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Age-Dependent Comparative Study of 4 Hz and 8 Hz EMF Exposure on Heart Muscle Tissue Hydration of Rats

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Open Journal of Biophysics 2019年第1期9卷 70-82页

作者： lilia Narinyan Sinerik Ayrapetyan UNESCO Chair—Life Sciences International Postgraduate Educational Center Yerevan Armenia

Previously we have shown that 4 Hz and 8 Hz EMF exposures have depressing effect on the thermodynamic activity of water, which decreases peroxide formation. It has also been shown that 4 Hz EMF-treated physiological solution modulates the growth and development of microbes and heart muscle contractility, but 8 Hz EMF has pronounced inhibitory effect on bacterial growth and development. Therefore, in order to elucidate the possible mechanism of 4 Hz and 8 Hz EMF effects on heart muscle function, in the present work the effects of 4 Hz and 8 Hz EMF exposures on heart muscle tissue hydration, the sensitivity of 4 Hz and 8 Hz EMF-induced tissue hydration to 10−4 M ouabain (Na+/K+ pump inhibition) and 10−9 M ouabain (activation of intracellular signaling system) as well as the effects of 4 Hz and 8 Hz EMF exposures on the number of Na+/K+ pump units in the membrane of both young and old rats have been studied. The obtained data allow us to suggest that 8 Hz EMF exposure has more pronounced age-dependent modulation effect on tissue hydration of heart muscle than 4 Hz EMF and this effect is sensitive to Na+/K+ pump activity and intracellular signaling system.

关键词： EMF Tissue Hydration Heart Na+/K+ Pump Na+/Ca2+ Exchange

Genetic Diversity and Association Analysis for Salinity Tolerance, Heading Date and Plant Height of Barley Germplasm Using Simple Sequence Repeat Markers

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Journal of Integrative Plant Biology 2008年第8期50卷 1004-1014页

作者： lilia Eleuch Abderrazek Jilal Stefania Grando Salvatore Ceccarelli Maria von Korff Schmising Hisashi Tsujimoto Amara Hajer Abderrazek Daaloul Michael Baum Laboratory of Genetics and Plant Breeding Department of Agronomy and Plant Biotechnology National Institute of Agronomy 1085 Tunis Tunisia International Centre for Agricultural Research in the Dry Areas (ICARDA) 5466 Aleppo Syria International Centre for Agricultural Research in the Dry Areas (ICARDA) 5466 Aleppo Syria Laboratory of Plant Genetics and Breeding Science Faculty of Agriculture Tottori UniversityTottori 680-8553 Japan

The objective of this study was to investigate the genetic diversity of barley accessions. Additionally, association trait analysis was conducted for grain yield under salinity, heading date and plant height. For this purpose, 48 barley genotypes were analyzed with 22 microsatellite simple sequence repeat （SSR） markers. Four of the 22 markers （Bmac316, scssr03907, HVM67 and Bmag770） were able to differentiate all barley genotypes. Cluster and principal coordinate analysis allowed a clear grouping between countries from the same region. The genotypes used in this study have been evaluated for agronomic performance in different environments. Conducting association analysis for grain yield under salinity conditions using TASSEL software revealed a close association of the marker Bmag749 （2H, bin 13） in two different environments with common significant alleles （175, 177）, whereas the HVHOTR1 marker （2H, bin 3） was only significant in Sakhar Egypt with alleles size being 158 and 161. Heading date also showed an association with scssr03907 through the common significant specific allele 111 and EBmac0415 markers in three different agro climatic locations, whereas HVCMA, scssr00103 and HVM67 were linked to heading date in the Egyptian environment only. The plant height association analysis revealed significant markers Bmag770 via the significant allele 152 and scssr09398.

关键词： association analysis genetic variability plant height polymorphism salinity, heading date simple sequence repeat.

