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Four centrosome-related genes to predict the prognosis and drug sensitivity of patients with colon cancer

World Journal of Gastrointestinal Oncology 2024年第5期16卷 1908-1924页

作者： Hui-yan Wang yan Diao Pei-Zhu Tan Huan liang Department of Clinical Laboratory Harbin Medical University Cancer HospitalHarbin 150086Heilongjiang ProvinceChina Department of Clinical Laboratory Heilongjiang Province HospitalHarbin 150000Heilongjiang ProvinceChina Translational Medicine Center of Northern China Harbin Medical UniversityHarbin 150081Heilongjiang ProvinceChina

BACKGROUND As the primary microtubule organizing center in animal cells,centrosome abnormalities are involved in human colon cancer.AIM To explore the role of centrosome-related genes(CRGs)in colon cancer.METHODS CRGs were collected from public databases.Consensus clustering analysis was performed to separate the Cancer Genome Atlas cohort.Univariate Cox and least absolute shrinkage selection operator regression analyses were performed to identify candidate prognostic CRGs and construct a centrosome-related signature(CRS)to score colon cancer patients.A nomogram was developed to evaluate the CRS risk in colon cancer patients.An integrated bioinformatics analysis was conducted to explore the correlation between the CRS and tumor immune microenvironment and response to immunotherapy,chemotherapy,and targeted therapy.Single-cell transcriptome analysis was conducted to examine the immune cell landscape of core prognostic genes.RESULTS A total of 726 CRGs were collected from public databases.A CRS was constructed,which consisted of the following four genes:TSC1,AXIN2,COPS7A,and MTUS1.Colon cancer patients with a high-risk signature had poor survival.Patients with a high-risk signature exhibited decreased levels of plasma cells and activated memory CD4+T cells.Regarding treatment response,patients with a high-risk signature were resistant to immunotherapy,chemotherapy,and targeted therapy.COPS7A expression was relatively high in endothelial cells and fibroblasts.MTUS1 expression was high in endothelial cells,fibroblasts,and malignant cells.CONCLUSION We constructed a centrosome-related prognostic signature that can accurately predict the prognosis of colon cancer patients,contributing to the development of individualized treatment for colon cancer.

关键词： Colon cancer Centrosome Signature Prognostic Immune microenvironment Therapy

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Non-invasive tests of non-alcoholic fatty liver disease

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Chinese Medical Journal 2022年第5期135卷 532-546页

作者： Guanlin Li Xinrong Zhang Huapeng Lin lilian yan liang Grace Lai-Hung Wong Vincent Wai-Sun Wong Department of Medicine and Therapeutics The Chinese University of Hong KongHong KongChina State Key Laboratory of Digestive Disease The Chinese University of Hong KongHong KongChina Medical Data Analytics Centre The Chinese University of Hong KongHong KongChina

For the detection of steatosis,quantitative ultrasound imaging techniques have achieved great progress in past years.Magnetic resonance imaging proton density fat fraction is currently the most accurate test to detect hepatic steatosis.Some blood biomarkers correlate with non-alcoholic steatohepatitis,but the accuracy is modest.Regarding liver fibrosis,liver stiffness measurement by transient elastography(TE)has high accuracy and is widely used across the world.Magnetic resonance elastography is marginally better than TE but is limited by its cost and availability.Several blood biomarkers of fibrosis have been used in clinical trials and hold promise for selecting patients for treatment and monitoring treatment response.This article reviews new developments in the non-invasive assessment of non-alcoholic fatty liver disease(NAFLD).Accumulating evidence suggests that various non-invasive tests can be used to diagnose NAFLD,assess its severity,and predict the prognosis.Further studies are needed to determine the role of the tests as monitoring tools.We cannot overemphasize the importance of context in selecting appropriate tests.

关键词： Fatty liver Non-alcoholic fatty liver disease Non-alcoholic steatohepatitis Liver fibrosis Cirrhosis Transient elastography FibroScan Magnetic resonance imaging

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Resource allocation for D2D-assisted haptic communications

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Digital Communications and Networks 2024年第1期10卷 63-74页

作者： yan Wu Chao Yue yang yang liang Ao College of Telecommunication Engineering Army Engineering University of PLANanjing210000China

