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Induced neural stem cells regulate microglial activation through Akt-mediated upregulation of CXCR4 and Crry in a mouse model of closed head injury

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Neural Regeneration Research 2025年第5期20卷 1416-1430页

作者： Mou Gao Qin Dong Dan Zou Zhijun Yang lili Guo Ruxiang Xu Department of Neurosurgery Sichuan Academy of Medical Sciences and Sichuan Provincial People’s HospitalSchool of MedicineUniversity of Electronic Science and Technology of ChinaChengduSichuan ProvinceChina Department of Neurosurgery Chinese PLA General HospitalBeijingChina Department of Neurology Fu Xing HospitalCapital Medical UniversityBeijingChina

Microglial activation that occurs rapidly after closed head injury may play important and complex roles in neuroinflammation-associated neuronal damage and *** previously reported that induced neural stem cells can modulate the behavior of activated microglia via CXCL12/CXCR4 signaling,influencing their activation such that they can promote neurological ***,the mechanism of CXCR4 upregulation in induced neural stem cells remains *** this study,we found that nuclear factor-κB activation induced by closed head injury mouse serum in microglia promoted CXCL12 and tumor necrosis factor-αexpression but suppressed insulin-like growth factor-1 ***,recombinant complement receptor 2-conjugated Crry(CR2-Crry)reduced the effects of closed head injury mouse serum-induced nuclear factor-κB activation in microglia and the levels of activated microglia,CXCL12,and tumor necrosis factor-α.Additionally,we observed that,in response to stimulation(including stimulation by CXCL12 secreted by activated microglia),CXCR4 and Crry levels can be upregulated in induced neural stem cells via the interplay among CXCL12/CXCR4,Crry,and Akt signaling to modulate microglial *** agreement with these in vitro experimental results,we found that Akt activation enhanced the immunoregulatory effects of induced neural stem cell grafts on microglial activation,leading to the promotion of neurological recovery via insulin-like growth factor-1 secretion and the neuroprotective effects of induced neural stem cell grafts through CXCR4 and Crry upregulation in the injured cortices of closed head injury ***,these beneficial effects of Akt activation in induced neural stem cells were positively correlated with the therapeutic effects of induced neural stem cells on neuronal injury,cerebral edema,and neurological disorders post–closed head *** conclusion,our findings reveal that Akt activation may enhance the immunoregulatory effects of induced neura

关键词： Akt signaling cerebral edema closed head injury Crry CXCR4 induced neural stem cell microglia neuroinflammation

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一种适用于混合三端直流输电线路的故障定位方法

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西安交通大学学报 2025年第1期59卷 37-46页

作者：高淑萍杨莉莉武心宇周晋宇宋国兵西安科技大学电气与控制工程学院西安710054 西安市电气设备状态监测与供电安全重点实验室西安710054 西安交通大学电气工程学院西安710049

针对因结构复杂导致的混合三端直流输电线路故障定位困难的问题,提出了一种结合变分模态分解算法与改进卷积神经网络(CNN)的故障定位方法(VMD-CNN)。首先,利用PSCAD/EMTDC软件构建混合三端直流输电系统模型,获得故障电流数据,应用克拉... 详细信息

针对因结构复杂导致的混合三端直流输电线路故障定位困难的问题,提出了一种结合变分模态分解算法与改进卷积神经网络(CNN)的故障定位方法(VMD-CNN)。首先,利用PSCAD/EMTDC软件构建混合三端直流输电系统模型,获得故障电流数据,应用克拉克变换对其解耦,获取故障电流的线模分量;其次,对得到的线模分量进行变分模态分解(VMD),得到多个本征模态函数(IMF)分量,选取特征信息最丰富的IMF分量作为VMD-CNN模型的输入;然后,利用高效的分类模型支持向量机(SVM)判别故障发生的区域,将提取到的IMF分量作为SVM输入进行训练学习,可以准确判断出故障发生区域;最后,搭建VMD-CNN模型进行故障定位,挖掘出行波信号中蕴藏的故障信息,同时通过麻雀搜索算法优化CNN中的超参数,实现混合三端直流输电线路的精确定位。仿真结果表明:过渡电阻为100Ω,不同故障位置情况下的定位相对误差均在0.17%以内;故障位置为460 km,不同过渡电阻情况下的定位相对误差均在0.25%以内;过渡电阻为50Ω,不同故障类型情况下的相对误差均在0.3%以内。所提方法能够提升不同故障位置、过渡电阻和故障类型下的定位准确性。

