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Nanoencapsulation of antioxidant peptides from Lupinus mutabilis in chitosan nanoparticles obtained by ionic gelling and spray freeze drying intended for colonic delivery

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Food Bioscience 2022年第6期50卷 603-613页

作者： Arturo Intiquilla Karim Jiménez-Aliaga Amparo Iris Zavaleta Alexander Gamboa Nelson Caro Mario Diaz Martin Gotteland lilian abugoch Cristian Tapia Laboratorio de Biología Molecular Facultad de Farmacia y BioquímicaUniversidad Nacional Mayor de San MarcosJirón Puno1002Lima 1Peru Departamento de Ciencia de los Alimentos y Tecnología Química Facultad de Ciencias Químicas y FarmacéuticasUniversidad de ChileSantos Dumont 964SantiagoChile Centro de investigación Austral Biotech Universidad de Santo TomasSantiago de ChileChile Facultad de Odontología Universidad de ChileSantiagoChile Departamento de Nutrición Facultad de MedicinaUniversidad de ChileChile.y Laboratorio de Microbiología y ProbióticosInstituto de Nutrición y Tecnología de Alimentos (INTA)Universidad de ChileChile y Núcleo Milenio en la Biología de la Microbiota IntestinalSantiagoChile

Oxidative stress has long been associated with the pathogenesis of inflammatory bowel disease(IBD),and it has been suggested that the combined administration of antioxidants and anti-inflammatory agents may be helpful for its *** from plant proteins,such as soybean glycinin tripeptide VPY,effectively inhibit pro-inflammatory mediators in intestinal epithelial and immune cells,which are both involved in the pathogenesis of *** study aimed to produce antioxidant biopeptides from proteins of Lupinus mutabilis seeds and then encapsulate them in chitosan nanoparticles(NPs)for colonic *** antioxidant peptide fraction of less than three kDa(UF3)was obtained and added at different concentrations(0.1–0.4 mg/ml)in chitosan *** NPs were prepared by gelation with tripolyphosphate(CTPP-UF3)or spray freeze-drying of the chitosan solution(SFDC-UF3).Sizes of 332±13 and 465±58 nm and maximum encapsulation efficiencies of 63.80 and 71.75%,respectively,were ***3 maintained its antioxidant capacity(>80%)and showed different release profiles in 1X PBS buffer at pH 7.4,depending on the encapsulation ***-IR showed hydrogen bonding and electrostatic interactions between the peptide and *** nanosystems maintained cell viability greater than 70%in colonic cell lines *** results show that both methods are appropriate for the nanoencapsulation of UF3 and can be used to design nanoparticles for colonic delivery.

关键词： Antioxidant Peptidic fraction Lupinus mutabilis,chitosan nanoparticles

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Assessment on the pollution of nitrogen and phosphorus of Beijing surface water based on GIS system and multivariate statistical approaches

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Journal of Environmental Sciences 2004年第6期16卷 981-986页

作者： lilian-fang LIGuo-xue LIAOXiao-yong CollegeofResourcesandEnvironmentalSciences ChineseAgriculturalUniversityBeijing100094China InstituteofGeographicalSciencesandNaturalResourcesResearch ChineseAcademyofSciencesBeijing100101China

This paper presented the characteristics of nitrogen and phosphorus pollution in Beijing surface water during the survey. A significant difference was found out in concentration distribution of various parameters of nitrogen and phosphorus. Most water bodies in five water systems were polluted by total nitrogen with the content even up to 120 mg/L which was higher than exceeded the fifth class standard of national surface water quality standard GB3838-2002 except for several segments of Chaobaihe and Yongdinghe. Ammonia and phosphorus showed a similar tendency of distribution with higher content in Daqinghe, Beiyunhe and Jiyunhe water systems, but with relatively low concentrations in Chaobaihe and Yongdinghe water systems. Meanwhile, nitrate was found at comparatively low content(mostly less than 10 mg/L) and could fit for corresponding water quality requirements. Totally, the water quality of Daqinghe, Jiyunhe and Beiyunhe river systems as well as the lower reaches of Yongdinghe and Chaobaihe was contaminated seriously with high content of total nitrogen and phosphorus. Through multivariate statistical approaches, it can be concluded that total nitrogen, ammonia and total phosphorus was highly correlated to chemical oxygen demand, biochemical oxygen demand, dissolved oxygen and electrical conductivity, which explained the same pollution source from anthropogenic activities.

关键词： surface water nitrogen phosphorus assessment GIS

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Using DragPushing to Refine Concept Index for Text Categorization

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Journal of Computer Science & Technology 2006年第4期21卷 592-596页

作者：程学旗谭松波 lilian Tang Division of Intelligent Software Systems Institute of Computing Technology Chinese Academy of SciencesBeijing 100080 P.R. China Department of Computing University of Surrey U.K.