Haptic communications is recognized as a promising enabler of extensive services by enabling real-time haptic control and feedback in remote environments,e.g.,teleoperation and autonomous driving.Considering the strict transmission requirements on reliability and latency,Device-to-Device(D2D)communications is introduced to assist haptic communications.In particular,the teleoperators with poor channel quality are assisted by auxiliaries,and each auxiliary and its corresponding teleoperator constitute a D2D pair.However,the haptic interaction and the scarcity of radio resources pose severe challenges to the resource allocation,especially facing the sporadic packet arrivals.First,the contentionbased access scheme is applied to achieve low-latency transmission,where the resource scheduling latency is omitted and users can directly access available resources.In this context,we derive the reliability index of D2D pairs under the contention-based access scheme,i.e.,closed-loop packet error probability.Then,the reliability performance is guaranteed by bidirectional power control,which aims to minimize the sum packet error probability of all D2D pairs.Potential game theory is introduced to solve the problem with low complexity.Accordingly,a distributed power control algorithm based on synchronous log-linear learning is proposed to converge to the optimal Nash Equilibrium.Experimental results demonstrate the superiority of the proposed learning algorithm.

关键词： Haptic communications D2D Power control Contention-based access Potential game

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Designing salt stress-resilient crops:Current progress and future challenges

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Journal of Integrative Plant Biology 2024年第3期66卷 303-329页

作者： Xiaoyan liang Jianfang Li Yongqing yang Caifu Jiang yan Guo State Key Laboratory of Plant Environmental Resilience College of Biological SciencesChina Agricultural UniversityBeijing 100094China State Key Laboratory of Nutrient Use and Management College of Resources and Environmental SciencesChina Agricultural UniversityBeijing 100194China Center for Crop Functional Genomics and Molecular Breeding China Agricultural UniversityBeijing 100094China Frontiers Science Center for Molecular Design Breeding China Agricultural UniversityBeijing 100193China

Excess soil salinity affects large regions of land and is a major hindrance to crop production worldwide.Therefore,understanding the molecular mechanisms of plant salt tolerance has scientific importance and practical significance.In recent decades,studies have characterized hundreds of genes associated with plant responses to salt stress in different plant species.These studies have substantially advanced our molecular and genetic understanding of salt tolerance in plants and have introduced an era of molecular design breeding of salt-tolerant crops.This review summarizes our current knowledge of plant salt tolerance,emphasizing advances in elucidating the molecular mechanisms of osmotic stress tolerance,salt-ion transport and compartmentalization,oxidative stress tolerance,alkaline stress tolerance,and the trade-off between growth and salt tolerance.We also examine recent advances in understanding natural variation in the salt tolerance of crops and discuss possible strategies and challenges for designing salt stress-resilient crops.We focus on the model plant Arabidopsis(Arabidopsis thaliana)and the four most-studied crops:rice(Oryza sativa),wheat(Triticum aestivum),maize(Zea mays),and soybean(Glycine max).

关键词： molecular design breeding salt stress-resilient crop salt tolerance

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Preparation and characterization of pH-responsive metal-polyphenol structure coated nanoparticles

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Food Science and Human Wellness 2024年第3期13卷 1303-1310页

作者： Qile Xia yan liang Ailing Cao yan Cao Luyun Cai Key Laboratory of Post-Harvest Handling of Fruits Food Science InstituteZhejiang Academy of Agricultural SciencesHangzhou 310021China Ningbo Research Institute College of Biosystems Engineering and Food ScienceZhejiang UniversityNingbo 315100China School of Biological and Chemical Engineering Zhejiang Engineering Research Center for Intelligent Marine Ranch EquipmentNingboTech UniversityNingbo 315100China College of Food Science and Engineering Bohai UniversityJinzhou 121013China Hangzhou Customs District Hangzhou 310007China

In this paper,tannic acid(TA)and Fe~(3+)were added to form a layer of metal-polyphenol network structure on the surface of the nanoparticles which were fabricated by zein and carbon quantum dots(CQDs)encapsulating phlorotannins(PTN).pH-Responsive nanoparticles were prepared successfully(zein-PTN-CQDs-Fe-~Ⅲ).Further,the formation of composite nanoparticles was confirmed by a series of characterization methods.The zeta-potential and Fourier transform infrared spectroscopy data proved that electrostatic interaction and hydrogen bonding are dominant forces to form nanoparticles.The encapsulation efficiency(EE)revealed that metal-polyphenol network structure could improve the EE of PTN.Thermogravimetric analysis and differential scanning calorimetry experiment indicated the thermal stability of zein-PTN-CQDs-Fe~Ⅲnanoparticles increased because of metal-polyphenol network structure.The pH-responsive nanoparticles greatly increased the release rate of active substances and achieved targeted release.

