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Lo.g-term o.tco.es after fractio.al flo. reserve-guided percutaneo.s co.o.ary interventio. in patients with severe co.o.ary steno.is

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Jo.rnal o. Geriatric Cardio.o.y 2019年第4期16卷 329-337页

作者： Ying-Hua ZHANG Jing LI Andreas J. Flammer Yo.hiki Matsuo.Mo.-Sik Lee Ryan J. Lenno. Malco.m R. Bell David R. Ho.mes Jo.n F. Bresnahan Charanjit S. Rihal lilach o. lerman Amir lerman Divisio. o. Cardio.o.y Xuanwu Hospital Capital Medical UniversityBeijingChina Divisio. o. Cardio.ascular Diseases Mayo ClinicRochesterUSA Cardio.ascular Center CardiologyUniversity Hospital ZurichSwitzerland Department o. Preventive Medicine Co.lege o. Medicine Konyang UniversityDaejeonSouth Korea Bio.edical Statistics Mayo ClinicRochesterUSA Divisio. o. Nephro.o.y and Hypertensio. Mayo ClinicRochesterUSA

o.jective To.explo.e the safety and efficacy o. FFR-guided percutaneo.s co.o.ary interventio. (PCI) in vessels with severe diameter steno.is. Metho.s & Results o. 1090 patients undergo.ng fractio.al flo. reserve (FFR) assessment fro. 2002 to.2009,we identified 167 patients in who. FFR was measured in at least o.e 70%–89% steno.ic lesio.. These patients were subdivided into.an FFR-defer gro.p (n = 49) if PCI was deferred (FFR > 0.80),and an FFR-perfo.m gro.p (n = 118) if PCI was perfo.med (FFR ≤ 0.80). Co.paratively,an additio.al 1176 patients undergo.ng PCI in at least o.e lesio. with 70%–89% steno.is but witho.t measurement o. FFR served as a co.tro. (angio.raphy- guided) gro.p. Clinical o.tco.es were co.pared during a median fo.lo.-up o. 49.0 mo.ths. The 5-year Kaplan-Meier estimated revascularizatio. rates were 16% in the FFR-defer gro.p and 33% in the FFR-perfo.m gro.p (P = 0.046). The incidence o. majo. adverse cardiac events were co.parable in these two.gro.ps (HR = 0.82,95% CI: 0.37–1.82,P = 0.63). The number o. stents placed was significantly lo.er in the FFR-guided gro.p (0.9 ± 0.8 vs. 1.4 ± 0.8,P o.clusio.s Functio.al revascularizatio. fo. lesio.s with visually severe steno.is is clinically safe and asso.iated with fewer stents use. This study suggests that extending the use o. FFR to.mo.e severe co.o.ary lesio.s may be reaso.able.

关键词： Fractio.al flo. reserve o.tco.e Percutaneo.s co.o.ary interventio. Severe steno.is Stent

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Augmented efficacy o. exo.eno.s extracellular vesicles targeted to.injured kidneys

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Signal Transductio. and Targeted Therapy 2020年第1期5卷 817-819页

作者： Xiao.Jun Chen Kai Jiang Christo.her M.Ferguso. Hui Tang Xiangyang Zhu Amir lerman lilach o.lerman Divisio. o. Nephro.o.y and Hypertensio. Mayo ClinicRochesterMNUSA Department o. Nephro.o.y The Second Xiangya Hospital of Central South UniversityChangshaHunanChina Department o. Cardio.ascular Diseases Mayo ClinicRochesterMNUSA

Dear Edito.,Extracellular vesicles(EVs)derived fro. mesenchymal stem/stro.al cells(MSCs)co.tain genetic and pro.ein material that stimulate tissue repair and amelio.ate injury in recipient *** o. particulate MSC-EVs o.er MSCs in treating kidney disease include better penetratio. o. injured glo.erular filtratio. barrier to.access po.o.ytes o. tubular ***,systemic EV delivery yields lo. kidney retentio. efficiency,limiting their regenerative benefits.1 Previo.sly,we co.ted adipo.e tissue-derived(AD)-MSC with antibo.ies against kidney injury mo.ecule(KIM)‐1(ab-KIM1),a pro.ein upregulated in damaged kidneys.2 Co.jugating ab-KIM1 did no. impair MSC functio. but increased their retentio. and reparative po.ency in murine renal artery steno.is(RAS).2 We hypo.hesized that ab-KIM1 co.jugatio. wo.ld similarly enhance retentio. o. exo.eno.sly delivered EVs in ischemic kidneys and co.fer superio. therapeutic benefits.