Periodic Solutions of Some Polynomial Differential Systems in R<sup>4</4>

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Journal of Applied Mathematics and Physics 2017年第1期5卷 194-223页

作者： Makhlouf Amar Bousbiat lilia Department of Mathematics University of Annaba Annaba Algeria

We provide sufficient conditions for the existence of periodic solutions of the polynomial fourth order differential system , where A is a 4 × 4 constant matrix, P1, P2, P3 and P4 are polynomials in the variables x, ... 详细信息

关键词： Periodic Solution Averaging Theory Differential System

Experimental determination and modeling of equilibrium moisture content from the sapwood of Mexican pine (Pinus pseudostrobus Lindl.)

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Forestry Studies in China 2011年第4期13卷 285-289页

作者： Juan RODRIGUEZ-RAMIREZ Sadoth SANDOVAL-TORRES lilia MEndez-LAGUNAS Artemio Carrillo PARRA Centro Interdisciplinario de Investigación para el Desarrollo Integral Regional (CIIDIR) Oaxaca Instituto Politécnico Nacional Oaxaca 71230 Mexico Facultad de Ciencias Forestales Universidad Autónoma de Nuevo León Linares Nuevo León 67700 Mexico

A desorption isotherm is a very important basis in the understanding of drying process. In this study, the desorption isotherms from the sapwood of Mexican pine （Pinus pseudostrobus Lindl.） were determined by the gravimetric method （discontinuous control of sample weight） at 30℃ and 50℃. The salt method was used in the range of water activities from 0.11 to 0.89. The results show that the desorption ability of Mexican pine sapwood increased with temperature at a given relative humidity. The experimental data was further simulated with the models, i.e., BET, GAB, Oswin and Henderson models. The GAB, Oswin and Henderson models allow the representation of the entire desorption isotherms. The BET model showed a better fit for water activity lower than 0.35, with a mean relative deviation of 0.0286 at 30℃ and 0.0167 at 50℃. Simultaneously, the BET model gave a better representation of moisture content in the monolayer saturation region. Overall, the GAB model ensured the best simulation of the entire isotherm, while the Henderson model displayed the worst simulation.

关键词： modeling isotherms Mexican pine sapwood

Murine models based on acute myeloid leukemia-initiating stem cells xenografting

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World Journal of Stem Cells 2018年第6期10卷 57-65页

作者： Cristina Mambet Mihaela Chivu-Economescu lilia Matei Laura Georgiana Necula Denisa Laura Dragu Coralia Bleotu Carmen Cristina Diaconu Cellular and Molecular Pathology Department Stefan S. Nicolau Institute of Virology Nicolae Cajal Institute Titu Maiorescu University

Acute myeloid leukemia(AML) is an aggressive malignant disease defined by abnormal expansion of myeloid blasts. Despite recent advances in understanding AML pathogenesis and identifying their molecular subtypes based on somatic mutations, AML is still characterized by poor outcomes, with a 5-year survival rate of only 30%-40%, the majority of the patients dying due to AML relapse. Leukemia stem cells(LSC) are considered to be at the root of chemotherapeutic resistance and AML relapse. Although numerous studies have tried to better characterize LSCs in terms of surface and molecular markers, a specific marker of LSC has not been found, and still the most universally accepted phenotypic signature remains the surface antigens CD34+CD38- that is shared with normal hematopoietic stem cells. Animal models provides the means to investigate the factors responsible for leukemic transformation, the intrinsic differences between secondary post-myeloproliferative neoplasm AML and de novo AML, especially the signaling pathways involved in inflammation and hematopoiesis. However, AML proved to be one of the hematological malignancies that is difficult to engraft even in the most immunodeficient mice strains, and numerous ongoing attempts are focused to develop "humanized mice" that can support the engraftment of LSC. This present review is aiming to in-troduce the field of AML pathogenesis and the concept of LSC, to present the current knowledge on leukemic blasts surface markers and recent attempts to develop best AML animal models.

