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Phylogeny,genetics,and the partial life cycle of Oncomegas wageneri in the Gulf of Mexico

current Zoology 2020年第3期66卷 275-283页

作者： Andrés MARTINEZ-AQUINO Víctor M.VIDAL-MARTINEZ F.Sara cEccARELLI Oscar MENDEZ lilia c.soler-jimenez M.Leopoldina AGUIRRE-MAcEDO Facultad de ciencias Universidad Autonoma de Baja CaliforniaCarretera Transpeninsular 3917Fraccionamiento PlayitasEnsenadaBaja California 22860Mexico Laboratorio de Patologia Acuatica Departamento de Recursos del MarCentro de Investigacion y de Estudios Avanzados del Instituto Politecnico NacionalUnidad MeridaCordemexCarretera Antigua a Progreso Km.6MeridaYucatan 97310Mexico Departamento de Biologia de la conservacion CONACYT-Centro de Investigacion Cientifica y de Educacion Superior de EnsenadaCarretera Ensenada-TjuanaEnsenadaBaja California 22860Mexico Laboratorio de Hidrobiologia Facultad de Biologia-XalapaUniversidad VeracruzanaCircuito Gonzalo Aguirre Beltran S/N Zona UniversitariaXalapaVeracruz 91090Mexico

Despite the diversity and ecological importance of cestodes,there is a paucity of studies on their life stages(i.e.,complete lists of intermediate,paratenic,and definitive hosts)and genetic *** example,in the Gulf of Mexico(GoM)98 species of cestodes have been reported to date;however,data on their intraspecific genetic variation and population genetic studies are *** trypanorhynch cestode,Oncomegas wageneri,is found(among other places)off the American Western Atlantic coast,including the GoM,and has been reported as an adult from stingrays and from several teleost species in its larval form(as plerocerci).This study represents the first report of 2 previously unregistered definitive hosts for ***,namely the Atlantic sharpnose shark Rhizoprionodon terraenovae and the southern stingray Hypanus *** this work,partial sequences of the 28S(region D1-D2)ribosomal DNA were analyzed to include *** within an eutetrarhynchoid phylogenetic *** *** individuals(which included plerocerci and adults)were recovered as monophyletic and Oncomegas celatus was identified as the sister species of ***,population genetic analyses of *** from the southern GoM were carried out using DNA sequences of the mitochondrial cytochrome c oxi-dase subunit 1(cOI)gene,which reflected high genetic variation and a lack of genetic structure among the 9 oceanographic sampling *** on these results,*** is panmictic in the southern *** extensive sampling along the species entire distribution is necessary to make more accurate inferences of population genetics of ***.

关键词： barcode cyclopsetta chittendeni population genetics Hypanus americanus Oncomegas Rhizoprionodon terraeno-vae 28S rDNA(D1-D2)

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Antioxidant effects of D-004, a lipid extract from the Roystonea regia fruit, on the plasma of healthy men

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Asian Journal of Andrology 2009年第3期11卷 385-392页

作者： Emesto Lopez Vivian Molina Jose Illnait Ambar Oyarzfibal lilia c. Femandez Rosa Mas Rafael Gamez Julio c. Fernandez Sonia jimenez Meilis Mesa Ivon Hollands Sarahi Mendoza Medical Surgical Research centre Havana 6990 Cuba centre of Natural Products from the National centre for Scientific Research Havana 6880 Cuba

The aim of thisstudy was to conduct a randomized, double-blind and placebo-controlled study to investigate the effects of D-004, a lipid extract of the Roystonea regia fruit that prevents testosterone- and phenylepinephrine- induced prostate hyperplasia in rodents, on plasma oxidative markers in healthy men. We enrolled male volunteers （20-55 years） in good health and without lower urinary tract symptoms. Thirty-four eligible participants were randomized to placebo or D-004 （320 mg） capsules administered daily for 6 weeks. An interim check-up and a final visit were conducted after 3 and 6 weeks of therapy, respectively. Physical examinations were performed at each visit, and laboratory tests were performed at baseline and at treatment completion. Oxidative variables included plasma malondialdehyde （MDA）, total hydroxyperoxides （TOH）, sulphydryl （SH） groups and total antioxidant status （TAS）. We assessed treatment compliance and addressed adverse experiences （AEs） at weeks 3 and 6. At week 6, with D-004, the mean reductions of plasma MDA （26.7%）, TOH （18.8%） and SH groups （31.6%）, and the mean increase of TAS （35.3%） were significantly different from those of placebo （P 〈 0.001 for plasma TAS, P 〈 0.0001 for all other comparisons）. D-004 did not differ from the placebo in safety indicators. There were two withdrawals （both in the D-004 group）, with one due to dyspepsia （the only AE during the trial）. In conclusion, D-004 displayed antioxidant effects on plasma oxidative markers in healthy men, which was consistent with findings from laboratory experimental studies.

