检索结果-南通市图书馆

NAC Transcription Factor OrE1 and Senescence- Induced BIFUNCTIONAL NUCLEASE1 （BFN1） Constitute a regulatory Cascade in Arabidopsis

引用

Molecular Plant 2013年第5期6卷 1438-1452页

作者： lilian r matallana-ramirez Mamoona rauf Sarit Farage-Barhom Hakan Dortay Gang-Ping Xue Wolfgang Droge-Laser Amnon Lers Salma Balazadeh Bernd Mueller-roeber University of Potsdam Institute of Biochemistry and Biology KarI-Liebknecht-Straβe 24-25 14476 Potsdam-Golm Germany Department of Postharvest Science of Fresh Produce. Volcani Center Agricultural Research Organization Israel CSIrO Plant Industry Brisbane Australia University of Wurzburg Julius-von-Sachs Institute Julius-von-Sachs Platz 2 97082 Wurzburg Germany Max-Planck Institute of Molecular Plant Physiology 14476 Potsdam-Golm Germany

Senescence is a highly regulated process that involves the action of a large number of transcription factors. The NAC transcription factor OrE1 （ANAC092） has recently been shown to play a critical role in positively controlling senescence in Arabidopsis thaliana; however, no direct target gene through which it exerts its molecular function has been identified previously. Here, we report that BIFUNCTIONAL NUCLEASE1 （BFN1）, a well-known senescence-enhanced gene, is directly regulated by OrE1. We detected elevated expression of BFN1 already 2 h after induction of OrE1 in estradiol-inducible OrE1 overexpression lines and 6 h after transfection of Arabidopsis mesophyll cell protoplasts with a 35S：OrE1 construct, OrE1 and BFN1 expression patterns largely overlap, as shown by promoter-reporter gene （GUS） fusions, while BFN1 expression in senescent leaves and the abscission zones of maturing flower organs was virtually absent in ore1 mutant background. In vitro binding site assays revealed a bipartite OrE1 binding site, similar to that of OrS1, a paralog of OrE1. A bipartite OrE1 binding site was identified in the BFN1 promoter; mutating the cis-element within the context of the full-length BFN1 promoter drastically reduced OrEl-mediated transactivation capacity in tran- siently transfected Arabidopsis mesophyll cell protoplasts. Furthermore, chromatin immunoprecipitation （CHIP） demon- strates in vivo binding of OrE1 to the BFN1 promoter. We also demonstrate binding of OrE1 in vivo to the promoters of two other senescence-associated genes, namely SAG29/SWEET15 and SINA1, supporting the central role of OrE1 during senescence.

关键词： Arabidopsis thaliana senescence transcription factor OrE1 BFN1 promoter.

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

IMpower210:A phase Ⅲ study of second-line atezolizumab vs. docetaxel in East Asian patients with non-small cell lung cancer

引用

Chinese Journal of Cancer research 2024年第2期36卷 103-113页

作者： Yi-Long Wu Shun Lu Gongyan Chen Jianxing He Jifeng Feng Yiping Zhang Liyan Jiang Hongming Pan Jianhua Chang Jian Fang Amy Cai lilian Bu Jane Shi Jinjing Xia Guangdong Lung Cancer Institute Guangdong Provincial Key Laboratory of Translational Medicine in Lung CancerGuangdong Provincial People's Hospital&Guangdong Academy of Medical SciencesSouthern Medical UniversityGuangzhou 510080China Shanghai Lung Cancer Center Shanghai Chest HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghai 200025China Department of respiration Harbin Cancer HospitalHarbin Medical UniversityHarbin 150081China Department of Thoracic Oncology and Surgery the First Affliated Hospital of Guangzhou Medical UniversityGuangzhou 510120China Department of Medical Oncology Jiangsu Cancer HospitalNanjing 210009China Department of Medical Oncology Zhejiang Cancer HospitalHangzhou 330022China Department of Pulmonary Medicine Shanghai Chest HospitalShanghai Jiao Tong UniversityShanghai 200030China Department of Medical Oncology Sir Run Run Shaw HospitalZhejiang University School of MedicineHangzhou 310016China Department of Medical Oncology Shenzhen HospitalCancer Hospital of Chinese Academy of Medical SciencesShenzhen 518116China Department of Thoracic Oncology Beijing Cancer HospitalBeijing 100142China Product Development Shanghai Roche Pharmaceutical LtdShanghai 201203China