关键词： Metal Phlorotannins Nanoparticles pH-Responsive Characterization

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Multi-Smart Meter Data Encryption Scheme Basedon Distributed Differential Privacy

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Big Data Mining and Analytics 2024年第1期7卷 131-141页

作者： Renwu yan yang Zheng Ning Yu Cen liang School of Electronic Electrical Engineering and PhysicsFujian University of TechnologyFuzhou 350118China Department of Computing Sciences at The College at Brockport State University of New YorkNew YorkNY 14420USA

Under the general trend of the rapid development of smart grids,data security and privacy are facing serious challenges;protecting the privacy data of single users under the premise of obtaining user-aggregated data has attracted widespread attention.In this study,we propose an encryption scheme on the basis of differential privacy for the problem of user privacy leakage when aggregating data from multiple smart meters.First,we use an improved homomorphic encryption method to realize the encryption aggregation of users’data.Second,we propose a double-blind noise addition protocol to generate distributed noise through interaction between users and a cloud platform to prevent semi-honest participants from stealing data by colluding with one another.Finally,the simulation results show that the proposed scheme can encrypt the transmission of multi-intelligent meter data under the premise of satisfying the differential privacy mechanism.Even if an attacker has enough background knowledge,the security of the electricity information of one another can be ensured.

关键词： smart grid homomorphic encryption data aggregation differential privacy cloud computing

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Small-diameter acellular porcine corneal stroma for peripheral corneal ulceration treatment

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International Journal of Ophthalmology(English edition) 2024年第5期17卷 831-837页

作者： Tian liang Xia Wang Jie Wu yan Cheng Department of Ophthalmology Xi’an No.1 HospitalXi’an 710002Shaanxi ProvinceChina

AIM:To evaluate the clinical efficacy of small-diameter acellular porcine corneal stroma(SAPS)for the treatment of peripheral corneal ulceration(PCU).METHODS:This retrospective clinical study included 18 patients(18 eyes)with PCU between April 2018 and December 2020.All patients had PCU and underwent lamellar keratoplasty with SAPS.Observation indicators included preoperative and postoperative best-corrected visual acuity(BCVA)and transparency of SAPS.The infection control rate in the surgical eye-lesion area was also calculated.RESULTS:Eighteen patients underwent lamellar keratoplasty with SAPS to treat PCU.None of the patients experienced rejection after 6mo(18/18)and 12mo(16/16)of follow-up.The BCVA(0.47±0.30)at the 6mo followup after operation was significantly improved compared with the baseline(0.99±0.80),and the difference was statistically significant(Z=-3.415,P<0.05).The BCVA at the 12mo follow-up after operation was not statistically significant compared to the 6mo(Z=0,P=1).With time,the SAPS graft gradually became transparent.At the 6mo(18/18)and 12mo(16/16)follow-up,none of the patients had recurrent corneal infection.CONCLUSION:SAPS is clinically effective in the treatment of PCU,improving the patient’s BCVA and reducing the incidence of rejection after keratoplasty.

关键词： acellular porcine corneal stroma lamellar keratoplasty infectious corneal ulcer

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Fine-grained grid computing model for Wi-Fi indoor localization in complex environments

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Journal of Electronic Science and Technology 2024年第1期22卷 42-52页

作者： yan liang Song Chen Xin Dong Tu Liu School of Computer Engineering Chengdu Technological UniversityChengdu611730China HAN Networks Corporation Limited Beijing100094China

The fingerprinting-based approach using the wireless local area network(WLAN)is widely used for indoor localization.However,the construction of the fingerprint database is quite time-consuming.Especially when the position of the access point(AP)or wall changes,updating the fingerprint database in real-time is difficult.An appropriate indoor localization approach,which has a low implementation cost,excellent real-time performance,and high localization accuracy and fully considers complex indoor environment factors,is preferred in location-based services(LBSs)applications.In this paper,we proposed a fine-grained grid computing(FGGC)model to achieve decimeter-level localization accuracy.Reference points(RPs)are generated in the grid by the FGGC model.Then,the received signal strength(RSS)values at each RP are calculated with the attenuation factors,such as the frequency band,three-dimensional propagation distance,and walls in complex environments.As a result,the fingerprint database can be established automatically without manual measurement,and the efficiency and cost that the FGGC model takes for the fingerprint database are superior to previous methods.The proposed indoor localization approach,which estimates the position step by step from the approximate grid location to the fine-grained location,can achieve higher real-time performance and localization accuracy simultaneously.The mean error of the proposed model is 0.36 m,far lower than that of previous approaches.Thus,the proposed model is feasible to improve the efficiency and accuracy of Wi-Fi indoor localization.It also shows high-accuracy performance with a fast running speed even under a large-size grid.The results indicate that the proposed method can also be suitable for precise marketing,indoor navigation,and emergency rescue.

