced by oestrogen deficiency,in ***(OVX)rats were used as animal model of postmenopausal metabolic *** OVX rats were treated with daily doses of tibolone(0.16 mg/kg)and the results were compared with control(sham-operated)and OVX untreated *** reduced the adiposity and the visceral adipocyte size in OVX *** insulin sensitivity was also improved,and a decrease in the activity of the adipose tissue hormone-sensitive lipase enzyme was *** lower lipolysis by visceral adipocytes,associated with the recovery of peroxisomalβ-oxidation by tibolone may have contributed to the reversion of NAFLD in treated OVX *** reduction of liver lipid contents resulted in a general improvement in the liver redox *** addition,tibolone reduced the mitochondrial ROS generation and restored the activity of glucose-6-phosphate *** also exerted antioxidant effects on inguinal adipose *** exerted several beneficial effects on cellular and metabolic dysfunctions induced by ovariectomy in *** important mode of action of tibolone was the reduction of the visceral adipocyte size,corroborating the relationship between this one and the development and progression of several comorbidities associated with metabolic syndrome.

关键词： Tibolone ovariectomy hepatic steatosis obesity oxidativestress

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