Objective: IMpower210(NCT02813785) explored the efficacy and safety of single-agent atezolizumab vs.docetaxel as second-line treatment for advanced non-small cell lung cancer(NSCLC) in East Asian patients.Methods: Key eligibility criteria for this phase Ⅲ, open-label, randomized study included age ≥18 years;histologically documented advanced NSCLC per the Union for International Cancer Control/American Joint Committee on Cancer staging system(7th edition);Eastern Cooperative Oncology Group performance status of 0 or 1;and disease progression following platinum-based chemotherapy for advanced or metastatic NSCLC. Patients were randomized 2:1 to receive either atezolizumab(1,200 mg) or docetaxel(75 mg/m^(2)). The primary study endpoint was overall survival(OS) in the intention-to-treat(ITT) population with wild-type epidermal growth factor receptor expression(ITT EGFr-WT) and in the overall ITT population.results: Median OS in the ITT EGFr-WT population(n=467) was 12.3 [95% confidence interval(95% CI),10.3-13.8] months in the atezolizumab arm(n=312) and 9.9(95% CI, 7.8-13.9) months in the docetaxel arm[n=155;stratified hazard ratio(Hr), 0.82;95% CI, 0.66-1.03]. Median OS in the overall ITT population was 12.5(95% CI, 10.8-13.8) months with atezolizumab treatment and 11.1(95% CI, 8.4-14.2) months(n=377) with docetaxel treatment(n=188;stratified Hr, 0.87;95% CI, 0.71-1.08). Grade 3/4 treatment-related adverse events(TrAEs) occurred in 18.4% of patients in the atezolizumab arm and 50.0% of patients in the docetaxel arm.Conclusions: IMpower210 did not meet its primary efficacy endpoint of OS in the ITT EGFr-WT or overall ITT populations. Atezolizumab was comparatively more tolerable than docetaxel, with a lower incidence of grade3/4 TrAEs.

关键词： Atezolizumab East Asia non-small cell lung cancer programmed death-ligand 1 inhibitors monoclonal antibody

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

COVID-19 impact in Crohn’s disease patients submitted to autologous hematopoietic stem cell transplantation

引用

World Journal of Hematology 2024年第1期11卷 1-8页

作者： Milton Artur ruiz roberto Luiz Kaiser Junior lilian Piron-ruiz Tainara Souza Pinho lilian Castiglioni Luiz Gustavo de Quadros Department of Bone Marrow Transplantation Associação Portuguesa de BeneficênciaSão Josédo Rio Preto SP 15090470Brazil Department of Surgery Kaiser Hospital DiaSão Josédo Rio Preto 08010-150São PauloBrazil Department of Bone Marrow Transplantation Beneficência Portuguesa HospitalSão Josédo Rio Preto 15090470São PauloBrazil FAMErP Faculdade de Medicina de São Josédo Rio PretoSão Josédo Rio Preto 15090000São PauloBrazil Beneficência Portuguesa Hospital ABC Medical SchoolSão Bernardo 15015110São PauloBrazil

BACKGrOUND Severe acute respiratory syndrome coronavirus 2 is the virus responsible for coronavirus disease 2019(COVID-19),a disease that has been blamed for inducing or exacerbating symptoms in patients with autoimmune diseases.Crohn's disease(CD)is an inflammatory bowel disease that affects genetically susceptible patients who develop an abnormal mucosal immune response to the intestinal microbiota.Patients who underwent hematopoietic stem cell transplantation(HSCT)are considered at risk for COVID-19.AIM To describe for the first time the impact of COVID-19 in CD patients who had undergone autologous,non-myeloablative HSCT.METHODS In this descriptive study a series of 19 patients were diagnosed with positive COVID-19.For two patients there were reports of the occurrence of two infectious episodes.Parameters related to HSCT,such as time elapsed since the procedure,vaccination status,CD status before and after infection,and clinical manifestations resulting from COVID-19,were evaluated.rESULTS Among the patients with COVID-19,three,who underwent Auto HSCT less than six months ago,relapsed and one,in addition to the CD symptoms,started to present thyroid impairment with positive anti-TPO.Only one of the patients required hospitalization for five days to treat COVID-19 and remained in CD clinical remission.Nine patients reported late symptoms that may be related to COVID-19.There were no deaths,and a statistical evaluation of the series of COVID-19 patients compared to those who did not present any infectious episode did not identify significant differences regarding the analyzed parameters.CONCLUSION Despite the change in CD status in three patients and the presence of nine patients with late symptoms,we can conclude that there was no significant adverse impact concerning COVID-19 in the evaluated patients who underwent HSCT to treat CD.