关键词： antioxidant benign prostate hyperplasia D-004 lipid peroxidation Roystonea regia

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First-principles search of hot superconductivity in La-X-H ternary hydrides

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npj computational Materials 2022年第1期8卷 1-8页

作者： Simone Di cataldo Wolfgang von der Linden lilia Boeri Institute of Theoretical and computational Physics Graz University of TechnologyNAWI Graz8010GrazAustria Dipartimento di Fisica Sapienza Universitàdi Roma00185RomaItaly centro Ricerche Enrico Fermi Via Panisperna89a00184RomaItaly

Motivated by the recent claim of hot superconductivity with critical temperatures up to 550 K in La + x hydrides,we investigate the high-pressure phase diagram of compounds that may have formed in the experiment,using first-principles calculations for evolutionary crystal structure prediction and *** from the hypothesis that the observed T_(c) may be realized by successive heating upon a pre-formed LaH_(10) phase,we examine plausible ternaries of lanthanum,hydrogen and other elements present in the diamond anvil cell: boron,nitrogen,carbon,platinum,gallium,*** find that only boron and,to a lesser extent,gallium form metastable superhydride-like structures that can host high-T_(c) superconductivity,but the predicted T_(c)’s are incompatible with the experimental *** results indicate that,while the claims of hot superconductivity should be reconsidered,it is very likely that unknown H-rich ternary or multinary phases containing lanthanum,hydrogen,and possibly boron or gallium may have formed under the reported experimental conditions,and that these may exhibit superconducting properties comparable,or even superior,to those of currently known hydrides.

关键词： hydrides boron superconductivity

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New therapeutic options opened by the molecular classification of gastric cancer

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World Journal of Gastroenterology 2018年第18期24卷 1942-1961页

作者： Mihaela chivu-Economescu lilia Matei Laura G Necula Denisa L Dragu coralia Bleotu carmen c Diaconu Department of cellular and Molecular Pathology Stefan S. Nicolau Institute of Virology Nicolae cajal Institute Titu Maiorescu University

Gastric cancer(Gc) is one of the most lethal and aggressive cancers, being the third cause of cancer related death worldwide. Even with radical gastrectomy and the latest generation of molecular chemotherapeutics, the numbers of recurrence and mortality remains high. This is due to its biological heterogeneity based on the interaction between multiple factors, from genomic to environmental factors, diet or infections with various pathogens. Therefore, understanding the molecular characteristics at a genomic level is critical to develop new treatment strategies. Recent advances in Gc molecular classification provide the unique opportunity to improve Gc therapy by exploiting the biomarkers and developing novel targeted therapy specific to each subtype. This article highlights the molecular characteristics of each subtype of gastric cancer that could be considered in shaping a therapeutic decision, and also presents the completed and ongoing clinical trials addressed to those targets. The implementation of the novel molecular classification system will allow a preliminary patient selection for clinical trials, a mandatory issue if it is desired to test the efficacy of a certain inhibitor to the given target. This will represent a substantial advance as well as a powerful tool for targeted therapy. Nevertheless, translating the scientific results into new personalized treatment opportunities is needed in order to improve clinical care, the survival and quality of life of patients with Gc.

关键词： Gastric cancer Molecular classification Immunotherapy Targeted therapy clinical trials

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An Exploratory Analysis of a Subjective Well-Being Model for chinese University Students

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Frontiers of Education in china 2020年第3期15卷 403-421页

作者： Xiaoxi DONG lilia c.DIBELLO Mehmet TÜREGÜN Ruth ABAN Adrian Dominican School of Education Barry UniversityMiami ShoresFL 33161-6695USA

college students experience great stress due to many factors,such as an uncertain future,academic responsibilities,and pressures imposed by social *** institutions of higher education are focusing on how to mediate stressful situations and increase the subjective well-being(SWB)of students to sustain a lifestyle focused on *** online survey used for this study focused on testing an exploratory SWB model by implementing partial least squares structural equation modeling(PLS-SEM)*** participants were 470 college-aged students enrolled in seven different institutions in six cities across *** yielded a good model fit(the Standardized Root Mean Squared Residual[SRMR]=.054)with the validity of manifest variables,reliability of the latent variables(LVs),and overall SWB model indicating moderate predictiveness(GoF R^(2)=.476)by the ***,all of the direct path coefficients and indirect path coefficients that consisted of four partial mediators and one full mediator yielded statistically significant results via ***,path coefficients for utilization of emotion to life satisfaction for the cognitive exercise group were significantly higher than for the non-cognitive exercise *** findings illustrated a good model fit for an exploratory SWB model that can predict an individual’s SWB,and cognitive and non-cognitive exercises had different effects on the individuals’SWB.