关键词：混合三端直流输电故障定位变分模态分解卷积神经网络麻雀搜索算法

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Adaptive back-stepping control on container ships for path following

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Journal of Systems Engineering and Electronics 2020年第4期31卷 780-790页

作者： ZHAO Yang DONG lili Physics and Engineering Department Taylor UniversityUpland IN 46989USA Department of Electrical Engineering and Computer Science Cleveland State UniversityCleveland OH 44115USA

A feedback-dominance based adaptive back-stepping(FDBAB) controller is designed to drive a container ship to follow a predefined path. In reality, current, wave and wind act on the ship and produce unwanted disturbances to the ship control *** FDBAB controller has to compensate for such disturbances and steer the ship to track the predefined(or desired) path. The difference between the actual and the desired path along which the ship is to sail is defined as the tracking error. The FDBAB controller is built on the tracking error model which is developed based on Serret-Frenet frame transformation(SFFT). In additional to being affected by external disturbances, the ship has more outputs than inputs(under-actuated), and is inherently *** back-stepping controller in FDBAB is used to compensate the nonlinearity. The adaptive algorithms in FDBAB is employed to approximate disturbances. Lyapunov's direct method is used to prove the stability of the control system. The FDBAB controlled system is implemented in Matlab/Simulink. The simulation results verify the effectiveness of the controller in terms of successful path tracking and disturbance rejection.

关键词： under-actuated nonlinear environmental disturbance path following Serret-Frenet frame transformation(SFFT) ship steering

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TWO-STEP MODULUS-BASED SYNCHRONOUS MULTISPLITTING ITERATION METHODS FOR LINEAR COMPLEMENTARITY PROBLEMS

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Journal of Computational Mathematics 2015年第1期33卷 100-112页

作者： lili Zhang LSEC. ICMSEC Academy of Mathematics and Systems Science Chinese Academy of Sciences Beijing 100190 China School of Mathematics and Information Science Henan University of Economics and LawZhengzhou 450046 China

To reduce the communication among processors and improve the computing time for solving linear complementarity problems, we present a two-step modulus-based syn- chronous multisplitting iteration method and the corresponding symmetric modulus-based multisplitting relaxation methods. The convergence theorems are established when the system matrix is an H＋-matrix, which improve the existing convergence theory. Numeri- cal results show that the symmetric modulus-based multisplitting relaxation methods are effective in actual implementation.

关键词： Linear complementarity problem Modulus-based method Matrix multisplit-ring Convergence.

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脂肪间充质干细胞来源外泌体改善放射性口腔黏膜炎

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中国组织工程研究 2025年第1期29卷 31-37页

作者：李杨付丽丽杨建堂遵义医科大学附属口腔医院贵州省遵义市563000

背景:头颈肿瘤放疗极易引起放射性口腔黏膜炎,严重影响患者的健康及肿瘤的治疗计划。间充质干细胞在多种疾病中表现出治疗潜力,外泌体是其发挥功能的重要因素之一。目前尚无脂肪间充质干细胞来源外泌体应用于放射性口腔黏膜炎的相关研... 详细信息