Concept index （CI） is a very fast and efficient feature extraction （FE） algorithm for text classification. The key approach in CI scheme is to express each document as a function of various concepts （centroids） present in the collection. However,the representative ability of centroids for categorizing corpus is often influenced by so-called model misfit caused by a number of factors in the FE process including feature selection to similarity measure. In order to address this issue, this work employs the ＂DragPushing＂ Strategy to refine the centroids that are used for concept index. We present an extensive experimental evaluation of refined concept index （RCI） on two English collections and one Chinese corpus using state-of-the-art Support Vector Machine （SVM） classifier. The results indicate that in each case, RCI-based SVM yields a much better performance than the normal CI-based SVM but lower computation cost during training and classification phases.

关键词： text classification information retrieval machine learning

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Image encryption based on a novel memristive chaotic system,Grain-128a algorithm and dynamic pixel masking

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Journal of Systems Engineering and Electronics 2022年第3期33卷 534-550页

作者： HUANG lilian SUN Yi XIANG Jianhong WANG Linyu College of Information and Communication Engineering Harbin Engineering UniversityHarbin 150001China Key Laboratory of Advanced Marine Communication and Information Technology-Ministry of Industry and Information Technology Harbin Engineering UniversityHarbin 150001China

In this paper,we first propose a memristive chaotic system and implement it by circuit *** chaotic dynamics and various attractors are analysed by using phase portrait,bifurcation diagram,and Lyapunov *** particular,the system has robust chaos in a wide parameter range and the initial value space,which is favourable to the security communication ***,we further explore its application in image encryption and present a new *** image processing,the external key is protected by the Grain-128a algorithm and the initial values of the memristive system are updated with the plain *** not only perform random pixel extraction and masking with the chaotic cipher,but also use them as control parameters for Brownian motion to obtain the permutation *** addition,multiplication on the finite field GF(2^(8))is added to further enhance the ***,the simulation results verify that the proposed image encryption scheme has better performance and higher security,which can effectively resist various attacks.

关键词： memristive chaotic system super-wide parameter range image encryption Grain-128a algorithm dynamic pixel masking

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关节镜下改良双束修复前交叉韧带Sherman Ⅰ型损伤

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中国组织工程研究 2025年第6期29卷 1192-1198页

作者：王昌兵赵立连傅楚滢李彦锦广州中医药大学附属佛山中医院运动医学科广东省佛山市528000

背景:前交叉韧带重建术后产生的腘绳肌肌力减弱、髌前区疼痛、重建后较高的骨关节炎发生率及本体感觉丧失等问题导致术后功能恢复不佳;前交叉韧带关节镜下修补结合动态或静态增强修补,保留了原有韧带结构,并取得了良好的近期疗效。目的... 详细信息

背景:前交叉韧带重建术后产生的腘绳肌肌力减弱、髌前区疼痛、重建后较高的骨关节炎发生率及本体感觉丧失等问题导致术后功能恢复不佳;前交叉韧带关节镜下修补结合动态或静态增强修补,保留了原有韧带结构,并取得了良好的近期疗效。目的:观察关节镜下改良双束修复前交叉韧带Sherman Ⅰ型损伤的功能疗效及影像学表现。方法:选择2020年1月至2022年9月在佛山市中医院运动医学科就诊的前交叉韧带损伤患者60例,根据治疗方案分为2组,每组30例,修复组采用双束修补结合内支架固定,重建组采用自体腘绳肌单束解剖重建。术后所有病例随访12个月,分别于术后3,6,12个月评估两组患者国际膝关节评分委员会评分、Lysholm评分及KT-1000患侧-健侧差值。结果与结论:①术后3个月,两组患者的国际膝关节评分委员会评分、Lysholm评分及KT-1000患侧-健侧差值比较差异均有显著性意义(P0.05);③结果表明,前交叉韧带修复保留了原有韧带结构,避免了因重建钻取较大的骨髓道及自体肌腱取出,可减少对原有正常结构的损伤,并发症少,术后早期疗效优于前交叉韧带保残重建,但术后6个月之后两组疗效无明显差异。

关键词：前交叉韧带韧带修复韧带重建腘绳肌内支架

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Estrogen rapid effects:a window of opportunity for the aging brain?