关键词： higher education subjective well-being(SWB) partial least squares structural equation modeling(PLS-SEM) psychological distress emotional intelligence(EI)

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In-silico synthesis of lowest-pressure high-T_(c) ternary superhydrides

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npj computational Materials 2022年第1期8卷 1119-1125页

作者： Roman Lucrezi Simone Di cataldo Wolfgang von der Linden lilia Boeri christoph Heil Institute of Theoretical and computational Physics Graz University of TechnologyNAWI Graz8010GrazAustria Dipartimento di Fisica Sapienza Universitàdi Roma00185RomeItaly Enrico Fermi Research center Via Panisperna 89 A00184RomeItaly

We report the theoretical prediction of two high-performing hydride superconductors BaSiH_(8)and SrSiH_(8).They are thermodynamically stable above pressures of 130 and 174 GPa,respectively,and metastable below *** anharmonic phonon calculations,we determine the minimum pressures of dynamical stability to be around 3 GPa for BaSiH8 and 27 GPa for SrSiH_(8),and using the fully anisotropic Migdal-Eliashberg theory,we predict Tc’s around 71 and 126 K,*** also introduce a method to estimate the lowest pressure of synthesis,based on the calculation of the enthalpy barriers protecting the BaSiH_(8)Fm3¯m structure from decomposition at various *** kinetic pressure threshold is sensibly higher than the one based on dynamic stability,but gives a much more rigorous limit for synthesizability.

关键词： synthesis stability high

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Synthesis, Structural Study and Phase Transitions characterization by Thermal Analysis and Vibrational Spectroscopy of an Ammonium Rubidium Arsenate Tellurate

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chemical Research in chinese Universities 2016年第6期32卷 902-911页

作者： GHORBEL Khouloud LITAIEM Hajer KTARI lilia GARcIA-GRANDA Santiago DAMMAK Mohamed Laboratoire de chimie Inorganique(LcI) Universitd de Sfax Facultd des Sciences de Sfax BP 1171 Sfax 3000 Tunisia Laboratoire de chimie Physique et Analytique Faeulte de Chimie Universitte d 'Oviedo Oviedo 33006 Espagne

The Rb2.42（NH4）0.58（HAsO4）（H2AsO4）. Te（OH）6 crystals（denoted by RbNAsTe） crystallize in the monoc-linic system, space group P21/n with the following parameters： a=1.3059（5） nm, b=0.6755（3） nm, c=1.6675（6） rim,β=94.126（4）°, Z=4 and V=1.46733（10） nm^3. Thermal analyses（DSc, DTA and TG） confirm the presence of the phasetransition and the temperatttre of the decomposition. The vibrational spectroscopy study at room temperature showthe presence and the independence of anionic groups, cationic groups, and give more importance to the hydrogenbonds. Raman spectra were recorded in the temperature range of 298--503 K. The temperature dependence of theRaman line shift, intensity reduction and the half width detects the phase transitions and confirms their nature. So, thephase transition at 453 K corresponds to the superprotonic-ionic conduction phase transition, and those at 483 and491 K correspond to the decomposition of our material.

关键词： RbNAsTe X-Ray diffraction Differential scanning calorimetry Phase transition Raman spectrometry

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Recent advances in gastric cancer early diagnosis

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World Journal of Gastroenterology 2019年第17期25卷 2029-2044页

作者： Laura Necula lilia Matei Denisa Dragu Ana I Neagu cristina Mambet Saviana Nedeianu coralia Bleotu carmen c Diaconu Mihaela chivu-Economescu Department of cellular and Molecular Pathology Stefan S.Nicolau Institute of Virology Faculty of Medicine Titu Maiorescu University

Gastric cancer(Gc) remains an important cause of cancer death worldwide with a high mortality rate due to the fact that the majority of Gc cases are diagnosed at an advanced stage when the prognosis is poor and the treatment options are limited. Unfortunately, the existing circulating biomarkers for Gc diagnosis and prognosis display low sensitivity and specificity and the Gc diagnosis is based only on the invasive procedures such as upper digestive endoscopy. There is a huge need for less invasive or non-invasive tests but also highly specific biomarkers in case of Gc. Body fluids such as peripheral blood, urine or saliva,stomach wash/gastric juice could be a source of specific biomarkers, providing important data for screening and diagnosis in Gc. This review summarized the recently discovered circulating molecules such as microRNAs, long non-coding RNAs, circular RNAs, which hold the promise to develop new strategies for early diagnosis of Gc.