背景:头颈肿瘤放疗极易引起放射性口腔黏膜炎,严重影响患者的健康及肿瘤的治疗计划。间充质干细胞在多种疾病中表现出治疗潜力,外泌体是其发挥功能的重要因素之一。目前尚无脂肪间充质干细胞来源外泌体应用于放射性口腔黏膜炎的相关研究。目的:探讨脂肪间充质干细胞来源外泌体在放射性口腔黏膜炎中的作用。方法:提取脂肪间充质干细胞及脂肪间充质干细胞来源外泌体并进行鉴定。通过3 Gy X射线辐射口腔黏膜上皮细胞诱导放射性口腔黏膜炎体外模型,在造模前给予脂肪间充质干细胞或脂肪间充质干细胞来源外泌体预处理48 h,EdU实验和克隆形成实验检测口腔黏膜上皮细胞的增殖能力。通过3 Gy X射线辐射构建放射性口腔黏膜炎小鼠模型,将脂肪间充质干细胞和脂肪间充质干细胞来源外泌体分别注入放射性口腔黏膜炎小鼠尾静脉,采用苏木精-伊红染色和免疫组化评估口腔黏膜上皮组织的炎症变化。结果与结论:(1)与对照组相比,脂肪间充质干细胞及脂肪间充质干细胞来源外泌体均可促进口腔黏膜上皮细胞克隆形成,增加口腔黏膜上皮细胞EdU阳性率;(2)脂肪间充质干细胞及脂肪间充质干细胞来源外泌体均能够缓解辐射处理小鼠口腔黏膜上皮组织的炎症;口腔黏膜上皮组织中CD45阳性细胞均减少,PCNA阳性细胞均增加。结果表明,脂肪间充质干细胞来源外泌体可促进口腔黏膜上皮细胞增殖,对放射性口腔黏膜炎小鼠口腔黏膜炎症具有缓解作用。

关键词：放射性口腔黏膜炎脂肪间充质干细胞外泌体头颈部肿瘤放疗口腔黏膜炎症恶性肿瘤

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A Preliminary study on the seismic conceptual design

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Earthquake Engineering and Engineering Vibration 2014年第S1期13卷 183-188页

作者： Zhao Zhen Xie lili Institute of Engineering Mechanics China Earthquake Administration Key Laboratory of Earthquake Engineering and Engineering Vibration China Earthquake Administration School of Civil Engineering Harbin Institute of Technology

The seismic conceptual design is an essential part of seismic design codes. It points out that the term 'seismic conceptual design' should imply three aspects,i.e.,the given concept itself,the specific provisions related to the given concept and the designing following the provisions. Seismic conceptual design can be classified into two categories: the strict or traditional seismic conceptual design and the generalized seismic conceptual design. The authors are trying to define for both conceptual designs their connotations and study their characteristics,in particular,the differences between them. Authors emphasize that both conceptual designs sound very close,however,their differences are apparent. The strict conceptual designs are usually worked out directly from engineering practice and/or lessons learnt from earthquake damage,while the generalized conceptual designs are resulted in a series of visions aiming to realize the general objectives of the seismic codes. The strict conceptual designs,(traditional conceptual designs) are indispensable elements of seismic codes in assuring designed structures safer and the generalized conceptual designs are playing key roles in directing to a more advanced and effective seismic codes.

关键词： Conceptual design Earthquakes

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On civil engineering disasters and their mitigation

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Earthquake Engineering and Engineering Vibration 2018年第1期17卷 1-10页

作者： Xie lili Qu Zhe Key Laboratory of Earthquake Engineering and Engineering Vibration Institute of Engineering MechanicsChina Earthquake Administration

Civil engineering works such as buildings and infrastructure are the carriers of human civilization. They are, however, also the origins of various types of disasters, which are referred to in this paper as civil engineering disasters. This paper presents the concept of civil engineering disasters, their characteristics, classification, causes, and mitigation technologies. Civil engineering disasters are caused primarily by civil engineering defects, which are usually attributed to improper selection of construction site, hazard assessment, design and construction, occupancy, and maintenance. From this viewpoint, many so-called natural disasters such as earthquakes, strong winds, floods, landslides, and debris flows are substantially due to civil engineering defects rather than the actual natural hazards. Civil engineering disasters occur frequently and globally and are the most closely related to human beings among all disasters. This paper emphasizes that such disasters can be mitigated mainly through civil engineering measures, and outlines the related objectives and scientific and technological challenges.