关键词： Inflammatory bowel disease Crohn disease SArS-CoV-2 COVID-19 Autologous hematopoietic stem cell transplantation Stem cell therapy

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Strategic Planning Practices of Hotels in Kenya

引用

Journal of Tourism and Hospitality Management 2024年第1期12卷 12-17页

作者： lilian M.Gikutha Florence W.Njau Naghea Jilo Kenya Utalii College NairobiKenya

This study broadens perspectives of strategic planning procedures in hotels by analyzing hotel managers’perspectives on hotel strategy formulation and planning.The study was a descriptive quantitative study that targeted managers from various Kenyan hotels.180 questionnaires were returned from a sample of 280 hotel managers who had attended management development programs at a hospitality school.The primary goal of the study was to analyze two aspects of the strategic planning process:strategy formulation and strategic planning.The findings revealed that hotels in Kenya have developed methods and are keen on scanning their external environments.However,with the product offerings being so comparable,competitive analysis played an important role in the context.Creating a unique or specialty offering was not a popular option for most hotels.Cost-cutting was the most favored strategic inclination to achieve desired results.The balanced scorecard was underutilized in the sector.While managers were involved in the strategic planning process,other lower cadre employees were not,they were provided with the targets for the hotels’organizational goals to be achieved.The findings reveal that with similar products and services,the industry creates a hostile business climate with fierce rivalry and must invest in the most obvious alternative of cost reduction to survive.Alternative product innovation is not common in this industry for developing a differentiation approach that allows a property to control a market.

关键词： hotels strategy formulation strategic planning

来源：

维普期刊数据库博看期刊评论

在线全文

学校读者我要写书评

暂无评论

Solar-driven CO_(2) conversion to methane and methanol using different nanostructured Cu_(2)O-based catalysts modified with Au nanoparticles

引用

Journal of Energy Chemistry 2024年第4期91卷 287-298页

作者： João Angelo Lima Perini lilian D.Moura Torquato Juliana Fde Brito Gustavo A.Andolpho Mateus A.Gonçalves Leonardo D.De Angelis Lucas D.Germano Susana I.Córdoba de Torresi Teodorico C.ramalho Maria V.Boldrin Zanoni São Paulo State University(UNESP) Institute of ChemistryRua Prof.Francisco Degni55AraraquaraSP 14800-060Brazil National Institute of Alternative Technologies for Detection Toxicological Evaluation and Removal of Micropollutants and Radioactive Substances(INCT-DATREM)São Paulo State University(UNESP)Institute of ChemistryRua Prof.Francisco Degni55AraraquaraSP 14800-060Brazil Laboratory of Molecular Modelling Department of ChemistryNatural Sciences InstituteFederal University of LavrasLavrasMG 37200-900Brazil Department of Chemistry Faculty of ScienceUniversity of Hradec KrálovéHradec Králové50003Czech Republic Instituto de Química Universidade de São PauloAv.Prof.Lineu Prestes 74805508-080São PauloSPBrazil

