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Optimising the oil phases of aluminium hydrogel-stabilised emulsions for stable,safe and efficient vaccine adjuvant

Frontiers of Chemical Science and Engineering 2022年第6期16卷 973-984页

作者： lili yuan Xiao-Dong Gao Yufei Xia Key Laboratory of Carbohydrate Chemistry and Biotechnology Ministry of EducationSchool of BiotechnologyJiangnan UniversityWuxi 214122China State Key Laboratory of Biochemical Engineering Institute of Process EngineeringChinese Academy of SciencesBeijing 100190China University of Chinese Academy of Sciences Beijing 100049China Innovation Academy for Green Manufacture Chinese Academy of SciencesBeijing 100190China

To increase antibody secretion and dose sparing,squalene-in-water aluminium hydrogel(alun^-stabilised emulsions(ASEs)have been developed,which offer increased surface areas and cellular interactions for higher antigen loading and enhanced immune ***,the squalene(oil)in previous attempts suffered from limited oxidation resistance,thus,safety and stability were *** a clinical translational perspective,it is imperative to screen the optimal oils for enhanced emulsion ***,because of the varying oleic to linoleic acid ratio,soybean oil,peanut oil,and olive oil were utilised as oil phases in the preparation of aluminium hydrogel-stabilised squalene-in-water emulsions,which were then screened for their stability and ***,the underlying mechanisms of oil phases and emulsion stability were unravelled,which showed that a higher oleic to linoleic acid ratio increased anti-oxidative capabilities but reduced the long-term storage stability owing to the relatively low zeta potential of the prepared *** a result,compared with squalene-in-water ASEs,soybean-in-water ASEs exhibited comparable immune responses and enhanced *** optimising the oil phase of the emulsion adjuvants,this work may offer an alternative strategy for safe,stable,and effective emulsion adjuvants.

关键词： pickering emulsion vaccine adjuvant alum-stabilised emulsion oleic to linoleic acid ratio stability

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Analysis of severe core damage accident progression for the heavy water reactor

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Nuclear Science and Techniques 2010年第4期21卷 251-256页

作者： TONG lili yuan Kai yuan Jingtian CAO Xuewu School of Mechanical Engineering Shanghai Jiao Tong University' Shanghai 200240 China

In this study,the severe accident progression analysis of generic Canadian deuterium uranium reactor 6 was preliminarily provided using an integrated severe accident analysis *** selected accident sequences were multiple steam generator tube rupture and large break loss-of-coolant accidents because these led to severe core damage with an assumed unavailability for several critical safety *** progressions of severe accident included a set of failed safety systems normally operated at full power,and initiative events led to primary heat transport system inventory blow-down or boil *** core heat-up and melting,steam generator response,fuel channel and calandria vessel failure were *** results showed that the progression of a severe core damage accident induced by steam generator tube rupture or large break loss-of-coolant accidents in a CANDU reactor was slow due to heat sinks in the calandria vessel and vault.

关键词：重水反应堆损坏事故蒸汽发生器堆芯 CANDU堆严重事故热传输系统事故分析

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Ecotoxicity assessment of soil irrigated with domestic wastewater using different extractions

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Frontiers of Environmental Science & Engineering 2015年第4期9卷 685-693页

作者： Wenyan LIANG lili SUI yuan ZHAO Feizhen LI Lijun LIU Di XIE College of Environmental Science and Engineering Beijing Forestry University Beijing 100083 China

The toxicity of soil irrigated with treated domestic wastewater （site A） and untreated gray wastewater （site B） were investigated. Soil extracts were prepared using distilled water, acid solvent （0.1 mol·L-1 HCl）, and organic solvent （acetone：petroleum ether：cyclohexane= 1：1：1） to understand the type of pollutants responsible for the ecotoxicity associated with wastewater irrigation. The soil toxicity was assessed using a luminescence inhibition assay with Vibrio fischeri for acute toxicity, a micronucleus assay with Vicia faba root tips and a single cell gel electrophoresis assay of mice lymphocytes for genotoxicity. The physicochemical properties and the heavy metal （HM） contents of the irrigated soil were also analyzed. The results indicated that the wastewater irrigation at site A had no effects on the soil properties. With the exception of Pb, Zn, Fe, and Mn, the accumulation of HMs （Cu, Ni, and Cr） occurred. However, the irrigation at site A did not result in obvious acute toxicity or genotoxicity in the soil. The soil properties changed greatly, and HMs （Cu, Ni, and Cr） accumulated in site B. There were significant increases in the acute toxic and genotoxic effects in the soils from site B. The ecotoxicity in site B came primarily from organic-extractable pollutants.

