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Neuroprotective effect of immunomodulatory peptides in rats with traumatic spinal cord injury

Neural Regeneration Research 2021年第7期16卷 1273-1280页

作者： Dulce Parra-Villamar lilia.a.bla.ca.-espinoza.elisa.ga.cia.vences Juan Herrera-garcía Adrian Flores-Romero Alberto Toscano-Zapien Jonathan Vilchis Villa Rodríguez Barrera-Roxana Soria Zavala Karla Antonio Ibarra Raúl Silva-garcía Unidad de Investigación Médica en Inmunología Hospital de PediatríaCentro Médico Nacional Siglo XXI/Instituto Mexicano del Seguro Social/Ciudad de MéxicoMéxico Centro de Investigación en Ciencias de la Salud(CICSA) Facultad de Ciencias de la SaludUniversidad Anáhuac MéxicoCampus NorteHuixquilucanEdo de MéxicoMéxico Centro de Investigación del Proyecto camina A.C Ciudad de MéxicoMéxico

Several therapies have shown obvious effects on structural conservation contributing to motor functional recovery after spinal cord injury(SCI).Nevertheless, neither strategy has achieved a convincing *** purposed a combined therapy of immunomodulatory peptides that individually have shown significant effects on motor functional recovery in rats with *** objective of this study was to investigate the effects of the combined therapy of monocyte locomotion inhibitor factor(MLIF), A91 peptide, and glutathione monoethyl ester(GSH-MEE) on chronic-stage spinal cord *** Sprague-Dawley rats underwent a laminectomy of the T9 vertebra and a moderate *** groups were included: sham, PBS, MLIF + A91, MLIF + GSH-MEE, A91 + GSH-MEE, and MLIF + A91 + *** months after injury, motor functional recovery was evaluated using the open field *** and white matter preservation was evaluated using hematoxylin & eosin staining and Luxol Fast Blue staining, *** number of motoneurons in the ventral horn and the number of axonal fibers were determined using hematoxylin & eosin staining and immunohistochemistry, *** deposition was evaluated using Masson's trichrome *** combined therapy of MLIF, A91, and GSH-MEE greatly contributed to motor functional recovery and preservation of the medullary parenchyma, white matter, motoneurons, and axonal fibres, and reduced the deposition of collagen in the lesioned *** combined therapy of MLIF, A91, and GSH-MEE preserved spinal cord tissue integrity and promoted motor functional recovery of rats after *** study was approved by the National Commission for Scientific Research on Bioethics and Biosafety of the Instituto Mexicano del Seguro Social under registration number R-2015-785-116(approval date November 30, 2015) and R-2017-3603-33(approval date June 5, 2017).

关键词： glutathione monoethyl ester monocyte locomotion inhibitor factor motor functional recovery neuroprotection neurorestoration peptides protective autoimmunity spinal cord injury

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A 4-year retrospective study of add-on therapy to the fixed combination of dorzolamide/timolol for the treatment of POAG

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International Journal of Ophthalmology(English edition) 2014年第2期7卷 330-334页

作者： Curt Hartleben-Matkin Diddier Prada Rafael Mancilla-vences Glaucoma Service Instituto de Oftalmología Fundación Conde de Valenciana Unidad de Investigación Biomédica en Cáncer Instituto Nacional de Cancerología de México Departamento de Informática Biomédica Faculty of Medicine Universidad Nacional Autónoma de México(UNAM) Laboratory of Environmental Epigenetics Harvard School of Public Health

AIM:To evaluate the long-term response to the fixed combination of dorzolamide/timolol in patients with primary open angle glaucoma(POAG)and the addition of other intraocular pressure(IOP)lowering medications such as prostaglandin analogs and ***:A retrospective,non-randomized,and descriptive clinical study was performed with 182 eyes diagnosed with *** were divided into three groups:a group with fixed combination of dorzolamide/timolol only,a second group with prostaglandin analogs plus fixed combination of dorzolamide/timolol,and a third group with the addition of brimonidine to the same fixed *** data were gathered retrospectively and the differences between groups were ***:IOP was reduced satisfactorily in all three groups;however,a progressive IOP reduction was noted in the group with the fixed combination plus prostaglandin *** this group,a progressive,significant and more homogeneous response of the reduction was noted in comparison with the other ***:IOP reduction was efficacious in all three *** addition of prostaglandin analogs showed progressive IOP reduction,progressive responseand absence of long-term *** did not show a significant additive effect.