关键词： kidney retentio. sized

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“No.hing burns like the co.d”: Cardio.ascular disease in frigid zo.es

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Frigid Zo.e Medicine 2022年第3期2卷 129-131页

作者： Ben lerman lilach o.lerman Scho.l o. Medicine Saint George UniversitySt.George’sGrenada Divisio. o. Nephro.o.y and Hypertensio. Mayo ClinicRochester 55905USA

Cardio.ascular disease(CVD)is the leading cause o. death glo.ally,with the majo.ity o. the adult po.ulatio. expo.ed to.multiple traditio.al o. no.-traditio.al CVD risk facto.s[1].Amo.g the latter,bo.h acute and lengthy expo.ures to.lo. temperatures can increase cardio.ascular risk,particularly in individuals with an underlying *** link between CVD and co.d weather is reflected in a well-do.umented peak in cardio.ascular deaths during the winter mo.ths[2].Fo. example,investigato.s in Germany fo.nd that a 10°C decrease in 5-day average temperature was asso.iated with a 1.10 relative risk o. myo.ardial infarctio.[3],while in China each 1°C decrease in temperature during a co.d wave increased the mo.tality risk fro. myo.ardial infarctio. by 1.82%[4].

关键词： cardio.ascular acute mo.tality

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o.yto.in and cancer: An emerging link

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Wo.ld Jo.rnal o. Clinical o.co.o.y 2018年第5期9卷 74-82页

作者： Ben lerman Trisheena Harricharran o.o.unseun o.o.unwo.i Department o. Bio.o.ical Sciences Hunter College of the City University of New York the Graduate Center Departments o. Bio.o.y and Bio.hemistry the City University of New York Jo.n and Sanfo.d I. Weill Department o. Medicine Weill Cornell Medicine Cornell University

The neuro.eptide ho.mo.e o.yto.in, which is released fro. the po.terio. pituitary gland, is invo.ved in a number o. physio.o.ical pro.esses. Understanding o. its effects is gradually increasing due to.new research in this area. While mo.tly reco.nized as a repro.uctive system ho.mo.e, o.yto.in also.regulates o.her o.gan systems such as the brain and cardio.ascular system. Recently, research has fo.used o. unraveling its invo.vement in cancer, and emerging evidence suggests a po.ential ro.e fo. o.yto.in as a cancer bio.arker. This review summarizes o.servatio.s linking o.yto.in and cancer, with a special emphasis o. pro.tate cancer, where it may pro.o.e cell pro.iferatio.. Research suggests that o.yto.in effects may depend o. cell type, co.centratio. o. the ho.mo.e, its interactio.s with o.her ho.mo.es in the micro.nviro.ment, and the precise lo.alizatio. o. its recepto. o. the cell membrane. Future research is needed to.further elucidate the invo.vement o. o.yto.in in cancer, and whether it co.ld be a clinical cancer bio.arker o. therapeutic target.

关键词： o.yto.in Cancer Pro.tate Pancreas Exercise

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Micro.RNAs Regulate Metabo.ic Syndro.e-induced Senescence in Adipo.e Tissue-derived Mesenchymal Stem Cells o. thro.gh P16/MAPK Pathway

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临床医学工程 2017年第S1期24卷 48-48页

作者： Yu Meng Alfo.so.Eirin lilach o.lerman Divisio.s o. Nephro.o.y and Hypertensio. Mayo Clinic Department o. Nephro.o.y the First Hospital Affiliated to Jinan University

Backgro.nd Mesenchymal stem cells(MSC)co.stitute an impo.tant repair system,but may be impaired by expo.ure to.cardio.ascular risk ***,adipo.e tissue-derived MSCs fro. pigs with the metabo.ic syndro.e(Met S)sho. decreased vitality.A gro.ing number o. micro.RNAs(mi RNAs)are reco.nized as key mo.ulato.s o. senescence,but their ro.e in regulating senescence in MSC in Mets is *** tested the hypo.hesis that Met S upregulates in MSC expressio. o. mi RNAs that can serve as po.t-transcriptio.al regulato.s o. senescence-asso.iated(SA)*** MSCs were co.lected fro. swine abdo.inal adipo.e tissue after 16 weeks o. Lean o. o.ese diet(n=6 each).Next-generatio. mi RNA sequencing(mi RNA-seq)was perfo.med to.identify mi RNAs up-o. do.n-regulated in Met S-MSC co.pare to.*** pathway analysis o. SA genes targeted by mi RNAs was perfo.med using gene o.to.o.y *** senescence was evaluated by p16 and p21 immuno.eactivity,H2AX pro.ein expressio.,and SA-beta-Galacto.idase *** additio.,gene expressio. o. p16,p21,MAPK3,and MAPK14 was studied after inhibitio. o. SA-mi *** Senescence bio.arkers were significantly elevated in Met S *** fo.nd the 7 upregulated mi RNAs,including mi R-27b,and 3 do.nregulated mi RNAs in Met S-MSCs,which regulate 35 SA genes,particularly MAPK *** o. mi R-27b in cultured MSC do.nregulated p16 and MARP3 *** Met S mo.ulate MSC expressio. o. SA-mi RNAs that may play the ro.e in mo.ulating their senescence,and the p16 pathway in Met S-MSCs senescence is the primary pathway.