关键词： ecotoxicology domestic wastewater soil irrigation risk assessment organic extraction

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Changing Perceptions of Marriage

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Women of China 1997年第8期 21-23页

作者： yuan lili

IN a Beijing hospital a group of young women from Heze, Shandong Province, work as temporary employees. When the Beijing No. 1 Hospital Attached to Beijing Medical Sciences University was recruiting oddjob helpers in ... 详细信息

关键词： Changing Perceptions of Marriage

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Carrying on the Tradition

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Women of China 1997年第6期 40-42页

作者： yuan lili

EVERY Sunday. childish voices can be heard coming from the Erlizhuang Residential Quarter in Haidian District, Beijing. It is the children of the Benzhen Children’s Peking Opera Art School. Wang Jinsheng, dean of the school, is not only a descendant of a well-known family in which several generations performed in the Peking opera, but also a teacher with more than 20 years’ teaching experience.

关键词： Carrying on the Tradition

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The axisymmetric Rayleigh waves in a semi-infinite elastic solid

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Theoretical & Applied Mechanics Letters 2020年第2期10卷 120-124页

作者： Ji Wang Shaoyun Wang Longtao Xie Yangyang Zhang lili yuan Jianke Du Han Zhang Piezoelectric Device Laboratory School of Mechanical Engineering and MechanicsNingbo UniversityNingbo315211 ZhejiangChina Noise and Vibration Laboratory Institute of AcousticsChinese Academy of Sciences100190 BeijingChina

It is well-known that Rayleigh wave,also known as surface acoustic wave(SAW),solutions in semiinfinite solids are plane waves with signatory properties like the distinct velocity and exponentially decaying deformation in the *** of Rayleigh waves are focused on the deformation and energy in the vicinity of surface of solids and less loss in the propagation.A generalized model of Rayleigh waves in axisymmetric mode is established and solutions are obtained with cylindrical *** is found that the Rayleigh waves also propagate in the axisymmetric mode with slow decay in radius,confirming the existence of surface acoustic waves is irrelevant to coordinate *** the other hand,the solutions can be treated as plane waves in regions far away from the ***,the particle trajectory of axisymmetric SAW is a line with constant slope rather than the signatory ellipse in Cartesian coordinate case.

关键词： Axisymmetric Rayleigh wave Solid Propagation Velocity

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China's Women Equestrians

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Women of China 1998年第2期 24-26页

作者： yuan lili A RONG

DURING the Eighth National Games held in Shanghai, horsemanship became a hot topic of conversation. Sixty-two athletes from ten teams—the delegations from the People’s Liberation Army, Beijing, Inner Mongolia Autonomous Region, Shanghai, Guangdong, Sichuan, Tibet Autonomous Region, Xinjiang Uygur Autonomous Region, the Hong Kong Special Administrative Region (HKSAR) and the Forest Industry Sports Association—attended the contest. This marked the first time the HKSAR delegation had sent athletes to

关键词： China’s Women Equestrians

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Qi Baishi's Descendant

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Women of China 1998年第1期 34-35页

作者： yuan lili A RONG

THE former home of Qi Baishi’ stands in Kuache Alley in the Xicheng District of Beijing. Qi Zilai, the granddaughter of Qi Baishi, still lives in the same room in the northwest corner of the courtyard where she was born. One day in 1942, her mother felt birth pangs right after her grandparents and father left, leaving only herself and an aunt at home. A midwife was quickly sent for, and by the time the grandparents had returned, the Qi family had a new granddaughter. The loud cry of the newborn baby brought indescribeable happiness to Qi Baishi, and he named her Zilai ("self-inviting") to express his fondness for this

关键词： newborn northwest corner mother District happiness lives quickly leaving stands

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Installing the World

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Women of China 1998年第11期 41-43页

作者： yuan lili LIRED LIU

THE art of installation is an art about concept," explains Qing Qing Chen. The artist wants her audience to look at the development of aesthetics from a pluralistic angle on life. Unlike the expressive format of "art in the frame," the art of installation belongs to the category of "non-framed art." The choice of materials used is as important to expression as the creator’s ideas. Whereas only certain materials can

关键词： World

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Two Generations of Attitudes Toward Life

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Women of China 1994年第2期 36-37页

作者： yuan lili LIN ZI

WANMINGS1 Apartments are one of several of Beijing’s newly-built residential areas. It is a group of about 20 multi-storey buildings with services such as a grocery store. But people are only able to move there throu... 详细信息

关键词： Two Generations of Attitudes Toward Life Zhang

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