This work describes the use of TiO_(2)nanotubes-based electrodes(TNT)modified with Cu_(2)O nanostructures and gold nanoparticles for the photoelectroreduction of CO_(2)to produce value-added compounds.A thin layer of polydopamine was used as both an adherent agent and an electron transfer mediator,due to itsπ-conjugated electron system.The highest production yield was achieved using a TNT@PDA/Nc/Au40%electrode,with Faradaic efficiencies of 47.4%(110.5μM cm^(-2))and 27.8%(50.4μM cm^(-2))for methanol and methane,respectively.The performance of the photoelectrodes was shown to be Cu_(2)O facet-dependent,with cubic structures leading to greater conversion of CO_(2)to methanol(43%)and methane(27%),compared to the octahedral morphology,while a higher percentage of metallic gold on the nanostructured Cu_(2)O surface was mainly important for CH4production.Density functional theory(DFT)calculations supported these findings,attributing the superior photoelectrocatalytic performance of the TNT@PDA/Nc/Au40%electrode for CH4generation to the formation of an OCH3intermediate bonded to Au atoms.Studies using isotope-labeling and analysis by gas chromatograph-mass(GC-MS)demonstrated that13CO_(2)was the source for photoelectrocatalytic generation of13CH3OH and13CH313CH2OH.

关键词： Cu_(2)O nanocubes Photoelectrocatalysis Polydopamine CO_(2) photoelectroreduction DFT calculations

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

我国城乡居民医疗保险制度的演变及改革方向

引用

中国农村卫生事业管理 2024年第5期44卷 319-324页

作者：孟立联四川天府健康产业研究院四川成都610040

文章从农村居民医疗保险制度入手,梳理了城乡居民医疗保险制度的由来及其演变,分析了农民在城乡居民医疗保险中的不利地位和城乡居民在医疗保险制度中的不利地位,比较了两类医疗保险制度的重大差别,提出建立有相同权利但有区别责任的全... 详细信息

文章从农村居民医疗保险制度入手,梳理了城乡居民医疗保险制度的由来及其演变,分析了农民在城乡居民医疗保险中的不利地位和城乡居民在医疗保险制度中的不利地位,比较了两类医疗保险制度的重大差别,提出建立有相同权利但有区别责任的全国统一的医疗保险制度的建议,并稳步推进医疗保险从应急疾病诊疗为中心向以健康保障为中心的转变。

关键词：城乡居民医疗保险历史演变农民,改革制度

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

精细化护理在小儿电子支气管镜术中的应用效果观察

引用

中国医药指南 2024年第10期22卷 140-142页

作者：胡丽莲厦门大学附属中山医院儿科厦门361004

目的分析在小儿电子支气管镜术中采取精细化护理管理的应用价值。方法将2023年1月至2023年12月厦门大学附属中山医院儿科收治的需行电子支气管镜的患儿作为观察对象,共120例,以随机数字表法分组,观察组60例患儿选择精细化护理,对照组6... 详细信息

目的分析在小儿电子支气管镜术中采取精细化护理管理的应用价值。方法将2023年1月至2023年12月厦门大学附属中山医院儿科收治的需行电子支气管镜的患儿作为观察对象,共120例,以随机数字表法分组,观察组60例患儿选择精细化护理,对照组60例患儿采取常规护理,比较两组患儿护理后家属对护理的满意度、恢复时间(体温正常、咳嗽消失、住院时间),观察两组患儿护理前后炎症状态[C-反应蛋白(CrP)、白介素-6(IL-6)、降钙素原(PCT)]水平、情绪状态[焦虑自评量表(SAS)、抑郁自评量表(SDS)]。结果两组患儿护理后,观察组护理满意度更高,体温正常时间、咳嗽消失时间、住院时间更短(P rP、IL-6、PCT水平对比差异无统计学意义(P> 0.05),观察组与对照组护理后比较上述指标可见,前者改善较后者更明显(P 0.05),观察组与对照组护理后比较上述指标可见,前者改善较后者更明显(P <0.05)。结论在行电子支气管镜术的小儿护理中采取精细化护理技术可提高技术对护理的满意度,缓解患儿不良情绪,使其积极配合,提高护理效果。

关键词：精细化护理小儿电子支气管镜

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

2019-2023年钦州市中心血站实验室室间质量评价回顾性分析

引用

齐齐哈尔医学院学报 2024年第3期45卷 264-268页

作者：韦莉莲钦州市中心血站检验科广西钦州535000

目的对钦州市中心血站参加国家卫生健康委(以下简称卫健委)临床检验中心室间质评结果进行回顾性总结分析,进一步提高血站实验室检测能力和质量管理水平。方法对2019—2023年参加卫健委临检中心组织的血型检测(ABO正反定型、rh(D)血型)... 详细信息