关键词： Mesenchymal stem cells Senescence Micro.RNA Metabo.ic syndro.e

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肾素-血管紧张素系统阻滞剂和阿司匹林协同治疗可减少颈动脉斑内核因子κB活化和C反应蛋白的表达

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世界核心医学期刊文摘（神经病学分册） 2005年第5期1卷 60-61页

作者： Sattler K.J.E. Wo.drum J.E. Galili o. A. lerman 雷翀 Divisio. o. Card io.ascular Diseases Mayo Clinic Rochester 200 First Street SW Rochester MN 5 5905 United States Dr.

Backgro.nd and Purpo.e -The lo.al renin-angio.ensin system (RAS) and cycl o.xygenase-2 co.tribute to.the activatio. o. nuclear facto. κ B(NFκ B) and C -reactive pro.ein (CRP). We hypo.hesized that the co.binatio. o. RAS blo.kers (RASb) and ASA reduces NFκ B and CRP within athero.clero.ic plaques . Metho.s -Patients undergo.ng caro.id endarterecto.y were divided into.gro.ps acco.ding to.treatment (RASb-acetylsalicylic acid [ASA], ASA, RASb, and co.tr o.). The expressio. o. NFκ B, CRP, and CD40L was analyzed thro.gh Western blo.s in the o.tained plaques. Results -Plaques fro. patients treated with the co.b inatio. o. RASb and ASA sho.ed lo.er expressio. o. NFκ B (25.4± 9.8 densito.et ric units [DU]) than tho.e o. the co.tro. gro.p (57.6± 13.2 DU, P=0.03) as well as lo.er expressio. o. CRP (20.9± 9.6 DU) than tho.e o. the o.her treatment gr o.ps (ASA 86.1± 13 DU, RASb 88.4± 31 DU, co.tro.s 67.8± 18.6, P=0.004). A neg ative expressio. o. NFκ B was asso.iated with a reduced incidence o. sympto.s c o.pared with a po.itive expressio. (5/33 [15.1% ] versus 14/35 [40% ], P=0.031 ). Co.clusio.s -The co.bined treatment with RASb and ASA decreases the express io. o. inflammato.y markers in athero.clero.is in humans. This study suppo.ts th e ro.e o. the lo.al RAS and cyclo.xygenase-2 in the pro.ressio. o. athero.cler o.is.

关键词： C反应蛋白阻滞剂粥样硬化斑块环氧化酶免疫印迹进展过程阴性患者症状发生率

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利用CT检测人体单肾肾小球滤过率

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国际医学放射学杂志 2015年第5期 482-483页

作者： S.H.Kwo. A.Saad S.M.Herrmann S.C.Texto. L.o.lerman 范淑璇 Divisio. o. Nephro.o.y and Hypertensio. Mayo Clinic

摘要目的检测利用64层CT推导出人体单肾肾小球滤过率(GFR)与通过碘对比剂清除率得到的数值一致这一假设,并以碘对比剂清除率作为参考标准。材料与方法伦理委员会批准本项符合HIPAA的研究,并获得了知情同意书。在受控条件下(包括钠摄取... 详细信息

摘要目的检测利用64层CT推导出人体单肾肾小球滤过率(GFR)与通过碘对比剂清除率得到的数值一致这一假设,并以碘对比剂清除率作为参考标准。材料与方法伦理委员会批准本项符合HIPAA的研究,并获得了知情同意书。在受控条件下(包括钠摄取及肾素-血管紧张素受阻)前

关键词：单肾 GFR 孤立肾碘对比剂肾小球肾单位 CT 滤过

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肾脏灌注和血流动力学:应用10%辐射剂量及HYPR降噪技术进行精确的活体CT测量

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国际医学放射学杂志 2009年第6期 584-584页

作者： A.N.Primak J.D.Krier L.o.lerman C.H.McCo.lo.gh 王霁胐 CT Clinical Inno.atio. Center Department of RadiologyMayo Clinic200 First St SWRochesterMN 55905USA

目的应用常规剂量的10%的低剂量图像采集及HYPR-局部重建(LR)降噪后处理技术行肾脏CT灌注成像,前瞻性研究此方法检测肾脏血流动力学和肾功能的准确性。材料与方法本研究经过动物保护和实验委员会批准。对10只麻醉后的猪分别进行常规剂量

关键词：血流动力肾脏 LR HYPR 常规剂量活体 CT

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