关键词： Biomarkers Gastric cancer Early diagnosis Genetic and epigenetic alterations circulating molecules

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High plasma levels of cOL10A1 are associated with advanced tumor stage in gastric cancer patients

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World Journal of Gastroenterology 2020年第22期26卷 3024-3033页

作者： Laura Necula lilia Matei Denisa Dragu Ioana Pitica Ana Iulia Neagu coralia Bleotu Simona Dima Irinel Popescu carmen c Diaconu Mihaela chivu-Economescu Department of cellular and Molecular Pathology Stefan S.Nicolau Institute of VirologyBucharest 030304Romania Titu Maiorescu University Faculty of MedicineBucharest 040441Romania Fundeni clinical Institute Bucharest 022328Romania

BAcKGROUND Gastric cancer(Gc)remains an aggressive malignancy with a high rate of mortality,being the third leading cause of cancer-related *** than one million newly diagnosed cases and 782685 deaths due to Gc were reported in *** is characterized by limited effective treatment options and the lack of consistent biomarkers for the diagnosis and prognosis of these *** discovery of new biomarkers useful in the early diagnosis of Gc is *** To evaluate the potential of cOL10A1 as a circulating biomarker for the diagnosis and prognosis of gastric adenocarcinoma *** Plasma and tissue obtained from 49 patients with gastric adenocarcinoma have been used in exploring the expression of ***-time PcR and western blot techniques were used to evaluate cOL10A1 level in gastric tumor tissue compared to normal adjacent *** circulating level of cOL10A1 was also evaluated by ELISA in plasma of gastric adenocarcinoma *** analysis was made in order to evaluate the potential of cOL10A1 as a biomarker for the diagnosis and prognosis of gastric adenocarcinoma *** Our results showed a significant increase in cOL10A1 gene expression and protein levels in gastric tumor tissue compared to adjacent normal tissue(PcOL10A1 seems to show an elevated expression from the beginning of carcinogenesis,in the early stages,and its increased level remains elevated during cancer progression.A significant increase of cOL10A1 plasma level in gastric adenocarcinoma patients was also ***,increased cOL10A1 plasma level was associated with poor survival of the *** cOL10A1 performed a diagnostic value in Gc with area under the receiver operating characteristic curve(AUc)of 0.9171(P=0.0002),sensitivity of 87.76%,and specificity of 100.0%.Furthermore,this study demonstrated the potential role of plasma cOL10A1 in the early detection of Gc,as in the early stage,we obtained an AUc of 0.8789(P=0.00

关键词： Gastric cancer cOL10A1 circulating biomarkers Early diagnosis Poor prognosis Tumor stage

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An overview of forensic operations performed following the terrorist attacks on November 13,2015,in Paris

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Forensic Sciences Research 2020年第3期5卷 202-207页

作者： Antoine Tracqui celine Deguette Tania Delabarde Yann Delannoy Isabelle Plu Isabelle Sec lilia Hamza Marc Taccoen Bertrand Ludes Medico-Legal Institute of Besancon Saint-Jacques HospitalBesanconFrance Medico-Legal Institute of Paris ParisFrance Forensic Medical Emergency Service Hotel-Dieu HospitalParisFrance Universite de Paris BABELCNRSParisFrance Medico-Legal Institute of Lille LilleFrance Sorbonne University ParisFrance Service d’Accueil des Urgences Hopital AvicenneBobignyFrance

On the evening of November 13,2015,the city of Paris and its surroundings was hit by a series of attacks committed by terrorist groups,using firearms and *** final toll was 140 people deceased(130 victims and 10 terrorists or their relatives)and more than 413 injured,making these attacks the worst mass killings ever recorded in Paris in *** article presents the forensic operations carried out at the Medicolegal Institute of Paris(MLIP)following these attacks.A total of 68 autopsies of bodies or body fragments and 83 external examinations were performed within 7 days,and the overall forensic operations(including formal identification of the latest victims)were completed 10 days after the *** this period,156 body presentations(some bodies were presented several times)were provided to families or *** the 130 civilian casualties,129 died from firearm wounds and one died from blast injuries after an *** the 10 terrorists or their relatives who were killed,eight died from suicide bombing,one was shot by police and one died from crush injuries due to partial collapse of a building following the police raid against a terrorist’s hideout after the *** mass shootings were perpetrated with AK-47 or Zastava M70 assault rifles using 7.62mm39mm *** the case of ballistic injuries,death was most often obviously caused by craniocerebral injuries,extensive organ lacerations and/or massive *** the terrorists killed by bombing,the lesion patterns were body transection,multiple amputations,extreme organ lacerations and the presence of foreign bodies owing to the shrapnel load(steel nuts,glass fragments)or the explosive charge fastening system of the *** discussion highlights the particular difficulties of interpretation encountered within the framework of ballistic injuries,a conclusion that should lead to a modest and realistic approach in these exceptional situations where forensic operat

关键词： Forensic sciences terrorist attacks Paris forensic identification firearms explosives

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