关键词： fixed combination, Cosopt® , dorzolamide/timolol, prostaglandin analogs, brimonidine, glaucoma

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Aging Effects on Neuromuscular Activity in Karate Practitioners

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Journal of Sports Science 2015年第5期3卷 203-213页

作者： AntOnio Manue VitOria vences de Brito Mario Andr Ferreira Rodrigues Wojciech Jan Cynarski carlos Gutiorrez garcia Sport Sciences School of Rio Maior Polytechnic Institute of Santar~m 2040-413 Rio Maior Portugal Life Quality Research Centre-CIEQV Complexo Andaluz Apartado 279 2001-904 SantarOm Portugal International Martial Arts and Combat Sports Scientific Society--IMACSSS 35-959 Rzeszow A. Towarnickiego Str. 3/17APoland Faculty of Physical Education University of RzeszEw Rzeszow 35-959 Poland Department of Physical and Sport Education Faculty of Physical and Sport Sciences University of Le6n Vegazana Campus24071-Le6n Spain

Aging leads to a general decline in body functions that affects quality of life. Sports practice is recommended as a means to attenuate the impact of the aging process. The aim of this study was to identify and analyze the neuromuscular activity and its patterns on active karate practitioners and assess the effects of the aging process. Two groups of black belt male karate practitioners, one with nine practitioners over 50 years old and the other with 21 practitioners aged between 20-30 years old performed the frontal kick mae-geri. Kinematic and electromyographic data of five muscles were collected from the right leg. Results showed two distinct periods of muscular activation in the mae-geri performance, with similar muscles activity patterns between groups. Nevertheless, some differences were found in the muscles＇ activity onset and offset, in root mean square and in inter-muscle delay and co-contraction periods. Those differences indicated that aging affects the neuromuscular activity in the mae-geri performance of the oldest karate practitioners. Nevertheless, the results showed that lifelong practice of karate can preserve the quality of the neuromuscular activity in older practitioners when they perform a kick, and this could be associated with benefits to balance control.

关键词： Aging motor control neuromuscular activity karate combat sports martial arts.

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Xenobiotic-Metabolizing Enzymes in Skeletal Muscle of Children and Adolescents

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Pharmacology & Pharmacy 2013年第2期4卷 231-239页

作者： Dora Molina-Ortiz José Francisco González-Zamora Rafael camacho-carranza Ocarol Lopez-Acosta Oscar Colin-Martinez Adriana Miriam Domínguez-Ramírez Araceli vences-Mejía Instituto de Investigaciones Biomédicas Universidad Nacional Autónoma de México México City México. Laboratorio de Cirugía Experimental INP México City México. Laboratorio de Farmacocinética y Farmacodinamia UAMX México City México. Laboratorio de Toxicología Genética Instituto Nacional de Pediatría (INP) México City México Servicio de Ortopedia INP México City.

Cytochrome P450 (CYP) enzymes metabolize endogenous compounds such as steroid hormones, fatty acids, and xenobiotics, including drugs and carcinogens. The skeletal muscle is highly exposed to circulating xenobiotics;nevertheless the knowledge on the expression of these enzymes not only in adult skeletal muscle but also in younger individuals has been very little. Therefore, the aim of the present study was to investigate the expression of CYP enzymes in healthy skeletal muscles of children and adolescents. This was investigated in a total of 18 biopsies taken from the quadriceps skeletal muscle of younger patients: 9 boys and 9 girls (≤18 years) by using specific antibodies in immunoblots and by RT-PCR mRNA analysis. The mRNA transcripts for CYP1B1 and CYP2E1 were consistently detected in all samples, but in the immunoblot only was identified CYP1B1 protein in four samples. Regarding CYP1A1, CYP3A4 and CYP3A5 enzymes in skeletal muscle, there were found in some samples in both techniques, although with significant inter-individual variations. Finally CYP2W1 only was detected in one sample belonging to the youngest patient. These data show that a range of CYP enzymes are expressed in the skeletal muscle of children and adolescents, suggesting that the metabolism of several xenobiotic chemicals to which humans are exposed takes place in muscle cells. Moreover, since the potential participation of muscles is a fact in pharmacokinetics of many therapeutic drugs, expression of CYPs in skeletal muscle may play an important role in drug-dependent toxicity.