关键词： Fine-grained grid computing (FGGC) Indoor localization Path loss Random forest Reference points(RPs)

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MP-3 microperimeter in early primary open angle glaucoma with a new pattern

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International Journal of Ophthalmology(English edition) 2024年第5期17卷 861-868页

作者： Shuang liang Li-Tao Wang Xiao-Li Liu Jia-liang Duan Dan-yan Liu Department of Ophthalmology of the Second Hospital of Hebei Medical University Shijiazhuang 050000Hebei ProvinceChina Department of Ophthalmology Shijiazhuang People’s HospitalShijiazhuang 050000Hebei ProvinceChina

AIM:To investigate macular microperimetry in patients with early primary open angle glaucoma(POAG)using a new custom-made pattern,and analyze the characteristics of macular sensitivity.METHODS:This case-control study included 38 patients with POAG,who were divided into pre-perimetric glaucoma(18 eyes of 18 patients),early-stage(20 eyes of 20 patients),and control(20 eyes of 20 patients)groups.All subjects underwent standard 24-2 humphrey visual field test.An MP-3 microperimeter with a new custom-made pattern(28 testing points distributed in four quadrants,covering the central 10°of the retina)was used to evaluate macular sensitivity.Ganglion cell complex(GCC)thicknesses were examined using an RS-3000 Advance OCT system.The features of structure and function were analysed per quadrant.RESULTS:The pre-perimetric glaucoma group had significantly lower inferior hemifield macular sensitivity compared to controls(P<0.05).The early-stage POAG group had significantly lower average,inferior hemifield,inferonasal,and inferotemporal mean sensitivities compared to the pre-perimetric glaucoma group(P<0.05),and lower macular sensitivity in all sectors compared to controls(P<0.05).Regarding GCC thickness,all sectors in the early-stage POAG group became thinner compared to those in controls(P<0.05);whereas all sectors in the early-stage POAG group,except the superonasal quadrant,became thinner compared to those in the pre-perimetric glaucoma group(P<0.05).Macular sensitivity and GCC thickness were significantly associated in each sector.The inferotemporal quadrant had the highest correlation coefficients(0.840).The structure-function relationship for the inferonasal and inferotemporal sectors was stronger compared to the corresponding superior sectors.CONCLUSION:Microperimetry reveals variations in macular sensitivity in patients with early glaucoma earlier than conventional perimetry,particularly in pre-perimetric glaucoma cases in which it might be undetectable by conventional methods.The new custom-made pattern may improve th

关键词： early primary open angle glaucoma macular sensitivity microperimetry optical coherence tomography ganglion cell complex

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Multiple Nanoparticles Coupling Strategy for Enhancing Optical Filter Performance of Spectral Splitter Used in Photovoltaic/Thermal System

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Journal of Thermal Science 2024年第1期33卷 368-382页

作者： liang Huaxu HUANG Xin WANG Fuqiang CHENG Ziming DONG yan School of Energy Science and Engineering Harbin Institute of TechnologyHarbin 150001China School of New Energy Harbin Institute of Technology at WeihaiWeihai 264209China School of Materials Science and Engineering Nanyang Technological UniversitySingapore 639798Singapore

Selective absorptive nanofluid can pre-absorb certain sunlight wavelength that cannot be used by PV and transmits remaining sunlight to the surface of PV,which can decouple PV from the thermal receiver spatially.In order to improve the harvesting of electricity and high-temperature thermal nanofluid,it is important to design an optimal optical filter window(transmit sunlight with wavelengths of 732-1067 nm to the surface of the photovoltaic cell and absorb the remaining sunlight).However,designing optimal optical filter is facing following challenges:(1) inherently narrow selective absorptivity property of single nanoparticle;(2) simplified numerical calculation method calculating transmittance;(3) ignoring the shape of the nanoparticle.In this study,the idea of using multiple nanoparticles coupling effect to design an optical filter is proposed,which can superimpose the narrow absorption bandwidth of different nanoparticles to obtain a wide absorption bandwidth of the whole system.In addition,an improved transmission method considering light-matter interaction at air/vessel and liquid/vessel interfaces is adopted to compute the transmittance.The results calculated by improved transmission method are more accurate than widely used traditional Lambert-Beer law,which is verified by experimental test.Furthermore,the effect of nanoparticle shape on spectral transmittance is also investigated,which shows that spiny Ag can approximately extend absorbance from 400 nm to 600 nm compared to nanosphere silver.Finally,the results show that optical filter efficiency of nanofluids with multiple nanoparticles coupling(Ag,spiny Ag,ZnO,ITO) can reached up to 35%.

关键词： solar energy PV/T nanofluid optimal optical filter radiative transfer spectral splitting

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