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Neural Regeneration Research 2022年第8期17卷 1629-1632页

作者： Ivanny Marchant Jana Stojanova lilian Acevedo Pablo Olivero Laboratorio de Modelamiento en Medicina Escuela de MedicinaUniversidad de ValparaísoViña del MarChile Interdisciplinary Centre for Health Studies(CIESAL) Universidad de ValparaísoViña del MarChile Servicio de Neurología Hospital Carlos van Buren ValparaísoChile Laboratorio de Estructura y Función Celular Escuela de MedicinaFacultad de MedicinaUniversidad de ValparaísoValparaísoChile Centro Interoperativo en Ciencias Odontológicas y Médicas Universidad de ValparaísoValparaísoChile

Estrogen produces several beneficial effects in healthy neurological tissues and exhibits cardioprotective *** therapy has been widely used to treat menopausal estrogen deficiency for more than 80 *** high initial expectations of cardioprotective effects,there has been substantial distrust following important randomized clinical trials,such as the Women’s Health ***,the timing of treatment in relation to the onset of menopause came under consideration and led to the proposal of the timing hypothesis,that early initial treatment is important,and benefits are lost as the timing since menopause becomes *** analyses of the Women’s Health Initiative data,together with more recent data from randomized and observational trials,consistently show reductions in coronary heart disease and mortality in younger menopausal *** cognitive function,the timing hypothesis is consistent with observations from basic and animal *** is some clinical evidence to support the benefits of hormonal therapy in this context,though skepticism remains due to the paucity of clinical trials of substantial length in younger menopausal *** is likely that the effects of estrogens on cognitive performance are due to rapid mechanisms,including mechanisms that influence Ca2+homeostasis dynamics,provide protection in a hostile environment and reduce inflammatory signals from neural *** the future,inflammatory profiles accounting for early signs of pathological inflammation might help identify the‘window of opportunity’to use estrogen therapy for successful cognitive protection.

关键词： aging cardiovascular prevention cognitive function estrogen hormone treatment inflammaging rapid effects timing hypothesis TRPV1 window of opportunity

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Syntheses and Crystal Structures of Two VO(IV) Schiff Base Complexes with Oxyammonia Ligand

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Chinese Journal of Structural Chemistry 2004年第8期23卷 865-869页

作者： lilian-Zhi XUTao WANGDa-Qi NIUMei-Ju JIHai-Wei SchoolofChemistryandChemicalEngineering LiaochengUniversityShandong252059China

Two novel VO(IV) Schiff base complexes, VO(SALHA)2[SALHA: salicyaldehyde- oxyammonia] and VO(o-VANHA)2 [o-VANHA: o-vanillin-oxyammonia], have been synthesized with salicyaldehyde or o-vanilline, hydroxylammonium chloride and vanadyl sulfate in absolute methanol, and their crystal structures were determined by single-crystal X-ray diffraction. The vanadium(IV) centers in both complexes are five-coordinate in a distorted square pyramidal geometry. VO(SALHA)2 (C14H12N2O5V, Mr = 339.20) crystallizes in the monoclinic system, space group P21/n with a = 14.716(9), b = 7.175(5), c = 14.716(9) ? b = 113.130(7), V = 1428.8(15) 3, Z = 4, Dc = 1.577 g/cm3, l = 0.71073 ? m(MoKa) = 0.720 mm-1, F(000) = 692, the final R = 0.0466 and wR = 0.0829 for 1561 observed reflections (I > 2s(I)). VO(o-VANHA)2 (C16H16N2O7V, Mr = 399.25) is of monoclinic, space group P21/n with a = 11.386(12), b = 10.405(10), c = 14.627(15) , b = 93.654(19), V = 1729(3) 3, Z = 4, Dc = 1.533 g/cm3, l = 0.71073 , m(MoKa) = 0.615 mm-1, F(000) = 820, the final R = 0.0513 and wR = 0.1129 for 1235 observed reflections (I > 2s(I)).

关键词： vanadium complex Schiff base crystal structure

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Clomazone dissipation, adsorption and translocation in four paddy topsoils

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Journal of Environmental Sciences 2004年第4期16卷 678-682页

作者： lilian-fang LIGuo-xue YANGRen-bin GUOZheng-yuan LIAOXiao-yong CollegeofResourcesandEnvironmentalSciences ChinaAgricultureUniversityBeijing100094China InstituteofAgricultureEnvironmentalProtection HunanAgricultureUniversityChangsha410128China InstituteofGeographicalSciencesandNaturalResourcesResearch ChineseAcademyofSciencesBeijing100101China