关键词： disaster hazard civil engineering disaster earthquake

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Multi-granularity sequence generation for hierarchical image classification

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Computational Visual Media 2024年第2期10卷 243-260页

作者： Xinda Liu lili Wang State Key Laboratory of Virtual Reality Technology and Systems Beihang UniversityBeijing 100191China Peng Cheng Laboratory Shengzhen 518000China

Hierarchical multi-granularity image classification is a challenging task that aims to tag each given image with multiple granularity labels *** methods tend to overlook that different image regions contribute differently to label prediction at different granularities,and also insufficiently consider relationships between the hierarchical multi-granularity *** introduce a sequence-to-sequence mechanism to overcome these two problems and propose a multi-granularity sequence generation(MGSG)approach for the hierarchical multi-granularity image classification ***,we introduce a transformer architecture to encode the image into visual representation ***,we traverse the taxonomic tree and organize the multi-granularity labels into sequences,and vectorize them and add positional *** proposed multi-granularity sequence generation method builds a decoder that takes visual representation sequences and semantic label embedding as inputs,and outputs the predicted multi-granularity label *** decoder models dependencies and correlations between multi-granularity labels through a masked multi-head self-attention mechanism,and relates visual information to the semantic label information through a crossmodality attention *** this way,the proposed method preserves the relationships between labels at different granularity levels and takes into account the influence of different image regions on labels with different *** on six public benchmarks qualitatively and quantitatively demonstrate the advantages of the proposed *** project is available at https://***/liuxindazz/mgs.

关键词： hierarchical multi-granularity classification vision and text transformer sequence generation fine-grained image recognition cross-modality attenti

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Influences of interphase on dynamic effective properties of composites reinforced by dispersed spherical particles

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Journal of University of Science and Technology Beijing 2006年第3期13卷 256-262页

作者： Peijun Wei lili Gu Applied Sciences School University of Sciences and Technology Beijing Beijing 100083 China Tangshan Iron ＆ Steel Group Co. Ltd Tangshan 063016 China

The influences of interphase on dynamic effective properties of composites reinforced by randomly dispersed spherical particles were studied. A thin homogeneous elastic interphase with different shear and bulk moduli, located between the reinforced particle and the host matrix, was introduced to model the interfacial bonding state. The effects of such an interphase on the coherent plane waves were studied numerically. Numerical simulations were carried out for SiC-Al composites with four typical cases of interphase. It was found that the property of interphase has significant influences on the effective propagation constants of coherent waves and the dynamic effective elastic moduli of the composites. The influences on the coherent longitudinal wave and the coherent shear waves were different and dependent upon the frequency range. Moreover, several imperfect interface models, i.e., the spring model, mass model, and spring-mass model, were studied numerically and compared with the interphase model, It was found that the spring model is a more suitable model than the mass model for the light and weak interphase whereas the mass model is a more suitable model than the spring model for the heavy and strong interphase.

关键词： composites effective property coherent wave interface model interphase multiple scattering

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Attenuation of peak ground accelerations from the great Wenchuan earthquake

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Earthquake Engineering and Engineering Vibration 2009年第2期8卷 179-188页

作者： Wang Dong Xie lili Institute of Engineering Mechanics China Earthquake Administration Harbin 150080 China School of Civil Engineering and Architecture Harbin Institute of Technology Harbin 150090 China

Over 800 accelerograms recorded by 272 ground-level stations during the Wenchuan earthquake are used to analyze the influence of rupture distance, local site conditions and azimuth on peak ground accelerations （PGAs）. To achieve a better understanding of the characteristics of ground motions, the spatial distributions of the EW, NS and UD components of PGAs are obtained. Comparisons between the EW and NS components, the fault-normal and fault-parallel components, and the vertical and horizontal components of PGAs are performed, and the regression formula of the vertical-to-horizontal ratio of PGAs is developed. The attenuation relationship of peak horizontal accelerations （PHAs） is compared with several contemporary attenuation relationships. In addition, an analysis of residuals is conducted to identify the potential effects of rupture distance, azimuth and site conditions on the observed values of PHAs. The analysis focuses on medium-hard soil site conditions, as they provided most of the data used in this study.

关键词： Wenchuan earthquake peak ground acceleration (PGA) attenuation rupture distance azimuth

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