目的对钦州市中心血站参加国家卫生健康委(以下简称卫健委)临床检验中心室间质评结果进行回顾性总结分析,进一步提高血站实验室检测能力和质量管理水平。方法对2019—2023年参加卫健委临检中心组织的血型检测(ABO正反定型、rh(D)血型)、血清学检测(HBsAg、HCV、HIV、抗TP、ALT)、血液筛查核酸检测(HBV-DNA、HCV-rNA、HIV-rNA)的质评结果进行回顾性分析。结果2019—2023年实验室每年参加11个项目的室间质评活动,其中血型检测项目分别完成45个质评样本检测,除2019年总符合率95%以外,其他年份总符合率均为100.00%;血清学检测项目分别完成75个质评样本检测,除2022年总符合率97%以外,其他年份总符合率均为100.00%;血液筛查核酸检测项目分别完成100个质评样本检测,符合率均为100.00%;对比卫健委临检中心反馈数据,提示本实验室检测过程可能存在影响检测结果的潜在风险因素。结论长期参加室间质评可监控实验室质量管理体系是否正常运行,有助于发现实验室存在的问题,及时采取纠正措施,持续改进,不断提高检验检测能力,保障临床用血安全。

关键词：室间质评实验室血液筛查

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

新加坡跨境电商市场研究:现状、趋势与进入策略

引用

中国商论 2024年第13期33卷 15-18页

作者：张丽莲深圳职业技术大学广东深圳518055

东南亚是目前全球互联网用户增长最快的区域,而新加坡是东南亚最成熟的电商市场。新加坡跨境电商市场拥有显著的发展优势,在未来几年还有很大的增长空间,移动电商将成为主流业态,社交电商增长迅速。新加坡消费者购买力旺盛,在线消费意愿... 详细信息

东南亚是目前全球互联网用户增长最快的区域,而新加坡是东南亚最成熟的电商市场。新加坡跨境电商市场拥有显著的发展优势,在未来几年还有很大的增长空间,移动电商将成为主流业态,社交电商增长迅速。新加坡消费者购买力旺盛,在线消费意愿强,并且注重品牌品质及购物体验,对中国商品有广泛的需求。新加坡跨境电商平台众多,各具特色;多数平台立足新加坡,辐射东南亚;其中的中资平台增长强劲,利好中国卖家。本文建议有意开拓新加坡电商市场的中国企业,首先要了解各地区的扶持政策,利用好政策福利;其次要优选电商平台,注重本地化经营;再次要强化供给侧改革,打造品牌精品;最后要紧跟社交娱乐购物潮流,打通多元营销渠道等。

关键词：新加坡跨境电商电商市场东南亚市场进入策略

来源：

维普期刊数据库博看期刊

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

循证理论下的责任制护理对脑瘫患儿心理状态及自理能力的影响

引用

中国医药指南 2024年第2期22卷 160-162页

作者：赖丽莲厦门市社会福利中心厦门361000

目的分析循证理论下的责任制护理对脑瘫患儿心理状态及自理能力的影响。方法将2020年1月至2021年1月厦门市社会福利中心收治的62例脑瘫患儿纳入研究对象,随机将患儿分为试验组(31例)和对照组(31例),对照组患儿采用常规护理干预,试验组... 详细信息

目的分析循证理论下的责任制护理对脑瘫患儿心理状态及自理能力的影响。方法将2020年1月至2021年1月厦门市社会福利中心收治的62例脑瘫患儿纳入研究对象,随机将患儿分为试验组(31例)和对照组(31例),对照组患儿采用常规护理干预,试验组融入循证理论下的责任制护理,对两组患儿护理前后自理能力、心理状态评估和对比。结果护理后两组患儿自理能力、心理状态评分均改善(均P<0.05),试验组自理能力、心理状态评分均高于对照组(P<0.05)。结论循证理论下的责任制护理有利于提高脑瘫患儿自理能力,改善患儿心理状态。

关键词：循证理论责任制护理脑瘫心理状态自理能力

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：