关键词： Cytochrome P450 Skeletal Muscle Children Adolescents

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A Highly Sensitive In Situ Hybridization Assay For Hpv Detection In Mexican Women:Potential Marker Of Cervical Intraepithelial Neoplasia

A Highly Sensitive In Situ Hybridization Assay For Hpv Detec...

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24th International Papillomavirus Conference and Clinical Workshop

作者： Luz del carmen Alarcon-Romero Elba Reyes-Maldonado Berenice Illades-Aguiar Eugenia Flores-Alfaro Gloria Fernondez-Tilapa Amalia vences Velozquez Esther Ivonne Lepez-Bayghen Victor gabriel Hernondez Chavez Marco Antonio Teran-Porcayo Escuela Nacional de Ciencias Biologicas IPNMexicoD.F.Facultad de Ciencias Quimico BiologicasUniversidad Autonoma de GuerreroChilpancingoGuerreroMexico Escuela Nacional de Ciencias Biologicas IPNMexicoD.F. Facultad de Ciencias Quimico Biologicas Universidad Autonoma de GuerreroChilpancingoGuerreroMexico Facultad de Ciencias Quimico Biologicas Universidad Autonoma de GuerreroChilpancingoGuerreroMexico Escuela Nacional de Ciencias Biologicas IPNMexicoD.F.Facultad de Ciencias Quimico BiologicasUniversidad Autonoma de GuerreroChilpancingoGuerreroMexico Escuela Nacional de Ciencias Biologicas IPNMexicoD.F.Facultad de Ciencias Quimico BiologicasUniversidad Autonoma de GuerreroChilpancingoGuerreroMexico Depatamento de Genetica y Biologia Molecular CIVESTAV-IPNMexicoD.F. Departamento de Anatomia patologica del Hospital de cardiologia del Centro Medico Nacional Siglo XXI del IMSS MexicoD.F Instituto Estatal de cancerologia“Dr Arturo Beltran Ortega” AcapulcoGuerreroMexico

＜正＞Background:HPV infection is initiated with episomal virus,as state that is characterized by diffuse in situ hybridization（ISH） *** signal pattern correlates with the productive phenotype of HPV Integrated HPV has been found in association with invasive cervical carcinoma,and this event is characterized by a nuclear punctate ISH signal.

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Overexpression Of Protein P16ink4a As A Marker Of Squamous Intraepithelial Lesions Induced By High Risk Hpv Infection In Mexican Women

Overexpression Of Protein P16ink4a As A Marker Of Squamous I...

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24th International Papillomavirus Conference and Clinical Workshop

作者： Luz del carmen Alarcon-Romero Elba Reyes-Maldonado Berenice Illades-Aguiar Eugenia Flores-Alfaro Amafia vences Velazquez Gloria Fernondez-Tilapa Esther Ivonne Lopez-Bayghen Ethel A garcia-Latorre Patricia Romero Neri Victor gabriel Hernandez Chavez Marco Antonio Teron-Porcayo Escuela Nacional de Ciencias Biologicas IPNMexicoD.F.Facultad de Ciencias Quimico BiologicasUniversidad Autonoma de GuerreroChilpancingo.GuerreroMexico Escuela Nacional de Ciencias Biologicas IPNMexicoD.F Facultad de Ciencias Quimico Biologicas Universidad Autonoma de GuerreroChilpancingo.GuerreroMexico Facultad de Ciencias Quimico Biologicas Universidad Autonoma de GuerreroChilpancingo.GuerreroMexico Escuela Nacional de Ciencias Biologicas IPNMexicoD.F.Facultad de Ciencias Quimico BiologicasUniversidad Autonoma de GuerreroChilpancingo.GuerreroMexico Escuela Nacional de Ciencias Biologicas IPNMexicoD.F.Facultad de Ciencias Quimico BiologicasUniversidad Autonoma de GuerreroChilpancingo.GuerreroMexico Depatamento de Genetica y Biologia Molecular CIVESTAV-IPNMexicoD.F Escuela Nacional de Ciencias Biologicas IPNMexicoD.F Clinica de Displasias ChilpancingoGuerreroMexico Departamento de Anatomia patologica Hospital de cardiologia Centro Medico Nacional Siglo XXI del IMSSMexicoD.F Instituto Estatal de cancerologia‘Dr Arturo Beltran Ortega’ AcapulcoGuerreroMexico

＜正＞Background:Expression of the high-risk human papillomavirus（hr-hpv）e7-gene replicating epithelial cells results in disruption of the prb-e2f complex and degradation of prb This leads to strong overexpression o...

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