Laboratory experiments about the dissipation, adsorption and translocation in four paddy topsoils were conducted in this paper. From the results it can be concluded as follows: the dissipation rate of clomazone differed greatly in different paddy soil derived from different parent materials. The half-lives for clomazone degradation in paddy soils ranged from 5.7 to 22.0 d. The order of clomazone dissipation rate was reddish yellow paddy soil > alluvial sandy paddy soil > yellow clayey paddy soil > purple sandy paddy soil. Clomazone sorption quantity was significantly correlated with organic carbon(R2=0.62) and clay content(R2=0.67) in the tested paddy soils. Positive correlation was found between apparent K d value and cation exchange content(CEC). The consequences for the adsorption of different soils were purple sandy paddy soil>yellow clayey paddy soil>reddish yellow paddy soil>alluvial sandy paddy soil. Under the simulated rainfall of 200 mm through four different unsaturated soil lysimeters over 24 h, clomazone was readily to be leached into lower surface soil and there was about 2.6%—4.2% of applied clomazone leached out of 20 cm cultivated soil layer. Translocation experiments showed that the order of clomazone leaching ability was: alluvial sandy paddy soil > reddish yellow paddy soil > yellow clayey paddy soil > purple sandy paddy soil. Simple regression results manifested that factors like CEC, organic carbon, clay, and adsorption rate constant had been negatively correlated with the percentage of clomazone loss from soil lysimeters.

关键词： clomazone dissipation adsorption translocation paddy topsoils

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Discrete Plane Segmentation and Estimation from a Point Cloud Using Local Geometric Patterns

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International Journal of Automation and computing 2008年第3期5卷 246-256页

作者： Yukiko Kenmochi lilian Buzer Akihiro Sugimoto Ikuko Shimizu Université Paris-Est Laboratoire d'Informatique de l'Institut Gaspard-MongeUMR CNRS 8049 A2SI-ESIEECité DescartesBP 9993162 Noisy-le-Grand CedexFrance Department of Computer Information and Communication SciencesTokyo University of Agriculture and Technology

This paper presents a method for segmenting a 3D point cloud into planar surfaces using recently obtained discretegeometry results. In discrete geometry, a discrete plane is defined as a set of grid points lying between two parallel planes with a small distance, called thickness. In contrast to the continuous case, there exist a finite number of local geometric patterns （LGPs） appearing on discrete planes. Moreover, such an LGP does not possess the unique normal vector but a set of normal vectors. By using those LGP properties, we first reject non-linear points from a point cloud, and then classify non-rejected points whose LGPs have common normal vectors into a planar-surface-point set. From each segmented point set, we also estimate the values of parameters of a discrete plane by minimizing its thickness.

关键词： Discrete plane image segmentation parameter estimation discrete geometry local geometric pattern (LGP)

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Organic carbon stock in topsoil of Jiangsu Province, China, and the recent trend of carbon sequestration

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Journal of Environmental Sciences 2005年第1期17卷 1-7页

作者： PANGen-xing lilian-qing ZHANGQi WANGXu-kui SUNXing-bin XUXiao-bo JIANGDing-an InstituteofResources EcosystemandEnvironmentofAgricultureNanjingAgriculturalUniversityNanjing210095China ExtensionCenterofSoilandFertilizerTechnology DepartmentofAgricultureJiangsuAdministrationNanjing210000China ExtensionCenterofSoilandFertilizerTechnology Donghai222300China ExtensionCenterofSoilandFertilizerTechnology Wujiang215200China ExtensionCenterofSoilandFertilizerTechnology Yixing214200China

Data collection of soil organic carbon(SOC) of 154 soil series of Jiangsu, China from the second provincial soil survey and of recent changes in SOC from a number of field pilot experiments across the province were collected. Statistical analysis of SOC contents and soil properties related to organic carbon storage were performed. The provincial total topsoil SOC stock was estimated to be 0 1 Pg with an extended pool of 0 4 Pg taking soil depth of 1 m, being relatively small compared to its total land area of 101700 km 2 One quarter of this topsoil stock was found in the soils of the Taihu Lake region that occupied 1/6 of the provincial arable area. Paddy soils accounted for over 50% of this stock in terms of SOC distribution among the soil types in the province. Experimental data from experimental farms widely distributed in the province showed that SOC storage increased consistently over the last 20 years despite a previously reported decreasing tendency during the period between 1950—1970 The evidence indicated that agricultural management practices such as irrigation, straw return and rotation of upland crops with rice or wheat crops contributed significantly to the increase in SOC storage. The annual carbon sequestration rate in the soils was in the range of 0 3—3 5 tC/(hm 2·a), depending on cropping systems and other agricultural practices. Thus, the agricultural production in the province, despite the high input, could serve as one of the practical methods to mitigate the increasing air CO 2

关键词： soil organic carbon soil carbon stock agricultural practice carbon sequestration paddy soil China

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