关键词： Acute myeloid leukemia Leukemia-initiating stem cells Antigen markers Murine models Xenografts

An overview of forensic operations performed following the terrorist attacks on November 13,2015,in Paris

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Forensic Sciences Research 2020年第3期5卷 202-207页

作者： Antoine Tracqui Celine Deguette Tania Delabarde Yann Delannoy Isabelle Plu Isabelle Sec lilia Hamza Marc Taccoen Bertrand Ludes Medico-Legal Institute of Besancon Saint-Jacques HospitalBesanconFrance Medico-Legal Institute of Paris ParisFrance Forensic Medical Emergency Service Hotel-Dieu HospitalParisFrance Universite de Paris BABELCNRSParisFrance Medico-Legal Institute of Lille LilleFrance Sorbonne University ParisFrance Service d’Accueil des Urgences Hopital AvicenneBobignyFrance

On the evening of November 13,2015,the city of Paris and its surroundings was hit by a series of attacks committed by terrorist groups,using firearms and *** final toll was 140 people deceased(130 victims and 10 terrorists or their relatives)and more than 413 injured,making these attacks the worst mass killings ever recorded in Paris in *** article presents the forensic operations carried out at the Medicolegal Institute of Paris(MLIP)following these attacks.A total of 68 autopsies of bodies or body fragments and 83 external examinations were performed within 7 days,and the overall forensic operations(including formal identification of the latest victims)were completed 10 days after the *** this period,156 body presentations(some bodies were presented several times)were provided to families or *** the 130 civilian casualties,129 died from firearm wounds and one died from blast injuries after an *** the 10 terrorists or their relatives who were killed,eight died from suicide bombing,one was shot by police and one died from crush injuries due to partial collapse of a building following the police raid against a terrorist’s hideout after the *** mass shootings were perpetrated with AK-47 or Zastava M70 assault rifles using 7.62mm39mm *** the case of ballistic injuries,death was most often obviously caused by craniocerebral injuries,extensive organ lacerations and/or massive *** the terrorists killed by bombing,the lesion patterns were body transection,multiple amputations,extreme organ lacerations and the presence of foreign bodies owing to the shrapnel load(steel nuts,glass fragments)or the explosive charge fastening system of the *** discussion highlights the particular difficulties of interpretation encountered within the framework of ballistic injuries,a conclusion that should lead to a modest and realistic approach in these exceptional situations where forensic operat

关键词： Forensic sciences terrorist attacks Paris forensic identification firearms explosives

Blockchain Driven Metaheuristic Route Planning in Secure Vehicular Adhoc Networks

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Computers, Materials & Continua 2022年第12期73卷 6461-6477页

作者： Siwar Ben Haj Hassine Saud SAlotaibi Hadeel Alsolai Reem Alshahrani lilia Kechiche Mrim M.Alnfiai Amira Sayed A.Aziz Manar Ahmed Hamza Department of Computer Science College of Science&Art at MahayilKing Khalid UniversitySaudi Arabia Department of Information Systems College of Computing and Information SystemUmm Al-Qura UniversitySaudi Arabia Department of Information Systems College of Computer and Information SciencesPrincess Nourah Bint Abdulrahman UniversityP.O.Box 84428Riyadh11671Saudi Arabia Department of Computer Science College of Computers and Information TechnologyTaif UniversityP.O.Box 11099Taif21944Saudi Arabia Department of Sciences and Technology Taif UniversityTaif P.O.Box 11099Taif21944Saudi Arabia Department of Information Technology College of Computers and Information TechnologyTaif UniversityTaif P.O.Box 11099Taif21944Saudi Arabia Department of Digital Media Faculty of Computers and Information TechnologyFuture University in EgyptNew Cairo11835Egypt Department of Computer and Self Development Preparatory Year DeanshipPrince Sattam bin Abdulaziz UniversityAlKharjSaudi Arabia

Nowadays,vehicular ad hoc networks(VANET)turn out to be a core portion of intelligent transportation systems(ITSs),that mainly focus on achieving continual Internet connectivity amongst vehicles on the *** VANET was utilized to enhance driving safety and build an ITS in modern *** safety is a main portion of VANET,the privacy and security of these messages should be *** this aspect,this article presents a blockchain with sunflower optimization enabled route planning scheme(BCSFO-RPS)for secure *** presented BCSFO-RPSmodel focuses on the identification of routes in such a way that vehicular communication is *** addition,the BCSFO-RPS model employs SFO algorithm with a fitness function for effectual identification of ***,the proposed BCSFO-RPS model derives an intrusion detection system(IDS)encompassing two processes namely feature selection and *** detect intrusions,correlation based feature selection(CFS)and kernel extreme machine learning(KELM)classifier is *** performance of the BCSFO-RPS model is tested using a series of experiments and the results reported the enhancements of the BCSFO-RPS model over other approaches with maximum accuracy of 98.70%.

关键词： VANET sunflower optimization machine learning blockchain intrusion detection

Targeting Wnt/β-catenin pathway in hepatocellularcarcinoma treatment

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World Journal of Gastroenterology 2016年第2期22卷 823-832页

作者： valery vilchez lilia turcios francesc marti roberto gedaly Department of Surgery Division of TransplantationCollege of MedicineUniversity of KentuckyLexingtonKY 40536-0284United States

Hepatocellular carcinoma(HCC) is one of the most common causes of cancer-related death worldwide. Liver cancer is generally related to hepatitis B or Cinfection and cirrhosis. Usually, patients with HCC are asymptomatic and are diagnosed at late stages when surgical treatment is no longer suitable. Limited treatment options for patients with advanced HCC are a major concern. Therefore, there is an urge for finding novel therapies to treat HCC. Liver cancer is highly heterogeneous and involved deregulation of several signaling pathways. Wnt/β-catenin pathway is frequently upregulated in HCC and it is implicated in maintenance of tumor initiating cells, drug resistance, tumor progression, and metastasis. A great effort in developing selective drugs to target components of the β-catenin pathway with anticancer activity is underway but only a few of them have reached phase Ⅰ clinical trials. We aim to review the role of β-catenin pathway on hepatocarcinogenesis and liver cancer stem cell maintenance. We also evaluated the use of small molecules targeting the Wnt/β-catenin pathway with potential application for treatment of HCC.

关键词： Hepatocellular carcinoma Wnt/β-cateninpathway Liver cancer stem cells Molecular therapy

Gastrointestinal cancer stem cells as targets for innovative immunotherapy

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World Journal of Gastroenterology 2020年第14期26卷 1580-1593页

作者： Mihaela Chivu-Economescu Laura G Necula lilia Matei Denisa Laura Dragu Ana I Neagu Irina Alexiu Coralia Bleotu Carmen Cristina Diaconu Department of Cellular and Molecular Pathology Stefan S.Nicolau Institute of VirologyBucharest 030304Romania Nicolae Cajal Institute Titu Maiorescu UniversityBucharest 040441Romania

The role of cancer stem cells in gastrointestinal cancer-associated death has been widely *** cancer stem cells(GCSCs)are considered to be responsible for tumor initiation,growth,resistance to cytotoxic therapies,recurrence and metastasis due to their unique *** properties make the current therapeutic trials against GCSCs ***,recent studies have shown that targeting stem cell surface markers or stemness associated pathways might have an additional off-target effect on the immune *** advances in oncology and precision medicine have opened alternative therapeutic strategies in the form of cancer *** approach differs from classical anti-cancer therapy through its mechanism of action involving the activation and use of a functional immune system against tumor cells,instead of aiming physically destruction of cancer cells through radio-or *** immunological approaches for GCSCs targeting involve the use of different immune cells and various immune mechanisms like targeting specific surface antigens,using innate immune cells like the natural killer and T cells,T-cell chimeric antigen receptor technology,dendritic cell vaccine,or immune checkpoint *** this respect,better understandings of immune regulatory mechanisms that govern anti-tumor response bring new hope in obtaining long-term remission for cancer therapy.

关键词： Immunotherapy Gastrointestinal cancer Cancer stem cells CAR-T Dendritic cells vaccines Immune checkpoints inhibitors